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| 1 | Effect of mixed rare earth oxides and CaCO_3 modification on the microstructure of an in-situ Mg_2Si/Al-Si composite显示文摘The effects of mixed rare earth oxides and CaCO3 on the microstructure of an in-situ Mg2Si/Al-Si hypereutectic alloy composite were investigated by optical microscope,scanning electron microscope,and energy dispersive spectrum analysis. The results showed that the morphol-ogy of the primary Mg2Si phase particles changed from irregular or crosses to polygonal shape,their sizes decreased from 75 μm to about 25 μm,and the compound of both the oxide and CaCO3 was better than either the single mixed rare earth oxides or CaCO3. | Liu, Zheng Lin, Jixing Jing, Qingxiu | 2009 | Rare Metals2009，28，2： | 9 |
| 2 | Biodegradable Zn–3Cu and Zn–3Cu–0.2Ti alloys with ultrahigh ductility and antibacterial ability for orthopedic applications显示文摘Zinc(Zn) and its alloys have been proposed as biodegradable implant materials due to their unique combination of biodegradability, biocompatibility, and biofunctionality. However, the insufficient mechanical properties of pure Zn greatly limit its clinical application. Here, we report on the microstructure, mechanical properties, friction and wear behavior, corrosion and degradation properties, hemocompatibility, and cytocompatibility of Zn–3 Cu and Zn–3 Cu–0.2 Ti alloys under three different conditions of as-cast(AC),hot-rolling(HR), and hot-rolling plus cold-rolling(HR + CR). The HR + CR Zn–3 Cu–0.2 Ti exhibited the best set of comprehensive properties among all the alloy samples, with yield strength of 211.0 MPa, ultimate strength of 271.1 MPa, and elongation of 72.1 %. Immersion tests of the Zn–3 Cu and Zn–3 Cu–0.2 Ti alloys in Hanks’ solution for 3 months indicated that the AC samples showed the lowest degradation rate,followed by the HR samples, and then the HR + CR samples, while the HR + CR Zn–3 Cu exhibited the highest degradation rate of 23.9 m/a. Friction and wear testing of the Zn–3 Cu and Zn–3 Cu–0.2 Ti alloys in Hanks’ solution indicated that the AC samples showed the highest wear resistance, followed by the HR samples, and then the HR + CR samples, while the AC Zn–3 Cu–0.2 Ti showed the highest wear resistance.The diluted extracts of HR + CR Zn–3 Cu and Zn–3 Cu–0.2 Ti at a concentration of ≤25 % exhibited noncytotoxicity. Furthermore, both the HR + CR Zn–3 Cu and Zn–3 Cu–0.2 Ti exhibited effective antibacterial properties against S. aureus. | Jixing Lin Xian Tong Kun Wang Zimu Shi Yuncang Li Matthew Dargusch Cuie Wen | 2021 | Journal of Materials Science & Technology2021，，9： | 3 |
| 3 | Report of epibenthic macrofauna found from Haima cold seeps and adjacent deep-sea habitats,South China Sea显示文摘This work reports on a preliminary taxonomic study of epibenthic macroinvertebrates collected or observed by underwater video at the Haima cold seeps and in adjacent deep-sea habitats,including a mud volcano feld and Ganquan Plateau,during an expedition in the South China Sea by the Chinese-manned submersible Shenhai Yongshi in May 2018.A total of 41 species belonging to 6 phyla were identifed,among which 34 species were collected from the Haima cold seeps.Mollusks and crustaceans that are specialized in reducing habitats were predominant in biotopes of the Haima cold seeps,whereas sponges and cold-water corals and their commensals were prominent in communities of the mud volcano feld and the slopes of Ganquan Plateau.The distribution and faunal composition of each taxonomic group are discussed. | Dong Dong Xinzheng Li Mei Yang Lin Gong Yang Li Jixing Sui Zhibin Gan Qi Kou Ning Xiao Junlong Zhang | 2021 | Marine Life Science & Technology2021，3，1： | 3 |
| 4 | Overweight, obesity, and their associations with insulin resistance and β -cell function among Chinese: a cross-sectional study in China显示文摘 | Gang Chen Chune Liu Jin Yao Qiqin Jiang Nianhui Chen Huibin Huang Jixing Liang Liantao Li Lixiang Lin | 2010 | Metabolism2010，，12： | 1 |
| 5 | Single-cell brain atlas of Parkinson's disease mouse model显示文摘Parkinson's disease(PD)is a neurodegenerative disease,leading to the impairment of movement execution.PD pathogenesis has been largely investigated,either limited to bulk transcriptomic levels or at certain cell types,which failed to capture the cellular heterogeneity and intrinsic interplays among distinct cell types.Here,we report the application of single-nucleus RNA-seq on midbrain,striatum,and cerebellum of theα-syn-A53 T mouse,a well-established PD mouse model,and matched controls,generating the first single cell transcriptomic atlas for the PD model mouse brain composed of 46,174 individual cells.Additionally,we comprehensively depicte the dysfunctions in PD pathology,covering the elevation of NF-k B activity,the alteration of ion channel components,the perturbation of protein homeostasis network,and the dysregulation of glutamatergic signaling.Notably,we identify a variety of cell types closely associated with PD risk genes.Taken together,our study provides valuable resources to systematically dissect the molecular mechanism of PD pathogenesis at the single-cell resolution,which facilitates the development of novel approaches for diagnosis and therapies against PD. | Jixing Zhong Gen Tang Jiacheng Zhu Weiying Wu Ge Li Xiumei Lin Langchao Liang Chaochao Chai Yuying Zeng Feiyue Wang Lihua Luo Jiankang Li Fang Chen Zhen Huang Xiuqing Zhang Yu Zhang Hongde Liu Xin Qiu Shengping Tang Dongsheng Chen | 2021 | Journal of Genetics and Genomics2021，48，4： | 1 |
| 6 | Microstructures, mechanical properties, corrosion, and biocompatibility of extruded Mg-Zr-Sr-Ho alloys for biodegradable implant applications显示文摘In this study,the microstructures,mechanical properties,corrosion behaviors,and biocompatibility of extruded magnesium-zirconiumstrontium-holmium(Mg-Zr-Sr-Ho)alloys were comprehensively investigated.The effect of different concentrations of Ho on the microstructural characteristics,tensile and compressive properties,corrosion resistance,and biocompatibility were investigated.The microstructures of the extruded Mg-1Zr-0.5Sr-xHo(x=0.5,1.5,and 4 wt.%)alloys consisted ofα-Mg matrix,fineα-Zr particles,and intermetallic phase particles of Mg_(17)Sr_(2) and Ho_(2)Mg mainly distributed at the grain boundaries.Extensive{1012}tensile twins were observed in the partially recrystallized samples of Mg-1Zr-0.5Sr-0.5Ho and Mg-1Zr-0.5Sr-1.5Ho.Further addition of Ho to 4 wt.%resulted in a complete recrystallization due to activation of the particle stimulated nucleation around the Mg_(17)Sr_(2) particles.The evolution of a rare earth(RE)texture was observed with the Ho addition,which resulted in the weakened basal and prismatic textures.Furthermore,a drastic increase of 200%in tensile elongation and 89%in compressive strain was observed with Ho addition increased from 0.5 to 4 wt%,respectively.The tension-compression yield asymmetry was significantly decreased from 0.62 for Mg-1Zr-0.5Sr-0.5Ho to 0.98 for Mg-1Zr-0.5Sr-4Ho due to the weakening of textures.Corrosion analysis of the extruded Mg-Zr-Sr-Ho alloys revealed the presence of pitting corrosion.A minimum corrosion rate of 4.98 mm y^(−1) was observed in Mg-1Zr-0.5Sr-0.5Ho alloy.The enhanced corrosion resistance is observed due to the presence of Ho_(2)O_(3) in the surface film which reduced galvanic effect.The formation of a stabilized surface film due to the Ho_(2)O_(3) was confirmed through the electrical impedance spectroscopy and XPS analysis.An in vitro cytotoxicity assessment revealed good biocompatibility and cell adhesion in relation to SaOS2 cells. | Faisal Kiani Jixing Lin Alireza Vahid Khurram Munir Cuie Wen Yuncang Li | 2023 | Journal of Magnesium and Alloys2023，11，1： | 1 |
| 7 | Titanium-niobium pentoxide composites for biomedical applications显示文摘The strength of titanium scaffolds with the introduction of high porosity decreases dramatically and may become inadequate for load bearing in biomedical applications.To simultaneously meet the requirements of biocompatibility,low elastic modulus and appropriate strength for orthopedic implant materials,it is highly desirable to develop new biocompatible titanium based materials with enhanced strength.In this study,we developed a niobium pentoxide(Nb2O5)reinforced titanium composite via powder metallurgy for biomedical applications.The strength of the Nb2O5 reinforced titanium composites(Ti-Nb2O5)is significantly higher than that of pure titanium.Cell culture results revealed that the Ti-Nb2O5 composite exhibits excellent biocompatibility and cell adhesion.Human osteoblast-like cells grew and spread healthily on the surface of the Ti-Nb2O5 composite.Our study demonstrated that Nb2O5 reinforced titanium composite is a promising implant material by virtue of its high mechanical strength and excellent biocompatibility. | Yuncang Li Khurram S.Munir Jixing Lin Cuie Wen | 2016 | Bioactive Materials2016，1，2： | 1 |
| 8 | Development of Ti-26Nb-1.2TiC shape memory composite for biomedical applications显示文摘Ti-Nb alloys have great potential in biomedical applications as bone-implant materials due to their low elastic modulus,superelasticity,high corrosion resistance,and good biocompatibility.However,the low yield strength and poor superelasticity of Ti-Nb alloys restrict their practical clinical applications.Here,we report the mechanical properties and superelasticity,corrosion behavior,and biocompatibility of a Ti-26 at.%Nb-1.2 vol.%TiC(Ti-26Nb-1.2TiC)shape memory composite(SMC)prepared by vacuum arc melting and hot rolling.The yield strength,critical stress for inducing martensitic transformation,and elongation of the Ti-26Nb-1.2TiC SMC and a Ti-26Nb alloy were 460 and 337 MPa,251 and 115 MPa,and 27.2%and 24.1%,respectively.The recovery rate of the SMC under 4%pre-strain reached 91.4%,which was 1.2 times that of the Ti-26Nb.Electrochemical tests in Hanks’solution revealed that the corrosion current density,passive current density,and corrosion rate of the SMC were lower than those of the Ti-26Nb.Both the Ti-26Nb alloy and Ti-26Nb-1.2TiC SMC showed good cell viability with grade 0 cytotoxicity in relation to MG-63 osteosarcoma cells. | Quanxiang Sun Dechuang Zhang Xian Tong Jianguo Lin Jixing Lin Yuncang Li Cuie Wen | 2023 | Journal of Materials Science & Technology2023，，22： | 0 |
| 9 | Transition-metal-free synthesis of 4-aminoisoquinolin-1(2H)-ones via a tandem reactionof arynes and oxazoles显示文摘A facile and transition-metal-free method for the synthesis of 4-amino isoquinolin-1(2H)-ones has beendeveloped. Arynes react with 4,5-disubstituted oxazoles through a tandem Diels–Alder reaction/dehydrogenation–aromatization/tautamerization process to produce 4-amino isoquinolin-1(2H)-ones in moderate to excellent yields. The reaction can be easily scaled up and the product can be transformed to isoquinoline derivatives efficiently. | Shaojun Liu Pei Xie Leifang Wu Jixing Zhao Zhihua Cai Lin He | 2022 | Organic Chemistry Frontiers2022，9，6： | 0 |
| 10 | Binary Zn–Ti alloys for orthopedic applications:Corrosion and degradation behaviors,friction and wear performance,and cytotoxicity显示文摘Zinc(Zn)and its biocompatible and biodegradable alloys have substantial potential for use in orthopedic implants.Nevertheless,pure Zn with a hexagonal close-packed crystal structure has only two independent slip systems,therefore exhibiting extremely low elongation and yield strength in its ascast condition,which restricts its clinical applications.In this study,as-cast Zn–xTi(titanium)(x=0.05,0.10,0.20,and 0.30 wt.%)binary alloys were hot-rolled and their microstructures,mechanical properties,wear resistance,and cytocompatibility were comprehensively investigated for orthopedic implant applications.The microstructures of both as-cast and hot-rolled Zn–xTi alloys consisted of anα-Zn matrix phase and a TiZn16 phase,while Zn–0.2 Ti and Zn–0.3 Ti exhibited a finerα-Zn phase due to the grainrefining effect of Ti.The hot-rolled Zn–0.2 Ti alloy exhibited the highest yield strength(144.5 MPa),ultimate strength(218.7 MPa),and elongation(54.2%)among all the Zn–x Ti alloys.The corrosion resistance of Zn–xTi alloys in Hanks’solution decreased with increasing addition of Ti,and the hot-rolled Zn–0.3 Ti alloy exhibited the highest corrosion rates of 432μm/y as measured by electrochemical testing and 57.9μm/y as measured by immersion testing.The as-cast Zn–xTi alloys showed lower wear losses than their hot-rolled counterparts.The extracts of hot-rolled Zn–x Ti alloys at concentrations of≤25%showed no cytotoxicity to MG-63 osteosarcoma cells and the extracts of Zn–xTi alloys exhibited enhanced cytocompatibility with increasing Ti content. | Kun Wang Xian Tong Jixing Lin Aiping Wei Yuncang Li Matthew Dargusch Cuie Wen | 2021 | Journal of Materials Science & Technology2021，，15： | 0 |
| 11 | Lake regime shift from submerged macrophyte to phytoplankton affected phosphorus speciation in sediment and eutrophic state in Caohai Lake,Guizhou,China显示文摘To understand the effect of regime shift in Caohai Lake in Yunnan-Guizhou Plateau,SW China from submerged macrophyte dominance to phytoplankton dominance on the specification and distribution of phosphorus and on ecological and environmental states,changes in phosphorus specification in the sediments and water were studied.The form,composition,and distribution of phosphorus in sediment were sampled in July 2020(before regime shift)and July 2021(after regime shift)were analyzed.Results reveal that phosphorus content in sediment was lower than that those of Erhai Lake and Dianchi Lake,Yunnan,SW China,on the same plateau,and was lower than those of Taihu Lake,Chaohu Lake,and Poyang Lake in the middle-lower Changjiang(Yangtze)River Plain.Organic phosphorus(Or-P)was the main form(up to 60%),followed by inactive phosphorus(Ina-P),and the active phosphorus(Act-P),the least,which is opposite to those of Taihu Lake and Poyang Lake in the middle-lower Changjiang River Plain in the eastern China.Or-P content was high,indicating a high potential risk of phosphorous release.After the regime shift,the total phosphorus in sediment decreased from 0.87±0.13 to 0.70±0.13 g/kg.The proportion of Or-P and Act-P decreased from 68.23% to 65.32% and from 5.35% to 4.69%,respectively.In contrast,the proportion of Ina-P increased from 26.42% to 29.99%.The Moran’s I index revealed that the heterogeneity of the spatial distributions of the total phosphorus(S-TP)and Act-P in the sediments before regime shift was significant(P<0.1).However,the heterogeneity of the spatial distributions of S-TP and the various forms of phosphorus after regime shift was not significant(P>0.05).The regime shift aggravated the eutrophication of the lake,the trophic level index(TLI)increased from 48.42 to 54.49(P<0.01),and the previously mesotrophic lake became a mildly eutrophic lake.The results of this study revealed the impact of regime shift in the lake from submerged macrophyte dominance to phytoplankton dominance on the composition and spatial distribution of phosphorus in sediments and provided a basis for the restoration of eutrophicated and aquatic ecosystem degraded lakes. | Jixing DONG Yanmin GUO Pinhua XIA Yuanbin TIAN Feifei ZHENG Anyan LI Tao LIN Ruiwen LI | 2023 | Journal of Oceanology and Limnology2023，41，6： | 0 |
| 12 | Improvements in mechanical, corrosion, and biocompatibility properties of Mg–Zr–Sr–Dy alloys via extrusion for biodegradable implant applications显示文摘In this study,extrusion was performed on Mg-Zr-Sr-Dy alloys for improving their mechanical,corrosion,and biocompatibility properties.Effects of extrusion and alloying elements on the microstructural characteristics,tensile and compressive strengths,corrosion behavior,and biocompatibility were investigated.The Mg-Zr-Sr-Dy alloys were composed of an α-Mg matrix containing {10■2} extension twins and secondary phases of intermetallic compounds Mg_(17)Sr_(2) and Mg_(2)Dy.Evolution of basal and rare earth(RE) textures was observed in the extruded alloys and an increase in Dy content to 2 wt.% resulted in texture randomization and strengthening of the RE component,mainly due to particle-stimulated nucleation and a change from discontinuous dynamic recrystallization to continuous dynamic recrystallization,which also led to an improved tension-compression yield asymmetry of 0.87.Extrusion of the alloys significantly enhanced their tensile and compressive properties due to improved distribution of alloying elements and formation of textures.Corrosion rates tested by hydrogen evolution testing,potentiodynamic polarization,and electrical impedance spectroscopy showed similar trends for each composition,and the lowest corrosion rate of 3.37 mmy^(-1) was observed for the Mg-1Zr-0.5Sr-1Dy in the potentiodynamic polarization testing.Dy_(2)O_(3) was observed in the inner layers of the Mg(OH)_(2) protective films,whose protective efficacy was confirmed by charge-transfer and film resistances.A comparison among the minimum CRs observed in this study and previously studied as-cast Mg-Zr-Sr-Dy and extruded Mg-Zr-Sr alloys,demonstrates that both the extrusion process and addition of Dy in Mg-Zr-Sr improved the CR.Similarly,extruded Mg-Zr-Sr-Dy alloys showed improved cell viability and adhesion of human osteoblast-like SaOS2 cells due to increased corrosion resistance and enhanced Sr distribution within the Mg matrix. | Faisal Kiani Jixing Lin Khurram Munir Cuie Wen Yuncang Li | 2023 | Journal of Magnesium and Alloys2023，11，10： | 0 |
| 13 | Effect of thermomechanical treatment on the mechanical and microstructural evolution of a β-type Ti-40.7Zr–24.8Nb alloy显示文摘In this study,the microstructural evolution and mechanical properties of a newly developed Ti-40.7Zr-24.8Nb(TZN)alloy after different thermomechanical processes were examined.As-cast TZN alloy plates were solutiontreated at 890℃ for 1 h,after which the thickness of the alloy plates was reduced by cold rolling at reduction ratios of 20%,56%,76%,and 86%.Stress-induced α”formation,{332}<113>β mechanical twinning,and kink band formation were observed in the cold-rolled TZN alloy samples.In the TZN sample after cold rolling at the 86%reduction ratio plus a recrystallization annealing at 890℃ for 1 h,the deformation products of a stressinducedα”phase,{332}<113>β mechanical twinning,and kink bands disappeared,resulting in a fine,equiaxed singleβ phase.The alloy samples exhibited elongation at rupture ranging from 7%to 20%,Young's modulus ranging from 63 to 72 GPa and tensile strength ranging from 753 to 1158 MPa.The TZN alloy sample after cold rolling and recrystallization annealing showed a yield strength of 803 MPa,a tensile strength of 848 MPa,an elongation at rupture of 20%,and an elastic admissible strain of 1.22%,along with the most ductile fractures during tensile testing. | Sertan Ozan Jixing Lin Weijie Weng Yaowu Zhang Yuncang Li Cuie Wen | 2019 | Bioactive Materials2019，4，1： | 0 |
| 14 | Impact of scandium and terbium on the mechanical properties,corrosion behavior,and biocompatibility of biodegradable Mg-Zn-Zr-Mn alloys显示文摘Magnesium(Mg)-based bone implants degrade rapidly in the physiological environment of the human body which affects their structural integrity and biocompatibility before adequate bone repair.Rare earth elements(REEs)have demonstrated their effectiveness in tailoring the corrosion and mechanical behavior of Mg alloys.This study methodically investigated the impacts of scandium(Sc)and terbium(Tb)in tailoring the corrosion resistance,mechanical properties,and biocompatibility of Mg–0.5Zn–0.35Zr–0.15Mn(MZZM)alloys fabricated via casting and hot extrusion.Results indicate that addition of Sc and Tb improved the strength of MZZM alloys via grain size reduction and solid solution strengthening mechanisms.The extruded MZZM–(1–2)Sc–(1–2)Tb(wt.%)alloys exhibit compressive strengths within the range of 336–405 MPa,surpassing the minimum required strength of 200 MPa for bone implants by a significant margin.Potentiodynamic polarization tests revealed low corrosion rates of as–cast MZZM(0.25 mm/y),MZZM–2Tb(0.45 mm/y),MZZM–1Sc–1Tb(0.18 mm/y),and MZZM–1Sc–2Tb(0.64 mm/y),and extruded MZZM(0.17 mm/y),MZZM–1Sc(0.15 mm/y),MZZM-2Sc(0.45 mm/y),MZZM-1Tb(0.17 mm/y),MZZM-2Tb(0.10 mm/y),MZZM–1Sc-1Tb(0.14 mm/y),MZZM-1Sc-2Tb(0.40 mm/y),and MZZM–2Sc–2Tb(0.51 mm/y)alloys,which were found lower compared to corrosion rate of high-purity Mg(~1.0 mm/y)reported in the literature.Furthermore,addition of Sc,or Tb,or Sc and Tb to MZZM alloys did not adversely affect the viability of SaOS2 cells,but enhanced their initial cell attachment,proliferation,and spreading shown via polygonal shapes and filipodia.This study emphasizes the benefits of incorporating Sc and Tb elements in MZZM alloys,as they effectively enhance corrosion resistance,mechanical properties,and biocompatibility simultaneously. | Khurram Munir Jixing Lin Xian Tong Arne Biesiekierski Yuncang Li Cuie Wen | 2024 | Journal of Magnesium and Alloys2024，12，2： | 0 |
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