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| 1 | Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management显示文摘Inflammatory bowel diseases(IBD) are chronic idiopathic inflammatory conditions characterized by relapsing and remitting episodes of inflammation which can affect several different regions of the gastrointestinal tract, but also shows extra-intestinal manifestations. IBD is most frequently diagnosed during peak female reproductive years, with 25% of women with IBD conceiving after their diagnosis. While IBD therapy has improved dramatically with enhanced surveillance and more abundant and powerful treatment options, IBD disease can have important effects on pregnancy and presents several challenges for maintaining optimal outcomes for mothers with IBD and the developing fetus/neonate. Women with IBD, the medical team treating them(both gastroenterologists and obstetricians/gynecologists) must often make highly complicated choices regarding conception, pregnancy, and post-natal care(particularly breastfeeding) related to their choice of treatment options at different phases of pregnancy as well as post-partum. This current review discusses current concerns and recommendations for pregnancy duringIBD and is intended for gastroenterologists, general practitioners and IBD patients intending to become,(or already) pregnant, and their families. We have addressed patterns of IBD inheritance, effects of IBD on fertility and conception(in both men and women), the effects of IBD disease activity on maintenance of pregnancy and outcomes, risks of diagnostic procedures during pregnancy and potential risks and complications associated with different classes of IBD therapeutics. We also have evaluated the clinical experience using 'top-down' care with biologics, which is currently the standard care at our institution. Post-partum care and breastfeeding recommendations are also addressed. | Pegah Hosseini-Carroll Monica Mutyala Abhishek Seth Shaheen Nageeb Demiana Soliman Moheb Boktor Ankur Sheth Jonathon Chapman James Morris Paul Jordan Kenneth Manas Felix Becker Jonathan Steven Alexander | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 4 |
| 2 | Mapping summer soybean and corn with remote sensing on Google Earth Engine cloud computing in Parana state – Brazil显示文摘Brazilian farming influences directly the worldwide economy.Thus,fast and reliable information on areas sown with the main crops is essential for planning logistics and public or private commodity market policies.Recent farming practices have embraced remote sensing to provide fast and reliable information on commodity dynamics.Medium-to-low resolution free orbital images,such as those from Landsat 8 and Sentinel 2,have been used for crop mapping;however,satellite image processing requires high computing power,especially when monitoring vast areas.Therefore,cloud data processing has been the only feasible option to deal with a large amount of orbital data and its processing and analysis.Thus,our goal was to develop a method to map the two main crops(soybeans and corn)in Paraná,one of the major Brazilian state producers.Landsat-8,Sentinel-2,SRTM+,and field data from 2016 to 2018 were used with the Simple Non-Iterative Clustering segmentation method and the Continuous Naive Bayes classifier,to identify cropped areas.A minimum global accuracy of 90%was found for both crops.Comparison with field data showed correlations of 0.96 and agreement coefficients no lower than 0.86.This ensures mapping quality when using Sentinel and/or Landsat imagery on the GEE platform. | Alex Paludo Willyan Ronaldo Becker Jonathan Richetti Laíza Cavalcante De Albuquerque Silva Jerry Adriani Johann | 2020 | International Journal of Digital Earth2020，13，12： | 2 |
| 3 | Development and Characterization of a Scalable Controlled Precipitation Process to Enhance the Dissolution of Poorly Water-Soluble Drugs显示文摘 | True L. Rogers Ian B. Gillespie James E. Hitt Kevin L. Fransen Cindy A. Crowl Christopher J. Tucker Gary B. Kupperblatt Joe N. Becker Deb L. Wilson Clifford Todd Charles F. Broomall Jonathan C. Evans Edmund J. Elder | 2004 | Pharmaceutical Research2004，，11： | 1 |
| 4 | Outcomes After Cardioversion and Atrial Fibrillation Ablation in Patients Treated With Rivaroxaban and Warfarin in the ROCKET AF Trial显示文摘 | Jonathan P. Piccini Susanna R. Stevens Yuliya Lokhnygina Manesh R. Patel Jonathan L. Halperin Daniel E. Singer Graeme J. Hankey Werner Hacke Richard C. Becker Christopher C. Nessel Kenneth W. Mahaffey Keith A.A. Fox Robert M. Califf Günter Breithardt | 2013 | Journal of the American College of Cardiology2013，，19： | 1 |
| 5 | Oxidative stress in malaria parasite-infected erythrocytes: host–parasite interactions显示文摘 | Katja Becker Leann Tilley Jonathan L. Vennerstrom David Roberts Stephen Rogerson Hagai Ginsburg | 2003 | International Journal for Parasitology2003，，2： | 1 |
| 6 | Practical Limitations of Bioresorbable Membranes in the Prevention of Intra-Abdominal Adhesions显示文摘 | Rizal Lim Jonathan M. Morrill Ryan C. Lynch Karen L. Reed Adam C. Gower Susan E. Leeman Arthur F. Stucchi James M. Becker | 2009 | Journal of Gastrointestinal Surgery2009，，1： | 1 |
| 7 | Developing and completing alibrary mobile technology survey to create a user- centered mobile presence显示文摘 | Danielle Andre Becker Ingrid Bonadie - Joseph Jonathan Cain | 2013 | Library Hi Tech2013，，4： | 1 |
| 8 | Intrathymic injection of anti-Fas monoclonal antibody prolongs murine non-vascularized cardiac allograft survival显示文摘 | Arjang Djamali Kenneth R. Waller Jonathan McAnulty Debra Hullett Bryan N. Becker Jon S. Odorico | 2004 | Transplant International2004，，6： | 1 |
| 9 | Antidiabetic profiling of veramycins,polyketides accessible by biosynthesis,chemical synthesis and precursor-directed modification显示文摘Seven new polyketides,termed veramycins,were isolated from a Streptomyces sp.from the Sanofi microbial strain collection along with their known congeners NFAT-133 and TM-123.Veramycin A,anα-pyrone congener of TM-123 and NFAT-133 showed an increased baseline deoxy-glucose uptake in the absence of insulin in a modified L6 rat skeletal muscle cell line(L6 GLUT4 AS160-like cells).In addition,both compounds slightly increased the sensitivity to insulin in this cell line.Total syntheses of NFAT-133,TM-123 and veramycin A were accomplished starting from a central building block,which bears the three contiguous stereogenic centers of this polyketide family.Our approach enables an efficient,selective and flexible access to all possible isomers of the stereotriad for further exploration of this series as a potential anti-diabetic lead structure as exemplified by the synthesis of an NFAT-133 epimer.Finally,the corresponding biosynthetic gene cluster(BGC)was identified by genome sequencing and gene inactivation.Based on feeding experiments,a biosynthetic pathway was proposed,which enabled access to new veramycin A analogs by precursor-directed biosynthesis. | Denis Dardić Nils Böhringer Alberto Plaza Florian Zubeil Juliane Pohl Svenja Sommer Leo Padva Jonathan Becker Maria A.Patras Mona-Katharina Bill Michael Kurz Luigi Toti Sven W.Görgens Sören M.M.Schuler AndréBillion Oliver Schwengers Paulus Wohlfart Alexander Goesmann Norbert Tennagels Andreas Vilcinskas Peter E.Hammann Till F.Schäberle Armin Bauer | 2022 | Organic Chemistry Frontiers2022，9，6： | 1 |
| 10 | Gastric cancer in women: A regional health-center seven year retrospective study显示文摘AIM: To investigate whether regional geography influences ethnic and gender trends for the development of gastric cancer(GC).METHODS: This retrospective analysis of the INVISION patient database at Louisiana State University Health Sciences Center-Shreveport(LSUHSC-S), a southern United States regional hospital, was performed from 2005-2011. Using the international statistical classification of diseases 9(ICD-9), inpatient, day surgery outpatient, and emergency outpatient diagnosis codes entered into medical records were used to identify GC patients. For each study year, the patients were evaluated for age, ethnicity, and gender, and each patient was counted only once throughout the study. Subsequent patient encounters were counted as visits and separated by inpatient and clinic visits. Complex or severe disease may require more frequent and intensive clinical management; therefore, we evaluated annual clinic visits as 'surrogate markers' of disease severity. Finally, we studied the primary diagnosis for Helicobacter pylori(H. pylori) infection(ICD-9 code 41.86) as an additional factor that might increase the risk of GC.RESULTS: A total of 285 patients were diagnosed with GC at LSUHSC-S between 2005 and 2011. African Americans(181 patients, 89 males and 92 females, 63.5% of total patients) had significantly higher frequencies of GC diagnosis compared with non-Hispanic whites(104 patients, 54 males and 50 females, 36.5% of total patients), at a ratio of 1.74(P = 0.002). Within each ethnic group, men and women were diagnosed at approximately equal annual rates. Our findings differed significantly from United States national trends, which found that African American females and white females had lower risks for GC than their corresponding male counterparts. The United States national trend between 2005 and 2011 showed that African Americans males had a higher incidence of GC, with an annual mean(per 100000) of 16.31 ± 0.76 compared with white males(9 ± 0.1, P < 0.001), African American females(8.7 ± 0.34, P < 0.001) and white females(4.05 ± 0.07, P < 0.001). Among the GC patients, the number of clinic visits was highest among African American males(195.1 ± 28.1), who had significantly more clinic visits than African Americans females(123 ± 13.02, P < 0.05), white males(41.57 ± 4.74, P < 0.001) and white females(35 ± 8.9, P < 0.001). Similar trends were found for inpatient visits, with an annual mean of 11.43 ± 1.5 forAfrican American males, followed by African American females(7.29 ± 1.36), white males(2.57 ± 0.69) and white females(1.57 ± 0.612). African American males had significantly more inpatient visits than white males(P < 0.001), and African American females had more inpatient visits than white females(P < 0.01). African American patients showed the highest frequency of H. pylori positive status, with approximately 72% vs 28% for the white patients. CONCLUSION: Increase in GC diagnoses among women at LSUHSC-S is significantly higher than United States national averages, suggesting local geographic and socioeconomic influences may alter GC disease course. | Kunal Suryawala Demiana Soliman Monica Mutyala Shaheen Nageeb Moheb Boktor Abhishek Seth Avinash Aravantagi Ankur Sheth James Morris Paul Jordan Kenneth Manas Urska Cvek Marjan Trutschl Felix Becker Jonathan Alexander | 2015 | World Journal of Gastroenterology2015，21，25： | 0 |
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