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| 1 | Diagnosis and management of bacterial infections in decompensated cirrhosis显示文摘Bacterial infections are one of the most frequent complications in cirrhosis and result in high mortality rates.Patients with cirrhosis have altered and impaired immunity,which favours bacterial translocation.Episodes of infections are more frequent in patients with decompensated cirrhosis than those with compensated liver disease.The most common and life-threatening infection in cirrhosis is spontaneous bacterial peritonitis followed by urinary tract infections,pneumonia,endocarditis and skin and soft-tissue infections.Patients with decompensated cirrhosis have increased risk of developing sepsis,multiple organ failure and death.Risk factors associated with the development of infections are severe liver failure,variceal bleeding,low ascitic protein level and prior episodes of spontaneous bacterial peritonitis (SBP).The prognosis of these patients is closely related to a prompt and accurate diagnosis.An appropriate treatment decreases the mortality rates.Preventive strategies are the mainstay of the management of these patients.Empirical antibiotics should be started immediately following the diagnosis of SBP and the first-line antibiotic treatment is third-generation cephalosporins.However,the efficacy of currently recommended empirical antibiotic therapy is very low in nosocomial infections including SBP,compared to community-acquired episodes.This may be associated with the emergence of infections caused by Enterococcus faecium and extended-spectrum β-lactamaseproducing Enterobacteriaceae,which are resistant to the first line antimicrobial agents used for treatment.The emergence of resistant bacteria,underlines the need to restrict the use of prophylactic antibiotics to patients with the greatest risk of infections.Nosocomial infections should be treated with wide spectrum antibiotics.Further studies of early diagnosis,prevention and treatment are needed to improve the outcomes in patients with decompensated cirrhosis. | Maria Pleguezuelo Jose Manuel Benitez Juan Jurado Jose Luis Montero Manuel De la Mata | 2013 | World Journal of Hepatology2013，5，1： | 44 |
| 2 | A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C显示文摘 | Bruno Sangro Carlos Gomez-Martin Manuel de la Mata Mercedes I?arrairaegui Elena Garralda Pilar Barrera Jose Ignacio Riezu-Boj Esther Larrea Carlos Alfaro Pablo Sarobe Juan José Lasarte Jose L. Pérez-Gracia Ignacio Melero Jesús Prieto | 2013 | Journal of Hepatology2013，，： | 6 |
| 3 | Reduced Exposure to Calcineurin Inhibitors Early After Liver Transplantation Prevents Recurrence of Hepatocellular Carcinoma显示文摘 | Manuel Rodríguez-Perálvarez Emmanuel Tsochatzis María Carmen Naveas Giulia Pieri Carmen García-Caparrós James O’Beirne Antonio Poyato-González Gustavo Ferrín-Sánchez Jose Luis Montero-álvarez David Patch Douglas Thorburn Javier Brice?o Manuel De la Mata A | 2013 | Journal of Hepatology2013，，： | 5 |
| 4 | Proteomic analysis for developing new biomarkers of hepatocellular carcinoma显示文摘AIM: To identify new markers of hepatocellular carcinoma (HCC) using a proteomic analysis. METHODS: Patients with liver cirrhosis of the three most frequent etiologies: hepatitis C virus, hepatitis B virus and alcoholic liver disease, were included in the study. The samples were analysed by 2D-electrophoresis in order to determine the differential protein expression. The proteins were separated according to the charge in immobilized pH 3-10 gradient strips and then by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Proteins of interest were excised, digested with trypsin and the resulting peptides were separated and identified. RESULTS: Three differentially expressed apolipoproteins (Apo) were identified based on the protein profile using proteomic techniques: Apo-A1, Apo-A4 and Apo-E. Apo-A4 levels were significantly lower in HCC than in non-HCC patients regardless of etiology (P < 0.01). Multivariate logistic regression showed that Apo-A4 and Apo-A1 were the only independent factors related to HCC diagnosis (P < 0.05). The receiver operating characteristic (ROC) curve including both Apo-A4 and Apo-A1 showed an area under the ROC of 0.944 (P < 0.001), a sensitivity of 0.89 and a specificity of 0.81 for diagnosis of HCC. CONCLUSION: Apo-A4 and Apo-A1 may be used clinically as biomarkers of HCC with a high sensibility and specificity. These findings may provide additional insights into the mechanism of HCC development and progression. | Maria Pleguezuelo Laura M Lopez-Sanchez Antonio Rodriguez-Ariza Jose L Montero Javier Briceno Ruben Ciria Jordi Muntane Manuel de la Mata | 2010 | World Journal of Hepatology2010，2，3： | 3 |
| 5 | Electronic structure, optical properties, and lattice dynamics in atomically thin indium selenide flakes显示文摘chalcogenide 单身者层的进步的叠与能为新地效果晶体管和 photonic 设备被利用的悦耳的性质产生二维的半导体的材料。然而, chalcogenide 家庭的一些成员的性质仍然保持未经勘探。铟硒化物(InSe ) 由于它在近红外线的、可控制的 p 类型并且 n 类型做和高化学稳定性的直接 bandgap 为应用是吸引人的。这里,我们揭示格子动力学,原子地薄的 InSe 薄片的光、电子的性质由 micromechanical 劈开准备了。拉曼活跃模式在取决于电子契约激动的薄片使硬或弄软。一进步光致发光山峰蓝移动为减少的薄片厚度被观察(象为三单个层的 0.2 eV 一样大) 。第一原则的计算在 bandgap 预言甚至更大的增加, 0.40 eV 为三单个层,并且为单个层的差不多 1.1 eV。这些结果与 Si 和 III-V 技术从为在纳米规模和兼容机的 optoelectronic 应用的这材料的通用性的观点是有希望的。 | Juan F. Sanchez-Royo Suillermo Munoz-Matutano Mauro Brotons-Gisbert Juan P. Martinez-Pastor Alfredo Segura Andres Cantarero Rafael Mata Josep Canet-Ferrer Gerard Tobias Enric Canadell Jose Marques-Hueso Brian D. Gerardot | 2014 | Nano Research2014，7，10： | 2 |
| 6 | Automating HAZOP studies using D-higraphs显示文摘 | Manuel Rodrlguez Jose Luis de la Mata | 2012 | Computers and Chemical En-inee6n2012，45，12： | 1 |
| 7 | Wireless-control strategy for parallel operation of distributed-generation inverters 显示文摘 | Guerrero Josep M Matas Jose de Vicufia Luis Garca | 2006 | IEEE Transactions on Industrial Electronics2006，53，5： | 1 |
| 8 | A wireless controller to enhance dynamic performance of parallel inverters in distributed generation system显示文摘 | Guerrero Josep M de Vicuna Luis Garcia Matas Jose | | 0，，05： | 1 |
| 9 | Wireless Control Strategy forParallel Operation of Distributed Generation Inverters显示文摘 | Josep M Guerrero Jose Matas | 2006 | IEEE Transactions on Industrial Electronics2006，53，5： | 1 |
| 10 | Hierar-chical Control of Droop-controlled AC and DC Microgrids-AGeneral Approach Toward Standardization显示文摘 | Josep M Guerrero Jose Matas Miguel Castilla | 2011 | IEEE Transac-tions on Industrial Electronics2011，58，1： | 1 |
| 11 | High-sensitivity C-reactive protein in high-grade carotid stenosis: risk marker for unstable carotid plaque显示文摘 | Beatriz Alvarez Garcia Carmen Ruiz Pilar Chacon Jose Alvarez Sabin Manuel Matas | 2003 | Journal of Vascular Surgery2003，，5： | 1 |
| 12 | Comparison of antibody responses to a potential combination of specific Glycolipids and proteins for test sensitivity improvement in tuberculosis serodiagnosis显示文摘 | Esther Julian Lurdes Matas Jose Alcaide | 2004 | Clinicl and Diagnosistic Laboratory Immunology2004，11，1： | 1 |
| 13 | Constructing Statistical Models for Arch Dam Deformation显示文摘 | Juan Mata Ant6nio Tavares de Castro Jose Sci da Costa | 2014 | Structural Control and Health Monitoring2014，21，3： | 1 |
| 14 | Reduced Exposure to Calcineurin Inhibitors Early After Liver Transplantation Prevents Recurrence of Hepatocellular Carcinoma显示文摘 | Manuel Rodríguez-Perálvarez Emmanuel Tsochatzis María Carmen Naveas Giulia Pieri Carmen García-Caparrós James O’Beirne Antonio Poyato-González Gustavo Ferrín-Sánchez Jose Luis Montero-álvarez David Patch Douglas Thorburn Javier Brice?o Manuel De la Mata A | 2013 | Journal of Hepatology2013，，： | 1 |
| 15 | A wireless controller to enhance dynamic performance of parallel inverters in distributed generation system显示文摘 | Guerrero J M Luis Garcia de Vicuna Jose Matas | 2004 | IEEE Transactions on Power Electronics2004，19，5： | 1 |
| 16 | Output impedance design of parallel-connected UPS inverters with wireless load-sharing control显示文摘 | Guerrero J M Luis Garcia de Vicuna Jose Matas | 2005 | IEEE Transactions on Power Electronics2005，52，4： | 1 |
| 17 | Counter factual Decomposition of Changes in Wage Distributions Using Quantile Regression显示文摘 | Machado Jose A F Jose Mata | | 0，，04： | 1 |
| 18 | Wireless-control strategy for parallel operation of distributed-generation inverters显示文摘 | Guerreo J M Jose matas Luis Garcfa de Vicuna | 2006 | IEEE Transaction on Industrial Electronics2006，53，： | 1 |
| 19 | Control strategy for flexible microgrid based on parallel line-interactive UPS systems显示文摘 | Guerreo J M Vasquez J C Matas Jose | 2009 | IEEE Transaction on Industrial Electronics2009，56，3： | 1 |
| 20 | Wireless-control strategy for parallel operation of distributed-generation inverters显示文摘 | Josep M G Jose Matas Luis Garcia de Vicuna | 2006 | IEEE Transactions on Industrial Electronics2006，53，5： | 1 |
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