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| 1 | Hyperferritinemia is a risk factor for steatosis in chronic liver disease显示文摘AIM: To investigate the relationship between ferritin and steatosis in patients with chronically abnormal liver function tests (LFTs) and high ferritin level. METHODS: One hundred and twenty-four consecutive patients with hyperferritinemia (male > 300 ng/mL, female > 200 ng/mL) were evaluated; clinical, biochemical and serological data, iron status parameters, HFE gene mutations and homeostasis model assessment score were obtained. Steatosis was graded by ultrasound as absent or present. Histology was available in 53 patients only. RESULTS: Mean level of ferritin was 881 ± 77 ng/mL in men and 549 ± 82 ng/mL in women. The diagnosis was chronic hepatitis C in 53 (42.7%), non-alcoholic fatty liver disease/non-alcoholic steatohepatitis in 57 (45.9%), and cryptogenic liver damage in 14 (11.3%). None was diagnosed as hereditary hemochromatosis (HH). Hepatic siderosis on liver biopsy was present in 17 of 54 (32%) patients; grade 1 in eight and grade 2 in nine. Overall, 92 patients (74.2%) had steatosis. By logistic regression, ferritin and γ-glutamyltransferase were independent predictors of steatosis. Ferritin levels were signifi cantly related to low platelet count, steatosis and hepatitis C virus infection. CONCLUSION: In a non-obese cohort of non-alcoholic patients with chronically abnormal LFTs without HH, high serum ferritin level is a risk factor for steatosis. | Anna Licata Maria Elena Nebbia Giuseppe Cabibbo Giovanna Lo Iacono Francesco Barbaria Virna Brucato Nicola Alessi Salvatore Porrovecchio Vito Di Marco Antonio Craxì Calogero Cammà | 2009 | World Journal of Gastroenterology2009，15，17： | 6 |
| 2 | Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells显示文摘 | Farhat V.N. Din Asta Valanciute Vanessa P. Houde Daria Zibrova Kevin A. Green Kei Sakamoto Dario R. Alessi Malcolm G. Dunlop | 2012 | Gastroenterology2012，，7： | 3 |
| 3 | Endothelial Cell markers and the risk of coronary heart disease:the prospective Epidemiological study of myocardial infarction(PRIME)study显示文摘 | SIMON C ALESSI MC | 2004 | Circulation2004，109，： | 1 |
| 4 | The role of actigraphy in the study of sleep and circadian rhythms显示文摘 | Cole R Alessi C | 2003 | Sleep2003，26，3： | 1 |
| 5 | PD98059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo 显示文摘 | Alessi DR Cuenda A Cohen P | 1995 | J Biol Chem1995，270，27： | 1 |
| 6 | PAI-1 produced ex vivo by human adipose tissue is relevant to PAI-1 blood level显示文摘 | Morange PE Alessi MC Verdier M | 1999 | Arterioscler Thromb Vasc Biol1999，19，5： | 1 |
| 7 | The PI3K-PDK1 connection:more than just a road to PKB显示文摘 | Vanhaesebroeck B Alessi DR | 2000 | Biochem J2000，346，3： | 1 |
| 8 | Supercritical fluids chromatography for impregnation optimization显示文摘 | Cortesi A Alessi P Kikic I | 2000 | Journal of Supercritical Fluids2000，19，： | 1 |
| 9 | Supercritieal anti-solventprecipitation processes: diferent ways for improving theperformances of drugs显示文摘 | Kikic I Alessi P CortesiA | 2002 | Chern Engr Trans2002，，2： | 1 |
| 10 | Diagnostic performance of standard electrocardiogram for prediction of infarct related artery and site of coronary occlusion in unselected STEMI patients undergoing primary percutaneous coronary intervention显示文摘 | Taglie-ri N Saia F Alessi L | 2014 | Eur Heart J Acute Cardiovasc Care2014，3，4： | 1 |
| 11 | Plasma TAFI antigen variations in healthy subjects显示文摘 | Chetaille P Alessi MC Kouassi D | 2000 | Thromb Haemost2000，83，6： | 1 |
| 12 | A new method for detection of delirium 显示文摘 | Inouye SK van Dyck CH Alessi CA et aL Clarifying confusion: The Confusion Assessment Method | 1990 | Ann Intern Med1990，113，12： | 1 |
| 13 | The regulation of salt transport and blood pressure by the WNK-SPAK/ OSR1 signalling pathway 显示文摘 | Richardson C Alessi DR | 2008 | CellSci2008，121，20： | 1 |
| 14 | Vocal fold scarring: Current concepts and management 显示文摘 | Benninger MS Alessi D Archer S | 1996 | Otolaryngol Head Neck Surg1996，115，： | 1 |
| 15 | Successful immunoglobulin treatment in a patient with neuromyotonia 显示文摘 | Alessi G De Reuck J De Bleecker J | 2000 | Clin Neurol Neurosurg2000，102，3： | 1 |
| 16 | Absence of PCR- detectable human papilloma virus in erythroplasia of Queyrat using a comparative control group 显示文摘 | Nasca MR Potenza MC Alessi L | 2010 | Sex Transm Infect2010，86，3： | 1 |
| 17 | Practice parameters for the use of actigraphy in the assessment of sleep and sleep disorders: an update for2007 显示文摘 | Morgenthaler T Alessi C Friedman L | 2007 | Sleep2007，30，： | 1 |
| 18 | Surgical treatment of visceral artery aneurysms: A 25-year experience显示文摘 | Raffaele Pulli Walter Dorigo Nicola Troisi Giovanni Pratesi Alessandro Alessi Innocenti Carlo Pratesi | 2008 | Journal of Vascular Surgery2008，，2： | 1 |
| 19 | High-pressure fluid phase equilibria: experimental methods and systems investigated (1978-1987) 显示文摘 | Fomari R E Alessi P Kikic I | 1990 | Fluid Phase Equilibria1990，57，： | 1 |
| 20 | Mol-ecular basis for the substrate specificity of protein kinase B;comparison with MAPKAP kinase-1 and p70 S6 kinase显示文摘 | ALESSI D R CAUDWELL F B ANDEJELKOVIC M | 1996 | FEBS Lett1996，399，： | 1 |
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