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| 1 | Functional interaction of endoplasmic reticulum stress and hepatitis B virus in the pathogenesis of liver diseases显示文摘Hepatitis B virus(HBV) is a non-cytopathic virus that causes acute and chronic inflammatory liver diseases,often leading to the pathogenesis of hepatocellular carcinoma(HCC). Although many studies for the roles of HBV on pathogenesis of the liver diseases,such as non-alcoholic fatty liver disease(NAFLD),hepatic inflammation,cirrhosis,and HCC,have been reported,the mechanisms are not fully understood. Endoplasmic reticulum(ER) and mitochondria have the protective mechanisms to restore their damaged function by intrinsic or extrinsic stresses,but their chronic dysfunctions are associated with the pathogenesis of the various diseases. Furthermore,HBV can affect intraor extracellular homeostasis through induction of ER and mitochondrial dysfunctions,leading to liver injury. Therefore,the mechanism by which HBV induces ER or mitochondrial stresses may be a therapeutic target for treatment of liver diseases. | so young kim yi yi kyaw jaehun cheong | 2017 | World Journal of Gastroenterology2017，23，43： | 12 |
| 2 | Association of chronic viral hepatitis B with insulin resistance显示文摘AIM:To investigate the relationship between chronic viral hepatitis B(CVHB) and insulin resistance(IR) in Korean adults.METHODS:A total of 7880 adults(3851 men,4029 women) who underwent a comprehensive medical examination were enrolled in this study.Subjects diagnosed with either diabetes mellitus,or any other disorder that could influence their insulin sensitivity,were rejected.Anthropometry,metabolic risk factors,hepatitis B surface antigen,hepatitis B surface antibody,hepatitis B core antibody,fasting plasma glucose and insulin were measured for all subjects.Homeostasis model assessment(HOMA),quantitative insulin check index(QUICKI),and Mf fm index were used for determining insulin sensitivity.Each participant was categorized into a negative,recovery,or CVHB group.To compare variables between groups,a t-test and/or one-way analysis of variance were used.Partial correlation coefficients were computed to present the association between insulin resistance and other variables.Multiple logistic regression analysis was used to assess the independent association between CVHB and IR.RESULTS:The mean age of men and women were 48.9 and 48.6 years,respectively.Subjects in the CVHB group had significantly higher waist circumference [(86.0 ± 7.7 cm vs 87.3 ± 7.8 cm,P = 0.004 in men),(78.3 ± 8.6 cm vs 80.5 ± 8.5 cm,P < 0.001 in women)],cystatin C [(0.96 ± 0.15 mg/dL vs 1.02 ± 0.22 mg/dL,P < 0.001 in men),(0.84 ± 0.15 mg/dL vs 0.90 ± 0.16 mg/dL,P < 0.001 in women)],fasting insulin [(5.47 ± 3.38 U/mL vs 6.12 ± 4.62 U/mL,P < 0.001 in men),(4.57 ± 2.82 U/mL vs 5.06 ± 3.10 U/mL,P < 0.001 in women)] and HOMA index [(1.24 ± 0.86 vs 1.43 ± 1.24,P < 0.001 in men),(1.02 ± 0.76 vs 1.13 ± 0.87,P = 0.033 in women)] compared to control group.The HOMA index revealed a positive correlation with body mass index(BMI)(r = 0.378,P < 0.001),waist circumference(r =0.356,P < 0.001),percent body fat(r = 0.296,P < 0.001),systolic blood pressure(r = 0.202,P < 0.001),total cholesterol(r = 0.134,P < 0.001),triglycerides(r = 0.292,P < 0.001),cystatin C(r = 0.069,P < 0.001) and uric acid(r = 0.142,P < 0.001).The QUICKI index revealed a negative correlation with BMI(r =-0.254,P < 0.001),waist circumference(r = 0-0.243,P < 0.001),percent body fat(r =-0.217,P < 0.001),systolic blood pressure(r =-0.132,P < 0.001),total cholesterol(r =-0.106,P < 0.001),triglycerides(r =-0.205,P < 0.001),cystatin C(r =-0.044,P < 0.001) and uric acid(r =-0.096,P < 0.001).For subjects identified with IR,the odds ratio of an accompanying diagnosis of chronic hepatitis B was 1.534(95% CI:1.158-2.031,HOMA index criteria) or 1.566(95% CI:1.124-2.182,QUICKI criteria) after adjustment for age,gender,BMI,and amount of alcohol consumption.CONCLUSION:Our study demonstrates that CVHB is associated with IR.CVHB may need to be monitored for occurrence of IR and diabetes mellitus. | Jeong Gyu Lee Sangyeoup Lee Yun Jin Kim Byung Mann Cho Joo Sung Park Hyung Hoi Kim JaeHun Cheong Dong Wook Jeong Yu Hyun Lee Young Hye Cho Mi Jin Bae Eun Jung Choi | 2012 | World Journal of Gastroenterology2012，18，42： | 10 |
| 3 | Improvement of Kalman filters for WLAN based indoor tracking显示文摘 | Jaegeol Yim Seunghwan Jeong Kiyoung Gwon Jaehun Joo | 2009 | Expert Systems With Applications2009，，1： | 2 |
| 4 | Improvement of Kalman filters for WLAN based indoor tracking显示文摘 | Jaegeol Yim Seunghwan Jeong Kiyoung Gwon Jaehun Joo | 2010 | Expert Systems with Applications2010，37，1： | 1 |
| 5 | Temkin vacuum electronics high power terahertz sources 显示文摘 | John H Booske Richard J Dobbs Colin D Joye Carol L Kory George R Neil Gunn-sik Park Jaehun Park Richard J | 2011 | IEEE transactions on terahertz science and technolo- gy2011，1，1： | 1 |
| 6 | Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein显示文摘 | Seishi M Jaehun C Shuichi K | 1994 | Biol Chem1994，269，15： | 1 |
| 7 | Electrophoretic mobility of poly(acrylic acid)-coated alumina particles显示文摘 | Prasad S. Bhosale Jaehun Chun John C. Berg | 2011 | Journal of Colloid And Interface Science2011，，1： | 1 |
| 8 | Characteristics of pressure distribution and solution to the problems mused by stack effect in high-rise residential buildings 显示文摘 | Jo JaeHun Idm Jae-Han Song Seung-Yeong | 2007 | Building and Environment2007，42，1： | 1 |
| 9 | Hepatitis C virus NS5A protein increases hepatic lipid accumulation via induction of activation and expression of PPARgamma显示文摘 | KyeongJin Kim Kook Hwan Kim Eunsin Ha Jin Young Park Naoya Sakamoto JaeHun Cheong | 2009 | FEBS Letters2009，，17： | 1 |
| 10 | Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway显示文摘 | KyeongJin Kim Kook Hwan Kim Hye Young Kim Hyun Kook Cho Naoya Sakamoto JaeHun Cheong | 2009 | FEBS Letters2009，，4： | 1 |
| 11 | HCV core protein induces hepatic lipid accumulation by activating SREBP1 and PPARγ显示文摘 | Kook Hwan Kim Sung Pyo Hong KyeongJin Kim Min Jung Park Kwang Jin Kim JaeHun Cheong | 2007 | Biochemical and Biophysical Research Communications2007，，4： | 1 |
| 12 | Relationship of meteorological factors and air pollutants with medical care utilization for gastroesophageal reflux disease in urban area显示文摘BACKGROUND Gastroesophageal reflux disease(GERD)is a highly prevalent disease of the upper gastrointestinal tract,and it is associated with environmental and lifestyle habits.Due to an increasing interest in the environment,several groups are studying the effects of meteorological factors and air pollutants(MFAPs)on disease development.AIM To identify MFAPs effect on GERD-related medical utilization.METHODS Data on GERD-related medical utilization from 2002 to 2017 were obtained from the National Health Insurance Service of Korea,while those on MFAPs were obtained from eight metropolitan areas and merged.In total,20071900 instances of GERD-related medical utilizations were identified,and 200000 MFAPs were randomly selected from the eight metropolitan areas.Data were analyzed using a multivariable generalized additive Poisson regression model to control for time trends,seasonality,and day of the week.RESULTS Five MFAPs were selected for the prediction model.GERD-related medical utilization increased with the levels of particulate matter with a diameter≤2.5μm(PM2.5)and carbon monoxide(CO).S-shaped and inverted U-shaped changes were observed in average temperature and air pollutants,respectively.The time lag of each variable was significant around nine days after exposure.CONCLUSION Using five MFAPs,the final model significantly predicted GERD-related medical utilization.In particular,PM2.5 and CO were identified as risk or aggravating factors for GERD. | Ho Seok Seo Jinwook Hong Jaehun Jung | 2020 | World Journal of Gastroenterology2020，26，39： | 1 |
| 13 | Hepatitis B Virus X Protein Induces Hepatic Steatosis Via Transcriptional Activation of SREBP1 and PPARγ显示文摘 | Kook Hwan Kim Hye–Jun Shin Kyeongjin Kim Hyun Mi Choi Sang Hoon Rhee Hyung–Bae Moon Hyeong Hoe Kim Ung Suk Yang Dae–Yeul Yu Jaehun Cheong | 2007 | Gastroenterology2007，，5： | 1 |
| 14 | Capacity fading mechanism of Li Fe PO4-based lithium secondary batteries for stationary energy storage显示文摘 | Kim Jaehun Woo Sangcheol Park Minsik | 2013 | Journal of Power Sources2013，229，： | 1 |
| 15 | Development of exosome membrane materialsfused microbubbles for enhanced stability and efficient drug delivery of ultrasound contrast agent显示文摘Lipid-coated microbubbles are widely used as an ultrasound contrast agent,as well as drug delivery carriers.However,the two main limitations in ultrasound diagnosis and drug delivery using microbubbles are the short half-life in the blood system,and the difficulty of surface modification of microbubbles for active targeting.The exosome,a type of extracellular vesicle,has a preferentially targeting ability for its original cell.In this study,exosome-fused microbubbles(Exo-MBs)were developed by embedding the exosome membrane proteins into microbubbles.As a result,the stability of Exo-MBs is improved over the conventional microbubbles.On the same principle that under the exposure of ultrasound,microbubbles are cavitated and self-assembled into nano-sized particles,and Exo-MBs are self-assembled into exosome membrane proteins-embedded nanoparticles(Exo-NPs).The Exo-NPs showed favorable targeting properties to their original cells.A photosensitizer,chlorin e6,was loaded into Exo-MBs to evaluate therapeutic efficacy as a drug carrier.Much higher therapeutic efficacy of photodynamic therapy was confirmed,followed by cancer immunotherapy from immunogenic cell death.We have therefore developed a novel ultrasound image-guided drug delivery platform that overcomes the shortcomings of the conventional ultrasound contrast agent and is capable of simultaneous photodynamic therapy and cancer immunotherapy. | Yongho Jang Jeehun Park Pilsu Kim Eun-Joo Park Hyungjin Sun Yujin Baek Jaehun Jung Tai-kyong Song Junsang Doh Hyuncheol Kim | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 1 |
| 16 | A soft com- puting approach to localization in wireless sensor networks显示文摘 | Sukhyun Yun Jaehun Lee Wooyong Chung | 2009 | Expert Systems with Applications2009，36，4： | 1 |
| 17 | The effects of surface modification on carbon felt electrodes for use in vanadium redox flow batteries显示文摘 | Kim Ki Jae Kim Youngjun Kim Jaehun | 2011 | Mater Chem Phys2011，131，12： | 1 |
| 18 | A New Genetic Approach for Structure Learning of Bayesian Networks: Matrix Genetic Algorithm显示文摘 | JAEHUN LEE WOO YONG CHUNG EUNTAI KIM SOOHAN KIM | 2010 | International Journal of Control Automation and Systems2010，8，2： | 1 |
| 19 | A New Genetic Approach for Structure Learning of Bayesian Networks: Matrix Genetic Algorithm 显示文摘 | Jaehun Lee Wooyong Chung Euntai Kim Soohan Kim | 2010 | International Journal of Control Automation and Systems2010，8，2： | 1 |
| 20 | Determinants of brain natriuretic peptide levels in patients with lone atrial fibrillation 显示文摘 | Sang HL Jaehun J Seung Hyuk C | 2006 | Cim J2006，70，： | 1 |
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