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| 1 | 白色脂肪组织褐变及其在多囊卵巢综合征治疗中的研究进展显示文摘棕色脂肪组织是人体主要的产热器官,参与多种代谢性疾病。多囊卵巢综合征患者普遍存在脂肪组织功能紊乱的特征,通过多种途径诱导白色脂肪组织褐变能够改善肥胖、胰岛素抵抗、高雄激素血症等症状,为多囊卵巢综合征的诊疗提供了新思路。故本文就白色脂肪组织褐变及其在多囊卵巢综合征治疗的研究进展进行综述。 | 相迪 张真真 万贵平 | 2020 | 航空航天医学杂志2020，31，6： | 2 |
| 2 | The evolving view of thermogenic fat and its implications in cancer and metabolic diseases显示文摘The incidence of metabolism-related diseases like obesity and type 2 diabetes mellitus has reached pandemic levels worldwide and increased gradually.Most of them are listed on the table of high-risk factors for malignancy,and metabolic disorders systematically or locally contribute to cancer progression and poor prognosis of patients.Importantly,adipose tissue is fundamental to the occurrence and development of these metabolic disorders.White adipose tissue stores excessive energy,while thermogenic fat including brown and beige adipose tissue dissipates energy to generate heat.In addition to thermogenesis,beige and brown adipocytes also function as dynamic secretory cells and a metabolic sink of nutrients,like glucose,fatty acids,and amino acids.Accordingly,strategies that activate and expand thermogenic adipose tissue offer therapeutic promise to combat overweight,diabetes,and other metabolic disorders through increasing energy expenditure and enhancing glucose tolerance.With a better understanding of its origins and biological functions and the advances in imaging techniques detecting thermogenesis,the roles of thermogenic adipose tissue in tumors have been revealed gradually.On the one hand,enhanced browning of subcutaneous fatty tissue results in weight loss and cancer-associated cachexia.On the other hand,locally activated thermogenic adipocytes in the tumor microenvironment accelerate cancer progression by offering fuel sources and is likely to develop resistance to chemotherapy.Here,we enumerate current knowledge about the significant advances made in the origin and physiological functions of thermogenic fat.In addition,we discuss the multiple roles of thermogenic adipocytes in different tumors.Ultimately,we summarize imaging technologies for identifying thermogenic adipose tissue and pharmacologic agents via modulating thermogenesis in preclinical experiments and clinical trials. | Xinpeng Yin Yuan Chen Rexiati Ruze Ruiyuan Xu Jianlu Song Chengcheng Wang Qiang Xu | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 1 |
| 3 | 小鼠急性肝损伤对棕色脂肪组织功能的影响及机制研究显示文摘目的探讨四氯化碳(CCl4)诱导的急性肝损伤小鼠在不同时间点对棕色脂肪组织的影响及相关机制。方法18只8周龄C57BL/6雄性小鼠随机分为对照组、CCl42周组、CCl44周组,每组6只,CCl4组注射CCl42次,对照组给予同剂量橄榄油。称重棕色脂肪组织;HE染色观察肝和棕色脂肪组织的病理变化;免疫组织化学和实时定量PCR检测棕色脂肪组织解偶联蛋白1(UCP1)的表达;酶联免疫吸附测定(ELISA)法检测血清中谷草转氨酶(AST)、谷丙转氨酶(ALT)和肿瘤坏死因子-α(TNF-α)的含量;Pearson法检验Ucp1 mRNA水平与TNF-α含量间的关系。结果与对照组相比,CCl42周组血清ALT、AST含量增多(P<0.01),棕色脂肪组织重量减少(P<0.05),UCP1蛋白表达减少(P<0.05),Ucp1 mRNA表达减少(P<0.05),血清中TNF-α含量增多(P<0.001);与CCl42周组相比,CCl44周组血清中ALT、AST含量减少(P<0.05),棕色脂肪组织重量增加(P<0.05),Ucp1 mRNA表达增多(P<0.01),血清中TNF-α含量减少(P<0.001);CCl42周组和CCl44周组Ucp1 mRNA水平与TNF-α含量均呈显著负相关(r=-0.950,P<0.01;r=-0.859,P<0.05)。结论急性肝损伤可导致棕色脂肪组织功能下降,机体产热减少,从而影响代谢稳态,机制可能与TNF-α含量升高有关。 | 冯妙 卜浩林 李丽红 郭林芝 苗宇船 郭建红 | 2020 | 中国比较医学杂志2020，30，4： | 1 |
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