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| 1 | Epidemiology of fungal infections in China显示文摘与 immunocompromised 主人的增加的数字,真菌的感染的流行病学的特征经历了世界范围的庞大的变化,在中国包括。在这份报纸,我们越过中国在真菌病上考察了存在数据总结可得到的流行病学的侧面。我们发现在中国的表面的真菌的感染的一般发生是稳定的,但是癣 capitis 的发生减少了,传播线路变化了。由对比,侵略真菌的感染的全面发生继续升起了。candidemia 的出现由除 C 以外的 Candida 种类引起了。albicans 和不平常的 Candida 种类最近在中国增加了的包括的一些。曲霉属菌引起的感染也在最近的年里宣传了,特别地与 azole 抵抗的曲霉属菌 fumigatus 的出现。cryptococcosis 的一个增加的趋势在中国被注意了,与 Cryptococcus neoformans var。grubii 圣 5 遗传型作为占优势的病原体孤立。回顾的研究建议了在中国的 Pneumocystis 肺病的流行病学的特征可能类似于在另外的发展中的国家的那些。地方性的真菌的感染例如在东北中国的 sporotrichosis,必须引起研究,诊断,并且处理警戒。当前,在中国的真菌病上的流行病学的数据可变、碎片。因此,关于在中国的真菌的感染的全国流行病学的研究是对改进国家健康的重要需要。 | Min Chen Yuan Xu Nan Hong Yali Yang Wenzhi Lei Lin Du Jingjun Zhao Xia Lei Lin Xiong Langqi Cai Hui Xu Weihua Pan Wanqing Liao | 2018 | Frontiers of Medicine2018，12，1： | 49 |
| 2 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 3 | Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway显示文摘Bacteremia induced by periodontal infection is an important factor for periodontitis to threaten general health. P. gingivalis DNA/virulence factors have been found in the brain tissues from patients with Alzheimer’s disease(AD). The blood-brain barrier(BBB) is essential for keeping toxic substances from entering brain tissues. However, the effect of P. gingivalis bacteremia on BBB permeability and its underlying mechanism remains unclear. In the present study, rats were injected by tail vein with P. gingivalis three times a week for eight weeks to induce bacteremia. An in vitro BBB model infected with P. gingivalis was also established. We found that the infiltration of Evans blue dye and Albumin protein deposition in the rat brain tissues were increased in the rat brain tissues with P. gingivalis bacteremia and P. gingivalis could pass through the in vitro BBB model. Caveolae were detected after P. gingivalis infection in BMECs both in vivo and in vitro. Caveolin-1(Cav-1) expression was enhanced after P. gingivalis infection.Downregulation of Cav-1 rescued P. gingivalis-enhanced BMECs permeability. We further found P. gingivalis-gingipain could be colocalized with Cav-1 and the strong hydrogen bonding between Cav-1 and arg-specific-gingipain(RgpA) were detected.Moreover, P. gingivalis significantly inhibited the major facilitator superfamily domain containing 2a(Mfsd2a) expression. Mfsd2a overexpression reversed P. gingivalis-increased BMECs permeability and Cav-1 expression. These results revealed that Mfsd2a/Cav-1 mediated transcytosis is a key pathway governing BBB BMECs permeability induced by P. gingivalis, which may contribute to P. gingivalis/virulence factors entrance and the subsequent neurological impairments. | Shuang Lei Jian Li Jingjun Yu Fulong Li Yaping Pan Xu Chen Chunliang Ma Weidong Zhao Xiaolin Tang | 2023 | International Journal of Oral Science2023，15，1： | 3 |
| 4 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 5 | Porothermoelastic response of an oil sand formation subjected to injection and micro-fracturing in horizontal wells显示文摘Stimulation of unconsolidated formations via horizontal wells has seen its vast implementation in the recent development of heavy oil reservoir to save the time and cost of preheating the reservoir before the steam-assisted gravity drainage(SAGD)process.A mathematical approach was proposed in this research that fully couples the hydraulic,mechanical and thermal responses of unconsolidated sandstone formations and also applies failure criteria for describing either shear dilation or tensile parting mechanism that generates microcracks.The approach was implemented to predict the porothermoelastic response of a pair of SAGD wells subject to injection and subsequent micro-fracturing using hot water.It was found that the predicted bottom hole pressures(BHPs)match closely with the field observed data.An elliptical dilation zone developed around the dual wells with relatively high pore pressure,porosity,permeability and temperature,implying good interwell hydraulic communication between both wells.The activation of microcracks dramatically accelerated the dissipation of pore pressure across the entire formation depth and also facilitated heat convection in between the dual wells,though to a lesser extent.In summary,the approach provides a convenient means to assist field engineers in the optimization of injection efficiency and evaluation of interference among multiple horizontal wells. | Botao Lin Han Meng Jingjun Pan Sen Chen | 2020 | Petroleum Science2020，17，3： | 2 |
| 6 | Regulation of actin cytoskeleton via photolithographic micropatterning显示文摘Actin cytoskeleton plays crucial roles in various cellular functions.Extracellular matrix(ECM)can modulate cell morphology by remodeling the internal cytoskeleton.To define how geometry of ECM regulates the organization of actin cytoskeleton,we plated individual NIH 3T3 cells on micropatterned substrates with distinct shapes and sizes.It was found that the stress fibers could form along the nonadhesive edges of T-shaped pattern,but were absent from the opening edge of V-shaped pattern,indicating that the organization of actin cytoskeleton was dependent on the mechanical environment.Furthermore,a secondary actin ring was observed on 50μm circular pattern while did not appear on 30μm and 40μm pattern,showing a size-dependent organization of actin cytoskeleton.Finally,osteoblasts,MDCK and A549 cells exhibited distinct organization of actin cytoskeleton on T-shaped pattern,suggesting a cell-type specificity in arrangement of actin cytoskeleton.Together,our findings brought novel insight into the organization of actin cytoskeleton on micropatterned environments. | Fulin Xing Haimei Zhang Mengyu Li Hao Dong Xuehe Ma Shiyu Deng Fen Hu Imshik Lee Leiting Pan Jingjun Xu | 2023 | Journal of Innovative Optical Health Sciences2023，16，2： | 1 |
| 7 | Aerodynamic Characteristic Research on Final Stage Stator of a Highly Loaded Fan显示文摘Due to corner separation and other complex three-dimensional flows existing in the highly loaded stator, which influences the fan performance significantly, highly loaded stator blades of a transonic fan with a maximum camber angle of 57° were studied in this paper and sector cascade experiment was adopted. In order to get the stator aerodynamic parameters as realistic as possible and conduct the experiment without the existence of rotor, an adjustable guide vane was designed to simulate the velocity magnitude and direction of the stator inlet flow. Results show that the adjustable guide vane can simulate the rotor outlet velocity direction and magnitude in most span range. The deviation angle is positive and the maximum value is nearly 21° because the severe separation is at 27% span. Corner separation exists on both pressure side and suction side and the location of separation initiation is determined. Finally, the stator blades were redesigned with some suction slots on the suction side. Experiment results show that the suction slots change the flow field structure, increase the capability of flow turning, and decrease the flow loss. | FU Wenguang SUN Peng ZHONG Jingjun PAN Ruochi LI Lili YANG Muxiao | 2018 | Journal of Thermal Science2018，27，6： | 1 |
| 8 | A novel obstacle avoidance heuristic algorithm of continuum robot based on FABRIK显示文摘Obstacle avoidance and path planning of continuum robots are challenging tasks due to the hyper-redundant degree of freedoms(DOFs)and restricted working environments.Meanwhile,most current heuristic algorithm-based obstacle avoidance algorithms exist with low computational efficiency,complex solution process,and inability to add global constraints.This paper proposes a novel obstacle avoidance heuristic algorithm based on the forward and backward reaching inverse kinematics(FABRIK)algorithm.The update of key nodes in this algorithm is modeled as the movement of charges in an electric field,avoiding complex nonlinear operations.The algorithm achieves the robustness of inverse kinematics and path tracking in complex environments by imposing constraints on key nodes and determining the location of obstacles in advance.This algorithm is characterized by a high convergence rate,low computational cost,and can be used for real-time applications.The proposed approach also has wide applicability and can be applied to both mobile and fixed-base continuum robots.And it can be further extended to the field of hyper-redundant robots.The algorithm's effectiveness is further validated by simulating the path tracking and obstacle avoidance of a five-segment continuum robot in various environments and comparisons with classical methods. | WU HaoRan YU JingJun PAN Jie PEI Xu | 2022 | Science China(Technological Sciences)2022，65，12： | 0 |
| 9 | Structural and functional studies of erythrocyte membrane-skeleton by single-cell and single-molecule techniques显示文摘As the indispensable oxygen-transporting cells,erythrocytes exhibit extreme deformability and amazing stability as they are subject to huge reversible shear stress and extrusion force during massive circulation in the body.The unique architecture of spectrin-actin-based membraneskeleton is considered to be responsible for such excellent mechanical properties of erythrocytes.Although erythrocytes have been recognized for more than 300 years,myriad questions about membrane-skeleton constantly attract people's attention.Here,we summarize the kinds of distinctive single-cell and single-molecule techniques that were used to investigate the structure and function of erythrocyte membrane-skeleton at macro and micro levels. | Fulin Xing Fen Hu Jianyu Yang Leiting Pan Jingjun Xu | 2019 | Journal of Innovative Optical Health Sciences2019，，1： | 0 |
| 10 | A novel double polymer modified hydrophobic/hydrophilic stationary phase for liquid chromatography显示文摘In this paper,norbornene imidazolium hexafluorophosphate(NM-MIm-PF6)was modified on the surface of aminopropyl silica by ring-opening metathesis polymerization(ROMP),and then oligo(ethylene glycol)methacrylate(OEGMA)were grafted on the surface by atom transfer radical polymerization(ATRP).Some characterizations in this article confirmed that the synthesis of P(NM-MIm-PF6)-SiPOEGMA(Pl-Si-P2)is successful.The P1-Si-P2 can separate sugars,amino acids,sulfonamides in a hydrophilic interaction mode and alkyl benzene,polycyclic aromatic hydrocarbon in a reverse phase mode.The experiment also found that the column has typical characte ristics of hydrophobic/hydrophilic separation mechanism.Compared to single hydrophobic C18 column and single hydrophilic Si-NH2 column,this P1-Si-P2 shows certain advantages. | Fangbin Fan Jingjun Pan Yijing Li Licheng Wang Shuai Wang Xiaojing Liang Yong Guo | 2020 | Chinese Chemical Letters2020，31，3： | 0 |
| 11 | Performances of a prototype point-contact germanium detector immersed in liquid nitrogen for light dark matter search显示文摘The CDEX-10 experiment searches for light weakly interacting massive particles, a form of dark matter, at the China Jinping Underground Laboratory, where approximately 10 kg of germanium detectors are arranged in an array and immersed in liquid nitrogen. Herein, we report on the experimental apparatus, detector characterization, and spectrum analysis of one prototype detector. Owing to the higher rise-time resolution of the CDEX-10 prototype detector as compared with CDEX-1 B, we identified the origin of an observed category of extremely fast events. For data analysis of the CDEX-10 prototype detector, we introduced and applied an improved bulk/surface event discrimination method. The results of the new method were compared to those of the CDEX-1 B spectrum. Both sets of results showed good consistency in the 0-12 ke Vee energy range, except for the 8.0 keV K-shell X-ray peak from the external copper. | Hao Jiang LiTao Yang Qian Yue KeJun Kang JianPing Cheng YuanJing Li Henry Tsz-King Wong M.A?artio?lu HaiPeng An JianPing Chang JingHan Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He Jin Wei Hu QingDong Hu HanXiong Huang LiPing Jia HauBin Li Hong Li Jian Min Li Jin Li Xia Li XueQian Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu YuanYuan Liu ZhongZhi Liu Hao Ma JingLu Ma Hui Pan Jie Ren XiChao Ruan B.Sevda Vivek Sharma ManBin Shen Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang JiMin Wang Li Wang Qing Wang Yi Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue SongWei Yang Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue XiongHui Zeng Ming Zeng Zhi Zeng FengShou Zhang YunHua Zhang MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu ZhongHua Zhu | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 0 |
| 12 | Design and modeling of continuum robot based on virtual-center of motion mechanism显示文摘Continuum robot has attracted extensive attention since its emergence.It has multi-degree of freedom and high compliance,which give it significant advantages when traveling and operating in narrow spaces.The flexural virtual-center of motion(VCM)mechanism can be machined integrally,and this way eliminates the assembly between joints.Thus,it is well suited for use as a continuum robot joint.Therefore,a design method for continuum robots based on the VCM mechanism is proposed in this study.First,a novel VCM mechanism is formed using a double leaf-type isosceles-trapezoidal flexural pivot(D-LITFP),which is composed of a series of superimposed LITFPs,to enlarge its stroke.Then,the pseudo-rigid body(PRB)model of the leaf is extended to the VCM mechanism,and the stiffness and stroke of the D-LITFP are modeled.Second,the VCM mechanism is combined to form a flexural joint suitable for the continuum robot.Finally,experiments and simulations are used to validate the accuracy and validity of the PRB model by analyzing the performance(stiffness and stroke)of the VCM mechanism.Furthermore,the motion performance of the designed continuum robot is evaluated.Results show that the maximum stroke of the VCM mechanism is approximately 14.2°,the axial compressive strength is approximately 1915 N/mm,and the repeatable positioning accuracies of the continuum robot is approximately±1.47°(bending angle)and±2.46°(bending direction). | Guoxin LI Jingjun YU Yichao TANG Jie PAN Shengge CAO Xu PEI | 2023 | Frontiers of Mechanical Engineering2023，18，2： | 0 |
| 13 | A novel shape memory alloy actuated soft gripper imitated hand behavior显示文摘The limited length shrinkage of shape memory alloy(SMA)wire seriously limits the motion range of SMA-based gripper.In this paper,a new soft finger without silicone gel was designed based on pre bent SMA wire,and the finger was back to its original shape by heating SMA wire,rather than relying only on heat exchange with the environment.Through imitating palm movement,a structure with adjustable spacing between fingers was made using SMA spring and rigid spring.The hook structure design at the fingertip can form self-locking to further improve the load capacity of gripper.Through the long thin rod model,the relationship of the initial pre bent angle on the bending angle and output force of the finger was analyzed.The stress-strain model of SMA spring was established for the selection of rigid spring.Three grasping modes were proposed to adapt to the weight of the objects.Through the test of the gripper,it was proved that the gripper had large bending amplitude,bending force,and response rate.The design provides a new idea for the lightweight design and convenient design of soft gripper based on SMA. | Jie PAN Jingjun YU Xu PEI | 2022 | Frontiers of Mechanical Engineering2022，17，4： | 0 |
| 14 | Regulation of intracellular Ca^2+/CaMKII signaling by TRPV4 membrane translocation during osteoblastic differentiation显示文摘Bone constantly remodels between resorption by osteoclasts and formation by osteoblasts;therefore the functions of osteoblasts are pivotal for maintaining homeostasis of bone mass.Transient receptor potential vanilloid 4(TRPV4),a type of mechanosensitive channel,has been reported to be a key regulator in bone remodeling.Howevei;the relationship between TRPV4 and osteoblast function remains largely elusive.Only little is known about the spatial distribution change of TRPV4 during osteoblastic differentiation and related signal events.Based on three-dimensional super-resolution microscopy,our results clearly showed a different distribution of TRPV4 in undifferentiated and differentiated osteoblasts,which reflected the plasma membrane translocation of TRPV4 along with prolonged differentiation.GSK1016790A(GSK101),the most potent agonist of TRPV4,triggered rapid calcium entry and calmodulin-dependent protein kinase II(CaMKII)phosphorylation via TRPV4 acti・vation in a differentiation-dependent manner,indicating that the abundance of TRPV4 at the cell surface resulting from differentiation may be related to the modulation of Ca2+response and CaMKII activity.These data provide compelling evidences for the plasma membrane translocation of TRPV4 during osteoblastic differentiation as well as demonstrate the regulation of downstream Ca2+/CaMKII signaling. | Fen Hu Yali Zhao Zhenhai Hui Fulin Xing Jianyu Yang Imshik Lee Xinzheng Zhang Leiting Pan Jingjun Xu | 2019 | Biophysics Reports2019，5，5： | 0 |
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