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| 1 | Driving gene-engineered T cell immunotherapy of cancer显示文摘妄想的抗原受体(汽车) 设计基因的 T 房间治疗保持潜力与终末期癌在病人的生活有有意义的差别。为十年,癌症治疗基于生物物理的参数,与到 debulk 的外科的切除术,由放射和化疗列在后面指向很快成长的肿瘤房间,当时主要 sparing 静止正常纸巾。一突破与 allogeneic 骨头髓发生了与白血病为病人移植,它提供了一有时药品治疗。为稳固的肿瘤的采纳房间治疗的地与发现被建立渗入肿瘤的淋巴细胞能与变形黑瘤被扩展并且使用到对待和甚至痊愈病人。肿瘤特定的 T 房间受体(TCR ) 被识别并且设计了进耐心的外部血淋巴细胞,它也被发现治疗肿瘤。然而,这些被耐心的 HLA 限制限制。紧随来汽车的产生,把抗体的优美识别与一个 T 房间的受动器功能相结合。为与先进 B 房间恶意的多重表格对待病人的指向 CD19 的汽车的来临取得了大成功,与多达 95% 反应率。然而,到稳固的肿瘤的适用的汽车治疗刚开始了,但是已经,某些因素被弄明白:肿瘤目标具有最大的重要性让临床医生不做伤害;并且稳固的肿瘤与 hematologic 相比对汽车治疗不同地作出回应。这里,我们考察临床的设计基因的 T 房间免疫疗法,它的成功,挑战,和未来的状态。 | Laura A Johnson Carl H June | 2017 | Cell Research2017，27，1： | 37 |
| 2 | History of the infantile hepatic hemangioma:From imaging to generating a differential diagnosis显示文摘We aim to provide an up-to-date summary of infantile hepatic hemangioma(IHH) and its misnomers and to dialectically present the differential diagnosis of these rare entities of the liver.Eligible peer-reviewed articles on hepatic infantile hemangiomas,published between 2000 and 2015,were reviewed for this study.IHH is the most common hepatic vascular tumor in children.Once a liver mass is identified in an infant,the differential diagnosis ranges from vascular malformations to benign and malignant tumors including mesenchymal hamartoma,hepatoblastoma,metastatic neuroblastoma,so careful physical examination,imaging studies,and,if indicated,tumor markers and biopsy,are of pivotal importance to ascertain the correct diagnosis.Despite the benign nature of IHHs,some of these lesions may demand medical and/or surgical intervention,especially for multiple and diffuse IHH.Complications can include hepatomegaly,hypothyroidism and cardiac failure.Therefore,a close follow-up is required until complete involution of the lesions.We propose an algorithm to guide the physicians towards the proper management of hepatic lesions. | Maria Gnarra Gerald Behr Alison Kitajewski June K Wu Sudha A Anupindi Carrie J Shawber Nick Zavras Dimitrios Schizas Chris Salakos Konstantinos P Economopoulos | 2016 | World Journal of Clinical Pediatrics2016，5，3： | 27 |
| 3 | Singular Boolean networks:Semi-tensor product approach显示文摘Singular Boolean networks are introduced in this paper.Via semi-tensor product of matrices and the matrix expression of logical functions,two kinds of the condensed algebraic expressions of singular Boolean networks are obtained.The normalization problem of singular Boolean networks is addressed;that is,under what condition singular Boolean networks can be converted into normal Boolean networks with algebraic restrictions.Then one sufcient condition and one necessary and sufcient condition are derived for the normalization problem.Furthermore,the solvability of singular Boolean networks is discussed and the concept of admissible initial values of singular Boolean networks is presented.Finally,fxed points and cycles of singular Boolean networks are also investigated. | FENG JunE YAO Juan CUI Peng | 2013 | Science China(Information Sciences)2013，56，11： | 15 |
| 4 | BRI1-Associated Receptor Kinase 1 Regulates Guard Cell ABA Signaling Mediated by Open Stomata 1 in Arabidopsis显示文摘有气孔的运动在为在植物纸巾和空气之间的光合作用和水平衡调整煤气的交换是批评的。植物荷尔蒙 abscisic 酸(骆驼毛的织物) 戏在在各种各样的不能生活的压力下面调整有气孔的闭合给角色调音。在这研究,我们在警卫房间骆驼毛的织物发信号揭示了 BAK1 的一个新奇角色。我们发现表明变异的 bak1 的 brassinosteroid (BR ) 比野类型的植物失去了更多的水并且在有气孔的闭合显示出骆驼毛的织物 insensitivity。导致骆驼毛的织物的 OST1 表示和生产也是的反应的氧种类(ROS ) 在 bak1 损害了。有 H 2 OST1 的 O 2, overexpression 完全没救 bak1 的 insensitivity 到骆驼毛的织物。我们证明 BAK1 在血浆膜附近与 OST1 形成建筑群并且 BAK1/OST1 建筑群在 planta 响应骆驼毛的织物被增加。Brassinolide,最活跃的 BR,在 BAK1/OST1 建筑群和 OST1 表示的导致骆驼毛的织物的形成上施加了否定效果。而且,我们发现 BAK1 和 ABI1 相对地调整 OST1 phosphorylation invitro,和那 ABI1 与 BAK1 交往并且禁止 BAK1 和 OST1 的相互作用。一起拿,我们的结果建议 BAK1 在警卫房间调整导致骆驼毛的织物的有气孔的闭合。 | Yun Shang Changbo Dai Myeong Min Lee June M. Kwak Kyoung Hee Nam | 2016 | Molecular Plant2016，9，3： | 13 |
| 5 | Effect of Combined Heavy Metal Pollution on Nitrogen Mineralization Potential,Urease and Phosphatase Activities in a Typic Udic Ferrisol显示文摘INTRODUCTIONAnthropogenicactivitiessuchasmining,smelting,electroplating,ore-refiningandlanddisposalofwasteshaveledtoanincreajseofheavymetalcolltelltsinthesoil(Chen,1996).Heavymetalaccumulationinthesoilimpactsanumberofsoilpropertiesthatmightbethepoten... | ZHENG CHUNRONG TU CONG and CHEN HUAIMAN(Laboratory of Material Cycling in Pedosphere, Institute of Soil Science, the Chinese Academy of Sciences,Nanjing 210008 (China))(Received April 20, 1999 revised June 2, 1999) | 1999 | Pedosphere1999，9，3： | 13 |
| 6 | A survey on applications of semi-tensor product method in engineering显示文摘Semi-tensor product(STP) of matrices has attracted more and more attention from both control theory and engineering in the last two decades. This paper presents a comprehensive survey on the applications of STP method in engineering. Firstly, some preliminary results on STP method are recalled.Secondly, some applications of STP method in engineering, including gene regulation, power system, wireless communication, smart grid, information security, combustion engine and vehicle control, are reviewed.Finally, some potential applications of STP method are predicted. | Haitao LI Guodong ZHAO Min MENG June FENG | 2018 | Science China(Information Sciences)2018，61，1： | 12 |
| 7 | ON THE TENSILE MECHANICAL PROPERTY OF Si-Mn TRIP STEELS AT HIGH STRAIN RATE显示文摘Tensile mechanical properties of 1.6Si-1.58Mn-0.195C TRIP (transformation-induced plasticity) steels under high strain rate and effects of DP (dual-phase) treatments were studied and compared to the quasi-static tensile behavior. The results show that the increasing of strain rate leads to increasing in their strengths and decreasing in the uniform elongation remarkably. Because the stable retained austenite in TRIP steel can transform to martensite during tensile testing and the material exhibits excellent characteristic of transformation induced plasticity, the plastic deformation behavior is evidently improved and the combination of strength and elongation is superior to that of dual-phase steel, although its strength is smaller than that of DP steel. However, DP treated steel shown lower elongation under dynamic tension in spite of higher strength. A model was proposed to explain the excellent elongation rate of TRIP steel compared with DP steel on the basis of SEM analysis and the strength of the components in microstructure. | X.C. Wei, L. Li, R.Y. Fu and W. ShiSchool of Materials Science and Engineering, Shanghai University, Shanghai 200072, China Manuscript received 18 June 2001 in revised form 7 November 2001 | 2002 | Acta Metallurgica Sinica(English Letters)2002，15，3： | 8 |
| 8 | Effect of Cr(Ⅵ) and p-Chloroaniline Interaction on Their Reaction Behaviors on Soil Colloids显示文摘INTRODUCTIONStudiesonheavymetalororganicpollutantsinsoilhaverecedelymadegreatprogressboththeoreticallyandpractically.However,pollutionisusuallydevelopedbynotasinglebutamulti-substratecomplex.Furtherunderstandingthemechanismsandprocedureofmulti-substr... | ZHOU DONGMEI and CHEN HUAIMAN(Laboratory of Material Cycling in Pedosphere, Institute of Soil Science, the Chinese Academy of Sciences,Nanjing 21O008 (China))(Received April 14, 1999 revised June 8, 1999) | 1999 | Pedosphere1999，9，3： | 8 |
| 9 | Durability of viral response after off-treatment in HBeAg positive chronic hepatitis B显示文摘AIM:To evaluate the durability in hepatitis B e antigen (HBeAg) positive chronic hepatitis B patients who discontinued antiviral treatment. METHODS:A total of 48 HBeAg positive chronic hepatitis B patients who were administered nucleoside analogues and maintained virological response for ≥ 6 mo [hepatitis B virus (HBV) DNA < 300 copies/mL and HBeAg seroconversion] before cessation of treatment were enrolled between February 2007 and January 2010. The criteria for the cessation of the antiviral treatment were defined as follows:(1) achievement of virological response; and (2) duration of consolidation therapy (≥ 6 mo). After treatment cessation, the patients were followed up at 3-6 mo intervals. The primary endpoint was serologic and virologic recurrence rates after withdrawal of antiviral treatment. Serologic recurrence was defined as reappearance of HBeAg positivity after HBeAg seroconversion. Virologic recurrence was defined as an increase in HBV-DNA level > 104 copies/mL after HBeAg seroconversion with previously undetectable HBV-DNA level. RESULTS:During the median follow-up period of 18.2 mo (range:5.1-47.5 mo) after cessation of antiviral treatment, the cumulative serological recurrence rate was 15 % at 12 mo. The median duration between the cessation of antiviral treatment and serologic recurrence was 7.2 mo (range:1.2-10.9 mo). Of the 48 patients with HBeAg positive chronic hepatitis, 20 (41.6%) showed virological recurrence. The cumulative virologic recurrence rates at 12 mo after discontinuing the antiviral agent were 41%. The median duration between off-treatment and virologic recurrence was 7.6 mo (range:4.3-27.1 mo). The mean age of the virological recurrence group was older than that of the non-recurrence group (46.7 ± 12.1 years vs 38.8 ± 12.7 years, respectively; P = 0.022). Age (> 40 years) and the duration of consolidation treatment (≥ 15 mo) were significant predictive factors for offtreatment durability in the multivariate analysis [P = 0.049, relative risk (RR) 0.31, 95% CI (0.096-0.998) and P = 0.005, RR 11.29, 95% CI (2.054-65.12), respectively]. Patients with age (≤ 40 years) who received consolidation treatment (≥ 15 mo) significantly showed durability in HBeAg positive chronic hepatitis B patients (P = 0.014). These results suggest that additional treatment for more than 15 mo after HBeAg seroconversion in patients who are ≤ 40 years old may be beneficial in providing a sustained virological response. CONCLUSION:Our data suggest that HBeAg seroconversion is an imperfect end point in antiviral treatment. Long-term consolidation treatment (≥ 15 mo) in younger patients is important for producing better prognosis in HBeAg positive chronic hepatitis B. | Myeong Jun Song Do Seon Song Hee Yeon Kim Sun Hong Yoo Si Hyun Bae Jong Young Choi Seung Kew Yoon Yong-Han Paik June Sung Lee Hyun Woong Lee Hyung Joon Kim | 2012 | World Journal of Gastroenterology2012，18，43： | 7 |
| 10 | Dissecting the dendritic cell controversy in chronic hepatitis B virus infection显示文摘增加内长的 T 房间免疫的治疗学的疫苗依靠树枝状的房间(DC ) 的 stimulatory 能力。在长期的肝炎 B 的 DC 的功能病毒(HBV ) 感染是长期的争论。因此,我们试图总结在长期的 HBV 病人调查 DC 功能决定普通观察是否能被拉的多重研究。我们发现测试 vivo 的 myeloid 和 plasmacytoid DC 大部分是的前的频率和功能在有 HBV 感染的病人未经触动、类似于那些健康施主 DC。主要例外是减少的 IFN-α由从长期的 HBV 病人的 plasmacytoid DC 的生产。这减少的 IFN-α生产在多重研究然而并非与病毒的负担与肝发炎相关,建议病毒的抗原有 DC 功能上的小效果。关于 DC 功能的混乱的多数从报导在 vitro 暴露于 HBV 的各种各样的来源的健康施主 DC 的减少的功能的研究产生。病毒的抗原的这些直接效果与从感染 HBV 的病人的数据相对照。在试金的变化使用了。 | Adam J. Gehring June Ann D'Angelo | 2015 | Cellular & Molecular Immunology2015，12，3： | 7 |
| 11 | Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression显示文摘Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain damages.To investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments,adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial irradiation.Cognitive impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after irradiation.We also detected the expression levels of neurogenic cell markers(doublecortin)and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor.Radiation-exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression.Sodium butyrate pretreatment reversed these changes.These findings suggest that sodium butyrate can improve radiation-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression.The study procedures were approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological Medical Sciences(approval No.KIRAMS16-0002)on December 30,2016. | Hae June Lee Yeonghoon Son Minyoung Lee Changjong Moon Sung Ho Kim In Sik Shin Miyoung Yang Sangwoo Bae Joong Sun Kim | 2019 | Neural Regeneration Research2019，14，9： | 7 |
| 12 | Astudyofanewretrievalalgorithmformeasurementofoceanicwindvectorsfieldusingsatellitemicrowavescatterometer显示文摘AstudyofanewretrievalalgorithmformeasurementofoceanicwindvectorsfieldusingsatellitemicrowavescatterometerLinMingsen,SunYing,Z... | Lin Mingsen Sun Ying Zheng Shuqing(Received February 10, 1997 accepted June 9, 1997) | 1998 | Acta Oceanologica Sinica1998，17，3： | 6 |
| 13 | Reprogramming fibroblasts into induced pluripotent stem cells with Bmil显示文摘 | Jai-Hee Moon June Seok Heo Jun Sung Kim Eun Kyoung Jun Jung Han Lee Aeree Kim Jonggun Kim Kwang Youn Whang Yong-Kook Kang Seungeun Yeo Hee-Joung Lim Dong Wook Han Dong-Wook Kim Sejong Oh Byung Sun Yoon Hans R Scholet Seungkwon You | 2011 | Cell Research2011，21，9： | 6 |
| 14 | CarbonisotopiccompositionandfluxofparticulateorganicmatterintheChangjingRiver显示文摘CarbonisotopiccompositionandfluxofparticulateorganicmatterintheChangjingRiverCaiDeling,HanYibing(ReceivedJune5,1996;acceptedJ... | Cai Deling Han Yibing(Received June 5, 1996 acceptedJuly 13, 1997) | 1998 | Acta Oceanologica Sinica1998，17，3： | 5 |
| 15 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 16 | Endoscopic and oncologic outcomes after endoscopic resection for early gastric cancer: 1370 cases of absolute and extended indications显示文摘 | Ji Yong Ahn Hwoon-Yong Jung Kee Don Choi Ji Young Choi Mi-Young Kim Jeong Hoon Lee Kwi-Sook Choi Do Hoon Kim Ho June Song Gin Hyug Lee Jin-Ho Kim Young Soo Park | 2011 | Gastrointestinal Endoscopy2011，，3： | 5 |
| 17 | Development and use of biomaterials as wound healing therapies显示文摘There is a vast number of treatments on the market for the management of wounds and burns,representing a multi-billion dollar industry worldwide.These include conventional wound dressings,dressings that incorporate growth factors to stimulate and facilitate the wound healing process,and skin substitutes that incorporate patientderived cells.This article will review the more established,and the recent advances in the use of biomaterials for wound healing therapies,and their future direction. | Rachael Zoe Murray Zoe Elizabeth West Allison June Cowin Brooke Louise Farrugia | 2019 | Burns & Trauma2019，7，1： | 5 |
| 18 | Hybrid multi-chip assembly of optical communication engines by in situ 3D nanolithography显示文摘Three-dimensional(3D)nano-printing of freeform optical waveguides,also referred to as photonic wire bonding,allows for efficient coupling between photonic chips and can greatly simplify optical system assembly.As a key advantage,the shape and the trajectory of photonic wire bonds can be adapted to the mode-field profiles and the positions of the chips,thereby offering an attractive alternative to conventional optical assembly techniques that rely on technically complex and costly high-precision alignment.However,while the fundamental advantages of the photonic wire bonding concept have been shown in proof-of-concept experiments,it has so far been unclear whether the technique can also be leveraged for practically relevant use cases with stringent reproducibility and reliability requirements.In this paper,we demonstrate optical communication engines that rely on photonic wire bonding for connecting arrays of silicon photonic modulators to InP lasers and single-mode fibres.In a first experiment,we show an eight-channel transmitter offering an aggregate line rate of 448 Gbit/s by low-complexity intensity modulation.A second experiment is dedicated to a four-channel coherent transmitter,operating at a net data rate of 732.7 Gbit/s-a record for coherent silicon photonic transmitters with co-packaged lasers.Using dedicated test chips,we further demonstrate automated mass production of photonic wire bonds with insertion losses of(0.7±0.15)dB,and we show their resilience in environmental-stability tests and at high optical power.These results might form the basis for simplified assembly of advanced photonic multi-chip systems that combine the distinct advantages of different integration platforms. | Matthias Blaicher Muhammad Rodlin Billah Juned Kemal Tobias Hoose Pablo Marin-Palomo Andreas Hofmann Yasar Kutuvantavida Clemens Kieninger Philipp-Immanuel Dietrich Matthias Lauermann Stefan Wolf Ute Troppenz Martin Moehrle Florian Merget Sebastian Skacel Jeremy Witzens Sebastian Randel Wolfgang Freude Christian Koos | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 19 | Histone methyltransferase NSD2 mediates the survival and invasion of triple-negative breast cancer cells via stimulating ADAM9-EGFR-AKT signaling显示文摘Triple-negative breast cancer (TNBC) is a heterogeneous disease with a poor prognosis due to the lack of an effective targeted therapy. Histone lysine methyltransferases (KMTs) have emerged as attractive drug targets for cancer therapy. However, the function of the majority of KMTs in TNBC has remained largely unknown. In the current study, we found that KMT nuclear receptor binding SET domain protein 2 (NSD2) is overexpressed in TNBC tumors and that its overexpression is associated with poor survival of TNBC patients. NSD2 regulates TNBC cell survival and invasion and is required for tumorigenesis and tumor growth. Mechanistically, NSD2 directly controls the expression of EGFR and ADAM9, a member of the ADAM (a disintegrin and metalloproteinase) family that mediates the release of growth factors, such as HB-EGF. Through its methylase activity, NSD2 overexpression stimulates EGFR-AKT signaling and promotes TNBC cell resistance to the EGFR inhibitor ge?tinib. Together, our results identify NSD2 as a major epigenetic regulator in TNBC and provide a rationale for targeting NSD2 alone or in combination with EGFR inhibitors as a targeted therapy for TNBC. | Jun-Jian Wang June X. Zou Hong Wang Zhi-Jian Duan Hai-Bin Wang Peng Chen Pei-Qing Liu Jian-Zhen Xu Hong-Wu Chen | 2019 | Acta Pharmacologica Sinica2019，40，8： | 4 |
| 20 | A simulation-based method to investigate occupant-centric controls显示文摘Occupant-centric control (OCC) strategies rely on different algorithms to learn and predict occupants’ patterns and preferences, then utilize these predictions to optimize building operations. However, testing different OCC algorithms or fine-tuning their configurations in real buildings can be a lengthy process. To this end, we present a framework for testing OCCs in a simulation environment prior to field implementation. The proposed workflow entails using synthetic occupant behaviour models and simulating OCC strategies to learn their preferences. The goal is to enable quick comparison of different OCC configurations under various scenarios by modifying occupant behaviour assumptions, as well as climate and design parameters. For proof-of-concept, the proposed method was applied in a case-study to simulate OCCs for lighting and heating/cooling setpoint adjustments in a single office under various occupant types, as well as OCC settings and design configurations. Results demonstrated the benefits of the proposed framework and its potential for providing a more holistic evaluation of OCCs under different scenarios. Using the proposed framework, building designers and operators can identify potential issues with OCCs and fine-tune their settings prior to field implementation. | Mohamed M.Ouf June Young Park H.Burak Gunay | 2021 | Building Simulation2021，14，4： | 4 |
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