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4篇 您的检索式:作者名="Runfeng Du"
    题名 作者 年代 出处 被引量
1Effect of micronization technology on physicochemical and antioxidant properties of dietary fiber from buckwheat hulls显示文摘Fengmei Zhu Bin Du Runfeng Li 2014Biocatalysis and Agricultural Biotechnology2014,3,3:1
2Effect of micronization technology on physicoehemical and antioxidant properties of dietary fiber from buckwheat hulls显示文摘Zhu Fengmei Du Bin Li Runfeng 2014Biocatalysis and Agri- cultural Biotechnology2014,3,:1
3Effect of microniza- tion technology on physicochemical and antioxidant properties of dietary fiber from buckwheat hulls显示文摘Zhu Fengmei Du Bin Li Runfeng 2014Bioeatalysis and Ag- ricultural Biotechnology2014,,3:1
4Early-Life Gut Microbiota Governs Susceptibility to Colitis via Microbial-Derived Ether Lipids显示文摘Localized intestine inflammation could induce short-term increases in colonic oxygenation and leads to increases in the aerobic bacteria population and reduction in the anaerobic bacteria population by changing the intestinal environment.However,the mechanisms involved and the associated functions of intestinal anaerobes in gut health still remain unclear.Here,we found that early-life depletion of gut microbiota exacerbated later colitis,while mid-life microbiota depletion showed partially reduced colitis.Notably,we observed that early-life gut microbiota depletion confers susceptibility to ferroptosis in colitis.In contrast,restitution of early-life microbiota conferred protection against colitis and inhibited ferroptosis triggered by gut microbiota dysbiosis.Similarly,colonization with anaerobic microbiota from young mice suppressed colitis.These results may attribute to high abundance of plasmalogen-positive(plasmalogen synthase[PlsA/R]-positive)anaerobes and plasmalogens(one of the common ether lipids)in young mice but reduced abundance in the development of inflammatory bowel disease.Early-life anaerobic bacteria elimination also resulted in the aggravation of colitis,while this aggravation phenotype was reverted by plasmalogen administration.Interestingly,plasmalogens inhibited ferroptosis triggered by microbiota dysbiosis.We further find that the alkenyl-ether group of plasmalogens was critical to colitis prevention and ferroptosis inhibition.These data point to one of the mechanisms by which the gut microbiota controls susceptibility to colitis and ferroptosis early in life via microbial-derived ether lipids.Yanjun Liu Chunhua Jiao Tao Zhang Xue Li Panpan Li Meishan Lu Zhan Ye Yanpeng Du Runfeng Du Wenlong Zhang Jie Xu Zhaojun Zheng Yongjiang Xu Changhu Xue Yi Zhang Yuanfa Liu 2023Research2023,,3:0
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