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| 1 | Colorectal liver metastases: Current management and future perspectives显示文摘The liver is the commonest site of metastatic disease for patients with colorectal cancer,with at least 25%developing colorectal liver metastases(CRLM)during the course of their illness.The management of CRLM has evolved into a complex field requiring input from experienced members of a multi-disciplinary team involving radiology(cross sectional,nuclear medicine and interventional),Oncology,Liver surgery,Colorectal surgery,and Histopathology.Patient management is based on assessment of sophisticated clinical,radiological and biomarker information.Despite incomplete evidence in this very heterogeneous patient group,maximising resection of CRLM using all available techniques remains a key objective and provides the best chance of long-term survival and cure.To this end,liver resection is maximised by the use of downsizing chemotherapy,optimisation of liver remnant by portal vein embolization,associating liver partition and portal vein ligation for staged hepatectomy,and combining resection with ablation,in the context of improvements in the functional assessment of the future remnant liver.Liver resection may safely be carried out laparoscopically or open,and synchronously with,or before,colorectal surgery in selected patients.For unresectable patients,treatment options including systemic chemotherapy,targeted biological agents,intraarterial infusion or bead delivered chemotherapy,tumour ablation,stereotactic radiotherapy,and selective internal radiotherapy contribute to improve survival and may convert initially unresectable patients to operability.Currently evolving areas include biomarker characterisation of tumours,the development of novel systemic agents targeting specific oncogenic pathways,and the potential reemergence of radical surgical options such as liver transplantation. | Jack Martin Angelica Petrillo Elizabeth C Smyth Nadeem Shaida Samir Khwaja HK Cheow Adam Duckworth Paula Heister Raaj Praseedom Asif Jah Anita Balakrishnan Simon Harper Siong Liau Vasilis Kosmoliaptsis Emmanuel Huguet | 2020 | World Journal of Clinical Oncology2020，11，10： | 5 |
| 2 | Successful surgical management of ruptured umbilical hernias in cirrhotic patients显示文摘Acute umbilical hernia rupture in patients with hepatic cirrhosis and ascites is an unusual,but potentially lifethreatening complication,with postoperative morbidity about 70% and mortality between 60%-80% after supportive care and 6%-20% after urgent surgical repair.Management options include primary surgical repair with or without concomitant portal venous system decompression for the control of the ascites.We present a retrospective analysis of our centre's experience over the last 6 years.Our cohort consisted of 11 consecutive patients(median age:53 years,range:36-63 years) with advanced hepatic cirrhosis and refractory ascites.Appropriate patient resuscitation and optimisation with intravenous fluids,prophylactic antibiotics and local measures was instituted.One failed attempt for conservative management was followed by a successful primary repair.In all cases,with one exception,a primary repair with non-absorbable Nylon,interrupted sutures,without mesh,was performed.The perioperative complication rate was 25% and the recurrence rate 8.3%.No mortality was recorded.Median length of hospital stay was 14 d(range:4-31 d).Based on our experience,the management of ruptured umbilical hernias in patients with advanced hepatic cirrhosis and refractory ascites is feasible without the use of transjugular intrahepatic portosystemic shunt routinely in the preoperative period,provided that meticulous patient optimisation is performed. | Nikolaos A Chatzizacharias J Andrew Bradley Simon Harper Andrew Butler Asif Jah Emmanuel Huguet Raaj K Praseedom Michael Allison Paul Gibbs | 2015 | World Journal of Gastroenterology2015，21，10： | 4 |
| 3 | Endoscopic Ultrasound-guided drainage of an abdominal fluid collection following Whipple's resection显示文摘Percutaneous aspiration and drainage of post-operative abdominal fluid collections is a well established standard technique. However,some fluid collections are not amenable to percutaneous drainage either due to location or the presence of surrounding visceral structures. Endoscopic Ultrasound (EUS) has been widely used for the drainage of pancreatitis-related abdominal fluid collections. However,there are no reports on the use of this technique in the post-operative setting. We report a case where the EUS-guided technique was used to drain a percutaneously inaccessible post-operative collection which had developed after Whipple's resection. | Asif Jah Neville Jamieson Emmanuel Huguet William Griffi ths Nicholas Carroll Raaj Praseedom | 2008 | World Journal of Gastroenterology2008，14，44： | 3 |
| 4 | Incidental non-benign gallbladder histopathology after cholecystectomy in an United Kingdom population: Need for routine histological analysis?显示文摘AIM To analyse the range of histopathology detected in the largest published United Kingdom series of cholecystectomy specimens and to evaluate the rational for selective histopathological analysis.METHODS Incidental gallbladder malignancy is rare in the United Kingdom with recent literature supporting selective histological assessment of gallbladders after routine cholecystectomy.All cholecystectomy gallbladder specimens examined by the histopathology department at our hospital during a five year period between March 2008 and March 2013 were retrospectively analysed.Further data was collected on all specimens demonstrating carcinoma,dysplasia and polypoid growths.RESULTS The study included 4027 patients.The majority(97%) of specimens exhibited gallstone or cholecystitis related disease.Polyps were demonstrated in 44(1.09%),the majority of which were cholesterol based(41/44).Dysplasia,ranging from low to multifocal high-grade was demonstrated in 55(1.37%).Incidental primary gallbladder adenocarcinoma was detected in 6 specimens(0.15%,5 female and 1 male),and a single gallbladder revealed carcinoma in situ(0.02%).This large single centre study demonstrated a full range of gallbladder disease from cholecystectomy specimens,including more than 1% neoplastic histology and two cases of macroscopically occult gallbladder malignancies.CONCLUSION Routine histological evaluation of all elective and emergency cholecystectomies is justified in a United Kingdom population as selective analysis has potential to miss potentially curable life threatening pathology. | Krashna Patel Khaled Dajani Satheesh Iype Nikolaos A Chatzizacharias Saranya Vickramarajah Susan Davies Rebecca Brais Siong S Liau Simon Harper Asif Jah Raaj K Praseedom Emmanuel L Huguet | 2016 | World Journal of Gastrointestinal Surgery2016，8，10： | 2 |
| 5 | Endoscopy in gastrointestinal bleeding显示文摘 | FORREST JAH FINLAYSON NDC SHEARMAN DJV | 1974 | Cancer1974，2，： | 1 |
| 6 | General competencies of problem-base learning (PBL)and non-PBL graduates显示文摘 | Katinka JAH Prince Patrick WLJ van Eija Henny PA Boshuizen | 2005 | Medical Education2005，，39： | 1 |
| 7 | General competencies of problem- base larning(PBL) and non-PBL graduates显示文摘 | katinka JAH Prince Patrick WLJ van Eija Henny PA Boshuizen | 2005 | Medical Education2005，39，39： | 1 |
| 8 | Micafungin versus fluconazole against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation显示文摘 | van Burik JAH Ratanatharathorn V Stepan DE | 2004 | Clin Infect Dis2004，39，10： | 1 |
| 9 | Tracheal intubation after induction of anaesthia with propofol,Alfentanyl and Lidocaine显示文摘 | Davidson JAH Gillespie JA | | 0，，： | 1 |
| 10 | Risk factors for ocular complications and poor visual acuity at presentation among patients with uveitis associated with juvenile idiopathic arthritis显示文摘 | Woreta F Thorne JE Jahs DA | | 0，，04： | 1 |
| 11 | Graded mesh generation and transformation显示文摘 | Xie G Ramaeker JAH | 1994 | Finite Elements in Analysis and Design1994，17，2： | 1 |
| 12 | Accuracy of MRI incomeparison with clinical and arthroscopic findings in ligamentous and meniscal injuries of the knee显示文摘 | Esmaili Jah AA Keyhani S Zarei R | 2005 | Acta Orthop Belg2005，71，2： | 1 |
| 13 | Plasma levels of high-energy compounds compared with severity of illness in critically ill patients in the intensive care unit显示文摘 | Sigurdsson GH Neglen P | 1998 | Surgery1998，124，1： | 1 |
| 14 | General competencies of problem-base learning(PBL) and non-PBL graduates显示文摘 | Katinka JAH Prince Patrick WLJ van Eija Henny PA Boshuizen | 2005 | Medical Education2005，，39： | 1 |
| 15 | 显示文摘 | Lenes M Wetzelaer G Jah Kooistra F B | 2008 | Adv Mater2008，20，11： | 1 |
| 16 | Endoscopy in gastrointestinal bleeding显示文摘 | Forrest JAH Finlayson NDC Shearman DJV | | 0，，： | 1 |
| 17 | Detection and orbit determination of a satellite executing low thrust maneuvers 显示文摘 | Kelecy T Jah M | 2009 | Acta Astronautica2009，66，5： | 1 |
| 18 | Transcriptional regulation of aquaporins in accessions of Arabidopsis in response to drought stress显示文摘 | ALEXANDERSSON E DANIELSON JAH RADE J | 2010 | Plant J2010，61，： | 1 |
| 19 | Multitarget passive coherent location with transmitter-origin and target-altitude uncertainties 显示文摘 | THARMARASA R SUBRAMANIAM M NADARA- JAH N | 2012 | IEEE Transactions on Aerospace and Electronic Systems2012，48，3： | 1 |
| 20 | Clavicular hook plate:complications of retaining the implant显示文摘 | Nadara jah R Mahaluxmivala J Amin A | 2005 | Injury2005，36，： | 1 |
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