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| 1 | Insulin-like growth factor(IGF)signaling in tumorigenesis and the development of cancer drug resistance显示文摘One of the greatest obstacles to current cancer treatment efforts is the development of drug resistance by tumors.Despite recent advances in diagnostic practices and surgical interventions,many neoplasms demonstrate poor response to adjuvant or neoadjuvant radiation and chemotherapy.As a result,the prognosis for many patients afflicted with these aggressive cancers remains bleak.The insulin-like growth factor(IGF)signaling axis has been shown to play critical role in the development and progression of various tumors.Many basic science and translational studies have shown that IGF pathway modulators can have promising effects when used to treat various malignancies.There also exists a substantial body of recent evidence implicating IGF signaling dysregulation in the dwindling response of tumors to current standard-of-care therapy.By better understanding both the IGF-dependent and-independent mechanisms by which pathway members can influence drug sensitivity,we can eventually aim to use modulators of IGF signaling to augment the effects of current therapy.This review summarizes and synthesizes numerous recent investigations looking at the role of the IGF pathway in drug resistance.We offer a brief overview of IGF signaling and its general role in neoplasia,and then delve into detail about the many types of human cancer that have been shown to have IGF pathway involvement in resistance and/or sensitization to therapy.Ultimately,our hope is that such a compilation of evidence will compel investigators to carry out much needed studies looking at combination treatment with IGF signaling modulators to overcome current therapy resistance. | Sahitya K.Denduluri Olumuyiwa Idowu Zhongliang Wang Zhan Liao Zhengjian Yan Maryam K.Mohammed Jixing Ye Qiang Wei Jing Wang Lianggong Zhao Hue H.Luu | 2015 | Genes & Diseases2015，2，1： | 21 |
| 2 | Role of tumor necrosis factor-alpha in the pathogenesis of atrial fibrillation显示文摘 | DENG Hai XUE Yu-mei ZHAN Xian-zhang LIAO Hong-tao GUO Hui-ming WU Shu-lin | 2011 | Chinese Medical Journal2011，，13： | 15 |
| 3 | Pancreatic duct stones in patients with chronic pancreatitis:surgical outcomes显示文摘BACKGROUND: Pancreatic duct stone (PDS) is a common complication of chronic pancreatitis. Surgery is a common therapeutic option for PDS. In this study we assessed the surgical procedures for PDS in patients with chronic pancreatitis at our hospital. METHOD: Between January 2004 and September 2009, medical records from 35 patients diagnosed with PDS associated with chronic pancreatitis were retrospectively reviewed and the patients were followed up for up to 67 months. RESULTS: The 35 patients underwent ultrasonography, computed tomography, or both, with an overall accuracy rate of 85.7%. Of these patients, 31 underwent the modified Puestow procedure, 2 underwent the Whipple procedure, 1 underwent simple stone removal by duct incision, and 1 underwent pancreatic abscess drainage. Of the 35 patients, 28 were followed up for 4-67 months. There was no postoperative death before discharge or during follow-up. After the modified Puestow procedure, abdominal pain was reduced in patients with complete or incomplete stone clearance (P>0.05). Steatorrhea and diabetes mellitus developed in several patients during a long-term follow-up. CONCLUSIONS: Surgery, especially the modified Puestow procedure, is effective and safe for patients with PDS associated with chronic pancreatitis. Decompression of intraductal pressure rather than complete clearance of all stones predicts postoperative outcome. | Liu, Bo-Nan Zhang, Tai-Ping Zhao, Yu-Pei Liao, Quan Dai, Meng-Hua Zhan, Han-Xiang | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，4： | 14 |
| 4 | Joint Inversion of the 3D P Wave Velocity Structure of the Crust and Upper Mantle under the Southeastern Margin of the Tibetan Plateau Using Regional Earthquake and Teleseismic Data显示文摘The special seismic tectonic environment and frequent seismicity in the southeastern margin of the Qinghai–Tibet Plateau show that this area is an ideal location to study the present tectonic movement and background of strong earthquakes in China's Mainland and to predict future strong earthquake risk zones. Studies of the structural environment and physical characteristics of the deep structure in this area are helpful to explore deep dynamic effects and deformation field characteristics, to strengthen our understanding of the roles of anisotropy and tectonic deformation and to study the deep tectonic background of the seismic origin of the block's interior. In this paper, the three-dimensional(3D) P-wave velocity structure of the crust and upper mantle under the southeastern margin of the Qinghai–Tibet Plateau is obtained via observational data from 224 permanent seismic stations in the regional digital seismic network of Yunnan and Sichuan Provinces and from 356 mobile China seismic arrays in the southern section of the north–south seismic belt using a joint inversion method of the regional earthquake and teleseismic data. The results indicate that the spatial distribution of the P-wave velocity anomalies in the shallow upper crust is closely related to the surface geological structure, terrain and lithology. Baoxing and Kangding, with their basic volcanic rocks and volcanic clastic rocks, present obvious high-velocity anomalies. The Chengdu Basin shows low-velocity anomalies associated with the Quaternary sediments. The Xichang Mesozoic Basin and the Butuo Basin are characterised by lowvelocity anomalies related to very thick sedimentary layers. The upper and middle crust beneath the Chuan–Dian and Songpan–Ganzi Blocks has apparent lateral heterogeneities, including low-velocity zones of different sizes. There is a large range of low-velocity layers in the Songpan–Ganzi Block and the sub–block northwest of Sichuan Province, showing that the middle and lower crust is relatively weak. The Sichuan Basin, which is located in the western margin of the Yangtze platform, shows high-velocity characteristics. The results also reveal that there are continuous low-velocity layer distributions in the middle and lower crust of the Daliangshan Block and that the distribution direction of the low-velocity anomaly is nearly SN, which is consistent with the trend of the Daliangshan fault. The existence of the low-velocity layer in the crust also provides a deep source for the deep dynamic deformation and seismic activity of the Daliangshan Block and its boundary faults. The results of the 3D P-wave velocity structure show that an anomalous distribution of high-density, strong-magnetic and high-wave velocity exists inside the crust in the Panxi region. This is likely related to late Paleozoic mantle plume activity that led to a large number of mafic and ultra-mafic intrusions into the crust. In the crustal doming process, the massive intrusion of mantle-derived material enhanced the mechanical strength of the crustal medium. The P-wave velocity structure also revealed that the upper mantle contains a low-velocity layer at a depth of 80–120 km in the Panxi region. The existence of deep faults in the Panxi region, which provide conditions for transporting mantle thermal material into the crust, is the deep tectonic background forthe area's strong earthquake activity. | LI Dahu LIAO Hua DING Zhifeng ZHAN Yan WU Pingping XU Xiaoming ZHENG Chen | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 12 |
| 5 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 6 | Left atrial enlargement and non-paroxysmal atrial fibrillation as risk factors for left atrial thrombus/spontaneous Echo contrast in patients with atrial fibrillation and low CHA2DS2-VASc score显示文摘Objective To determine the risk factors for thromboembolism in lower risk patients with non-valvular atrial fibrillation(AF)and low CHA2DS2-VASc scores,which remain undefined.Methods We retrospectively analyzed the baseline clinical characteristics,routine laboratory parameters,and echocardiographic measurements of 705 patients(71.1%male;mean age:52.10±9.64 years)with low CHA2DS2-VASc score(0 or 1;1 point for female sex)out of 1346 consecutive patients with non-valvular AF who underwent transesophageal echocardiography(TEE)at Guangdong Cardiovascular Institute between January 2013 and December 2015.Results Patients with left atrial thrombus(LAT)or spontaneous echo contrast(SEC)on TEE(24/705,4%)showed a higher incidence rate of vascular disease(54.2%vs.32.9%,P=0.045)and non-paroxysmal AF(79.2%vs.29.4%,P<0.001),larger left atrial diameter(43.08±4.59 vs.36.02±5.53 mm,P<0.001),and lower left ventricular ejection fraction(58.23±8.82%vs.64.15±7.14%,P<0.001)than those without.Multivariate logistic regression analysis identified left atrial diameter[odds ratio(OR)=1.171,95%confidence interval(CI):1.084–1.265,P<0.001]and non-paroxysmal AF(OR=3.766,95%CI:1.282–11.061,P=0.016)as independent risk factors for LAT/SEC.In ROC curve analysis,a left atrial dimeter cutoff of 37.5 mm yielded 95.0%sensitivity and 62.7%specificity(AUC:0.847,P<0.0001,95%CI:0.793–0.914).Conclusion In patients with non-valvular AF with low CHA2DS2-VASc score,the presence of LAT or SEC was associated with left atrial enlargement,which had moderate predictive value,and non-paroxysmal AF. | Wei-Dong LIN Yu-Mei XUE Fang-Zhou LIU Xian-Hong FANG Xian-Zhang ZHAN Hong-Tao LIAO Gary Tse Shu-Lin WU | 2020 | Journal of Geriatric Cardiology2020，17，3： | 8 |
| 7 | Aerosolized STAT1 Antisense Oligodeoxynucleotides Decrease the Concentrations of Inflammatory Mediators in Bronchoalveolar Lavage Fluid in Bleomycin-Induced Rat Pulmonary Fibrosis显示文摘It has been demonstrated that alveolar macrophages (AMs) play a key role in the pathogenesis of pulmonary fibrosis by releasing a variety of cytokines and inflammatory mediators. In addition, abnormal signal transducer and activator of transcription-1 (STAT1) activation in AMs may play a pivotal role in the process of alveolitis and pulmonary fibrosis. In this study, we transfected STAT1 antisense oligodeoxynucleotide (ASON) into rats by aerosolization, and then investigated the effect of STAT1 ASON on inflammatory mediators such as TGF-β, PDGF and TNF-α in bronchoalveolar lavage fluid (BALF) from rats with bleomycin (BLM)-induced rat pulmonary fibrosis. Our results showed that STAT1 ASON by aerosolization could enter into lung tissues and AMs. STAT1 ASON could inhibit mRNA and protein expressions of STAT1 and ICAM-1 in AMs of rat with pulmonary fibrosis, and had no toxic side effect on liver and kidney. Aerosolized STAT1 ASON could ameliorate the alveolitis through inhibiting the secretion of inflammatory mediators in BLM-induced rat pulmonary fibrosis. These results suggest that aerosolized STAT1 ASON might be considered as a promising new strategy in the treatment of pulmonary fibrosis. | Ming Zeng Bin Liao Chen Zhu Wenjun Wang Xiaoqin Zhan Xianming Fan | 2008 | Cellular & Molecular Immunology2008，5，3： | 8 |
| 8 | Grain refinement of Mg-Al alloys inoculated by MgAl_(2)O_(4)powder显示文摘As a potent nucleating substrate forα-Mg grain,MgAl_(2)O_(4) powder was used to inoculate the Mg-Al melt in this study.The effects of MgAl_(2)O_(4)amount,holding time and Al content on the grain size and grain refining ratio of the inoculated Mg-Al alloys are systematically investigated.The results show that the minimum grain size of Mg-3Al alloy is achieved by adding 2wt.%MgAl_(2)O_(4)powder and this alloy exhibits higher grain refining ratio than Mg-5Al and Mg-8Al alloys.The crystallographic misfit calculation indicates the wellmatching and possible orientation relationships(ORs)betweenα-Mg and MgAl_(2)O_(4).Among these predicted ORs,[10–10]α−Mg//[110]MgAl2O4 in(0002)α−Mg//(1–13)MgAl2O4 possesses the smallest misfit,i.e.,2.34%(fr).Both results of the experiment and crystallographic calculation demonstrate that the grain refinement of Mg-Al alloys is attributed to the MgAl_(2)O_(4)particles acting as the heterogeneous nucleation substrates forα-Mg grains. | Hengbin Liao Meiyan Zhan Chengbo Li Zhiqiang Ma Jun Du | 2021 | Journal of Magnesium and Alloys2021，9，4： | 7 |
| 9 | Keyhole Foraminotomy via a Percutaneous Posterior Full-endoscopic Approach for Cervical Radiculopathy:An Advanced Procedure and Clinical Study显示文摘Endoscopic cervical foraminotomy is increasingly used for cervical spondylotic radiculopathy(CSR),but there is great concern about radiation exposure because of the heavy dependence of this surgical method on fluoroscopy.The objective of this study was to introduce in detail an advanced surgical technique of keyhole foraminotomy via a percutaneous posterior full-endoscopic approach as a treatment for CSR and investigate its clinical outcomes.We retrospectively reviewed 33 consecutive patients with CSR who underwent keyhole foraminotomy via a percutaneous posterior full-endoscopic approach from October 2015 to April 2017.The patients’general characteristics,including operative time,blood loss,hospital stay,complications,and recurrence,were obtained.Clinical outcomes were evaluated using the visual analogue scale(VAS)for radicular pain,the neck disability index(NDI)for functional assessment,and the modified MacNab criteria for patient satisfaction.All operations were successfully performed(mean operation time,62 min),with no measurable blood loss or severe related complications.The mean follow-up was 25 months.The VAS and NDI scores were significantly improved as compared with those in the preoperative period(preoperative vs.final follow-up:7.6±1.6 vs.3.83±7.34 for VAS,P<0.01;69.5%±10.5%vs.17.54%±13.40%for NDI,P<0.01).Of the 33 patients,32(97.0%)had good-to-excellent global outcomes and all patients obtained symptomatic improvement.In conclusion,keyhole foraminotomy via a percutaneous posterior full-endoscopic approach is an efficient,safe,and feasible procedure for the treatment of CSR.Its simplified single-step blunt incision for localization appears to decrease radiation exposure risks. | Rong-jin LUO Yu SONG Zhi-wei LIAO Hui-peng YIN Sheng-feng ZHAN Sai-deng LU Chao CHEN Cao YANG | 2020 | Current Medical Science2020，40，6： | 7 |
| 10 | STACKING SEQUENCE OPTIMIZA-TION OF LAMINATED COMPOSITE CYLINDER SHELL FOR MAXIMAL BUCKLING LOAD显示文摘A new optimization method for the optimization of stacking of composite glass fiber laminates is developed. The fiber orientation and angle of the layers of the cylindrical shells are sought considering the buckling load. The proposed optimization algorithm applies both finite element analysis and the mode-pursuing sampling (MPS)method. The algorithms suggest the optimal stacking sequence for achieving the maximal buckling load. The procedure is implemented by integrating ANSYS and MATLAB. The stacking sequence designing for the symmetric angle-ply three-layered and five-layered composite cylinder shells is presented to illustrate the optimization process, respectively. Compared with the genetic algorithms, the proposed optimization method is much faster and efficient for composite staking sequence plan. | TANG Qian LIAO Xiaoyun GAO Zhan | 2008 | Chinese Journal of Mechanical Engineering2008，21，4： | 4 |
| 11 | Risk factors for postoperative pancreatic fistula in patients with insulinomas:analysis of 292 consecutive cases显示文摘BACKGROUND:Pancreatic fistula (PF) remains the most challenging complication in pancreatic surgery,yet few published studies have focused on the risk factors for postoperative PF in patients undergoing surgery for insulinomas.METHODS:From January 1990 to February 2010,a total of 292 patients with insulinomas underwent surgery at Peking Union Medical College Hospital.Demographic data,intraoperative procedures,and postoperative data were collected.Particular attention was paid to variables associated with PF as defined by the International Study Group of Pancreatic Fistula (ISGPF).Univariate and multivariate analyses were used to identify possible risk factors for PF.RESULTS:PF was found in 132 (45.2%) patients,of whom 90 were classified into ISGPF grade A,33 grade B,and 9 grade C.Multivariate analysis showed that male patients (OR=2.56;P=0.007) and operative time >180minutes (OR=3.756;P<0.0001) were independent risk factors for clinical PF.Pancreatic resection with stapler was a protective factor for both total PF (OR=0.022;P=0.010) and clinical PF (OR=0.097;P=0.007).CONCLUSIONS:Male gender and operative time >180minutes were independent risk factors for clinical PF,while pancreatic resection with a stapler was a protective factor.Whether body mass index (BMI) and other variables during operation are risk factors of PF needs further study. | Zhao, Yu-Pei Zhan, Han-Xiang Cong, Lin Zhang, Tai-Ping Liao, Quan Dai, Meng-Hua Cai, Li-Xing Zhu, Yu | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 3 |
| 12 | Predictive value of red cell distribution width on left atrial thrombus or left atrial spontaneous echo contrast in patients with non-valvular atrial fibrillation显示文摘ObjectiveTo 在左 atrial 血栓( LAT )或左 atrial 上评估红房间分发宽度( RDW )的预兆的价值在有纤维性颤动( AF ) .MethodsWe 考察了的非瓣膜的 atrial 的病人的自发的回响对比( LASEC )作为非瓣膜的 AF 被诊断并且经历了 transesophageal echocardiography ( T )在里面的 692 个病人从2014年4月的广东心血管的研究所到2015年12月。基线临床的特征,血常规的实验室测试,心动电流描记器大小是 analyzed.ResultsEighty -- 四个病人在 T 下面与 LAT/LASEC 被检查。吝啬的 RDW 水平与 non-LAT/LASEC 病人相比在 LAT/LASEC 病人是显著地更高的(13.59% | Xian-Zhang ZHAN Wei-Dong LIN Fang-Zhou LIU Yu-Mei XUE Hong-Tao LIAO Xin LI Xian-Hong FANG Hai DENG Jun HUANG Yang-Qiu LI Jo-Jo HAI Hung-Fat Tse Shu-Lin WU | 2018 | Journal of Geriatric Cardiology2018，15，6： | 3 |
| 13 | Predictive value of serum uric acid on left atrial spontaneous echo contrast in non-valvular atrial fibrillation patients显示文摘ObjectivesTo 调查在浆液之间的关系尿酸( SUA )和左 atrial 在纤维性颤动( AF ) patients.MethodsWe 回顾地屏蔽了的非瓣膜的 atrial 的自发的回响对比(LA秒)在 radiofrequency 以前经历了 transesophageal echocardiography 的有 AF 的 1,476 个连续就医的病人导管脱离,在广东医院将军的左 atrial 附器闭合和电的 cardioversion 。所有病人的临床的基线特征上的数据与左 atrial 血栓从电子医药记录和病人的 analyzed.ResultsAfter 排除被收集, 1,354 个病人进入了现在的学习, 57 是 LA 秒。吝啬的女 SUA 水平(380.88 ±94.35 µ mol/L 对 323.37 ±72.19 µ mol/L, P <0.001 ) 并且男 SUA 水平(416.97 ±98.87 µ mol/L 对 367.88 ±68.50 µ mol/L, P = 0.008 ) 比在控制在有 LA 秒的病人更高显著地是两个。吝啬的左 atrial 尺寸(41.32 ±5.12 公里对 36.12 ±5.66 公里, P <0.001 ) 在有 LA 秒的病人是显著地更大的。在 multivariate 回归分析, SUA 水平是为 LA 秒的一个独立风险因素(或:1.008, P <0.001 ) 。在操作典型曲线分析的接收装置,在为在女性和男性预言 LA 秒的 SUA 的曲线下面的相应区域分别地是 0.670 和 0.657。SUA 水平在有 LA-SEC.ConclusionSUA 的非瓣膜的 AF 病人是显著地更高的水平是一个独立风险因素并且在南部的中国在非瓣膜的 AF 病人之中为 LA 秒有中等预兆的价值。 | Hong-Tao LIAO Fang-Zhou LIU Yu-Mei XUE Xian-Zhang ZHAN Xian-Hong FANG Jun HUANG Wei WEI Fang RAO Hai DENG Yang LIU Wei-Dong LIN Shu-Lin WU | 2015 | Journal of Geriatric Cardiology2015，12，6： | 3 |
| 14 | The immunologic and hematopoietic profiles of mesenchymal stem cells derived from different sections of human umbilical cord显示文摘间充质的干细胞(MSC ) 广泛地在 allogeneic 干细胞移植被使用了。我们比较了 immunologic, MSC 的造血的特征源于整个人的脐的绳索(UC ) ,以及从 UC 的不同的节,包括羊膜的膜(AM ) ,沃顿的果冻(WJ ) ,和脐的容器(紫外) 。房间显型被流动 cytometry 检验。淋巴细胞转变测试和混合淋巴细胞反应被执行评估从 UC 导出的 MSC 的免疫调节的活动。cytokines 的 mRNA 表示被即时聚合酶链反应检测。造血的功能被文化 co MSC 学习, CD34 + 房间从绳索血孤立。我们的结果显示出包括 UC 与这四不同的节分开的那 MSC, WJ,紫外,并且 AM 有类似的生物特征。所有 MSC 有多系区别能力并且能区分进造骨细胞, adipocytes,和 chondrocytes。MSC 也以一种剂量依赖者方式禁止了 allogeneic T 房间的增长。cytokines 的相对 mRNA 表示被检验,并且结果显示出比 MSC 的有的更高的 interleukin-6 (IL6 ) , IL11,干细胞因素,和 FLT3 表示从 UC 的特定的节导出的那 UCMSC。当 co 有教养时, CD34 + 房间有高繁殖效率, MSC 源于 UC, UCMSC 在之中是最有效的喂层的不同的节。我们的学习证明 MSC 能与支持特征的类似的 immunomodulation 和造血作用从整个 UC 或 UC 的特定的节被孤立。 | Man Xu Bin Zhan Yuanlin Liu Jin Zhang Hongxia Sheng Rui Shi Li Liao Na Liu Jiangwei Hu Jun Wang Hongmei Ning Ting Liu Yi Zhang Hu Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 3 |
| 15 | Lathyranoic acid A:Firstsecolathyrane diterpoid in nature from Euphorbia lathyris显示文摘 | Liao S G Zhan Z J Yang S P | 2005 | OrgLett2005，7，7： | 1 |
| 16 | Knowledge sharing modeling technology for enterprise knowledge management 显示文摘 | Zhan Pei - zhi Liao Wen - he | 2005 | Journal of South China University of Technology: Natural Science Edition2005，33，7： | 1 |
| 17 | Lathyranoic acid A:first secolathyrane diterpenoid in nature from Euphorbia lathyris显示文摘 | Liao S G Zhan Z J Yang S P | 2005 | Org Lett2005，7，7： | 1 |
| 18 | Curcumin improves TNBS-induced colitis in rats by inhibiting IL-27 expression via the TLR4/NF-κB signaling pathway显示文摘 | Zeng Z Zhan L Liao H | 2013 | Planta Med2013，79，2： | 1 |
| 19 | Recombinant Fv-Hsp70 Protein Mediates Neuroprotection After Focal Cerebral Ischemia in Rats显示文摘 | Xinhua Zhan Bradley P. Ander Isaac H. Liao James E. Hansen Chester Kim Douglas Clements Richard H. Weisbart Robert N. Nishimura Frank R. Sharp | 2010 | Stroke2010，，3： | 1 |
| 20 | Recombinant Fv-Hsp70 protein mediates neuroprotection after focal cerebral ische, mia in rats 显示文摘 | Zhan X Ander BP Liao IH | 2010 | Stroke2010，41，3： | 1 |
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