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| 1 | LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer显示文摘Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with NPC.We prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth weeks.Specific responses to LMP2 were detected by enzyme-linked immunospot(ELISPOT)assay at week 0 and at the fifth and eighth weeks.Local clinicians performed the follow-up and tracking of patients.Results We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical assay.Twenty-nine patients with NPC were enrolled in this clinical trial.The LMP2-DCs vaccine was well tolerated in all of the patients.Boosted responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with NPC.The follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in non-responders.Conclusion In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with NPC.Specific CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing. | ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan ZHOU Ling TANG Min Zhong SJ O`Brien LAN Jiao ZHOU Xiang Yang WANG Yong Li TANG Juan ZHOU Zhi Xiang DU Hai Jun LIN Hui | 2020 | Biomedical and Environmental Sciences2020，33，11： | 2 |
| 2 | Expression of 11β-hydroxysteroid dehydrogenase 1 and 2 in patients with chronic rhinosinusitis and their possible contribution to local glucocorticoid activation in sinus mucosa显示文摘 | Jun YJ Park SJ Kim TH | 2014 | J Allergy Clin Immunol2014，134，4： | 1 |
| 3 | Effect of noradrenaline on the spontaneous contraction and ionic current in the antral circular muscle of guinea-pig stomach显示文摘 | Jun JY Lee SJ Kim SJ | 1993 | Kor J Physiol1993，27，2： | 1 |
| 4 | Region-specific phosphorylation of ERK5-MEF2C in the rat frontal cortex and hippocampus after electroconvulsive shock显示文摘 | Yoon SC Ahn YM Jun SJ | 2005 | Prog Neuropsychopharmacol Biol Psychiatry2005，29，5： | 1 |
| 5 | Fucosterol is a selective liver X receptor modulator that regulates the expression of key genes in cholesterol homeostasis in macrophages,hepatocytes,and intestinal cells显示文摘 | Hoang MH Jia Y Jun HJ Lee JH Lee BY Lee SJ | | 0，，46： | 1 |
| 6 | Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells显示文摘 | Hoang MH Jia Y Jun H J Lee JH Lee DH Hwang BY Kim WJ Lee HJ Lee SJ | | 0，，12： | 1 |
| 7 | Cyanidin,a natural flavonoid,is an agonistic ligand for liver X receptor α and β and reduces cellular lipid accumulation in macrophages and hepatocytes显示文摘 | Jia Y Hoang MH Jun H J Lee JH Lee SJ | | 0，，14： | 1 |
| 8 | Induction of ABCA1 and ABCG1 expression by the liver X receptor modulator cineole in macrophages显示文摘 | Jun H J Hoang MH Yeo SK Jia Y Lee SJ | | 0，，02： | 1 |
| 9 | Taurine is a liver X receptor-α ligand and activates transcription of key genes in the reverse cholesterol transport without inducing hepatic lipogenesis显示文摘 | Hoang MH Jia Y Jun HJ Lee JH Hwang KY Choi DW Um S J Lee BY You SG Lee SJ | | 0，，06： | 1 |
| 10 | Serum YKL-40 levels correlate with infarct volume,stroke severity,and functional outcome in acute ischemic stroke patients显示文摘 | Park HY Jun CD Jeon SJ | 2012 | PLoS One2012，7，51： | 1 |
| 11 | The clinical characteristics and risk factors for the adjacet segment degeneration in instrumented lumbar fusion显示文摘 | Jun HM Jee SJ Byung Joo J | 2008 | Spinal Disord Tech2008，5，： | 1 |
| 12 | Comparative in vitro activities of car- bapenem antimicrobial agents against 264 penicillin-resistant Strepta- coccus pneumoniae isolates from Korea 显示文摘 | Choi SH Park SJ Jun JB | 2007 | Diagn Microbiol Infect Dis2007，58，1： | 1 |
| 13 | Antibacterial and biofilm removal activity of a podoviridae Staphylococcus aureus bacteriophage SAP-2 and a derived recombinant eell-wall-dagrading enzyme 显示文摘 | Son JS Lee SJ Jun SY | 2010 | Appl Mierobiol Bioteehnol2010，86，5： | 1 |
| 14 | Region - specific Phosphorylation of ERK5 - MEF2C in the Rat Frontal Cortex and Hippocampus after Elec- troconvulsive Shock 显示文摘 | Yoon SC Ahn YM Jun SJ | 2005 | Ping Neuropsychopharmacol Biol Psychia try2005，29，5： | 1 |
| 15 | Endogenous production of hydrogen sulfide in human sinus mucosa and its expressionlevels are altered in patients with chronic rhinosinusitis with and without nasal polyps显示文摘 | Hwang JW Jun YJ Park SJ | 2014 | Am J Rhinol Allergy2014，28，1： | 1 |
| 16 | Comparative in vitro activities of carbapenem antimicrobial agents against 264 penicillin-resistant Streptococcus pneumoniae isolates from Korea 显示文摘 | Choi SH Park SJ Jun JB Lee SR Jeon MH Kwon HH | 2007 | Diagn Microbiol Infect Dis2007，58，1： | 1 |
| 17 | Region-specific phosphorylafion of ERKS-MEF2C in the rat frontal codex and hippocampus after electroconvulsive shock 显示文摘 | Yoon SC Alan YM Jun sJ | 2005 | Ping Neuro-psychopharmacol Biol Psychiatry2005，29，5： | 1 |
| 18 | Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor显示文摘 | CAMMETT TJ JUN SJ COHEN EB | 2010 | Proc Natl Acad Sci USA2010，107，8： | 1 |
| 19 | Preclinical safety evaluationof intravenously administered SAL200 containing the recombinantphage andolysin SAL-1 as a pharmaceutical ingredient 显示文摘 | Jun SY Jung GM Yoon SJ | 2014 | Antimicrob Agents Chemother2014，58，4： | 1 |
| 20 | The clinical characteristics and risk factors for the adjacent segment degeneration in instrumented lumbar fusion显示文摘 | Jun HM Jee SJ Byung Joo J | 2008 | J Spinal Disord Tech2008，21，5： | 1 |
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