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| 1 | 英国能源长远规划:唯一现实的脱碳道路显示文摘有人认为,设立容量市场会在英国引发第二轮“追逐天然气的热潮”,这似乎很有可能,因为计划要关闭一些工厂. | Jonathan Lane | 2012 | 低碳世界2012，，10： | 1 |
| 2 | Comparative Validation of a Novel Risk Score for Predicting Bleeding Risk in Anticoagulated Patients With Atrial Fibrillation显示文摘 | Gregory Y.H. Lip Lars Frison Jonathan L. Halperin Deirdre A. Lane | 2011 | Journal of the American College of Cardiology2011，，2： | 1 |
| 3 | Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy显示文摘Although targeted therapies have proven effective and even curative in human leukaemia, resistance often ensues. IDH enzymes are mutated in ~20% of human AML, with targeted therapies under clinical evaluation. We here characterize leukaemia evolution from mutant IDH2 (mIDH2)-dependence to independence identifying key targetable vulnerabilities of mIDH2 leukaemia that are retained during evolution and progression from early to late stages. Mechanistically, we find that mIDH2 leukaemia are metastable and vulnerable at two distinct levels. On the one hand, they are characterized by oxidative and genotoxic stress, in spite of increased 1-carbon metabolism and glutathione levels. On the other hand, mIDH2 leukaemia display inhibition of LSD1 and a resulting transcriptional signature of all-trans retinoic acid (ATRA) sensitization, in spite of a state of suppressed ATRA signalling due to increased levels of PIN1. We further identify GSH/ROS and PIN1/LSD1 as critical nodes for leukaemia maintenance and the combination of ATRA and arsenic trioxide (ATO) as a key therapeutic modality to target these vulnerabilities. Strikingly, we demonstrate that the combination of ATRA and ATO proves to be a powerfully synergistic and effective therapy in a number of mouse and human mIDH1/2 leukemic models. Thus, our findings pave the way towards the treatment of a sizable fraction of human AMLs through targeted APL-like combinatorial therapies. | Vera Mugoni Riccardo Panella Giulia Cheloni Ming Chen Olga Pozdnyakova Dina Stroopinsky Jlenia Guarnerio Emanuele Monteleone Jonathan David Lee Lourdes Mendez Archita Venugopal Menon Jon Christopher Aster Andrew A. Lane Richard Maury Stone Ilene Galinsky José Cervera Zamora Francesco Lo-Coco Manoj Kumar Bhasin David Avigan Letizia Longo John Gerard Clohessy Pier Paolo Pandolfi | 2019 | Cell Research2019，29，6： | 1 |
| 4 | Parenchymal Echo Texture Predicts Testicular Salvage After Torsion: Potential Impact on the Need for Emergent Exploration显示文摘 | Jonathan D. Kaye Edan Y. Shapiro Selwyn B. Levitt Steven C. Friedman Jordan Gitlin Jaime Freyle Lane S. Palmer | 2008 | The Journal of Urology2008，，4： | 1 |
| 5 | Three dimensional digital product definitions显示文摘 | Lane Jonathan B Smith | 1994 | Annual Forum Proceedings-American Hell-copter Society1994，，3： | 1 |
| 6 | Concurrent liquid chromatographic separation and photodiode array detection of retinol, tocopherols, all-trans-α-carotene,al1 trans-β-carotene and the mono-cis isomers of β-carotene in extracts of human plasma显示文摘 | Jonathan R Lane Lisa W Webb Robert V Acuff | 1997 | Journal of chromatography A1997，787，： | 1 |
| 7 | Connecting supplier and DoD blockchains for transparent part tracking显示文摘Blockchains have been around for more than ten years,and since 2015,a plethora of systems have been launched to target more flexible use cases.More recently,several enterprise blockchain systems,such as Consensys Quorum and Hyperledger Fabric,have been launched to make blockchain simpler to apply in complex organizational configurations.In this paper,we identify a specific Department of Defense use case,extrapolate requirements,and perform a thorough assessment of the different layers of the blockchain stack to identify the existing state of the art and undertake a gap analysis of the technology for this context.We describe a platform that meets many of these challenges and show how we architected,designed,and implemented a solution for this use case for deployment at NAVAIR.This solution connects transactions from two separate blockchain systems,Consensys Quorum and Hyperledger Fabric,by using a graph-based approach that preserves privacy while enabling full transparency across the military and supplier networks. | Francis Asuncion Adam Brinckman Dwayne Cole Jeffrey Curtis Matt Davis Timothy Dunlevy Calvin Farmer Andrew Harrison Daniel P.Johnson Joshua Joyce Chris Klubertanz Jonathan Lane John Martin Jarek Nabrzyski Joel Neidig Deysi Olivares Gregory Robinson Gabriel Rodriguez Chris Root Karen Rowand Al Salour Jeff Score David Scott Ian Taylor Chandler Thompson Huy Truong Xiqun Wang Dale Warren | 2021 | Blockchain(Research and Applications)2021，2，3： | 1 |
| 8 | Steward: Scaling Byzantine Fault-Tolerant Replication to Wide Area Networks显示文摘 | Amir Yair Danilov Claudiu Dolev Danny Kirsch Jonathan Lane John Nita-Rotaru Cristina Olsen Josh Zage David | 2010 | IEEE Transactions on Dependable and Secure Computing2010，，1： | 1 |
| 9 | Familiarity with a female does not affect a male's courtship intensity in garter snakes Thamnophis sirtalis parietalis显示文摘 | Richard SHINE Jonathan K. WEBB Amanda LANE Robert T. MASON | 2012 | Current Zoology2012，58，6： | 0 |
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