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| 1 | Lactobacillus salivarius alleviates inflammation via NF-κB signaling in ETEC K88-induced IPEC-J2 cells显示文摘Background:Enterotoxigenic Escherichia coli(ETEC)K88 commonly colonize in the small intestine and keep releasing enterotoxins to impair the intestinal barrier function and trigger inflammatory reaction.Although Lactobacillus salivarius(L.salivarius)has been reported to enhance intestinal health,it remains to be seen whether there is a functional role of L.salivarius in intestinal inflammatory response in intestinal porcine epithelial cell line(IPEC-J2)when stimulated with ETEC K88.In the present study,IPEC-J2 cells were first treated with L.salivarius followed by the stimulation of ETEC K88 for distinct time period.ETEC K88 adherent status,pattern recognition receptors(PRRs)mRNA,mitogen-activated protein kinase(MAPK)and nuclear factor-κB(NF-κB)activation,the release of pro-inflammation cytokines and cell integrity were examined.Results:Aside from an inhibited adhesion of ETEC K88 to IPEC-J2 cells,L.salivarius was capable of remarkably attenuating the expression levels of interleukin(IL)-1β,tumor necrosis factor-α(TNF-α),IL-8,Toll-like receptor(TLR)4,nucleotide-binding oligomerization domain(NOD)-like receptor pyrin domain-containing protein(NLRP)3 and NLRP6.This alternation was accompanied by a significantly decreased phosphorylation of p38 MAPK and p65 NF-κB during ETEC K88 infection with L.salivarius pretreatment.Western blot analysis revealed that L.salivarius increased the expression levels of zona occludens 1(ZO-1)and occludin(P<0.05)in ETEC K88-infected IPEC-J2 cells.Compared with ETEC K88-infected groups,the addition of L.salivarius as well as extra inhibitors for MAPKs and NF-κB to ETEC K88-infected IPEC-J2 cells had the capability to reduce pro-inflammatory cytokines.Conclusions:Collectively,our results suggest that L.salivarius might reduce inflammation-related cytokines through attenuating phosphorylation of p38 MAPK and blocking the NF-κB signaling pathways.Besides,L.salivarius displayed a potency in the enhancement of IPEC-J2 cell integrity. | Jiayun Qiao Zeyang Sun Dongmei Liang Haihua Li | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 11 |
| 2 | Construction of Redox Responsive Vesicles Based on a Supra-Amphiphile for Enzyme Confinement显示文摘 | Tiezheng Pan Huixin Zou Hongcheng Sun Yao Liu Shengda Liu Quan Luo Zeyuan Dong Jiayun Xu Junqiu Liu | 2017 | Chinese Journal of Chemistry2017，35，6： | 2 |
| 3 | Bifunctional flexible electrochromic energy storage devices based on silver nanowire flexible transparent electrodes显示文摘Flexible electrochromic energy storage devices(FECESDs)for powering flexible electronics have attracted considerable attention.Silver nanowires(AgNWs)are one kind of the most promising flexible transparent electrodes(FTEs)materials for the emerging flexible devices.Currently,fabricating FECESD based on AgNWs FTEs is still hindered by their intrinsic poor electrochemical stability.To address this issue,a hybrid AgNWs/Co(OH)_(2)/PEDOT:PSS electrode is proposed.The PEDOT:PSS could not only improve the resistance against electrochemical corrosion of AgNWs,but also work as functional layer to realize the color-changing and energy storage properties.Moreover,the Co(OH)_(2)interlayer further improved the color-changing and energy storage performance.Based on the improvement,we assembled the symmetrical FECESDs.Under the same condition,the areal capacitance(0.8 mF cm^(−2))and coloration efficiency(269.80 cm^(2)C−1)of AgNWs/Co(OH)_(2)/PEDOT:PSS FECESDs were obviously higher than AgNWs/PEDOT:PSS FECESDs.Furthermore,the obtained FECESDs exhibited excellent stability against the mechanical deformation.The areal capacitance remained stable during 1000 times cyclic bending with a 25 mm curvature radius.These results demonstrated the broad application potential of the AgNWs/Co(OH)_(2)/PEDOT:PSS FECESD for the emerging portable and multifunctional electronics. | He Zhang Fangyuan Sun Ge Cao Dongyan Zhou Guofan Zhang Jiayun Feng Shang Wang Fengyu Su Yanqing Tian Yan Jun Liu Yanhong Tian | 2023 | International Journal of Extreme Manufacturing2023，5，1： | 1 |
| 4 | Obesity, Insulin Resistance, NASH and Hepatocellular Carcinoma显示文摘 | Jun Yu Jiayun Shen Ting Ting Sun Xiang Zhang Nathalie Wong | 2013 | Seminars in Cancer Biology2013，，： | 1 |
| 5 | Chemical proteomic profling with photoaffinity labeling strategy identifies antimalarial targets of artemisinin显示文摘Present research on the antimalarial mechanisms of artemisinin(ART)is mainly focused on covalent drug binding targets alkylated by free radicals,while non-covalent binding targets have rarely been reported.Here,we developed a novel photoaffinity probe of ART to globally capture and identify the antimalarial target proteins of ART through chemical proteomics.The results demonstrated that ART can bind to par-asite proteins by both covalent and non-covalent modification,and these may jointly contribute to the antimalarial effects.Our work enriches the research on the antimalarial targets of ART,and provides a new perspective for further exploring the antimalarial mechanism of ART. | Peng Gao Jiayun Chen Peng Sun Jianyou Wang Huan Tang Fei Xia Liwei Gu Huimin Zhang Chen Wang Yin Kwan Wong Yinhua Zhu Chengchao Xu Jigang Wang | 2023 | Chinese Chemical Letters2023，34，12： | 1 |
| 6 | Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma显示文摘 | Tian Yuan Wong Vincent W.S. Wong Grace L.H. Yang Weiqin Sun Hanyong Shen Jiayun Tong Joanna H.M. Go Minnie Y.Y. Cheung Yue S. Lai Paul B.S. Zhou Mingyan Xu Gang Huang Tim H.M. Yu Jun To Ka F. Cheng Alfred S.L. Chan Henry L.Y | 2015 | Cancer Research2015，，22： | 1 |
| 7 | A study of transarterial infusion chemotherapy of gemcitabine plus three dimensional conformal radiotherapy for local advanced pancreatic cancer显示文摘Objective: To evaluate the clinical effect of transarterial infusion chemotherapy of gemcitabine plus three dimen- sional conformal radiotherapy on patients with local advanced pancreatic cancer. Methods: Fifty-one patients with local ad- vanced pancreatic cancer from June 2002 to February 2004 were enrolled, twenty-four patients of combined group were treat- ed with transarterial infusion chemotherapy of gemcitabine plus three dimensional conformal radiotherapy, while twenty-seven patients of control group were treated only with transarterial infusion chemotherapy of gemcitabine. Results: There were significant statistical differences between two groups in clinical benefit response (91.7% versus 74.1%, P < 0.01) and overall remission rate (70.8% versus 33.3%, P < 0.01). The 6-month survival rate, 12-month survival rate and 24-month survival rate of combined group were 83.3%, 62.5% and 37.5% respectively, while that of control group were 55.6%, 33.3% and 11.1% respectively. This showed significant difference between the two groups. Conclusion: Transarterial infusion chemotherapy of gemcitabine plus three dimensional conformal radiotherapy may be better than single transarterial infusion chemotherapy of gemcitabine in improving survival rates and elongating survival time of patients with local advanced pancreatic cancer. | Zhaojun Ding Yanwei Sun Jiayun Zhou | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，3： | 1 |
| 8 | High-Performance Blue Quasi-2D Perovskite Light-Emitting Diodes via Balanced Carrier Confinement and Transfer显示文摘Extensive investigation of the passivating agents has been performed to suppress the perovskite defects.However,very few attentions have been paid to rationally design the passivating agents for the balance of the carrier confinement and transfer in quasi-2D perovskites,which is essential to achieve high-performance perovskite LEDs(PeLEDs).In this work,tributylphosphine oxide(TBPO)with moderate carbon chain length is demonstrated as a decent passivator for the quasi-2D perovskites by strengthening the carrier confinement for massive radiative recombination within the perovskites,and more importantly providing efficient carrier transfer in the quasi-2D perovskites.Benefiting from these interesting optoelectronic properties of TBPO-incorporated perovskites,we achieve high-efficient blue PeLEDs with an external quantum efficiency up to 11.5%and operational stability as long as 41.1 min without any shift of the electroluminescence spectra.Consequently,this work contributes an effective approach to promote the carrier confinement and transfer for high-performance and stable blue PeLEDs. | Zhenwei Ren Jiayun Sun Jiahao Yu Xiangtian Xiao Zhaojin Wang Ruijia Zhang Kai Wang Rui Chen Yu Chen Wallace C.H.Choy | 2022 | Nano-Micro Letters2022，14，4： | 1 |
| 9 | Obesity, Insulin Resistance, NASH and Hepatocellular Carcinoma显示文摘 | Jun Yu Jiayun Shen Ting Ting Sun Xiang Zhang Nathalie Wong | 2013 | Seminars in Cancer Biology2013，，： | 1 |
| 10 | Bioresponsive cisplatin crosslinked albumin hydrogel served for efficient cancer combination therapy显示文摘Combination therapy is one of the potential strategies for tackling complicated tumor treatments like drug resistance.In this work,we have generated a therapeutic cisplatin-crosslinked albumin hydrogel(BC-Gel)that allows the local release of L-Buthionine-sulfoximine(BSO),cisplatin,and glucose oxidase(GOx)with distinct release kinetics.The BC-Gel with favorable biostimuli degradability and injectability could release therapeutic agents in a programmed manner within the tumor microenvironment(TME).The preferentially released BSO significantly suppressed the glutathione(GSH)-related cisplatin resistance and sensitized the tumor cells to cisplatin by inhibiting theγ-glutamylcysteine synthetase.Meanwhile,cisplatin achieved a sequential release and long-term treatment following the bioresponsive gel degradation under the combined action of chloride ions(Cl−)and proteinase in the body.In addition,the overproduced H_(2)O_(2)of GOx-catalyzed glucose oxidation accelerated the depletion of existed GSH within cells and further weakened the cisplatin resistance,achieving enhanced tumor treatment together with a strong cell-killing effect.The above sequential drug release strategy based on the dual GSH depletion effect breaks the balance of the GSH-mediated redox TME and enhances the sensitivity of A549 cells to cisplatin forcefully,and provides a promising way for temporal control of drug release as well as efficient cancer combination therapy. | An Yan Zherui Zhang Jiamei Gu Xiaoran Ding Yongchen Chen Jingjing Du Shu Wei Hongcheng Sun Jiayun Xu Shuangjiang Yu Junqiu Liu | 2023 | Nano Research2023，16，2： | 1 |
| 11 | Artificial Photosynthesis(AP):From Molecular Catalysts to Heterogeneous Materials显示文摘The development of green and renewable energy sources is in high demand due to energy shortage and productivity development.Artificial photosynthesis(AP)is one of the most effective ways to address the energy shortage and the greenhouse effect by converting solar energy into hydrogen and other carbon-based high value-added products through the understanding of the mechanism,structural analysis,and functional simulation of natural photosynthesis.In this review,the development of AP from natural catalysts to artificial catalysts is described,and the processes of oxygen production,hydrogen production,and carbon fixation are sorted out to understand the properties and correlations of the core functional components in natural photosynthesis,to provide a better rational design and optimization for further development of advanced heterogeneous materials. | JI Yuancheng XU Jiayun SUN Hongcheng LIU Junqiu | 2022 | Chemical Research in Chinese Universities2022，38，3： | 0 |
| 12 | High-Performance Transmission Mechanism Design of Multi-Stream Carrier Aggregation for 5G Non-Standalone Network显示文摘Multi-stream carrier aggregation is a key technology to expand bandwidth and improve the throughput of the fifth-generation wireless communication systems.However,due to the diversified propagation properties of different frequency bands,the traffic migration task is much more challenging,especially in hybrid sub-6 GHz and millimeter wave bands scenario.Existing schemes either neglected to consider the transmission rate difference between multistream carrier,or only consider simple low mobility scenario.In this paper,we propose a low-complexity traffic splitting algorithm based on fuzzy proportional integral derivative control mechanism.The proposed algorithm only relies on the local radio link control buffer information of sub-6 GHz and mmWave bands,while frequent feedback from user equipment(UE)side is minimized.As shown in the numerical examples,the proposed traffic splitting mechanism can achieve more than 90%link resource utilization ratio for different UE transmission requirements with different mobilities,which corresponds to 10%improvement if compared with conventional baselines. | Jun Yu Shunqing Zhang Jiayun Sun Shugong Xu Shan Cao | 2023 | China Communications2023，20，8： | 0 |
| 13 | Substituent engineering in g-C_(3)N_(4)/COF heterojunctions for rapid charge separation and high photo-redox activity显示文摘The heterojunction composed of covalent organic frameworks(COFs)with adjustable structure and other photocatalysts has great potential in the field of photocatalysis.However,effectively enhancing the photocatalytic performance of organic heterojunctions by designing the structure of COFs has not been explored.Herein,TPB-TP-COFs fabricated from 1,3,5-tris(4-amino-phenyl)benzene(TPB)and terephthalaldehyde(TP)with different substituents(−H,−OH,−OCH_(3),−Br and−F groups),were applied to construct g-C_(3)N_(4)/COFs.The performance improvement of the heterojunction could be affected by substituents,and only−OCH_(3) groups can significantly improve both the photocatalytic phenol oxidation and Cr(Ⅵ)reduction.DFT calculation demonstrated that the substituents will affect the electron cloud distribution of CBM,and the location of CBM in the TPB segment is beneficial for the charge transport between TPB-TP-OCH_(3) and g-C_(3)N_(4).The enhanced charge transfer from g-C_(3)N_(4) to TPB segment and the improved light absorption of TPB-TP-OCH_(3) jointly optimize the photocatalytic redox capacity of g-C_(3)N_(4)/TPB-TP-OCH_(3).On the basis of this study,regulating the electronic effects of semiconductors played a vital role in improving photocatalytic performance in organic heterojunctions. | Jiayun Guo Dongge Ma Fulin Sun Guilin Zhuang Qi Wang Abdullah M.Al-Enizi Ayman Nafady Shengqian Ma | 2022 | Science China Chemistry2022，65，9： | 0 |
| 14 | Trojan nanobacteria hybridized with prodrug nanocapsules for efficient combined tumor therapy显示文摘Live bacteria-based drug delivery systems have been raised as promising tools for enhancing drug delivery into tumors due to their active tumor targeting and easy surface modifiability.In this work,a“Trojan nanobacteria hybrid”,E.coli@highly integrated nanocapsules(HINCs)hybrid(HINE-Hybrid),was successfully constructed with HINCs of prodrug based on covalent selfassembly and the facultative anaerobic bacterium E.coli MG 1655 for combined chemotherapy,photothermal therapy(PTT),and chemodynamic therapy(CDT).HINCs were constructed by covalent cross-linking of pillar[5]arene derivatives and cisplatin prodrug linker,which can be endocytosed and lysed to release therapeutic agents.Under the near-infrared(NIR)light(at 808 nm)irradiation,the system temperature can be significantly increased by HINCs,which further leads to the highly efficient generation of reactive oxygen species(ROS).In addition,HINE-Hybrid shows significant antitumor effects in in vitro and in vivo studies and also promotes immune cell infiltration and antitumor cytokine expression in the tumor microenvironment(TME).HINEHybrid exerts its anticancer properties efficiently due to selective enrichment and multiplication of E.coli at tumor sites,which is important for the construction of bacterial-assisted antitumor platforms. | Mingsong Zang Yuancheng Ji Xiaoran Ding Zhengwei Xu Jinxing Hou Jianxin Sun Jiayun Xu Shuangjiang Yu Hongcheng Sun Tingting Wang Junqiu Liu | 2023 | Nano Research2023，16，7： | 0 |
| 15 | DeepPredict:A Zone Preference Prediction System for Online Lodging Platforms显示文摘Online lodging platforms have become more and more popular around the world.To make a booking in these platforms,a user usually needs to select a city first,then browses among all the prospective options.To improve the user experience,understanding the zone preferences of a user's booking behavior will be helpful.In this work,we aim to predict the zone preferences of users when booking accommodations for the next travel.We have two main challenges:(1)The previous works about next information of Points Of Interest(Pals)recommendation are mainly focused on users'historical records in the same city,while in practice,the historical records of a user in the same city would be very sparse.(2)Since each city has its own specific geographical entities,it is hard to extract the structured geographical features of accommodation in different cities.Towards the difficulties,we propose DeepPredict,a zone preference prediction system.To tackle the first challenge,DeepPredict involves users'historical records in all the cities and uses a deep learning based method to process them.For the second challenge,DeepPredict uses HERE places API to get the information of pals nearby,and processes the information with a unified way to get it.Also,the description of each accommodation might include some useful information,thus we use Sent2Vec,a sentence embedding algorithm,to get the embedding of accommodation description.Using a real-world dataset collected from Airbnb,DeepPredict can predict the zone preferences of users'next bookings with a remarkable performance.DeepPredict outperforms the state-of-the-art algorithms by 60%in macro Fl-score. | Yihan Ma Hua Sun Yang Chen Jiayun Zhang Yang Xu Xin Wang Pan Hui | 2021 | Journal of Social Computing2021，2，1： | 0 |
| 16 | Propofol protects against high glucose-mediated endothelial injury via inhibition of COX2 and iNOS expressions显示文摘Perioperative hyperglycemia is a common metabolic disorder in the clinic.Hyperglycemia,via upregulation of E74-like ETS transcription factor 3(ELF3),induces cyclooxygenase 2(COX2)and inducible nitric oxide synthase(iNOS)expressions,thus leading to endothelial apoptosis and vascular endothelial injury.Propofol is a widely used anesthetic.In the present study,we explored whether and how propofol protects against high glucose-induced COX2 and iNOS expressions in human umbilical vein endothelial cells(HUVECs).We found that high glucose level decreases cell viability and increases COX2 and iNOS expressions in HUVECs.Our data also indicated that ELF3 overexpression participates in high glucose-mediated cell viability reduction and high glucose-induced COX2 and iNOS expressions.Moreover,propofol treatment improves high glucose-mediated reduction in cell viability and decreases COX2 and iNOS expressions via inhibition of ELF3 expressions.Furthermore,specificity protein 1(SP1)was found to regulate ELF3 expression,thus mediating endothelial injury.Propofol inhibits high glucose-induced SP1 expression.High glucose increases the abundance of SP1 bound to the ELF3 promoter,which can be reversed by propofol treatment.The protective effect of propofol is reversed by SP1 overexpression.In conclusion,propofol downregulates high glucose-induced SP1 expression,thus attenuating high glucose-induced ELF3 expression,inhibiting high glucose-induced COX2 and iNOS expressions,and improving high glucose-mediated cell viability reduction in HUVECs. | Jiayun Shao Juan Ding Lihong Lu Wenting Hou Fei Wang Zhirong Sun Hui Jiang Yanjun Zhao | 2022 | Acta Biochimica et Biophysica Sinica2022，54，4： | 0 |
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