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| 1 | Restoration of common bile duct diameter within 2 weeks after endoscopic stone retraction is a preventive factor for stone recurrence显示文摘Background: Little information is available about the relationship between restoration of common bile duct(CBD) diameter after endoscopic stone retraction and recurrence of CBD stones in elderly patients.The present study was to determine whether restoration of CBD diameter is a preventive factor for CBD stone recurrence in elderly patients who underwent endoscopic retrograde cholangiopancreatography(ERCP).Methods: From January 2006 to December 2010, 238 patients underwent the first and the second session of ERCP for the removal of CBD stones. Among them, 173 were over 65 years old. These patients were divided into recurrent group and non-recurrent group. Restoration of CBD diameter and patients' characteristics were compared.Results: There was no statistical difference in patients' characteristics, associated diseases, or ERCP-related complications between the two groups. Reduction of CBD diameter was significantly larger in the nonrecurrent group(2.7 ± 1.7 mm) compared to that in the recurrent group(1.4 ± 2.3 mm, P = 0.002). The proportion of patients with restoration of CBD diameter were significantly lower in the recurrent group(6/42, 14.3%) compared with that in the non-recurrent group(67/131, 51.1%)(P < 0.01).Conclusions: There is an inverse relationship between restoration of CBD diameter and CBD stone recurrence. Therefore, patients without restoration of CBD diameter within 2 weeks after endoscopic stone removal should be monitored more frequently. | Jin Jeon Sung Uk Lim Chang-Hwan Park Chung-Hwan Jun Seon-Young Park Jong-Sun Rew | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，3： | 25 |
| 2 | Proton pump inhibitor administration delays rebleeding after endoscopic gastric variceal obturation显示文摘AIM:To clarify the efficacy of proton pump inhibitors(PPIs)after endoscopic variceal obturation(EVO)with N-butyl-2-cyanoacrylate.METHODS:A retrospective study was performed on16 liver cirrhosis patients with gastric variceal bleeding that received EVO with injections of N-butyl-2-cyanoacrylate at a single center(Kyung Hee University Hospital at Gangdong)from January 2008 to December 2012.Medical records including patient characteristics and endoscopic findings were reviewed.Treatment results,liver function,serum biochemistry and cirrhosis etiology were compared between patients receiving PPIs and those that did not.Furthermore,the rebleeding interval was compared between patients that received PPI treatment after EVO and those who did not.RESULTS:The patient group included nine males and seven females with a mean age of 61.8±11.7years.Following the EVO procedure,eight of the 12patients that received PPIs and three of the four nonPPI patients experienced rebleeding.There were no differences between the groups in serum biochemistry or patient characteristics.The rebleeding rate was not significantly different between the groups,however,patients receiving PPIs had a significantly longer rebleeding interval compared to non-PPI patients(22.2±11.2mo vs 8.5±5.5 mo;P=0.008).The duration of PPI use was not related to the rebleeding interval.A total of six patients,who had ulcers at the injection site,exhibited a shorter rebleeding interval(16.8±5.9 mo)than patients without ulcers(19.9±3.2 mo),though this difference was not statistically significant.CONCLUSION:PPI therapy can extend the rebleeding interval,and should therefore be considered after EVO treatment for gastric varices. | Won Seok Jang Hyun Phil Shin Joung Ⅱ Lee Kwang Ro Joo Jae Myung Cha Jung Won Jeon Jun Uk Lim | 2014 | World Journal of Gastroenterology2014，20，45： | 17 |
| 3 | Retrospective analysis of extra-gastrointestinal stromal tumors显示文摘AIM:To investigate the clinicopathologic features of patients with extra-gastrointestinal stromal tumors(EGISTs)in South Korea.METHODS:A total of 51 patients with an EGIST were identified.The clinicopathologic features,including sex,age,location,tumor size,histology,mitotic rate,immunohistochemical features,genetic status and survival data,were analyzed.RESULTS:The median age was 55 years(range:29-80years),and male:female ratio was 1:1.04.The most common site was in the mesentery(n=15)followed by the retroperitoneum(n=13)and omentum(n=8).The median tumor size was 9.0 cm(range:2.6-30.0cm)and the median mitotic rate was 5.0/50HPF.(1/50-185/50).KIT was analyzed in 16,which revealed 10cases with wild-type KIT and 6 cases with an exon 11mutation.Among 51 patients,31 patients had undergone surgery,and 10 had unresectable disease and had taken palliative imatinib,which resulted in 22.7 mo of progression-free survival.Of the patients who had undergone surgery,18 did not take adjuvant imatinib,and 8 of these were categorized as'high risk'according to the risk criteria.However,the relapse-free survival was not different(P=0.157)between two groups.CONCLUSION:Because the biologic behaviors of GISTs differ according to the location of the tumor,a more stratified strategy is required for managing EGISTs including incorporation of molecular features. | Jun Ho Yi Byeong-Bae Park Jung Hun Kang In Gyu Hwang Dong Bok Shin Sun Jin Sym Hee Kyung Ahn Soon Il Lee Do Hyoung Lim Keon Woo Park Young-Woong Won Sung Hee Lim Se Hoon Park | 2015 | World Journal of Gastroenterology2015，21，6： | 9 |
| 4 | Conservation and Diversification of the SHR-SCR- SCL23 Regulatory Network in the Development of the Functional Endodermis in Arabidopsis Shoots显示文摘部分地, Arabidopsis thaliana 根的功能的内皮的开发被 GRAS 抄写因素控制,也就是短根(SHR ) ,衣衫褴褛的人(SCR ) ,并且像衣衫褴褛的人 23 (SCL23 ) 。最近, SHR-SCR-SCL23 规章的模块为内皮的说明也是必要的,这被显示出(作为捆鞘知道) 在叶子。与在根对 SHR-SCR-SCL23 规章的网络的角色被知道的相比,不过, SHR, SCR,和 SCL23 的分子的相互作用更不在射击被理解。这里,我们证明 SHR 与 SCL23 形成蛋白质建筑群在射击调整 SCL23 的抄写,类似于 SCR 的规定模式表示。我们的结果显示 SHR 充当主人管理者直接激活 SCR 和 SCL23 的表示。在 SHR-SCR-SCL23 网络,我们发现了一以前 SCL23 调制 SHR 的否定反馈循环铺平的 uncharacterized。通过分子、基因、生理、词法的分析,我们也表明 SHR-SCR-SCL23 模块在内皮的形成起一个关键作用(作为淀粉鞘知道) 在胚轴。一起拿,我们的结果在根和射击在内皮开发提供新卓见进 SHR-SCR-SCL23 网络的规章的角色。 | Eun Kyung Yoon Souvik Dhar Mi-Hyun Lee Jae Hyo Song Shin Ae Lee Gyuree Kim Sejeong Jang Ji Won Choi Jeong-Eun Choe Jeong Hoe Kim Myeong Min Lee Jun Lim | 2016 | Molecular Plant2016，9，8： | 6 |
| 5 | Reprogramming fibroblasts into induced pluripotent stem cells with Bmil显示文摘 | Jai-Hee Moon June Seok Heo Jun Sung Kim Eun Kyoung Jun Jung Han Lee Aeree Kim Jonggun Kim Kwang Youn Whang Yong-Kook Kang Seungeun Yeo Hee-Joung Lim Dong Wook Han Dong-Wook Kim Sejong Oh Byung Sun Yoon Hans R Scholet Seungkwon You | 2011 | Cell Research2011，21，9： | 6 |
| 6 | Cultivation of microalgae for biodiesel production:A review on upstream and downstream processing显示文摘Fluctuating market price of fossil fuel and overwhelming emission of greenhouse gases to the atmosphere have resulted in climate change and have been a global concern in this decade. Hence, biodiesel has become an alternative option to fossil diesel as it is renewable and environmentally friendly. Nevertheless, this alternative fuel that is usually derived from terrestrial oil crops will cause shortage in food supply and deforestation if mass production is realized. In recent years, cultivation of aquatic microorganism(particularly microalgae) to produce biodiesel is considered as a practical solution due to their high growth rate and ability to synthesize large quantity of lipid within their cell. However, the development of energy and cost-efficiency of microalgae cultivation system are the main issues in producing renewable microalgae biodiesel. Of late, wastewater or organic compost has been used as the cultivation medium as it can provide sufficient nutrients to sustain microalgae growth.Microalgae cultivation method and system are vitally important as these factors undoubtedly affect the final microalgae biomass and lipid yield. In this review, the cultivation system of microalgae, nutrients demanded for microalgae production, cell harvesting and drying, microalgae oil extraction, and utilization of microalgae biomass for biodiesel production are introduced and discussed. It is anticipated to convey clearer perspectives in upstream and downstream processes in microalgae-derived biodiesel production. | Xin Bei Tan Man Kee Lam Yoshimitsu Uemura Jun Wei Lim Chung Yiin Wong Keat Teong Lee | 2018 | Chinese Journal of Chemical Engineering2018，26，1： | 6 |
| 7 | Bacterial entombment by intratubular mineralization following orthograde mineral trioxide aggregate obturation: a scanning electron microscopy study显示文摘The time domain entombment of bacteria by intratubular mineralization following orthograde canal obturation with mineral trioxide aggregate(MTA) was studied by scanning electron microscopy(SEM). Single-rooted human premolars(n560) were instrumented to an apical size #50/0.06 using ProF ile and treated as follows: Group 1(n510) was filled with phosphate buffered saline(PBS); Group 2(n510) was incubated with Enterococcus faecalis for 3 weeks, and then filled with PBS; Group 3(n520) was obturated orthograde with a paste of OrthoM TA(BioM TA, Seoul, Korea) and PBS; and Group 4(n520) was incubated with E. faecalis for 3 weeks and then obturated with OrthoM TA–PBS paste. Following their treatments, the coronal openings were sealed with PBS-soaked cotton and intermediate restorative material(IRM), and the roots were then stored in PBS for 1, 2, 4, 8 or 16 weeks. After each incubation period, the roots were split and their dentin/MTA interfaces examined in both longitudinal and horizontal directions by SEM. There appeared to be an increase in intratubular mineralization over time in the OrthoM TA-filled roots(Groups 3 and 4). Furthermore, there was a gradual entombment of bacteria within the dentinal tubules in the E. faecalis inoculated MTA-filled roots(Group 4). Therefore, the orthograde obturation of root canals with OrthoM TA mixed with PBS may create a favorable environment for bacterial entombment by intratubular mineralization. | Jun Sang Yoo Seok-Woo Chang So Ram Oh Hiran Perinpanayagam Sang-Min Lim Yeon-Jee Yoo Yeo-Rok Oh Sang-Bin Woo Seung-Hyun Han Qiang Zhu Kee-Yeon Kum | 2014 | International Journal of Oral Science2014，6，4： | 5 |
| 8 | High heat loading performance of actively cooled W/Cu FGM-based components显示文摘A functionally graded material-based actively water-cooled tungsten-copper mockup with a dimension of 30 mm×30 mm×25 mm was designed and fabricated by infiltration-brazing method.The thicknesses of the pure W layer and W/Cu graded layer were 2 and 3 mm,respectively.High heat flux tests were performed on the mockup using an e-beam device.There is no damage occurring on the joint after heat loading at 5 MW/m2.The temperature on the pure W surface is less than 500°C after irradiation for 100 s at 5 MW/m2,while the temperature on the brazing seam/copper surface is around 200°C. | Zhang-jian Zhou Jun Tan Dan-dan Qu Hua Li Young-jin yum Hyun-woo Lim | 2011 | International Journal of Minerals,Metallurgy and Materials2011，18，4： | 5 |
| 9 | Cytogenetic and molecular aberrations of multiple myeloma patients: a single-center study in Singapore显示文摘 | LIM Alvin Soon Tiong LIM Tse Hui SEE Karen Hsu Shien NG Yit Jun TAN Yu Min CHO0 Natasha Swee Lian LIM Sherry Xin Er YEE Yenny LAU Lai Ching TIEN Sim Leng Kumar Sathish TAN Daryl Chen Lung | 2013 | Chinese Medical Journal2013，，10： | 4 |
| 10 | 韩国低危前列腺癌患者的分级和分期的升高:一项多中心研究显示文摘与美国82%的局限性前列腺癌发病率相比,韩国局限性前列腺癌病例仅为54%。此外,在根治性前列腺切除后,半数韩国患者的肿瘤分级提高。我们研究了低危前列腺癌患者在根治性前列腺切除后分级和/或分期升高的危险因素。我们回顾性性分析了Honam省5家医院1159例接受根治性前列腺切除的患者的医学记录。收集了术前的标准临床病理学参数,根治性前列腺切除的标本给予分级和分期,我们把“预后不佳”定义为Gleason 评分大于等于7,或病理分期大于等于T3。应用多元回归模型分析评价术后病理分期提高的相关因素。在1159例患者中,324例归类为临床低危组,154例(47.5%)患者既有分级的提高也有分期的提高。多变量分析显示,术前血清前列腺抗原水平(odds ratio [OR], 1.131; 95%confidence interval [CI], 1.007-1.271; P= 0.037), 穿刺组织的肿瘤阳性百分率 (OR: 1.018; 95% CI: 1.002-1.035; P= 0.032),和小前列腺体积(〈30ml)(OR: 2.280; 95% CI: 1.351-3.848; P=0.002)是不良预后的预测指标。总体讲,47.5%的低危患者术后分期增加。对于我们的研究组,目前的危险度分级标准可能过于宽松。 | Insang Hwang Donghoon Lim Young Beom Jeong Seung Chol Park Jun Hwa Noh Dong Deuk Kwon Taek Won Kang | 2015 | Asian Journal of Andrology2015，17，5： | 4 |
| 11 | Association of C(-106)T Polymorphism in Aldose Reductase Gene with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Mellitus显示文摘Objective To identify the possible association between C(-106)T polymorphism of the aldose reductase(ALR) gene and diabetic retinopathy(DR) in a cohort of Chinese patients with type 2 diabetes mellitus(T2DM).Methods From November 2009 to September 2010,patients with T2DM were recruited and assigned to DR group or diabetic without retinopathy(DWR) group according to the duration of diabetes and the grading of 7-field fundus color photographs of both eyes.Genotypes of the C(-106)T polymorphism(rs759853) in ALR gene were analyzed using the MassARRAY genotyping system and an association study was performed.Results A total of 268 T2DM patients(129 in the DR group and 139 in the DWR group) were included in this study.No statistically significant differences were observed between the 2 groups in the age of diabetes onset(P=0.10) and gender(P=0.78).The success rate of genotyping for the study subjects was 99.6%(267/268),with one case of failure in the DR group.The frequencies of the T allele in the C(-106)T polymorphism were 16.0%(41/256) in the DR group and 19.4%(54/278) in the DWR group(P=0.36).There was no significant difference in the C(-106)T genotypes between the 2 groups(P=0.40).Compared with the wild-type genotype,odds ratio(OR) for the risk of DR was 0.7(95% CI,0.38-1.3) for the heterozygous CT genotype and 0.76(95% CI,0.18-3.25) for the homozygous TT genotype.The risk of DR was positively associated with microalbuminuria(OR=4.61;95% CI,2.34-9.05) and insulin therapy(OR=3.43;95% CI,1.94-6.09).Conclusions Microalbuminuria and insulin therapy are associated with the risk of DR in Chinese patients with T2DM.C(-106)T polymorphism of the ALR gene may not be significantly associated with DR in Chinese patients with T2DM. | Yu Deng Xiu-fen Yang Hong Gu Apiradee Lim Munkhtulga Ulziibat Torkel Snellingen Jun Xu Kai Ma Ning-pu Liu | 2014 | Chinese Medical Sciences Journal2014，29，1： | 4 |
| 12 | Endoscopic submucosal dissection vs endoscopic mucosal resection for colorectal polyps:A meta-analysis and metaregression with single arm analysis显示文摘BACKGROUND Endoscopic submucosal dissection(ESD)has shown to be effective in management of colorectal neoplasm in the Asian countries,while its implementation in Western countries where endoscopic mucosal resection(EMR)is preferred is still debatable.AIM To compare the surgical,histological,and oncological outcomes between ESD and EMR in the treatment of colorectal polyps,with subgroup analysis comparing the efficacy of ESD and EMR between Japan and the rest of the world.METHODS Embase and Medline databases were searched from inception to October 2020 in accordance with PRISMA guidelines for studies comparing en bloc,complete resection,margin involvement,resection time,need for additional surgery,complications,and recurrence rate of ESD with EMR.RESULTS Of 281344 colorectal polyps from 21 studies were included.When compared to EMR,the pooled analysis revealed ESD was associated with higher en bloc and complete resection rate,and lower lateral margin involvement and recurrence.ESD led to increased procedural time,need for additional surgery,and perforation risk.No significant difference in bleeding risk was found between the two groups.Meta-regression analysis suggested only right colonic polyps correlated with an increased perforation risk in ESD.Confounders including polyp size and invasion depth did not significantly influence the en bloc and complete resection rate,bleeding risk and recurrence.In subgroup analysis,Japan performed better than the rest of the world in both ESD and EMR with perforation risk of 4%and 0.0002%,respectively,as compared to perforation risk of 8%and 1%,respectively,in reports coming from rest of the world.CONCLUSION ESD resulted in better resection outcomes and lower recurrence compared to EMR.With appropriate training,ESD is preferred over EMR as the first-line therapy for resection of colorectal polyps,without restricting to lesions greater than 20 mm and those with high suspicion of submucosal invasion. | Xiong Chang Lim Kameswara Rishi Yeshayahu Nistala Cheng Han Ng Snow Yunni Lin Darren Jun Hao Tan Khek-Yu Ho Choon-Seng Chong Mark Muthiah | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 13 | Morphologic factors of biliary trees are associated with gallstone-related biliary events显示文摘AIM: To determine the risk factors for gallstone-related biliary events.METHODS: This retrospective cohort study evaluated magnetic resonance cholangiopancreatography imagesfrom 141 symptomatic and 39 asymptomatic gallstone patients who presented at a single tertiary hospital between January 2005 and December 2012.RESULTS: Logistic regression analysis showed significant differences between symptomatic and asymptomatic patients with gallstones in relation to the number of gallstones,the angle between the long axis of the gallbladder and the cystic duct,and the cystic duct diameter.Multivariate analysis showed that the number of gallstones(OR = 1.27,95%CI: 1.03-1.57; P = 0.026),the angle between the long axis of the gallbladder and the cystic duct(OR = 1.02,95%CI: 1.00-1.03; P = 0.015),and the diameter of the cystic duct(OR = 0.819,95%CI: 0.69-0.97; P = 0.018) were significantly associated with biliary events.The incidence of biliary events was significantly elevated in patients who had the presence of more than two gallstones,an angle of > 92° between the gallbladder and the cystic duct,and a cystic duct diameter < 6 mm.CONCLUSION: These findings will help guide the treatment of patients with asymptomatic gallstones.Clinicians should closely monitor patients with asymptomatic gallstones who exhibit these characteristics. | Jin-Seok Park Don Haeng Lee Jun Hyeok Lim Seok Jeong Young Sun Jeon | 2015 | World Journal of Gastroenterology2015，21，1： | 4 |
| 14 | Nanocomposite quasi-solid-state electrolyte for high-safety lithium batteries显示文摘Rechargeable lithium batteries are attractive power sources for electronicdevices and are being aggressively developed for vehicular use. Nevertheless,problems with their safety and reliability must be solved for the large-scale useof lithium batteries in transportation and grid-storage applications. In this study,a unique hybrid solid-state electrolyte composed of an ionic liquid electrolyte(LiTFSI/Pyr14TFSI) and BaTiO3 nanosize ceramic particles was prepared withouta polymer. The electrolyte exhibited high thermal stability, a wide electrochemicalwindow, good ionic conductivity of 1.3×10-3 S-cm-1 at 30 ℃, and a remarkably highlithium-ion transference number of 0.35. The solid-state LiFePO4 cell exhibited thebest electrochemical properties among the reported solid-state batteries, along witha reasonable rate capability. Li/LiCoO2 cells prepared using this nanocompositesolid electrolyte exhibited high performance at both room temperature and a hightemperature, confirming their potential as lithium batteries with enhanced safetyand a wide range of oDerating temrperatures. | Hyunji Choi Hyun Woo Kim Jae-Kwang Kim Young Jun Lim Youngsik Kim Jou-Hyeon Ahn | 2017 | Nano Research2017，10，9： | 4 |
| 15 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 16 | Chronic hepatitis B: whom to treat and for how long? Propositions, challenges, and future directions显示文摘 | Sang Hoon Ahn Henry L. Y. Chan Pei-Jer Chen Jun Cheng Mahesh K. Goenka Jinlin Hou Seng Gee Lim Masao Omata Teerha Piratvisuth Qing Xie Hyung Joon Yim Man-Fung Yuen | 2010 | Hepatology International2010，，1： | 3 |
| 17 | The alternative of CubeSat-based advanced infrared and microwave sounders for high impact weather forecasting显示文摘近年来,小卫星技术的发展给传统气象卫星提供了经济有效的替补方案。本文针对可能出现的传统气象卫星的缺失情形,借助快速的区域观测系统模拟试验,探索了利用小卫星填补空缺的可能性。研究表明,单个小卫星,无论是近红外高光谱还是微波探测仪,都能够对局地强风暴天气的预报有所改进。然而,为了填补传统卫星缺失带来的影响,需要发射三颗甚至更多的小卫星来增加观测的覆盖面,以弥补小卫星精度略低、通道略少的缺陷。 | LI Zhenglong LI Jun SCHMIT Timothy J. WANG Pei LIM Agnes LI Jinlong NAGLE Fredrick W. BAI Wenguang OTKIN Jason A. ATLAS Robert HOFFMAN Ross N. BOUKABARA Sid-Ahmed ZHU Tong BLACKWELL William J. PAGANO Thomas S. | 2019 | Atmospheric and Oceanic Science Letters2019，12，2： | 3 |
| 18 | A case of Clostridium difficile infection complicated by acute respiratory distress syndrome treated with fecal microbiota transplantation显示文摘Acute respiratory distress syndrome is a life-threatening disorder caused mainly by pneumonia.Clostridium difficile infection(CDI)is a common nosocomial diarrheal disease.Disruption of normal intestinal flora by antibiotics is the main risk factor for CDI.The use of broadspectrum antibiotics for serious medical conditions can make it difficult to treat CDI complicated by acute respiratory distress syndrome.Fecal microbiota transplantation is a highly effective treatment in patients with refractory CDI.Here we report on a patient with refractory CDI and acute respiratory distress syndrome caused by pneumonia who was treated with fecal microbiota transplantation. | Ji Eun Kim Tae-Geun Gweon Chang Dong Yeo Young-Seok Cho Gi Jun Kim Jae Young Kim Jong Wook Kim Hyunho Kim Hye Won Lee Taeseok Lim Hyoju Ham Hyun Jin Oh Yeongbok Lee Jaeho Byeon Sung Soo Park | 2014 | World Journal of Gastroenterology2014，20，35： | 3 |
| 19 | Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia显示文摘脂肪质的织物(蝙蝠) 演的布朗在由生产热维持身体温度的一个基本角色。是的蝙蝠知道仅仅在哺乳动物和人的出生不满一月的婴儿存在在精力新陈代谢由于它的重要功能为肥胖和糖尿病的治疗收到了大注意,此后,人的成年人有功能的蝙蝠,这最近被报导。另外,米黄色的 adipocytes,在白脂肪质的组织(WAT ) 的棕色的 adipocytes,也被显示了参加整个身体新陈代谢。证据的多重线证明蝙蝠或 / 并且米黄色的 adipocytes 的移植或激活颠倒了肥胖并且改进了胰岛素敏感。而且,许多基因在蝙蝠激活包含了或米黄色的房间的招募被发现了,从而为未来提供新有希望的策略到对待肥胖和新陈代谢的疾病的蝙蝠激活的临床的申请。这评论在在蝙蝠和癌症极度瘦弱之间的新陈代谢的方面和关系集中于蝙蝠功能的最近的进展,伴有减少的身体重量并且在癌症病人增加了精力开销的病理学的进程。减少蝙蝠质量和它的活动在的内在的可能的机制老也被讨论。 | Meng Dong Jun Lin Wonchung Lim Wanzhu Jin Hyuek Jong Lee | 2018 | Frontiers of Medicine2018，12，2： | 3 |
| 20 | Value-added Impact of Geostationary Hyperspectral Infrared Sounders on Local Severe Storm Forecasts——via a Quick Regional OSSE显示文摘Accurate atmospheric temperature and moisture information with high temporal/spatial resolutions are two of the key parameters needed in regional numerical weather prediction(NWP) models to reliably predict high-impact weather events such as local severe storms(LSSs). High spectral resolution or hyperspectral infrared(HIR) sounders from geostationary orbit(GEO) provide an unprecedented source of near time-continuous, three-dimensional information on the dynamic and thermodynamic atmospheric fields—an important benefit for nowcasting and NWP-based forecasting. In order to demonstrate the value of GEO HIR sounder radiances on LSS forecasts, a quick regional OSSE(Observing System Simulation Experiment)framework has been developed, including high-resolution nature run generation, synthetic observation simulation and validation, and impact study on LSS forecasts. Results show that, on top of the existing LEO(low earth orbit) sounders, a GEO HIR sounder may provide value-added impact [a reduction of 3.56% in normalized root-mean-square difference(RMSD)] on LSS forecasts due to large spatial coverage and high temporal resolution, even though the data are assimilated every 6 h with a thinning of 60 km. Additionally, more frequent assimilations and smaller thinning distances allow more observations to be assimilated, and may further increase the positive impact from a GEO HIR sounder. On the other hand, with denser and more frequent observations assimilated, it becomes more difficult to handle the spatial error correlation in observations and gravity waves due to the limitations of current assimilation and forecast systems(such as a static background error covariance). The peak reduction of 4.6% in normalized RMSD is found when observations are assimilated every 3 h with a thinning distance of 30 km. | Zhenglong LI Jun LI Pei WANG Agnes LIM Jinlong LI Timothy J.SCHMIT Robert ATLAS Sid-Ahmed BOUKABARA Ross N.HOFFMAN | 2018 | Advances in Atmospheric Sciences2018，35，10： | 3 |
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