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| 1 | ELASTIC BEHAVIOR ANALYSIS OF 3D ANGLE-INTERLOCK WOVEN CERAMIC COMPOSITES显示文摘为 angle-interlockwoven 的有弹性的行为分析的一个微机械模型陶器的 composites 在这篇论文被建议。这个模型由在空间,在邻近的纱之间的洞和纱的实际剖面图几何学认为纤维是波动和连续性考虑实际织物结构。基于 laminate 理论,编织的 3D 角度联锁的有弹性的性质陶器的 composites 被预言。交叉的纬的不同数字几乎有一样的有弹性的 moduli。陶器的矩阵的厚度在有弹性的 moduli 上有小效果。当波动比率增加纵的模量减少和另外的幼仔的 moduli 增加时。在理论预言和试验性的结果之间的好同意在分析编织的 3Dangle-interlock 的有弹性的性质表明建议模型的可行性陶器的 composites。这篇论文的结果验证分析聚酯矩阵 composites 的方法对编织陶器的 composites 合适的事实。 | Chang Yanjun Jiao Guiqiong Wang Bo Liu Wei | 2006 | Acta Mechanica Solida Sinica2006，19，2： | 11 |
| 2 | Propofol differentially induces unconsciousness and respiratory depression through distinct interactions between GABAa receptor and GABAergic neuron in corresponding nuclei显示文摘Propofol is the most commonly used intravenous anesthetic worldwide.It can induce loss of consciousness prior to the occurrence of severe respiratory suppression,which is also a pharmacodynamic feature of all general anesthetics.However,the neural mechanisms underlying this natural phenomenon are controversial and highly related to patient safety.In the present study,we demonstrated that the pharmacodynamic effects of propofol(50 and 100 μM)on suppression of consciousness-related excitatory postsynaptic currents in the medial prefrontal cortex(mPFC)and centromedian nucleus of the thalamus(CMT)were lower than those in the kernel respiratory rhythmogenesis nucleus pre-Botzinger complex(PrBo).Furthermore,we unexpectedly found that the GABAa receptor β3 subunit is the key target for propofol's action and that it is mutually and exclusively expressed in GABAergic neurons.It is also more abundant in the mPFC and CMT,but mainly co-localized with GABAergic neurons in the PrBo.As a result,the differentiated expression pattern should mediate more neuron suppression through the activation of GABAergic neurons in the mPFC and CMT at low doses of propofol(50 μM).However,PrBo GABAergic neurons were only activated by propofol at a high dose(100 μM).These results highlight the detailed pharmacodynamic effects of propofol on consciousness-related and respiration-related nuclei and provide the distinct interaction mechanism between the β3 subunit and GABAergic neurons in mediating the suppression of consciousness compared to the inhibition of respiration. | Junli Jiang Yingfu Jiao Po Gao Wen Yin Wei Zhou Yunchun Zhang Yanjun Liu Daxiang Wen Yuan Wang Liang Zhou Tian Yu Weifeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 11 |
| 3 | Activation of anterior thalamic reticular nucleus GABAergic neurons promotes arousal from propofol anesthesia in mice显示文摘Propofol is widely used for the induction and maintenance of anesthesia,which causes a rapid loss of consciousness.However,the mechanisms underlying the hypnosis effect of propofol are still not fully understood.The thalamic reticular nucleus(TRN)is crucial for regulating wakefulness,sleep rhythm generation,and sleep stability,while the role of TRN in the process of propofol-induced anesthesia is still unknown.Here,we investigated the function of the anterior TRN in propofol general anesthesia.Our results demonstrated that the neural activity of anterior TRN is suppressed during propofol anesthesia,whereas it is robustly activated from anesthesia by recording the calcium signals using fiber photometry technology.The results showed that the activation of anterior TRN neurons by chemogenetic and optogenetic methods shortens the emergency time without changing the induction time.Conversely,chemogenetic or optogenetic inhibition of the TRN neurons leads to a delay in the recovery time.Our study showed that anterior TRN is crucial for behavioral arousal without affecting the induction time of propofol anesthesia. | Yanjun Liu Bing Chen Yirong Cai Yuan Han Ying Xia Nanqi Li Bingqian Fan Tianjie Yuan Junli Jiang Po Gao Weifeng Yu Yingfu Jiao Wenxian Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 3 |
| 4 | Hippocampus is more vulnerable to neural damages induced by repeated sevoflurane exposure in the second trimester than other brain areas显示文摘During the rapidly developing and sensitive period of the central nervous system (CNS), a harmful stimulus may have serious consequences. The effect of anesthetic exposure on the development of the offspring’s CNS during pregnancy is still unclear and has been widely concerned. In the present study, we compared the susceptibility of the hippocampus with those of other brain regions in offsprings when the mother mice were exposed to repeated sevoflurane. We found that other than affecting motor sensation, emotion, or social behavior of offspring mice, repeated sevoflurane exposure induced significant memory deficiency. Compared with other brain regions, the hippocampus, which is the key component of the brain serving for learning and memory, was more vulnerable to repeated sevoflurane exposure. We also found that repeated sevoflurane exposure to mother mice could inhibit the axon development of hippocampal neurons. We also predicted that N6-methyladenosine modification of mRNA might play an essential role in the vulnerability of the hippocampus to sevoflurane, while the underlying cellular mechanism needs to be explored in the future. Our study may provide a new perspective for studying the mechanism of hippocampus-specific injury induced by sevoflurane exposure. | Bing Chen Yanjun Liu Yirong Cai Dan Tang Saihong Xu Po Gao Weifeng Yu Yingfu Jiao Wenxian Li | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 3 |
| 5 | Phase Ⅲ Clinical Trials of the Cell Differentiation Agent-2 (CDA-2): Therapeutic Efficacy on Breast Cancer, Non-Small Cell Lung Cancer and Primary Hepatoma显示文摘 | Fengyi Feng Qing Lu Changquan Ling Yang Zhang Fengzhan Qin Huaqing Wang Wenxia Huang Shunchang Jiao Qiang Chen Mingzhong Li Yunzhong Zhu Meizhen Zhou Jun Ren Yetao Gao Jingpo Zhao Rongsheng Zheng Wenhua Zhao Zhiqiang Meng Fang Li Qizhong Zhang Dongli Zhao Liyan Xu Yongqiang Zhang Yanjun Zhang Zhenjiu Wang Shuonqi Liu Ming C. Liau | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 3 |
| 6 | EFFECT OF Z-PINS’ DIAMETER,SPACING AND OVERLAP LENGTH ON CONNECTING PERFORMANCE OF CMC SINGLE LAP JOINT显示文摘The effect of through-thickness reinforcement by composite pins (Z-pins) on the static tensile strength and failure mechanisms of the joints made from ceramic matrix composite (CMC) is investigated. Overlap length of the single lap joint is 15 mm, 20 mm, 23 mm, 37 mm, and 60 mm, respectively. The experimental results indicate that the final failure modes of the joints can be divided into two groups, (a) the bond-line stops debonding until crack encounters Z-pins; and then the adherends break at the location of Z-pins, when overlap length is more than 20 mm; (b) the bond-line detaches entirely and Z-pins are drawn from adherends, when overlap length is equal to 15 mm. A simple effcient computational approach is presented for analyzing the benefit of through-thickness pins for restricting failure in the single lap joints. Here, the mechanics problem is simplified by representing the effect of the pins by tractions acting on the fracture surfaces of the cracked bond-line. The tractions are prescribed as functions of the crack displacement, which are available in simple forms that summarize the complex deformations to a reasonable accuracy. The resulting model can be used to track the evolution of complete failure mechanisms, for example, bond-line initial delamination and ultimate failure associated with Z-pin pullout, ultimate failure of the adherends. The paper simulates connecting performance of the single lap joints with different Z-pins’ diameter, spacing and overlap length; the numerical results agree with the experimental results; the numerical results indicate enlarging diameter and decreasing spacing of Z-pins are in favor of improving the connecting performance of the joints. By numerical analysis method, the critical overlap length that lies between two final failure modes is between 18 mm and 19 mm, when Z-pins’ diameter and spacing are 0.4 mm, 5 mm, respectively. | Yongqiang Tao Guiqiong Jiao Bo Wang Yanjun Chang | 2008 | Acta Mechanica Solida Sinica2008，21，5： | 3 |
| 7 | APPLICATION AND THEORETICAL ANALYSIS OF C/SiC COMPOSITES BASED ON CONTINUUM DAMAGE MECHANICS显示文摘Based on the thermodynamic theory,an orthotropic damage constitutive model was developed to describe the nonlinear mechanical behavior of C/SiC composites.The diferent nonlinear kinematic and isotropic hardening functions were adopted to describe accurately the damage evolution processes.The damage variables were defined with the damaged modulus and the initial undamaged modulus on energy equivalence principle.The initial orthotropy and damage coupling were presented in the damage yield function.Tensile and in-plane shear loading and unloading tests were performed,and a good agreement between the model and the experimental results was achieved. | Yanjun Chang Guiqiong Jiao Keshi Zhang Bo Wang Jiannwen Ju | 2013 | Acta Mechanica Solida Sinica2013，26，5： | 3 |
| 8 | Reliability evaluation of the communication network in wide area protection显示文摘 | DAI Zhihui WANG Zengping JIAO Yanjun | | 0，，04： | 1 |
| 9 | Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis,prognosis and drug target discovery显示文摘Disease progression prediction and therapeutic drug target discovery for Coronavirus disease 2019(COVID-19)are particularly important,as there is still no effective strategy for severe COVID-19 patient treatment.Herein,we performed multi-platform omics analysis of serial plasma and urine samples collected from patients during the course of COVID-19.Integrative analyses of these omics data revealed several potential therapeutic targets,such as ANXA1 and CLEC3B.Molecular changes in plasma indicated dysregulation of macrophage and suppression of T cell functions in severe patients compared to those in non-severe patients.Further,we chose 25 important molecular signatures as potential biomarkers for the prediction of disease severity.The prediction power was validated using corresponding urine samples and plasma samples from new COVID-19 patient cohort,with AUC reached to 0.904 and 0.988,respectively.In conclusion,our omics data proposed not only potential therapeutic targets,but also biomarkers for understanding the pathogenesis of severe COVID-19. | Yuming Li Guixue Hou Haibo Zhou Yanqun Wang Hein Min Tun Airu Zhu Jingxian Zhao Fei Xiao Shanwen Lin Dongdong Liu Dunrong Zhou Lang Mai Lu Zhang Zhaoyong Zhang Lijun Kuang Jiao Guan Qiushi Chen Liyan Wen Yanjun Zhang Jianfen Zhuo Fang Li Zhen Zhuang Zhao Chen Ling Luo Donglan Liu Chunke Chen Mian Gan Nanshan Zhong Jincun Zhao Yan Ren Yonghao Xu | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 10 | Reliability evaluation of the communication network in wide-area protection显示文摘 | Dai Zhihui Wang Zengping Jiao Yanjun | 2011 | IEEE Trans on Power Delivery2011，26，4： | 1 |
| 11 | Reliability eval-uation of the communication network in wide-area protection显示文摘 | DAI Zhihui WANG Zengping JIAO Yanjun | 2011 | IEEE Transactions on Power Delivery2011，26，4： | 1 |
| 12 | Bayes monte-carlo assessment method of protection systems reliability based on small failure sample data显示文摘 | DAI Zhihui WANG Zengping JIAO Yanjun | 2014 | IEEE Transactions on Power Delivery2014，29，4： | 1 |
| 13 | Effects of ARHI on breast cancer cell biological behavior regulated by microRNA-221显示文摘 | Ying Li Mei Liu Yanjun Zhang Chun Han Junhao You Junlan Yang Cheng Cao Shunchang Jiao | 2013 | Tumor Biology2013，，6： | 1 |
| 14 | Study on Tissue Culture and Rapid Propagation of Platycodon grandiflorus显示文摘With seeds as experimental materials,MS was used as the basic medium to combine different species and concentrations of auxin and mitogen for proliferation,elongation and rooting culture. The best combination of medium and the most suitable medium were selected. The results showed that the best formula for the medium was MS + 0. 5 mg/L BA + 0. 5 mg/L IAA + 30 g/L sucrose in the proliferation culture,MS + 0. 25 mg/L BA + 0. 5 mg/L IAA + 30 g/L sucrose in the elongation culture,and MS + 0. 5 mg/L IAA + 20 g/L sucrose in the rooting culture respectively. The experimental results will be applied in the rapid propagation and breeding of high-quality seedlings of Platycodon grandiflorus. | Huiying JIAO Yaqi QIAO Yi PEI Zhichen LIU Yanjun LIU Ya SU Chenxi WANG Jiangli NIE | 2018 | Asian Agricultural Research2018，10，10： | 0 |
| 15 | The Binarity of Early-type Stars from LAMOST medium-resolution Spectroscopic Survey显示文摘Massive binaries play significant roles in many fields.Identifying massive stars,particularly massive binaries,is of great importance.In this paper,by adopting the technique of measuring the equivalent widths of several spectral lines,we identified 9382 early-type stars from the LAMOST medium-resolution survey and divided the sample into four groups,T1(~O-B4),T2(~B5),T3(~B7)and T4(~B8-A).The relative radial velocities RVrelwere calculated using Maximum Likelihood Estimation.The stars with significant changes of RVreland at least larger than 15.57 km s-1 were identified as spectroscopic binaries.We found that the observed spectroscopic binary fractions for the four groups are 24.6%±0.5%,20.8%±0.6%,13.7%±0.3%and 7.4%±0.3%,respectively.Assuming that orbital period(P)and mass ratio(q)have intrinsic distributions as f(P)∝Pπ(1 | Yanjun Guo Jiao Li Jianping Xiong Jiangdan Li Luqian Wang Heran Xiong Feng Luo Yonghui Hou Chao Liu Zhanwen Han Xuefei Chen | 2022 | Research in Astronomy and Astrophysics2022，22，2： | 0 |
| 16 | Release behavior of soluble salts in MSWI bottom ash used as road basement materials under continuous rainfall conditions显示文摘The bottom ash is increasingly used as a substitute aggregate material in road construction in China,and road salting is the major salt source in groundwater.Continuous rainfall releases soluble salts from the bottom ash subgrade into the surrounding soil and groundwater,resulting in potential hazards.Different methods were employed to simulate and collect runoff water during rainfall events,including batch leaching test,dynamic leaching test and constant head test,to assess environmental impact of bottom ash as road basement materials under continuous rainfall conditions.This study simulated the seepage of bottom ash backfill roads under different rainfall intensities,rainfall times,and rainfall pH values.A comprehensive sampling and laboratory testing program was undertaken to characterize the environmental impact of soluble salts from bottom ash.The obtained results reveal that the leaching concentrations of Cl^(−)and SO_(4)^(2−)exceed the limit specified in the class V standard of surface water,which are 2.06–2.17 times and 1.08–1.25 times,respectively.By examining the long-term environmental influence under the condition of continuous rainfall,the leaching of Cl^(−)mainly occurs in the early leaching stage,and the maximum leaching concentration reaches 19,700 mg/L.The release concentration of Cl^(−)begins to be lower than the class V standard of surface water when continuous rainfall approaches the total rainfall for 13 months.The cumulative release of Cl^(−)in the bottom ash is 2.8–5.4 mg/g.Both rainfall intensity and rain pH affect the release of Cl^(−).The obtained results derived from the constant head tests indicate that stagnant water caused by rainfall deteriorates the release of soluble salt into the groundwater in only 1 day,especially at the early stage of 12 h.This work provides some basic information about how to minimize damage to the surrounding environment caused by the leaching of salt in bottom ash. | Lingqin Zhao Dongming Zhang Yanjun Hu Qianqian Guo Long Jiao Nan Zhou Francesco Di Maio | 2023 | Waste Disposal and Sustainable Energy2023，5，4： | 0 |
| 17 | Early-Life Gut Microbiota Governs Susceptibility to Colitis via Microbial-Derived Ether Lipids显示文摘Localized intestine inflammation could induce short-term increases in colonic oxygenation and leads to increases in the aerobic bacteria population and reduction in the anaerobic bacteria population by changing the intestinal environment.However,the mechanisms involved and the associated functions of intestinal anaerobes in gut health still remain unclear.Here,we found that early-life depletion of gut microbiota exacerbated later colitis,while mid-life microbiota depletion showed partially reduced colitis.Notably,we observed that early-life gut microbiota depletion confers susceptibility to ferroptosis in colitis.In contrast,restitution of early-life microbiota conferred protection against colitis and inhibited ferroptosis triggered by gut microbiota dysbiosis.Similarly,colonization with anaerobic microbiota from young mice suppressed colitis.These results may attribute to high abundance of plasmalogen-positive(plasmalogen synthase[PlsA/R]-positive)anaerobes and plasmalogens(one of the common ether lipids)in young mice but reduced abundance in the development of inflammatory bowel disease.Early-life anaerobic bacteria elimination also resulted in the aggravation of colitis,while this aggravation phenotype was reverted by plasmalogen administration.Interestingly,plasmalogens inhibited ferroptosis triggered by microbiota dysbiosis.We further find that the alkenyl-ether group of plasmalogens was critical to colitis prevention and ferroptosis inhibition.These data point to one of the mechanisms by which the gut microbiota controls susceptibility to colitis and ferroptosis early in life via microbial-derived ether lipids. | Yanjun Liu Chunhua Jiao Tao Zhang Xue Li Panpan Li Meishan Lu Zhan Ye Yanpeng Du Runfeng Du Wenlong Zhang Jie Xu Zhaojun Zheng Yongjiang Xu Changhu Xue Yi Zhang Yuanfa Liu | 2023 | Research2023，，3： | 0 |
| 18 | The Formation Model for Marine Potash Deposits within China's Small Continental Blocks显示文摘Chinese geologists have always been expecting to find out a large scale of potash deposits in marine basins,but only one small-middle scale industrial solid potash deposit had been found at Mengyejing in Langping-Simao | LIU Chenglin WANG Licheng ZHAO Yanjun CAO Yangtong JIAO Pengcheng SHEN Lijian ZHANG Hua | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 0 |
| 19 | Evolution of Quaternary Depositional Environments in Lop Nor,Xinjiang:Sedimentary Records from LDK01 Drilling显示文摘Lop Nur is located in the interior of Asian and the lowest part in the eastern Tarim Basin.It is the final destination of major river systems in Tarim Basin and the accumulation center of salt materials(Xia,1987). | Lü Fenglin LIU Chenglin JIAO Pengcheng ZHAO Yanjun | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 0 |
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