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| 1 | Protective action of glutamine in rats with severe acute liver failure显示文摘BACKGROUND Severe acute liver failure(SALF) is a rare, but high-mortality, rapidly evolving syndrome that leads to hepatocyte degeneration with impaired liver function.Thioacetamide(TAA) is a known xenobiotic, which promotes the increase of the formation of reactive oxygen species. Erythroid 2-related factor 2(Nrf2) activates the antioxidant protection of cells. Studies have evidenced the involvement of inflammatory mediators in conditions of oxidative stress.AIM To evaluate the antioxidant effects of glutamine on Nrf2 activation and NFκBmediated inflammation in rats with TAA-induced IHAG.METHODS Male Wistar rats(n = 28) were divided into four groups: control,control+glutamine, TAA, and TAA + glutamine. Two TAA doses(400 mg/kg)were administered intraperitoneally, 8 h apart. Glutamine(25 mg/kg) was administered at 30 min, 24 h, and 36 h. At 48 h, blood was collected for liver integrity analysis [aspartate aminotransferase(AST), alanine aminotransferase(ALT), and alkaline phosphatase(ALP)]. The liver was harvested for histology and assessment of oxidative stress [thiobarbituric acid-reactive substances(TBARS), catalase(CAT), glutathione peroxidase(GPx), glutathione S-transferase(GST), glutathione(GSH), Nrf2, Kelch-like ECH-associated protein 1(Keap1),NADPH quinone oxidoreductase1(NQO1), superoxide dismutase(SOD)] and inflammatory process.RESULTS TAA caused disruption of the hepatic parenchyma, with inflammatoryinfiltration, massive necrosis, and ballooning degeneration. Glutamine mitigated this tissue damage, with visible regeneration of hepatic parenchyma; decreased TBARS(P < 0.001), GSH(P < 0.01), IL-1β, IL6, and TNFα levels(P <0.01) in hepatic tissue; and decreased blood levels of AST, ALT, and ALP(P <0.05). In addition, CAT, GPx, and GST activities were restored in the glutamine group(P<0.01, P <0.01, and P <0.001, respectively vs TAA alone). Glutamine increased expression of Nrf2(P < 0.05), NQO1, and SOD(P < 0.01), as well as levels of IL-10(P <0.001), while decreasing expression of Keap1, TLR4, NFκB(P < 0.001), COX-2 and iNOS,(P < 0.01), and reducing NO_2 and NO_3 levels(P < 0.05).CONCLUSION In the TAA experimental model of IHAG, glutamine activated the Nrf2 pathway,thus promoting antioxidant protection, and blunted the NFκB-mediated pathway, reducing inflammation. | Elizangela G Schemitt Renata M Hartmann Josieli R Colares Francielli Licks Jéferson O Salvi Cláudio A Marroni Norma P Marroni | 2019 | World Journal of Hepatology2019，11，3： | 5 |
| 2 | Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions显示文摘 | Renate Hammerstingl Alexander Huppertz Josy Breuer Thomas Balzer Anthony Blakeborough Rick Carter Lluis Castells Fusté Gertraud Heinz-Peer Werner Judmaier Michael Laniado Riccardo M. Manfredi Didier G. Mathieu Dieter Müller Koenraad Mortelè Peter Reimer M | 2008 | European Radiology2008，，： | 2 |
| 3 | A wireless controller to enhance dynamic performance of parallel invertel in distributed generation systems 显示文摘 | JOSEP M GUERRERO LUIS GARCA DE VICU 1 A JOSI MATAS | 2004 | IEEE Transactions on Power Electronics2004，19，5： | 1 |
| 4 | Visual Space Perception and Visually Directed Action显示文摘 | Jack M Loomis Naofumi Fujita Josi A Da Silva Sergio S Fukusima | 1992 | Journal of Experimental Psychology:Human Perception and Performance (S0096-1523)1992，18，4： | 1 |
| 5 | Oxidative stress biomarkers in Senegal sole,Solea senegalensis, to assess the impact of heavy metal pollution in a Huelva estuary (SW Spain) :seasonal and spatial variation 显示文摘 | OLIVA M JOSI V J GRAVATO C | 2012 | Ecotoxicology and Environmental Safety2012，75，： | 1 |
| 6 | Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions显示文摘 | Renate Hammerstingl Alexander Huppertz Josy Breuer Thomas Balzer Anthony Blakeborough Rick Carter Lluis Castells Fusté Gertraud Heinz-Peer Werner Judmaier Michael Laniado Riccardo M. Manfredi Didier G. Mathieu Dieter Müller Koenraad Mortelè Peter Reimer M | 2008 | European Radiology2008，，3： | 1 |
| 7 | Synthesis of bioeompatible, mesoporous Fe304 nano/microspheres with large sur- face area for magnetic resonance imaging and therapeutic applications 显示文摘 | XUAN Shouhu WANG Feug LAI Josie M Y | 2011 | ACS Appl Mater Interface2011，3，2： | 1 |
| 8 | Vertex component a- nalysis: a fast algorithm to unmix hyperspectral data 显示文摘 | JOSI M P JOSE M N BIOUCAS D | 2005 | IEEE Transactions on Geoscience and Remote Sensing2005，43，： | 1 |
| 9 | Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy: comparison with intraoperative and histopathologic findings in focal liver lesions显示文摘 | Renate Hammerstingl Alexander Huppertz Josy Breuer Thomas Balzer Anthony Blakeborough Rick Carter Lluis Castells Fusté Gertraud Heinz-Peer Werner Judmaier Michael Laniado Riccardo M. Manfredi Didier G. Mathieu Dieter Müller Koenraad Mortelè Peter Reimer M | 2008 | European Radiology2008，，3： | 1 |
| 10 | Review on thermal en- ergy storage with phase change: materials, heat transfer analysis and applications显示文摘 | BELIN ZALBA JOSI M M LUISA F C | 2003 | Applied Thermal Engineering2003，23，： | 1 |
| 11 | Pharmacokinetic behaviour of R-(+) - and S- (-) -amlodipine after single enantiomer administration 显示文摘 | Luka J Josi DJ Kremser M | 1997 | Journal of Chromatography B: Biomedical Sciences and Applications1997，703，12： | 1 |
| 12 | New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes显示文摘 | Libby Gillian Donnelly Louise A Donnan Peter T Alessi Dario R Morris Andrew D Evans Josie M M | 2009 | Diabetes Care2009，，： | 1 |
| 13 | Development of a source emission model for atmospheric pollutants in the Barcelona Area显示文摘 | Montserrat Costa Josi M Baldasand | 1995 | Atmospheric Environment1995，30，2： | 1 |
| 14 | Role of the support on the activity of silica-supported TiO2 photocatalysts: Structure of the TiO2/SBA-15 photocatalysts显示文摘 | MAP JA-JOSI~ L M RAFAEL V G JOSI~ A | 2005 | Catalysis Today2005，101，： | 1 |
| 15 | High- solids-content batch miniemulsion polymerization 显示文摘 | LOURDES LOPEZ DE ARBINA JOSI M ASUA | 1992 | Poly- mer1992，33，22： | 1 |
| 16 | Synthesis of large,high-solid-content latexes by miniemulsion polymer- ization 显示文摘 | MARCELO DO AMARAL JOSI M ASUA | 2004 | Journal of Polymer Science: PartA : Polymer Chemistry2004，42，17： | 1 |
| 17 | Galvanic coupling between metal substrate and polyaniliue act wlic blends : corrosion protection mechanism 显示文摘 | TORRES1 R M ROBERTO M TORRESI SOLANGE DE SOUZA JOSIE PEREIRA DA SILVA | 2005 | Electrochimica Acta2005，50，11： | 1 |
| 18 | Biochemical changes and quality loss during chilled storage of farmed turbot (Psetta maxima)显示文摘 | SANTIAGO P A CARMEN P JOSI~ M G | 2005 | Food Chemistry2005，90，3： | 1 |
| 19 | Melatonin prevents oxidative stress,inflammatory activity,and DNA damage in cirrhotic rats显示文摘BACKGROUND Cirrhosis is an important health problem characterized by a significant change in liver parenchyma.In animals,this can be reproduced by an experimental model of bile duct ligation(BDL).Melatonin(MLT)is a physiological hormone synthesized from serotonin that has been studied for its beneficial properties,including its antioxidant potential.AIM To evaluate MLT’s effects on oxidative stress,the inflammatory process,and DNA damage in an experimental model of secondary biliary cirrhosis.METHODS Male Wistar rats were divided into 4 groups:Control(CO),CO+MLT,BDL,and BDL+MLT.MLT was administered(20 mg/kg)daily beginning on day 15 after biliary obstruction.On day 29 the animals were killed.Blood samples,liver tissue,and bone marrow were collected for further analysis.RESULTS BDL caused changes in biochemical and histological parameters and markers of inflammatory process.Thiobarbituric acid(0.46±0.01)reactive substance levels,superoxide dismutase activity(2.30±0.07)and nitric oxide levels(2.48±0.36)were significantly lower(P<0.001)n the groups that received MLT.DNA damage was also lower(P<0.001)in MLT-treated groups(171.6±32.9)than the BDL-only group(295.5±34.8).Tissue damage and the expression of nuclear factor kappa B,interleukin-1β,Nrf2,NQO1 and Hsp70 were significantly lower in animals treated with MLT(P<0.001).CONCLUSION When administered to rats with BDL-induced secondary biliary cirrhosis,MLT effectively restored the evaluated parameters. | Josieli R Colares Renata M Hartmann Elizângela G Schemitt Sandielly R B Fonseca Marilda S Brasil Jaqueline N Picada Alexandre S Dias Aline F Bueno Cláudio A Marroni Norma P Marroni | 2022 | World Journal of Gastroenterology2022，28，3： | 1 |
| 20 | Probiotics in aquaculture: The need, principles and mechanisms of action and screening processes 显示文摘 | Kesarcodi-Watson A Kaspar H Josie Lategan M | 2008 | Aquaculture2008，274，1： | 1 |
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