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| 1 | Singular Boolean networks:Semi-tensor product approach显示文摘Singular Boolean networks are introduced in this paper.Via semi-tensor product of matrices and the matrix expression of logical functions,two kinds of the condensed algebraic expressions of singular Boolean networks are obtained.The normalization problem of singular Boolean networks is addressed;that is,under what condition singular Boolean networks can be converted into normal Boolean networks with algebraic restrictions.Then one sufcient condition and one necessary and sufcient condition are derived for the normalization problem.Furthermore,the solvability of singular Boolean networks is discussed and the concept of admissible initial values of singular Boolean networks is presented.Finally,fxed points and cycles of singular Boolean networks are also investigated. | FENG JunE YAO Juan CUI Peng | 2013 | Science China(Information Sciences)2013，56，11： | 15 |
| 2 | A survey on applications of semi-tensor product method in engineering显示文摘Semi-tensor product(STP) of matrices has attracted more and more attention from both control theory and engineering in the last two decades. This paper presents a comprehensive survey on the applications of STP method in engineering. Firstly, some preliminary results on STP method are recalled.Secondly, some applications of STP method in engineering, including gene regulation, power system, wireless communication, smart grid, information security, combustion engine and vehicle control, are reviewed.Finally, some potential applications of STP method are predicted. | Haitao LI Guodong ZHAO Min MENG June FENG | 2018 | Science China(Information Sciences)2018，61，1： | 12 |
| 3 | Ferric oxide nanosheet-engineered Mg alloy for synergetic osteosarcoma photothermal/chemodynamic therapy显示文摘Osteosarcoma(OS)is a malignant tumor with a high rate of recurrence.Recently,biodegradable Mg-based implants have become a new therapeutic platform for bone-related diseases.However,poor biosafety and deficient intelligent tumor-killing ability of Mg-based implants are still the main challenges for the pre-cise treatment of OS.Herein,based on the excellent catalytic and photothermal conversion properties of nanozyme ferric oxide(Fe_(3)O_(4)),a novel two-step hydrothermal method for in situ preparation of Fe_(3)O_(4)nanosheets on the surface of plasma electrolytic oxidation(PEO)-treated Mg alloy using Mg-Fe layered double hydroxides(Mg-Fe LDH)as precursor was proposed.Compared with Mg alloy,there were no obvious corrosion cracks on the surface of Fe_(3)O_(4)nanosheets-coated Mg alloy(Fe_(3)O_(4)-NS)immersed in 0.9 wt.%NaCl for 14 days,which demonstrated the corrosion resistance of Mg alloy was significantly enhanced.Cytocompatibility experiments and hemolysis assay confirmed the great biocompatibility of Fe_(3)O_(4)-NS,especially,hemolysis ratio was lower than 1%.Meanwhile,Fe_(3)O_(4)-NS presented excellent cat-alytic oxidation capacity in the presence of H_(2)O_(2),and its temperature can significantly increase from 27℃to approximately 56℃under NIR irradiation.Therefore,intelligent responsive Fe_(3)O_(4)nanosheets-engineered Mg-based implants demonstrated excellent antitumor properties in vivo and in vitro due to their photothermal and chemodynamic synergetic effects.This study provides a novel approach for the preparation of Fe_(3)O_(4)coatings on the surface of Mg alloys and a new strategy for the treatment of OS. | Huihui Du Dongdong Zhang Ru Xu Juning Xie Shiwei Guan Shuhan Chen Feng Peng Shi Qian Xuanyong Liu | 2023 | Journal of Materials Science & Technology2023，，7： | 2 |
| 4 | Mg(OH)_(2)nanosheets on Ti with immunomodulatory function for orthopedic applications显示文摘Macrophages play a vital role for guiding the fate of osteogenesisrelated cells.It is well known that nano-topography and bioactive ions can directly enhance osteogenic behavior.However,the effects of nano-structure combined with bioactive ions release on macrophage polarization and the following osteogenesis and angiogenesis are rarely reported.Herein,Mg(OH)_(2)films with nano-sheet structures were constructed on the surface of Ti using hydrothermal treatment.The film presented nanosheet topography and sustained release of Mg ions.The results of in vitro culture of bone marrow-derived macrophages(BMDMs),including PCR,western blot and flow cytometry suggested that the nano-Mg(OH)_(2)films were more favorable for macrophages polarizing to tissue healing M2 phenotype.Moreover,air-pouch model confirmed that the nano-Mg(OH)_(2)film coated Ti would induce milder inflammation and thinner fibrous layer in vivo,compared with untreated Ti.Furthermore,macrophages-conditioned culture mediums were collected from nano-Mg(OH)_(2)coated Ti group was superior for the osteogenic behaviors of mice bone marrow stem cells and the angiogenic behaviors of human umbilical vein endothelial cells.With harmonious early inflammatory response and subsequently improved osteogenesis and angiogenesis,the nano-Mg(OH)_(2)coated Ti is promising for orthopedic applications. | Yue He Mengyu Yao Jielong Zhou Juning Xie Changxiang Liang Dong Yin Shuaihao Huang Yu Zhang Feng Peng Shi Cheng | 2022 | Regenerative Biomaterials2022，9，1： | 1 |
| 5 | Effect of excess Y_2O_3 addition on the physical properties of melt processed YBCO bulks显示文摘The YBCO superconductors with Y2O3 addition were prepared by a modified melt textured process and the effects of excess Y2O3 addition on the physical properties of melt textured YBCO have been investigated. It is found that the melt temperature of YBCO samples decreases drastically with the increasing Y2O3, and the maximum levitation forces are drastically different for samples with different Y2O3 addition. It is also found that the optimal Y2O3 addition to YBCO is about 10wt%. Considering the microstructure and the starting composition, the results are well discussed and interpreted. | YANG Wanmin1,2,3, ZHOU Lian2, FENG Yong2, ZHANG Pingxiang2, WU Minzhi3 & W. GAWALEK3 1. Department of Physics, Shaanxi Normal University, Xi抋n 710062, China 2. Northwest Institute for Nonferrous Metal Research. Xi抋n 710016, China 3. Institute fur Physikalische Hochtechnologie e.V(IPHT), Jena, Germany Correspondence should be addressed to Yang Wanmin (email: wm-yang@sohu.com) Received June 27, 2003 | 2004 | Science China(Physics,Mechanics & Astronomy)2004，47，1： | 0 |
| 6 | Shifting focus from bacteria to host neutrophil extracellular traps of biodegradable pure Zn to combat implant centered infection显示文摘The widespread use of orthopedic implants to support or replace bones is increasingly threatened by the risk of incurable bacterial infections,impenetrable microbial biofilms,and irreversible antibiotic resistance.In the past,the development of anti-infective biomaterials focused solely on direct antibacterial properties while ignoring the host’s immune response.Inspired by the clearance of infection by the innate neutrophil response and partici-pation in anti-infectious immunity of Zn ions,we report an innovative neutrophil extracellular traps(NETs)strategy,induced by biodegradable pure Zn,which achieved therapeutic efficacy toward biomaterial-related infections.Our in vitro and in vivo data showed that pure Zn was favorable for NETs formation by promoting the release of DNA fibers and granule proteins in a reactive oxygen species(ROS)-dependent manner,thereby retraining and degrading bacteria with an efficiency of up to 99.5%.Transcriptome analysis revealed that cytoskeletal rearrangement and toll-like receptor(TLR)signaling pathway were also involved in Zn-induced NETs formation.Furthermore,the in vivo results of a Staphylococcus aureus(S.aureus)-infected rat model veri-fied that pure Zn potentiated the bactericidal capability of neutrophils around implants,and promoted osseointegration in S.aureus-infected rat femurs.This antibacterial immunity concept lays a foundation for the development of other antibacterial biomaterials and holds great promise for treating orthopedic infections. | Feng Peng Juning Xie Haiming Liu Yufeng Zheng Xin Qian Ruixiang Zhou Hua Zhong Yu Zhang Mei Li | 2023 | Bioactive Materials2023，，3： | 0 |
| 7 | Black Mn-containing layered double hydroxide coated magnesium alloy for osteosarcoma therapy, bacteria killing, and bone regeneration显示文摘Osteosarcoma (OS) tissue resection with distinctive bactericidal activity, followed by regeneration of bone de-fects, is a highly demanded clinical treatment. Biodegradable Mg-based implants with desirable osteopromotive and superior mechanical properties to polymers and ceramics are promising new platforms for treating bone-related diseases. Integration of biodegradation control, osteosarcoma destruction, anti-bacteria, and bone defect regeneration abilities on Mg-based implants by applying biosafe and facile strategy is a promising and challenging topic. Here, a black Mn-containing layered double hydroxide (LDH) nanosheet-modified Mg-based implants was developed. Benefiting from the distinctive capabilities of the constructed black LDH film, including near-infrared optical absorption and reactive oxygen species (ROS) generation in a tumor-specific microenvi-ronment, the tumor cells and tissue could be effectively eliminated. Concomitant bacteria could be killed by localized hyperthermia. Furthermore, the enhanced corrosion resistance and synergistic biofunctions of Mn and Mg ions of the constructed black LDH-modified Mg implants significantly facilitated cell adhesion, spreading and proliferation and osteogenic differentiation in vitro, and accelerated bone regeneration in vivo. This work offers a new platform and feasible strategy for OS therapeutics and bone defect regeneration, which broadens the biomedical application of Mg-based alloys. | Dongdong Zhang Shi Cheng Ji Tan Juning Xie Yu Zhang Shuhan Chen Huihui Du Shi Qian Yuqing Qiao Feng Peng Xuanyong Liu | 2022 | Bioactive Materials2022，7，11： | 0 |
| 8 | Syntheses of Substituted Indan-1-onesand Indenes显示文摘The syntheses of three novel substituted indanones namely 2,7 dimethylindan 1 one, 2 methyl 4,7 diethylindan 1 one and 2,4 dimethyl 7 methoxyindan 1 one are described. These indanones were prepared by different routes involving intramolecular ring closure of aryl substituted compounds by Friedel Crafts reaction. The t butyl was used as the positional protective group in the selective preparation of 2,7 dimethylindan 1 one. The corresponding indenes were prepared by reduction and dehydration reactions from these indanones. | YASIN Tariq *, FAN Zhi qiang ** and FENG Lin xian (Department of Polymer Science and Engineering,Zhejiang University, Hangzhou 310027, P. R. China) (Received June 14, 1998) | 1999 | Chemical Research in Chinese Universities1999，15，3： | 0 |
| 9 | Microfluidic Immunoprecipitation for Post-Translational Modified Protein Purification显示文摘In this paper, we report an antibody functionalized microimmunopreci- pitation(μIP) method used for enrich lowabundant post-translational modified(PTM) proteins. The device is fabricated by inert, nontoxic and disposable polydimethylsiloxane(PDMS) using a silane-based chemical modification protocol, which yield antibody-terminated PDMS surfaces. In this study, the μIP device is specifically designed for the purification of carbonylated protein, a representative example here to illustrate the potential applications for any other PTMs, which could be immuno-tagged by specific antibodies. The test model in vitro oxidized bovine serum albumin(BSA) was first derivitized by dinitrophenylhydrazide(DNPH) and then captured by the anti-DNP immobilized on this μIP device. The surface functional group mapping was systematically analyzed and validated by fluorescence microscopy. Quantitative study of DNP-derivatized carbonylated protein capture recovery and elution efficiency of the device was also studied. We also envision that this proteome enrichment μIP device can be assembled with other lab-on-a-chip components, such as microelectrophoresis or micro-chromatographic devices for follow-up protein analysis. This selective enrichment of modified proteins greatly facilitates the study of low abundant protein biomarkers discovery. | XIA Hu Bobby Mathew Tom John Hisham Hegab June Feng | 2012 | Chinese Journal of Biomedical Engineering(English Edition)2012，21，2： | 0 |
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