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| 1 | Immune therapies in pancreatic ductal adenocarcinoma: Where are we now?显示文摘Pancreatic ductal adenocarcinoma(PDAC)is one of the deadliest cancers,mostly due to its resistance to treatment.Of these,checkpoint inhibitors(CPI)are inefficient when used as monotherapy,except in the case of a rare subset of tumors harboring microsatellite instability(<2%).This inefficacy mainly resides in the low immunogenicity and non-inflamed phenotype of PDAC.The abundant stroma generates a hypoxic microenvironment and drives the recruitment of immunosuppressive cells through cancerassociated-fibroblast activation and transforming growth factorβsecretion.Several strategies have recently been developed to overcome this immunosuppressive microenvironment.Combination therapies involving CPI aim at increasing tumor immunogenicity and promoting the recruitment and activation of effector T cells.Ongoing studies are therefore exploring the association of CPI with vaccines,oncolytic viruses,MEK inhibitors,cytokine inhibitors,and hypoxia-and stroma-targeting agents.Adoptive T-cell transfer is also under investigation.Moreover,translational studies on tumor tissue and blood,prior to and during treatment may lead to the identification of biomarkers with predictive value for both clinical outcome and response to immunotherapy. | Marc Hilmi Laurent Bartholin Cindy Neuzillet | 2018 | World Journal of Gastroenterology2018，24，20： | 6 |
| 2 | The human Cyr61 gene is a transcriptional target of transforming growth factor beta in cancer cells显示文摘 | Bartholin L Wessner LL Chirgwin JM | 2007 | Cancer Lett2007，246，2： | 1 |
| 3 | Thermal treatment of wood:Analysis of the obtained product显示文摘 | BOURGOIS J BARTHOLIN M C GUYONNET R | 1989 | Wood Science and Technology1989，23，4： | 1 |
| 4 | Influence of the polysaccharide addition method on the properties of fresh mortars 显示文摘 | POINOT T BARTHOLIN M C GOV1N A | 2015 | Cem Concr Res2015，70，： | 1 |
| 5 | Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function显示文摘 | Bartholin L Maguer-Satta V Hayette S | 2002 | Oncogene2002，21，14： | 1 |
| 6 | Infrared Evidence for the Grafting of Ester Groups on Polyvinyl Chloride Stabilized by Zinc and Calcium Stearates显示文摘 | Bartholin M Bensemra N Tran V H Guyot A | 1990 | Polym Bull1990，23，： | 1 |
| 7 | Regulation of human erythropoiesis by activin A,BMP2,and BMP4,members of the TGFbeta family显示文摘 | Maguer-Satta V Bartholin L Jeanpierre S Ffrench M Martel S Magaud J P | 2003 | Exp Cell Res2003，282，： | 1 |
| 8 | The human Cyr61 gene is a transcriptional target of transforming growth factor beta in cancer cells显示文摘 | Bartholin L Wessner LL Chirgwin JM | 2007 | Cancer Lett2007，246，： | 1 |
| 9 | A 1400-year treering record of summer temperatures in Fennoscandia显示文摘 | Briffa K R Bartholin T S Eckstein D | 1991 | Nature1991，346，： | 1 |
| 10 | Maternal TGIF is required for vascularization of the embryonic placenta显示文摘 | Bartholin L Melhuish TA Powers SE | 2008 | Dev Biol2008，319，2： | 1 |
| 11 | Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta family 显示文摘 | Maguer-Satta V Bartholin L Jeanpierre S | 2003 | Exp Cell Res2003，282，2： | 1 |
| 12 | Prevention of urethral stricture recurrence using clean intermittent self cathterisation显示文摘 | ] KJAEERGARD B WALTER S BARTHOLIN J | 1994 | Jr J Urol1994，73，6： | 1 |
| 13 | FLRG, an activin-binding protein, is a new target of TGFbeta transcription activation through smad proteins 显示文摘 | Bartholin L Maguer-Satta V Hayette S | 2001 | Oncogene2001，20，39： | 1 |
| 14 | Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin a function 显示文摘 | Laurent Bartholin Vea Ronique Maguer-Satta Sandrine Hayette | 2002 | Oncogene2002，21，16： | 1 |
| 15 | Food spoilage—interactions between food spoilage bacteria显示文摘 | Lone Gram Lars Ravn Maria Rasch Jesper Bartholin Bruhn Allan B Christensen Michael Givskov | 2002 | International Journal of Food Microbiology2002，，1： | 1 |
| 16 | Identification of NF-kappaB responsive elements in follistatin related gene (FLRG) promoter 显示文摘 | Bartholin L Guindon S Martel S | 2007 | Gene2007，393，12： | 1 |
| 17 | The human CYR61 gene is a transcriptional target of transforming growth factor beta in cancer cells显示文摘 | Bartholin L Wessner LL Chirgwin JM | 2007 | Cancer Lett2007，246，12： | 1 |
| 18 | The human Cyr61 gene is a transcriptional target of transforming growth factor beta in cancer ceils 显示文摘 | Bartholin L Wessner LL Chirgwin JM | 2007 | Cancer Lett2007，246，12： | 1 |
| 19 | Decarboxylase inhibitors显示文摘 | Pletscher A | 1975 | Phermacol Ther1975，1，： | 1 |
| 20 | Fennoscandi- an summers from AD 500: temperature changes on short and long time scales 显示文摘 | BRIFFA K R JONES P D BARTHOLIN T S | 1992 | Climate Dynamics1992，7，： | 1 |
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