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| 1 | Comparative effect of electroacupuncture and moxibustion on the expression of substance P and vasoactive intestinal peptide in patients with irritable bowel syndrome显示文摘OBJECTIVE: To compare the impacts of electroacupuncture(EA) and moxibustion(Mox) on the primary gastrointestinal symptoms and the expressions of colonic mucosa-associated neuropeptide substance P(SP) and vasoactive intestinal peptide(VIP)in patients with either diarrhea-predominant or constipation-predominant irritable bowel syndrome(IBS-D and IBS-C,respectively).METHODS: Eighty-five IBS patients were randomly allocated to the EA and Mox groups. Zusanli(ST 36)and Shangjuxu(ST 37) were selected as acupoints for electroacupuncture or warm moxibustion treatment once a day for 14 consecutive days. Before and after the treatment sessions,a Visual Analog Pain Scale and the Bristol Stool Form Scale were used to evaluate gastrointestinal symptoms. There were four dropout cases,leaving 81 participants(41 with IBS-D and 40 with IBS-C) who volunteered to undergo colonoscopy before and after the treatment sessions. During colonoscopy,sigmoid mucosa were collected to detect SP and VIP expression using immunohistochemistry assay.RESULTS: Both EA and Mox treatments were effective at relieving abdominal pain in IBS-D and IBS-C patients. However,Mox was more effective at reducing diarrhea in IBS-D patients,whereas EA was more effective at improving constipation in IBS-C patients. EA and Mox treatments both down-regulated the abnormally increased SP and VIP expression in the colonic mucosa,with no significant difference shown between the two treatments.CONCLUSION: Both EA and Mox treatments are effective at ameliorating gastrointestinal symptoms by reducing SP and VIP expression in the colonic mucosa of IBS patients. | Lu Zhenzhong Yin Xiaojun Teng Weijun Chen Yuehua Sun Jie Zhao Jimeng Wang Anqi Bao Chunhui Shi Yin | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 24 |
| 2 | Effects of electroacupuncture and Chinese kidney-nourishing medicine on polycystic ovary syndrome in obese patients显示文摘OBJECTIVE: To explore the effect of electroacupuncture and Chinese kidney-nourishing medicine on insulin (INS), adiponectin (APN), leptin (LEP), and glucolipid metabolism of obese patients with polycystic ovary syndrome (PCOS). METHODS: Sixty-seven obese PCOS patients were randomly divided into two groups. Thirty-three patients in the acupuncture-medicine group were treated three times a week with electroacupuncture at the Tianshu (ST 25), Zhongwan (CV 12), Qihai (CV 6), Sanyinjiao (SP 6), Geshu (BL 17), and Cil-iao (BL 32) acupoints. They also took the Chinese drug, Tiankui capsule, for 3 months as a course of treatment. Point-taking and treatment in the electroacupuncture group of 34 patients was the same as those in the acupuncture-medicine group. We observed and compared the changes in the obesity-related indexes of body weight (BW), body mass index (BMI), and waist-hip ratio (WHR), as well as fasting plasma glucose (FPG), fasting insulin (FINS), APN, and LEP. RESULTS: BW, BMI, WHR, and FINS decreased and insulin sensitivity index (ISI) and APN were higher in the acupuncture-medicine group than in the electroacupuncture group (P<0.01). There was no obvious difference in LEP between the two groups (P>0.05). CONCLUSION: Acupuncture combined with medicine is better than just electroacupuncture for obese PCOS patients by improving obesity-related indexes, insulin sensitivity, and APN level. This indicates that acupuncture-medicine therapy is worth clinical popularization. | Liqing Yu Yanjun Liao Huangan Wu Jimeng Zhao Luyi Wu Yin Shi Jianqiao Fang | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 15 |
| 3 | Fault feature enhancement of gearbox in combined machining center by using adaptive cascade stochastic resonance显示文摘The difficulty to select the best system parameters restricts the engineering application of stochastic resonance(SR) . An adaptive cascade stochastic resonance(ACSR) is proposed in the present study. The proposed method introduces correlation theory into SR,and uses correlation coefficient of the input signals and noise as a weight to construct the weighted signal-to-noise ratio(WSNR) index. The influence of high frequency noise is alleviated and the signal-to-noise ratio index used in traditional SR is improved accordingly. The ACSR with WSNR can obtain optimal parameters adaptively. And it is not necessary to predict the exact frequency of the target signal. In addition,through the secondary utilization of noise,ACSR makes the signal output waveform smoother and the fluctuation period more obvious. Simulation example and engineering application of gearbox fault diagnosis demonstrate the effectiveness and feasibility of the proposed method. | LI Bing LI JiMeng HE ZhengJia | 2011 | Science China(Technological Sciences)2011，54，12： | 6 |
| 4 | Influence of herb-partitioned moxibustion at Qihai (CV6) and bilateral Tianshu (ST25) and Shangjuxu (ST37) acupoints on toll-like receptors 4 signaling pathways in patients with ulcerative colitis显示文摘OBJECTIVE: To evaluate the efficacy of herb-partitioned moxibustion(HPM) at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints in relieving symptoms and the immune regulation of HPM on the toll-like receptors 4(TLR4) signaling pathway in ulcerative colitis(UC) patients.METHODS: A randomized, single-blind study was conducted 63 patients to receive HPM or sham HPM treatment. The efficacy outcomes included scores of the Mayo, Baron, inflammatory bowel disease questionnaire(IBDQ), self-rating depression scale(SDS), self-rating anxiety scale(SAS). HE staining was used to observe the histopathological changes of the colon. The expression of inflammatory cytokines and TLR4 signaling pathway related molecules were determined by enzyme-linked immunosorbent assay and immunohistochemistry.RESULTS: Baron, SDS, SAS scores were significantly decreased in moxibustion group(P < 0.05), IBDQ score was significantly greater in the moxibustion group than in the sham moxibustion group(P < 0.05). Histopathology of mucosal biopsies showed that both two groups improved in mucosa after treatment. The expression levels of tumor necrosis factor-α, interleukin-2, interleukin-12, interferon-γ, and TLR4, lipopolysaccharide, myeloid differentiation factor 88, interleukin receptor associated kinase, tumor necrosis factor receptor associated factor 6 and nuclear factor kappa-B p65 were significantly lower in the moxibustion group than in the sham moxibustion group(P < 0.05).CONCLUSION: This study showed that HPM at Qihai(CV6), Tianshu(ST25) and Shangjuxu(ST37) acupoints is effective to relieve symptoms, anxiety, depression and improving life quality in UC patients,which may be related to the immune regulation of HPM on TLR4 signaling pathway. | QI Qin Hyoyoung Im LI Kunshan GU Muen WU Huangan YANG Ling HUANG Yan ZHAO Jimeng CUI Yunhua LIU Huirong WU Luyi | 2021 | Journal of Traditional Chinese Medicine2021，41，3： | 5 |
| 5 | Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer显示文摘Enolase 2(ENO2)is a key glycolytic enzyme in the metabolic process of glycolysis,but its potential function in pancreatic ductal adenocarcinoma(PDAC)is unclear.In this study,we observed a significant overexpression of ENO2 in PDAC tissues,and its expression was correlated with metastasis and poor prognosis in PDAC patients.K394 was identified as a major acetylation site in ENO2 that regulates its enzymatic activity,cell metabolism and PDAC progression.Knockdown of ENO2 suppressed tumor growth and liver metastasis in PDAC.Re-expression of wild-type(WT)ENO2,but not the K394 acetylation mimetic mutant,could reverse the decreased tumor malignancy.We further characterized histone deacetylase 3(HDAC3)and P300/CBP-associated factor(PCAF)as the potential deacetylase and acetyltransferase for ENO2,respectively.HDAC3-mediated deacetylation was shown to lead to ENO2 activation and enhancement of glycolysis.Importantly,insulin-like growth factor-1(IGF-1)was found to decrease K394 acetylation and stimulate ENO2 activity in a dose-and time-dependent manner.The PI3K/AKT/mTOR pathway facilitated the phosphorylation of HDAC3 on S424,which promoted K394 deacetylation and activation of ENO2.Linsitinib,an oral small-molecule inhibitor of IGF-1R,could inhibit IGF-1-induced ENO2 deacetylation by HDAC3 and the PI3K/AKT/mTOR pathway.Furthermore,linsitinib showed a different effect on the growth and metastasis of PDAC depending on the overexpression of WT versus K394-mutant ENO2.Our results reveal a novel mechanism by which acetylation negatively regulates ENO2 activity in the metastasis of PDAC by modulating glycolysis.Blockade of IGF-1-induced ENO2 deacetylation represents a promising strategy to prevent the development of PDAC. | Yan Zheng Chao Wu Jimeng Yang Yue Zhao Huliang Jia Min Xue Da Xu Feng Yang Deliang Fu Chaoqun Wang Beiyuan Hu Ze Zhang Tianen Li Shican Yan Xuan Wang Peter J.Nelson Christiane Bruns Lunxiu Qin Qiongzhu Dong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 6 | Evolution of linear mitoehon- drial DNA in three known lineages of PolytomeUa显示文摘 | David R Jimeng H Robert W | 2010 | Cur Gen2010，56，5： | 1 |
| 7 | Comparative and phylogenomic studies on the mitochondrial genomes of Pentatomomorpha(Insecta:Hemiptera:Heteroptera)显示文摘 | Hua Jimeng Li Ming Dong Pengzhi | 2008 | BMC Genomics2008，9，： | 1 |
| 8 | Spectroscopic properties and energy transfer of Eu 2+ /Tb 3+ co-doped high silica glass显示文摘 | Yinglong Shen Qiang Zhang Jimeng Cheng Qiuchun Sheng Shuang Liu Wentao Li W. Chewpraditkul Danping Chen | 2013 | Materials Letters2013，，： | 1 |
| 9 | Sparse spatial spectral estimation: A covariance fitting algorithm, performance and regularization显示文摘 | ZHENG Jimeng Kaveh M | 2013 | IEEE Transactions on Signal Processing2013，61，11： | 1 |
| 10 | Herb-partitioned moxibustion regulated the miRNA expression profile in the thyroid tissues of rats with experimental autoimmune thyroiditis显示文摘OBJECTIVE:To observe the effect of herb-partitioned moxibustion(HPM)on the miRNA expression profile of thyroid tissue in experimental autoimmune thyroiditis(EAT)rats.METHODS:Rats were randomly divided into normal control(NC)group,EAT model(EAT)group,HPM group and western medicine(Med)group.EAT model rats were prepared by a combined immunization with complete and incomplete Freund’s adjuvant emulsified with porcine thyroglobulin and iodine.Rats in the HPM group were treated with HPM,while rats in the Med group were treated with levothyrocine(1μg/2 m L)by gavage.HE staining was used to observe the pathological morphological changes of thyroid tissue,ELISAs was uaed to detect the serum concentrations of TGAb,TPOAb,FT3,FT4,TSH.We then performed high-throughput mi RNA sequencing to analyse the mi RNA expression profiles in the thyroid tissues,followed by a bioinformatics analysis.RT-q PCR was used to verify the identified differentially expressed mi RNAs.RESULTS:HPM improved the thyroid tissue morphology and reduced serum TPOAb,TGAb,TSH concentration in EAT rats(P<0.05),but with no obvious effect on FT3 and FT4 concentration.While the TSH,FT3 and FT4 concentration was significantly changed in the Med group(P<0.01 or P<0.05)compared with that of EAT group.Sequencing results showed that a total of 17 mi RNAs were upregulated,and 4 were downregulated in the EAT rats,in which the expression levels of mi R-346 and mi R-331-5 p were reversed by HPM.The target genes of the mi RNAs that regulated by HPM wereassociated with a variety of immune factors and immune signals.RT-q PCR verification showed that the expression of mi RNA-346 and mi RNA-331-5 p was consistent with the sequencing results.CONCLUSIONS:HPM could regulate the the expression of mi RNA-346 and mi RNA-331-5 p,then act on their target genes to immune and inflammation-related pathways,which may be one of the mechanisms of HPM on EAT rats. | WANG Zhaoqin CUI Yunhua HUANG Yan WU Huangan ZHAO Jimeng HE Jinsen LIU Huirong ZHENG Handan WU Luyi HU Zhihai LIU Yanan | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 1 |
| 11 | An electrical-coupling-suppressing MEMS gyroscope with feed-forward coupling compensation and scalable fuzzy control显示文摘This paper proposes a novel electrical coupling suppressing and drive closed loop control method for a MEMS gyroscope with feed-forward coupling compensation(FCC) and scalable fuzzy control. Theoretical analysis of the novel method is described in detail, and it is very simple to realize. Experimental results demonstrate that the electrical anti-resonant peaks located at the amplitude-frequency and phase-frequency responses are both eliminated by FCC control, and the height of the amplitude resonant peak increases more than 24 d B over 1800 Hz span. In addition, the overshoot of the transient response with scalable fuzzy control is smaller than 5%, and the settling time is less than 15 ms. The stabilities of the resonant amplitude and phase of the drive-mode velocity with scalable fuzzy control are about 15 ppm and 11 ppm, respectively. The scale factor of the gyroscope is measured to be 33.98 m V/deg/s with nonlinearity about 0.08%. Furthermore, the bias instability of the gyroscope with wavelet analysis is improved to be about 6.3 deg/h from 25.2 deg/h of the gyroscope without wavelet analysis. | Chunhua HE Jimeng ZHANG Qiancheng ZHAO Qinwen HUANG Zhenchuan YANG Dacheng ZHANG Guizhen YAN | 2017 | Science China(Information Sciences)2017，60，4： | 1 |
| 12 | Centralities in Large Networks: Algorithms and Observations 显示文摘 | KANG U PAPADIMITRIOU S SUN JIMENG | 2011 | SIAM / Omnipress2011，，： | 1 |
| 13 | Quantitative Study of Individual Emotional States ih Social Networks 显示文摘 | Tang Jie Zhang Yuan Sun Jimeng | 2012 | IEEE Transactions on Affective Computing2012，3，2： | 1 |
| 14 | Effect of Tb 3+ concentration and sensitization of Ce 3+ on luminescence properties of terbium doped phosphate scintillating glass显示文摘 | Dongbing He Chunlei Yu Jimeng Cheng Shunguang Li Lili Hu | 2010 | Journal of Alloys and Compounds2010，，5： | 1 |
| 15 | Sensory nerves directly promote osteoclastogenesis by secreting peptidyl-prolyl cis-trans isomerase D(Cyp40)显示文摘Given afferent functions,sensory nerves have recently been found to exert efferent effects and directly alter organ physiology.Additionally,several studies have highlighted the indirect but crucial role of sensory nerves in the regulation of the physiological function of osteoclasts.Nonetheless,evidence regarding the direct sensory nerve efferent influence on osteoclasts is lacking.In the current study,we found that high levels of efferent signals were transported directly from the sensory nerves into osteoclasts.Furthermore,sensory hypersensitivity significantly increased osteoclastic bone resorption,and sensory neurons(SNs)directly promoted osteoclastogenesis in an in vitro coculture system.Moreover,we screened a novel neuropeptide,Cyp40,using an isobaric tag for relative and absolute quantitation(iTRAQ).We observed that Cyp40 is the efferent signal from sensory nerves,and it plays a critical role in osteoclastogenesis via the aryl hydrocarbon receptor(AhR)-Ras/Raf-p-Erk-NFATc1 pathway.These findings revealed a novel mechanism regarding the influence of sensory nerves on bone regulation,i.e.,a direct promoting effect on osteoclastogenesis by the secretion of Cyp40.Therefore,inhibiting Cyp40 could serve as a strategy to improve bone quality in osteoporosis and promote bone repair after bone injury. | Junqin Li Bin Liu Hao Wu Shuaishuai Zhang Zhuowen Liang Shuo Guo Huijie Jiang Yue Song Xing Lei Yi Gao Pengzhen Cheng Donglin Li Jimeng Wang Yang Liu Di Wang Nazhi Zhan Jing Xu Lin Wang Guozhi Xiao Liu Yang GuoXian Pei | 2023 | Bone Research2023，11，4： | 0 |
| 16 | Publisher’s Note显示文摘The editorial office decided to start from Volume 4,Issue 3 with the page range starting from 1 and henceforth the page range of all issues onwards will continue to start from 1. | Jimeng Li | 2020 | Visual Informatics2020，4，4： | 0 |
| 17 | Longitudinal connection effect on initial support steel frames in tunnels--Take the traffic tunnels as examples显示文摘Most tunnel projects are designed with cross-sectional loads,and the inhomogeneity of the longitudinal forces is ignored.In theory,such a support structure can resist large loads,but in practice,large deformation,concrete cracking,steel frame distortion,and other phenomena often occur in tunnels under poor surrounding rock conditions.Hence,the longitudinal stability of the tunnel must be considered.In this study,the mechanism of longitudinal connecting ribs(LCRs)of tunnels was investigated through element tests,theoretical analyses,and numerical simulations,and the effect of the LCRs was evaluated experimentally.The applicability of the constitutive relations and boundary conditions of the numerical model was verified.The instability mode of the steel frame reflecting the longitudinal stress gradient of the tunnel was analyzed,and the longitudinal surrounding rock pressure and the verified numerical model were applied to analyze the LCR using the load structure method.The results indicate the following:(1)LCRs can effectively improve the ultimate bearing capacity and stability of a structure and reduce the area and degree of damage;(2)Two types of instability modes occur in tunnel steel frames,and the main factor is bending failure caused by the axial force;(3)The distance sensitivity of the LCR in the tunnel is higher than the stiffness sensitivity.For large deformations of tunnels,double rows of rebars with a spacing of less than 1.5 m should be used as longitudinal connections. | Kaimeng Ma Jichun Zhang Junru Zhang Zhiyong Wang Jimeng Feng | 2022 | Underground Space2022，7，4： | 0 |
| 18 | REDUCTION OF NON-POINT SOURCE POLLUTION IN THE YONG'AN RIVER BY CONSTRUCTED WETLAND BASED ON 9 YEARS OF MONITORING显示文摘The agricultural and livestock activities surrounding the rivers flowing into the lakes have caused non-point source pollution, leading to excessive amounts of nutrient salts in downstream rivers. Introducing river water into constructed wetlands along river course has proven to be an effective solution for decreasing nitrogen(N) and phosphorus(P) loads. This paper reports 9 years of monitoring the Yong’an River and its surrounding constructed wetlands in the upper reaches of Erhai Lake, located in Yunnan Province, China. This study analyzed the main types of pollutants in the river, and evaluated the removal efficiency of pollutants by the constructed wetlands. The findings indicate that total nitrogen(TN) and nitrate nitrogen(NO_(3)^(–)-N) are the primary pollutants in the Yong’an River, which exhibit variation throughout the year corresponding to the alternating wet and dry seasons. Although constructed wetlands are effective in removing NO_(3)^(-)-N and P, their efficacy in removing ammonium nitrogen(NH_(4)^(+)-N)and organic pollutants is limited. This limitation can be attributed to the lack of timely disposal of aquatic plant residues. This research contributes to the understanding of the potential issues that may arise during the extended use of constructed wetlands and provides solutions to address them. | Huaji LIU Jian SHEN Jimeng FENG Xinze WANG | 2023 | Frontiers of Agricultural Science and Engineering2023，10，4： | 0 |
| 19 | Effect of Deep Cryogenic Treatment on Electrical Conductivity of Cu-Base Multicomponent Alloy显示文摘 | Shuqing Chen Jimeng Li Xiaojie Zhao | 2014 | 材料科学与工程(中英文B版)2014，4，2： | 0 |
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