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| 1 | 长爪沙鼠的遗传多样性分析显示文摘利用17个微卫星DNA标记对Z:ZCLA长爪沙鼠封闭群、野生群和近交系进行遗传多样性分析,评估群体内的遗传变异和群体间的遗传分化。结果表明:在Z:ZCLA封闭群和野生群中共有9个微卫星DNA标记获得稳定的结果,分别为AF200940、AF200941、AF200942、AF200945、AF200946、AF200947、D11Mit128、PKC和SCN,共检测到41个等位基因,每个基因的等位基因数从1~7不等,片段大小在120~283bp之间,所有位点的平均期望杂合度(He)和多态信息含量(PIC)值分别为0.5032和0.4656,Z:ZCLA封闭群和野生群9个微卫星位点平均有效等位基因数分别为2.78和2.89,平均基因杂合度分别为0.3704和0.3893,平均多态信息含量分别为0.3256和0.3344,两个群体都表现为中度多态,Z:ZCLA封闭群较野生群稍低;在3个近交系中共有8个位点获得稳定的扩增结果,分别为AF200941、AF200942、AF200945、AF200946、AF200947、D11Mit128、PKC和SCN,共检测到11个等位基因,片段大小在140~241bp之间,其中5个位点在群体内表现为单态纯合,3个位点在群体内表现为单态杂合,所有位点在群体内和群体间均呈单态性,表明这3个长爪沙鼠品系基本符合近交系的要求,微卫星标记技术适用于近交系长爪沙鼠的遗传检测。 | 丁贤明 钱宝珍 Matsuda Junichiro Koura Minako 萨晓婴 施张奎 | 2008 | 遗传2008，30，7： | 16 |
| 2 | Machine-learning-assisted discovery of polymers with high thermal conductivity using a molecular design algorithm显示文摘The use of machine learning in computational molecular design has great potential to accelerate the discovery of innovative materials.However,its practical benefits still remain unproven in real-world applications,particularly in polymer science.We demonstrate the successful discovery of new polymers with high thermal conductivity,inspired by machine-learning-assisted polymer chemistry.This discovery was made by the interplay between machine intelligence trained on a substantially limited amount of polymeric properties data,expertise from laboratory synthesis and advanced technologies for thermophysical property measurements.Using a molecular design algorithm trained to recognize quantitative structure—property relationships with respect to thermal conductivity and other targeted polymeric properties,we identified thousands of promising hypothetical polymers.From these candidates,three were selected for monomer synthesis and polymerization because of their synthetic accessibility and their potential for ease of processing in further applications.The synthesized polymers reached thermal conductivities of 0.18–0.41 W/mK,which are comparable to those of state-of-the-art polymers in non-composite thermo-plastics. | Stephen Wu Yukiko Kondo Masa-aki Kakimoto Bin Yang Hironao Yamada Isao Kuwajima Guillaume Lambard Kenta Hongo Yibin Xu Junichiro Shiomi Christoph Schick Junko Morikawa Ryo Yoshida | 2019 | npj Computational Materials2019，，1： | 14 |
| 3 | Characteristics of gas evolution profiles during coal pyrolysis and its relation with the variation of functional groups显示文摘Strict relation between the substituents or functional groups attached to the coal macromolecules and the generation of the volatile products, e.g., CH4 H2O, CO, CO2, etc., during the coal pyrolysis is an important but confusing subject. In this paper, quadrupole mass spectronletry, gas chromatography, and ^l3C nuclear magnetic resonance are applied to real-time monitoring the formations of volatile products, off-line quantitative determination of the total products from the pyrolysis of a sub-bituminous coal (SC), and the changes of diverse substitents in the SC along with coke foamation, respectively. These measurements are also performed for the pyrolysis of a caking coal to contrast SC. The qualitative and quantitative data reveal that, during coal pyrolysis, the functional groups related with the formation of CO, i.e., ether, carbonyl, and anhydride, can directly gen erate CO via bond breaking, or take a detour of the formation of other intermediates via condensation and recombination firstly. Moreover, the formations of CO2 and CH4 are related to the direct removal of -COO- and -CH3,respectively. | Lu Zhang Shichao Qi Norihiro Takeda Shinji Kudo Junichiro Hayashi Koyo Norinaga | 2018 | International Journal of Coal Science & Technology2018，5，4： | 7 |
| 4 | Nomograms for colorectal cancer:A systematic review显示文摘AIM: To assist in the selection of suitable nomograms for obtaining desired predictions in daily clinicalpractice.METHODS: We conducted electronic searches for journal articles on colorectal cancer(CRC)-associated nomograms using the search terms colon/rectal/colorectal/nomogram. Of 174 articles initially found, we retrieved 28 studies in which a nomogram for CRC was developed.RESULTS: We discuss the currently available CRCassociated nomograms, including those that predict the oncological prognosis, the short-term outcome of treatments, such as surgery or neoadjuvant chemoradiotherapy, and the future development of CRC. Developing nomograms always presents a dilemma. On the one hand, the desire to cover as wide a patient range as possible tends to produce nomograms that are too complex and yet have C-indexes that are not sufficiently high. Conversely, confining the target patients might impair the clinical applicability of constructed nomograms.CONCLUSION: The information provided in this review should be of use in selecting a nomogram suitable for obtaining desired predictions in daily clinical practice. | Kazushige Kawai Eiji Sunami Hironori Yamaguchi Soichiro Ishihara Shinsuke Kazama Hiroaki Nozawa Keisuke Hata Tomomichi Kiyomatsu Junichiro Tanaka Toshiaki Tanaka Takeshi Nishikawa Joji Kitayama Toshiaki Watanabe | 2015 | World Journal of Gastroenterology2015，21，41： | 5 |
| 5 | Effect of herbal medicine Juzentaihoto on hepatic and intestinal heat shock gene expression requires intestinal microflora in mouse显示文摘AIM: To evaluate the role of intestinal microflora in the effects of multi-herbal medicine on gene expression in the gut and liver. METHODS: The multi-herbal medicine Juzentaihoto (JTX) was administered to five germ-free mice and regular mice for 2 wk. Among the results of the comprehensive gene chip analysis of the intestine and liver, we featured heat shock proteins (HSPs) 70 and 105 because their gene expression changed only in the presence of microflora. Real-time RT-PCR was performed to confirm the expression levels of these HSP genes. To determine whether JTX acts directly on the HSP genes, sodium arsenite (SA) was used to induce the heat shock proteins directly. To examine the change of the intestinal microflora with administration of JTX, the terminal restriction fragment polymorphism (T-RFLP) method was used. To identify the changed bacteria, DNA sequencing was performed. RESULTS: Heat shock protein gene expression,documented by gene chip and real-time RT-PCR, changed with the administration of JTX in the regular mice but not in the germ-free mice. JTX did not suppress the direct induction of the HSPs by SA. T-RFLP suggested that JTX decreased unculturable bacteria and increased Lactobacillus johnsoni. These data suggested that JTX changed the intestinal microflora which, in turn, changed HSP gene expression. CONCLUSION: Intestinal microflora affects multi-herbal product JTX on the gene expression in the gut and liver. | Miho Kato Atsushi Ishige Naoko Anjiki Masahiro Yamamoto Yoshifumi Irie Mitsue Taniyama Ryoko Kibe Junichiro Oka Yoshimi Benno Kenji Watanabe | 2007 | World Journal of Gastroenterology2007，13，16： | 5 |
| 6 | Serum Neutrophil Gelatinase-associated Lipocalin(NGAL)Is Elevated in Patients with Asthma and Airway Obstruction显示文摘Neutrophilic airway inflammation is one of the features of severe asthma.Neutrophil gelatinase-associated lipocalin(NGAL),or lipocalin-2,is a glycoprotein associated with neutrophilic inflammation and can be detected in blood.Recently,blood NGAL levels have been reported to be elevated in chronic obstructive pulmonary disease.However,the clinical significance of serum NGAL levels in patients with asthma has not been elucidated.The aim of this study was to explore the association between serum NGAL level and clinical parameters in patients with asthma.Sixty.one non-smoking people with stable asthma were enrolled in this study.All patients underwent blood ollction and pulmonary function tests.The associations between serum NGAL levels and clinical parameters were analyzed retrospectively.Serum NGAL levels in patients with asthma and obstructive ventilatory defect were higher than those in patients with asthma without obstructive ventilatory defect(76.4±51.4 ng/mL vs.39.3±27.4 ng/mL,P=0.0019).Serum NGAL levels were correlated with forced expired flow at 50%of vital capacity%predicted and forced expired flow at 75%of vital capacity%predicted(r=-0.3373,P=0.0078 and r=0.2900,P=0.0234,respectively).Results of a multiple regression analysis demonstrated that serum NGAL level was independently associated with obstructive ventilatory defect.Serum NGAL levels were elevated in patients with asthma and obstructive ventilatory defect.NGAL may be involved in airway remodeling possibly mediated by neutrophilic inflammation in asthma. | Junichiro Kawagoe Yuta Kono Yuki Togashi Mayuko Ishiwari Kazutoshi Toriyama Chika Yajima Hideaki Nakayama Satoshi Kasagi Shinji Abe Yasuhiro Setoguchi | 2021 | Current Medical Science2021，41，2： | 5 |
| 7 | Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study显示文摘 | Narikazu Boku Seiichiro Yamamoto Haruhiko Fukuda Kuniaki Shirao Toshihiko Doi Akira Sawaki Wasaburo Koizumi Hiroshi Saito Kensei Yamaguchi Hiroya Takiuchi Junichiro Nasu Atsushi Ohtsu | 2009 | Lancet Oncology2009，，11： | 5 |
| 8 | Breakthrough therapy for peritoneal carcinomatosis of gastric cancer:Intraperitoneal chemotherapy with taxanes显示文摘The effect of chemotherapy on peritoneal carcinomatosis(PC) of gastric cancer remains unclear.Recently,the intraperitoneal(IP) administration of taxanes [e.g.,paclitaxel(PTX) and docetaxel(DOC)] during the perioperative period has shown promising results.Herein,we summarized the rationale and methodology for using IP chemotherapy with taxanes and reviewed the clinical results.IP administered taxanes remain in the IP space at an extremely high concentration for 48-72 h.The drug directly infiltrates peritoneal metastatic nodules from the surface and then produces antitumor effects,making it ideal for IP chemotherapy.There are two types of perioperative IP chemotherapy with taxanes: neoadjuvant intraperitoneal and systemic chemotherapy and sequential perioperative intraperitoneal chemotherapy(SPIC).In SPIC,patients receive neoadjuvant IP chemotherapy and the same regimen of IP chemotherapy after cytoreductive surgery(CRS) until disease progression.Usually,a taxane dissolved in 500-1000 m L of saline at ordinary temperature is administered through an IP access port on an outpatient basis.According to phase Ⅰ?studies,the recommended doses(RD) are as follows: IP DOC,45-60 mg/m2; IP PTX [without intravenous(IV) PTX],80 mg/m2; and IP PTX(with IV PTX),20 mg/m2.Phase Ⅱ studies have reported a median survival time of 14.4-24.6 mo with a 1-year overall survival of 67%-78%.A phase Ⅲ study comparing S-1 in combination with IP and IV PTX to S-1 with IV cisplatin started in 2011.The prognosis of patients who underwent CRS was better than that of those who did not; however,this was partly due to selection bias.Although several phase Ⅱ studies have shown promising results,a randomized controlled study is needed to validate the effectiveness of IP chemotherapy with taxanes for PC of gastric cancer. | Hironori Yamaguchi Joji Kitayama Hironori Ishigami Shinsuke Kazama Hiroaki Nozawa Kazushige Kawai Keisuke Hata Tomomichi Kiyomatsu Toshiaki Tanaka Junichiro Tanaka Takeshi Nishikawa Kensuke Otani Koji Yasuda Soichiro Ishihara Eiji Sunami Toshiaki Watanabe | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 3 |
| 9 | Intestinal anisakiasis can cause intussusception in adults:An extremely rare condition显示文摘We report an extremely rare case of adult intussusception caused by anisakiasis. A 41-year-old man was admitted into our hospital for right lower abdominal colicky pain. Ultrasonography and computed tomography revealed the presence of intussusception. As pneumodynamic resolution by colonoscopy failed, surgery was performed. The anisakis body was found in the submucosal layer of the resection specimen. The patient was discharged 9 d after the operation. Anisakiasis may cause intussusception in any country where sushi or sashimi now exists as a popular food. If suspicious, detailed clinical interview as to food intake prior to symptom development is crucial. | Tomofumi Miura Akira Iwaya Takao Shimizu Junpei Tsuchiya Junichiro Nakamura Satoshi Yamada Tsutomu Miura Masahiko Yanagi Hiroyuki Usuda Iwao Emura Toru Takahashi | 2010 | World Journal of Gastroenterology2010，16，14： | 3 |
| 10 | 三菱重工地面燃气轮机热障涂层研究进展显示文摘燃气轮机联合循环热效率的提高,要求涡轮进口温度不断增加。目前,三菱重工(MHI)已经积极参与日本国家项目,通过发展1700℃级燃气轮机,以使联合循环热效率实现达到62%指标。在此国家项目中开发的部分组件技术适用于1600℃级燃气轮机M501J,它具有世界上最高的涡轮进口温度。而热障涂层(TBC)是实现此目标的最关键技术之一。在发展先进的热障涂层中,在MHI工厂中建立名为T点的试验电厂是有必要的。在真实热部件中制备的先进TBC可以在工厂中进行验证,并且运行后的效果可以得到反馈。本文讨论了TBC的开发以及在三菱重工实际电厂中的验证。 | Yoshifumi Okajima Daisuke Kudo Naotoshi Okaya Taiji Torigoe Hideaki Kaneko Masahiko Mega Eisaku Ito Junichiro Masada Keizo Tsukagoshi 吴琼 | 2014 | 热喷涂技术2014，，3： | 2 |
| 11 | TTF-1 is useful for primary site determination in duodenal metastasis显示文摘We report here on a case of duodenal metastasis from primary lung adenocarcinoma. A 69-year old man was diagnosed with primary lung adenocarcinoma. Four courses of combined chemotherapy with carboplatin and paclitaxel associated with irradiation of 60 Gy shrunk the lung tumor. However, soon after,the para-aortic lymph node became swollen. Esophagogastroduodenoscopy revealed three duodenal tumors. Differential diagnosis between malignant lymphoma and metastatic duodenal cancer was endoscopically difficult. The histology of biopsied specimens was poorly differentiated adenocarcinoma. Immunohistochemical analysis revealed a positive reaction for thyroid transcription factor-1 (TTF-1). Thus, we concluded that these were metastatic duodenal tumors from lung adenocarcinoma. Two courses of gemcitabine led to a complete remission in this duodenal metastasisand para-aortic lymph node swelling with only scarring remaining in computed tomography. He is now on the continuous generalized chemotherapy. In conclusion, duodenal metastasis from primary lung adenocarcinoma is rare and hard to diagnose. In such an instance, TTF-1 immunostaining is crucial to obtain the correct diagnosis. | Tomofumi Miura Yuichi Shimaoka Junichiro Nakamura Satoshi Yamada Tsutomu Miura Masahiko Yanagi Kazuhiro Sato Hiroyuki Usuda Iwao Emura Toru Takahashi | 2010 | World Journal of Gastrointestinal Oncology2010，2，9： | 2 |
| 12 | Masking Agents in the Spectrophotometric Determination of Metal Ions with 2-(5-Bromo-2-Pyridylazo)-5-Diethylaminophenol and Non-ionic Surfactant显示文摘 | Junichiro Miura | 1989 | Analyst1989，114，10： | 2 |
| 13 | Effects of scheduling and ascites-associated macrophages on combined antiproliferative activity of alpha-2b interferon and gamma-interferon in a clonogenic assay显示文摘 | Junichiro Higashihara Toshiaki Saito Michael E. Berens Charles E. Welander | 1988 | Cancer Chemotherapy and Pharmacology1988，，3： | 2 |
| 14 | RadonPy:automated physical property calculation using all-atom classical molecular dynamics simulations for polymer informatics显示文摘The spread of data-driven materials research has increased the need for systematically designed materials property databases.However,the development of polymer databases has lagged far behind other material systems.We present RadonPy,an open-source library that can automate the complete process of all-atom classical molecular dynamics(MD)simulations applicable to a wide variety of polymeric materials.Herein,15 different properties were calculated for more than 1000 amorphous polymers.The MD-calculated properties were systematically compared with experimental data to validate the calculation conditions;the bias and variance in the MD-calculated properties were successfully calibrated by a machine learning technique.During the high-throughput data production,we identified eight amorphous polymers with extremely high thermal conductivity(>0.4 W∙m^(–1)∙K^(–1))and their underlying mechanisms.Similar to the advancement of materials informatics since the advent of computational property databases for inorganic crystals,database construction using RadonPy will promote the development of polymer informatics. | Yoshihiro Hayashi Junichiro Shiomi Junko Morikawa Ryo Yoshida | 2022 | npj Computational Materials2022，，1： | 2 |
| 15 | Tunable Separation of Single-Walled Carbon Nanotubes by Dual-Surfactant Density Gradient Ultracentrifugation显示文摘我们在场在由密度坡度 ultracentrifugation (DGU ) 的围单人赛的碳 nanotubes (SWNT ) 的分离的表面活化剂的效果的系统的研究。通过快活的密度,层位置,和用胆汁盐钠 deoxycholate (文档) 和 anionic 的 SWNT 分离的光吸收度系列的分析腌钠 dodecyl 硫酸盐(SDS ) ,我们在产出不同 DGU 结果澄清这二表面活化剂的角色和相互作用。这里描述的分离机制能也在由预言不同开始的配方的结果的品质上设计新 DGU 实验帮助,改进 DGU 的功效并且简化 post-DGU 分别。 | Pei Zhao Erik Einarsson Georgia Lagoudas Junichiro Shiomi Shohei Chiashi Shigeo Maruyama | 2011 | Nano Research2011，4，7： | 2 |
| 16 | Time-domain terahertz spectroscopy in high magnetic fields显示文摘There are a variety of elementary and collective terahertz-frequency excitations in condensed matter whose magnetic field dependence contains significant insight into the states and dynamics of the electrons involved.Often,determining the frequency,temperature,and magnetic field dependence of the optical conductivity tensor,especially in high magnetic fields,can clarify the microscopic physics behind complex many-body behaviors of solids.While there are advanced terahertz spectroscopy techniques as well as high magnetic field generation techniques available,a combination of the two has only been realized relatively recently.Here,we review the current state of terahertz time-domain spectroscopy(THz-TDS)experiments in high magnetic fields.We start with an overview of time-domain terahertz detection schemes with a special focus on how they have been incorporated into optically accessible high-field magnets.Advantages and disadvantages of different types of magnets in performing THz-TDS experiments are also discussed.Finally,we highlight some of the new fascinating physical phenomena that have been revealed by THz-TDS in high magnetic fields. | Andrey BAYDIN Takuma MAKIHARA Nicolas Marquez PERACA Junichiro KONO | 2021 | Frontiers of Optoelectronics2021，14，1： | 2 |
| 17 | Carbon-supported AuPd bimetallic nanoparticles synthesized by high-energy electron beam irradiation for direct formic acid fuel cell显示文摘 | Yuji Ohkubo Masashi Shibata Satoru Kageyama Satoshi Seino Takashi Nakagawa Junichiro Kugai Hiroaki Nitani Takao A. Yamamoto | 2013 | Journal of Materials Science2013，，5： | 2 |
| 18 | Study on an Undershot Cross-Flow Water Turbine显示文摘This study aims to develop a water turbine suitable for ultra-low heads in open channels, with the end goal being the effective utilization of unutilized hydroelectric energy in agricultural water channels. We performed tests by applying a cross-flow runner to an open channel as an undershot water turbine while attempting to simplify the structure and eliminate the casing. We experimentally investigated the flow fields and performance of water turbines in states where the flow rate was constant for the undershot cross-flow water turbine mentioned above. In addition, we compared existing undershot water turbines with our undershot cross-flow water turbine after attaching a bottom plate to the runner. From the results, we were able to clarify the following. Although the effective head for cross-flow runners with no bottom plate was lower than those found in existing runners equipped with a bottom plate, the power output is greater in the high rotational speed range because of the high turbine efficiency. Also, the runner with no bottom plate differed from runners that had a bottom plate in that no water was being wound up by the blades or retained between the blades, and the former received twice the flow due to the flow-through effect. As a result, the turbine efficiency was greater for runners with no bottom plate in the full rotational speed range compared with that found in runners that had a bottom plate. | Yasuyuki Nishi Terumi Inagaki Yanrong Li Ryota Omiya Junichiro Fukutomi | 2014 | Journal of Thermal Science2014，23，3： | 2 |
| 19 | Performance and Internal Flow of Cross-Flow Fan with Inlet Guide Vane 显示文摘 | junichiro Fukutomi Rei Nakamura | 2005 | JSME International Journal2005，48，4： | 1 |
| 20 | Damping properties of building in Japan 显示文摘 | Kenichi Suda Naoki Satake Junichiro Ono Atsushi Sasaki | 1996 | Journal of Wind Engineering and Industrial Aerodynamics1996，59，： | 1 |
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