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| 1 | A Brief Overview of ChatGPT:The History,Status Quo and Potential Future Development显示文摘ChatG PT,an artificial intelligence generated content (AIGC) model developed by OpenAI,has attracted worldwide attention for its capability of dealing with challenging language understanding and generation tasks in the form of conversations.This paper briefly provides an overview on the history,status quo and potential future development of ChatGPT,helping to provide an entry point to think about ChatGPT.Specifically,from the limited open-accessed resources,we conclude the core techniques of ChatGPT,mainly including large-scale language models,in-context learning,reinforcement learning from human feedback and the key technical steps for developing ChatGPT.We further analyze the pros and cons of ChatGPT and we rethink the duality of ChatGPT in various fields.Although it has been widely acknowledged that ChatGPT brings plenty of opportunities for various fields,mankind should still treat and use ChatG PT properly to avoid the potential threat,e.g.,academic integrity and safety challenge.Finally,we discuss several open problems as the potential development of ChatGPT. | Tianyu Wu Shizhu He Jingping Liu Siqi Sun Kang Liu Qing-Long Han Yang Tang | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，5： | 18 |
| 2 | Large aperture N31 neodymium phosphate laser glass for use in a high power laser facility显示文摘Large aperture Nd:phosphate laser glass is a key optical element for an inertial confinement fusion(ICF) facility. N31,one type of neodymium doped phosphate glasses, was developed for high peak power laser facility applications in China. The composition and main properties of N31 glass are given, together with those of LHG-8, LG-770, and KGSS-0180 Nd:phosphate laser glasses, from Hoya and Schott, and from Russia. The technologies of pot melting, continuous melting, and edge cladding of large size N31 phosphate laser glass are briefly described. The small signal gain profiles of N31 glass slabs from both pot melting and continuous melting at various values of the pumping energy of the xenon lamp are presented. N31 glass is characterized by a stimulated emission cross section of 3.8 × 10-20cm2 at 1053 nm,an absorption coefficient of 0.10–0.15% cm-1at laser wavelength, small residual stress around the interface between the cladding glass and the laser glass, optical homogeneity of ~2 × 10-6in a 400 mm aperture, and laser damage threshold larger than 42 J/cm2 for a 3 ns pulse width at 1064 nm wavelength. | Lili Hu Shubin Chen Jingping Tang Biao Wang Tao Meng Wei Chen Lei Wen Junjiang Hu Shunguang Li Yongchun Xu Yasi Jiang Junzhou Zhang Zhonghong Jiang | 2014 | High Power Laser Science and Engineering2014，2，1： | 8 |
| 3 | Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation显示文摘Severe acute pancreatitis-associated acute lung injury(SAP-ALI) is a serious disease associated with high mortality. Emodin has been applied to alleviate SAP-ALI;however, the mechanism remains unclear. We report that the therapeutic role of emodin in attenuating SAP-ALI is partly dependent on an exosomal mechanism. SAP rats had increased levels of plasma exosomes with altered protein contents compared to the sham rats. These infused plasma exosomes tended to accumulate in the lungs and promoted the hyper-activation of alveolar macrophages and inflammatory damage. Conversely,emodin treatment decreased the plasma/pancreatic exosome levels in the SAP rats. Emodin-primed exosomes showed less pro-inflammatory effects in alveolar macrophages and lung tissues than SAP exosomes. In detail, emodin-primed exosomes suppressed the NF-κB pathway to reduce the activation of alveolar macrophage and ameliorate lung inflammation by regulating PPARγ pathway, while these effects were amplified/abolished by PPARγ agonist/antagonist. Blockage of pancreatic acinar cell exosome biogenesis also exhibited suppression of alveolar macrophage activation and reduction of lung inflammation. This study suggests a vital role of exosomes in participating inflammation-associated organ-injury,and indicates emodin can attenuate SAP-ALI by reducing the pancreatic exosome-mediated alveolar macrophage activation. | Qian Hu Jiaqi Yao Xiajia Wu Juan Li Guixiang Li Wenfu Tang Jingping Liu Meihua Wan | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 7 |
| 4 | Effect of glutathione on in vivo biodistribution and clearance of surface-modified small Pd nanosheets显示文摘Plasmonic Pd nanosheets have been emerging as promising materials for application in near-infrared(NIR) photothermal therapy(PTT) of cancer. However, animal in mice studies indicated that the original synthesized poly(vinylpyrrolidone)(PVP)-protected small Pd nanosheets(Pd-PVP) and some further surface-modified small Pd nanosheets such as Pd-PEG(SH) easily accumulated in reticuloendothelial system(RES) organs(liver, spleen, etc.) and were difficult to be cleared from these organs quickly. In the work, we surprisingly found that glutathione(GSH) could promote the clearance of surface-modified small Pd nanosheets(e.g. Pd-PVP, Pd-PEG(SH) and Pd-GSH) from the RES organs efficiently. The effects of GSH on the biodistribution and clearance of different surface-modified Pd nanosheets were investigated. Our results indicated that these surface-modified Pd nanosheets with or without GSH added caused no morbidity at target primary organs, and GSH can promote the clearance of different surface-modified Pd nanosheets in the order of Pd-PVP≈Pd-PEG(SH)>Pd-GSH. This study suggests that glutathione could be an attractive reagent for promoting nanomaterials eliminated from the reticuloendothelial systems(RES). | Yizhuan Huang Xiaolan Chen Saige Shi Mei Chen Shaoheng Tang Shiguang Mo Jingping Wei Nanfeng Zheng | 2015 | Science China Chemistry2015，58，11： | 3 |
| 5 | Strategies for improving fertilizer phosphorus use efficiency in Chinese cropping systems显示文摘A four-year project,entitled'The mechanisms of fraction transformation and high use efficiency of P fertilizer in Chinese cropping systems'commenced in 2017.The project was established to answer three key questions and looked at 17 cropping systems on ten soils.First,we asked what are the dynamics of transformation,fixation and mobilization of P fertilizers in soil-cropping systems?Second,what are the mechanisms of soil-cropmicrobe interactions by which P fertilizer can be efficiently used?Third,how to manipulate the processes of P use in cropping systems?The targets of this project are(1)to explore the mechanisms of P fixation,the pathways of loss of P availability and the threshold of migration of fertilizer P in the field;(2)to uncover mechanisms by which soil legacy P is mobilized through root physiological and morphological processes and through arbuscular mycorrhizal fungi and P-solubilizing bacteria in rhizosphere and hyphosphere;(3)to estimate the biological potential of crops for high efficiency P absorption and use;(4)to innovate new approaches for improving the efficiency of P fertilizers.The outcomes will provide theoretical support for setting standards for limitation of P fertilizer application rate in the main cropping zones of China. | Gu FENG Jingping GAI Xionghan FENG Haigang LI Lin ZHANG Keke YI Jialong LV Yiyong ZHU Li TANG Yilin LI | 2019 | Frontiers of Agricultural Science and Engineering2019，6，4： | 2 |
| 6 | Magnetostriction of Pseudobinary Compounds Pr_(0.15)Tb_xDy_(0.85-x)Fe_2(x=0 to 0.85)显示文摘The compound ingots of Pr0.15TbxDy0.85-xFe2 (x=0 to 0.85) were prepared by arc melting in a water Cu boat using arc furnace under a purified Ar atmosphere. Appropriate annealing (850℃, 100 h) can obtain single Laves phase compound. The magnetostriction for these systems will rise obviously when partially substituted Tb or Dy by Pr. | Yangxian LI and Jingping QU (Hebei University of Technology, Tianjin 300130, China) Chengchun TANG, Guangheng WU and Wenshan ZHAN (State Key Laboratory for Magnetism, Institute of Physics, CAS, BeiJing 100080, China) | 2000 | Journal of Materials Science & Technology2000，16，6： | 2 |
| 7 | Monolithic edge-cladding process for the elliptical disk of N31-type Nd-doped high-power laser glass显示文摘This paper investigates the monolithic edge-cladding process for the elliptical disk of N31-type Nd-doped phosphate laser glass,which will be utilized under liquid cooling conditions for high-power laser systems.The thermal stress,interface bubbles and residual refiectivity,which are due to high-temperature casting and bonding during the monolithic edge-cladding process,are simulated and determined.The applied mould is optimized to a rectangular cavity mould,and the casting temperature is optimized to 1000℃.The resulting lower bubble density makes the mean residual refiectivity as low as 6.75×10^(-5),which is enough to suppress the amplified spontaneous emission generated in the Nd-glass disk,and the resulting maximum optical retardation is converged to 10.2–13.3 nm/cm,which is a favourable base for fine annealing to achieve the stress specification of less than or equal to 5 nm/cm.After fine annealing at the optimized 520℃,the maximum optical retardation is as low as 4.8 nm/cm,and the minimum transmitted wavefront peak-to-valley value is 0.222 wavelength(632.8 nm).An N31 elliptical disk with the size of 194 mm×102 mm×40 mm can be successfully cladded by the optimized monolithic edge-cladding process,whose edge-cladded disk with the size of 200 mm×108 mm×40 mm can achieve laser gain one-third higher than that of an N21-type disk of the same size. | Huiyu Chen Min Qian Youkuo Chen Xin Wang Jingping Tang Lei Wen Junjiang Hu Wei Chen Shubin Chen Lili Hu | 2022 | High Power Laser Science and Engineering2022，10，2： | 1 |
| 8 | Gynecologic infections seen in ThinPrep cytological test in Wuhan, China显示文摘这研究试图分析流行细菌,在 ThinPrep cytological 测试(TCT ) 的 Candida, Trichomonas,和人的乳头状瘤病毒(HPV ) 感染表现在中国武汉的女人上。ThinPrep 油迹被二个独立富有经验的病理学家屏蔽并且从 2008 ~ 2010 报导了。46 866 ThinPrep 油迹的一个总数被学习,并且有发炎的油迹被分析。44 162 个注册病人,发炎变化被观察在 21 935 (49.7%) 并且在 6884 的特定的感染(31.4%) 。检测的感染如下:细菌, 5663 (82.3%) ;Candida, 825 (12.0%) ;Trichomonas, 273 (4.0%) ;并且 HPV, 148 (2.1%) 。重要变化在在 2010 前后经历了 TCT 的女人之中在细菌和 Candida 的流行被发现。< 啜 class= “ a-plus-plus ” > 2 揭示了在 2010 以后在油迹发现的特定的感染的一个增加的比例(P = 0.000 ) 。在结论,细菌的感染在 ThinPrep 油迹是最可检测的,由 Candida 和 Trichomonas 列在后面。TCT 识别的感染的流行被发现在在中国的以前的文学类似。 | Hang Zhou Yao Jia Jian Shen Shaoshuai Wang Xiong Li Ru Yang Kecheng Huang Ting Hu Fangxu Tang Jin Zhou Jingping Yuan Lei Huang Xun Tian Zhilan Chen Qinghua Zhang Changyu Wang Ling Xi Dongrui Deng Hui Wang Ding Ma Shuang Li | 2014 | Frontiers of Medicine2014，8，2： | 1 |
| 9 | A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism显示文摘Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified legs.Because of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was approved.Preclinical release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were introduced.We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude mice.After the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers.When followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells.Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged site.No infusion or local treatment-related adverse events occurred.Thus,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity. | Lianju Qin Jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li Guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai Jing Guo Qiang Wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing Wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian Wang Zhonglan Su Yan Lu Di Wu Jingping Shi Wei Liu Li Dong Yinbing Pan Baiqiao Zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie Wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui Wang Yanyan Pan Ling Wang Xianrong Xu Jing Zhao Xiuqin Wang Cuiping Liu Ningxia Liang Changying Xing Jiayin Liu Ningning Wang | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 10 | THE ADSORPTION BEHAVIORS OF 2,6-DICHLOROPHENOL ONTO HYPERCROSSLINKED RESINS显示文摘 | WANG Jingping LI Zhixia ZHANG Gencheng FEI Zhenghao TANG Shuhe | 2006 | Chinese Journal of Reactive Polymers2006，15，2： | 0 |
| 11 | Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice显示文摘Osteoporosis(OP)is a systemic skeletal disease that primarily affects the elderly population,which greatly increases the risk of fractures.Here we report that Kindlin-2 expression in adipose tissue increases during aging and high-fat diet fed and is accompanied by decreased bone mass.Kindlin-2 specific deletion(K2KO)controlled by Adipoq-Cre mice or adipose tissue-targeting AAV(AAV-Rec2-CasRx-sgK2)significantly increases bone mass.Mechanistically,Kindlin-2 promotes peroxisome proliferator-activated receptor gamma(PPARγ)activation and downstream fatty acid binding protein 4(FABP4)expression through stabilizing fatty acid synthase(FAS),and increased FABP4 inhibits insulin expression and decreases bone mass.Kindlin-2 inhibition results in accelerated FAS degradation,decreased PPARγactivation and FABP4 expression,and therefore increased insulin expression and bone mass.Interestingly,we find that FABP4 is increased while insulin is decreased in serum of OP patients.Increased FABP4 expression through PPARγactivation by rosiglitazone reverses the high bone mass phenotype of K2KO mice.Inhibition of FAS by C75 phenocopies the high bone mass phenotype of K2KO mice.Collectively,our study establishes a novel Kindlin-2/FAS/PPARγ/FABP4/insulin axis in adipose tissue modulating bone mass and strongly indicates that FAS and Kindlin-2 are new potential targets and C75 or AAV-Rec2-CasRx-sgK2 treatment are potential strategies for OP treatment. | Wanze Tang Zhen Ding Huanqing Gao Qinnan Yan Jingping Liu Yingying Han Xiaoting Hou Zhengwei Liu Litong Chen Dazhi Yang Guixing Ma Huiling Cao | 2023 | Acta Pharmaceutica Sinica B2023，13，11： | 0 |
| 12 | Evaluation of several recently developed sampling strategies within the coarse pixel scale for validation of coarse-resolution satellite albedo products显示文摘Due to the spatial heterogeneity and the spatial scale mismatch between in situ and satellite-based measurements,optimal ground sampling should be made to increase the representativeness of in situ observations. Therefore,many ground sampling strategies have been proposed,but their performance within the coarse pixel has not been evaluated. Hence,this study evaluated four typical methods regarding their ability to obtain pixel scale ground ‘truth’. Random combination (RC) performs best,with the always fewest samples to satisfy representativeness errors (REs) of 3% in the case of a small number of samples. When the goal of sampling is to obtain in situ measurements with REs close to 0 at the expense of increasing the number of samples,cumulative representativeness sampling (CRS) is more effective than RC in less heterogeneous areas. Geo-statistical model-based sampling (GSS) does not work well because the number of samples within the coarse pixel scale cannot support a robust semi-variogram model. Stratified sampling (SS) is highly dependent on spatial heterogeneity and does not work well in the case of small sample sizes. This study gives important guidance for ground sample deployment within the coarse pixel for validation of coarse-resolution satellite albedo products over a heterogeneous surface. | Rongqi Tang Xiaodan Wu Jingping Wang Qicheng Zeng Zheng Li Jianguang Wen | 2022 | International Journal of Digital Earth2022，15，1： | 0 |
| 13 | Expert consensus on digital guided therapy for endodontic diseases显示文摘Digital guided therapy(DGT)has been advocated as a contemporary computer-aided technique for treating endodontic diseases in recent decades.The concept of DGT for endodontic diseases is categorized into static guided endodontics(SGE),necessitating a meticulously designed template,and dynamic guided endodontics(DGE),which utilizes an optical triangulation tracking system.Based on cone-beam computed tomography(CBCT)images superimposed with or without oral scan(OS)data,a virtual template is crafted through software and subsequently translated into a 3-dimensional(3D)printing for SGE,while the system guides the drilling path with a real-time navigation in DGE.DGT was reported to resolve a series of challenging endodontic cases,including teeth with pulp obliteration,teeth with anatomical abnormalities,teeth requiring retreatment,posterior teeth needing endodontic microsurgery,and tooth autotransplantation.Case reports and basic researches all demonstrate that DGT stand as a precise,time-saving,and minimally invasive approach in contrast to conventional freehand method.This expert consensus mainly introduces the case selection,general workflow,evaluation,and impact factor of DGT,which could provide an alternative working strategy in endodontic treatment. | Xi Wei Yu Du Xuedong Zhou Lin Yue Qing Yu Benxiang Hou Zhi Chen Jingping Liang Wenxia Chen Lihong Qiu Xiangya Huang Liuyan Meng Dingming Huang Xiaoyan Wang Yu Tian Zisheng Tang Qi Zhang Leiying Miao Jin Zhao Deqin Yang Jian Yang Junqi Ling | 2023 | International Journal of Oral Science2023，15，4： | 0 |
| 14 | THERMODYNAMICS ADSORPTION OF MANGANESE ION ON 1-(2-PYRIDYLAZO)-2-NAPHTHOL-6-SULPHONIC ACID IMPREGNATED RESIN显示文摘An ion-exchange resin of type 201×7 was impregnated with the reagent 1-(2-Pyridylazo)-2-naphthol-6-sulphonic Acid (PAN-S). The adsorption characteristics of PAN-S resin for manganese ion were studied on the static equilibrium adsorption. Within temperature range of 288K^313K and the concentration range investigated, equilibrium data for the adsorption of manganese ions from aqueous solutions by PAN-S resin were obtained and correlated with Freundlich and Langmuir equation. The results showed that the process of the adsorption of manganese ions from aqueous solution by PAN-S was an exothermic process. Estimations of the isothermic enthalpy change of adsorption,free energy change and entropy of adsorption are reported,and the adsorption behaviors are reasonably interpreted. | TANG Shuhe WANG Jingping CHEN Jian | 2008 | Chinese Journal of Reactive Polymers2008，17，1： | 0 |
| 15 | THE ADSORPTION BEHAVIORS OF TOLUENE ON HYPERCROSSLINKED RESINS显示文摘Investigation of the adsorption characteristics of toluene on two hypercrosslinked resins. The static and the kinetic adsorption were studied. The equilibrium adsorption date was fitted to freundlich adsorption isotherm models to evaluate the model parameters. The enthalpy, free energy, entropy are indicative of an exothermic, a spontaneous and disorder decreasing process. Experimental results show that the two adsorbents are better than the Amberlite XAD-4 for removing the toluene in aqueous solutions. | WANG Jingping FEI Zhenghao TANG Shuhe | 2005 | Chinese Journal of Reactive Polymers2005，14，1： | 0 |
| 16 | Transcriptome analysis reveals tumor antigen and immune subtypes of melanoma显示文摘Purpose:To screen potential tumor antigens for melanoma vaccine development and identify different immune subtypes.Methods:Transcriptional data(HTSEQ-FPKM)and clinical information of a 472 Melanoma cohort GDC TCGA Melanoma(SKCM)were downloaded from the UCSC XENA website(http://gffzz797b50e9334d4ed4houkf5x9nb0qu6on0.ffgz.tsg.suse.edu.cn/).Subsequently,transcriptome data and clinical information of 210 melanoma cohort GSE65904 were downloaded from Gene Expression Omnibus(GEO),a large global public database.All the transcriptome expression data matrices were log2 transformed for subsequent analysis.GEPIA,TIMER,and IMMPORT databases are also used for analysis.Cell function experiments were performed to validate the role of the IDO1 gene in melanoma cell line A375.Results:Our study provides potential tumor antigens for vaccine development in melanoma patients:GZMB,GBP4,CD79A,APOBEC3F,IDO1,JCHAIN,LAG3,PLA2G2D,XCL2.In addition,we divide melanoma patients into two immune subtypes that have significant differences in tumor immunity and may have different responses to vaccination.In view of the unclear role of IDO1 in melanoma,we selected IDO1 for cell assay validation.Cell function assay showed that IDO1 was significantly overexpressed in the melanoma A375 cell line.After IDO1 knockdown,the activity,invasion,migration and healing ability of A375 cell lines were significantly decreased.Conclusion:Our study could provide a reference for the development of vaccines for melanoma patients. | JIAHENG XIE MENGMENG OU PAN YU DAN WU QIKAI TANG YUAN CAO JING HANG LU YIN TINGHONG XIANG MING WANG JINGPING SHI | 2023 | Oncology Research2023，31，3： | 0 |
| 17 | Synthesis and Magnetostriction of (Ce_xTb_(1-x))_(0.5)Pr_(0.5)Fe_2 Compounds显示文摘The structural and magnetostrictive properties of (CexTb1-x)0.5Pr0.5Fe2 were investigated. Ceconcentration must exceed x=0.6 in order to obtain the pure Laves phase. The magnetostriction and anisotropy constant increase with the Tb-content in this system. The anisotropy value of PrFe2 is lower than that of isostructural DyFe2. From the X-ray step-scanned data we found that λ111 of PrFe2 is 1310x10-6. A large increase of magnetostriction can be observed under a small prestress of 6 MPa for Ce0.5Pr0.5Fe2. | Yangxian LI, Guizhi XU and Jingping QU (School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China) Chengchun TANG, Guangheng WU and Wenshan ZHAN (State Key Laboratory for Magnetism, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China) | 2000 | Journal of Materials Science & Technology2000，16，2： | 0 |
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