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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | Spatiotemporal Variations and Regional Transport of Air Pollutants in Two Urban Agglomerations in Northeast China Plain显示文摘Characteristics of air pollution in Northeast China(NEC) received less research attention in the past comparing to other heavily polluted regions in China.Spatiotemporal variations of six criteria air pollutants(PM10, PM2.5, SO2, NO2, O3 and CO) in Central Liaoning Urban Agglomeration(CLUA) and Harbin-Changchun Urban Agglomeration(HCUA) in NEC Plain were analyzed in this study based on three-year hourly observations of air pollutants and meteorological variables from 2015 to 2017.The results indicated that the annual mean concentrations of air pollutants are generally higher in the middle and southern regions in NEC Plain and lower in the northern region.Megacities such as Shenyang, Harbin and Changchun experience severe air pollution, with a three-year averaged air quality index(AQI) larger than 80, far exceeding the daily AQI standard at the first-level of 50 in China.The annual mean PM and SO2 concentrations decrease most significantly in NEC urban agglomerations from 2015 to 2017, followed by CO and NO2, while O3 shows a slight increasing trend.All the six pollutants exhibit obvious seasonal and diurnal variations, and these variations are dictated by local emission and meteorological conditions.PM2.5 and O3 concentrations in NEC urban agglomerations strongly depend on wind conditions.High O3 concentrations at different cities usually occur in presence of strong winds but are independent on wind direction(WD), while high PM2.5 is usually accompanied by weak winds and poor dispersion condition, and sometimes also occur when the northerly or southerly winds are strong.Regional transport of air pollutants between NEC urban agglomerations is common.A severe haze event on November 1–4, 2017 is examined to demonstrate the role of regional transport on pollution. | LI Xiaolan HU Xiaoming SHI Shuaiyi SHEN Lidu LUAN Lan MA Yanjun | 2019 | Chinese Geographical Science2019，29，6： | 9 |
| 3 | Urotensin Ⅱ promotes monocyte chemoattractant protein-1 expression in aortic adventitial fibroblasts of rat显示文摘 | Zhang Yonggang Bao Shilin Kuang Zejian Ma Yanjun Hu Yanchao Mao Yanyan | 2014 | Chinese Medical Journal2014，，10： | 7 |
| 4 | Empirical analysis of airport network and critical airports显示文摘Air transport network, or airport network, is a complex network involving numerous airports. Effective management of the air transport system requires an in-depth understanding of the roles of airports in the network. Whereas knowledge on air transport network properties has been improved greatly, methods to find critical airports in the network are still lacking. In this paper, we present methods to investigate network properties and to identify critical airports in the network. A novel network model is proposed with airports as nodes and the correlations between traffic flow of airports as edges. Spectral clustering algorithm is developed to classify airports. Spatial distribution characteristics and intraclass correlation of different categories of airports are carefully analyzed. The analyses based on the fluctuation trend of distance-correlation and power spectrum of time series are performed to examine the self-organized criticality of the network. The results indicate that there is one category of airports which dominates the self-organized critical state of the network. Six airports in this category are found to be the most important ones in the Chinese air transport network. The flights delay occurred in these six airports can propagate to the other airports, having huge impact on the operation characteristics of the entire network. The methods proposed here taking traffic dynamics into account are capable of identifying critical airports in the whole air transport network. | Cong Wei Hu Minghua Dong Bin Wang Yanjun Feng Cheng | 2016 | Chinese Journal of Aeronautics2016，29，2： | 7 |
| 5 | Isorhapontigenin protects against doxorubicin-induced cardiotoxicity via increasing YAP1 expression显示文摘As an effective anticancer drug, the clinical limitation of doxorubicin(Dox) is the time-and dose-dependent cardiotoxicity. Yes-associated protein 1(YAP1) interacts with transcription factor TEA domain 1(TEAD1) and plays an important role in cell proliferation and survival. However, the role of YAP1 in Dox-induced cardiomyopathy has not been reported. In this study, the expression of YAP1 was reduced in clinical human failing hearts with dilated cardiomyopathy and Dox-induced in vivo and in vitro cardiotoxic model. Ectopic expression of Yap1 significantly blocked Dox-induced cardiomyocytes apoptosis in TEAD1 dependent manner. Isorhapontigenin(Isor) is a new derivative of stilbene and responsible for a wide range of biological processes. Here, we found that Isor effectively relieved Doxinduced cardiomyocytes apoptosis in a dose-dependent manner in vitro. Administration with Isor(30 mg/kg/day, intraperitoneally, 3 weeks) significantly protected against Dox-induced cardiotoxicity in mice. Interestingly, Isor increased Dox-caused repression in YAP1 and the expression of its target genes in vivo and in vitro. Knockout or inhibition of Yap1 blocked the protective effects of Isor on Dox-induced cardiotoxicity. In conclusion, YAP1 may be a novel target for Dox-induced cardiotoxicity and Isor might be a new compound to fight against Dox-induced cardiotoxicity by increasing YAP1 expression. | Panxia Wang Minghui Wang Yuehuai Hu Jianxing Chen Yanjun Cao Cui Liu Zhongkai Wu Juan Shen Jing Lu Peiqing Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 7 |
| 6 | Temperature dependent Raman and photoluminescence of vertical WS2/MoS2 monolayer heterostructures显示文摘Heterostructures from two-dimensional transition-metal dichalcogenides MX_2 have emerged as a hot topic in recent years due to their various fascinating properties. Here, we investigated the temperature dependent Raman and photoluminescence(PL) spectra in vertical stacked WS_2/MoS_2 monolayer heterostructures. Our result shows that both E_(2g)~1 and A_(1g) modes of WS_2 and MoS_2 vary linearly with temperature increasing from 300 to 642 K. The PL measurement also reveals strong temperature dependencies of the PL intensity and peak position. The activation energy of the thermal quenching of the PL emission has been found to be equal to 69.6 meV. The temperature dependence of the peak energy well follows the bandgap shrinkage of bulk semiconductor. | Zhijian Hu Yanjun Bao Ziwei Li Yongji Gong Rui Feng Yingdong Xiao Xiaochun Wu Zhaohui Zhang Xing Zhu Pulickel M. Ajayan Zheyu Fang | 2017 | Science Bulletin2017，62，1： | 5 |
| 7 | Recent advances in persulfate-based advanced oxidation processes for organic wastewater treatment显示文摘In recent years,with the emergence of new pollutants,the effective treatment of wastewater has become very important.Persulfate-based advanced oxidation processes have been successfully applied to the treatment of wastewater,such as wastewater containing antibiotics,pharmaceuticals and personal care products,dyes,endocrine-disrupting chemicals,chlorinated organic pollutants,and phenolics,for the degradation of refractory organic contaminants.This paper summarizes the production of sulfate radicals,which can be generated by the activation of persulfate via conventional and emerging approaches.The existing problems of persulfate-based advanced oxidation processes were analyzed in detail,including residual sulfates,coexisting factors(coexisting inorganic anions and natural organic matter),and energy consumption.This paper proposes corresponding possible solutions to the problems mentioned above,and this paper could provide a reference for the application of persulfate-based advanced oxidation processes in actual wastewater treatment. | Ke Tian Limin Hu Letian Li Qingzhu Zheng Yanjun Xin Guangshan Zhang | 2022 | Chinese Chemical Letters2022，33，10： | 5 |
| 8 | Fabrication of Crack-Free Flattened Bamboo and Its Macro-/MicroMorphological and Mechanical Properties显示文摘This work aimed to help the bamboo industry develop methodology for producing imperfection-free bamboo boards that can serve either decorative or structural benefit to consumers seeking to engage with the bioeconomy.Specifically,softened and slotted bamboo tubes were handled by a roller device with nails to render crack-free flattened bamboo board.Softening temperature and time were optimized herein according to findings regarding chemical composition and board mechanical properties.The optimal softening parameters for saturated steam heat treatment is proved to be 160°C for 8 min.The flattened bamboo board possesses an increased bending strength of 101.5 MPa and a decreased bending modulus of 7.7 GPa,being compared with only-softened bamboo.The corresponding changing mechanism is determined in-depth by the micro-morphological and mechanical results based on in-situ SEM and AFM technologies.Under the action of nails and rolling processes,the bamboo texture becomes compact with crushed and fragmented conduit walls.The resulting cell cavity then becomes stretched and compressed,taking on a morphology which allows for the mechanical penalties associated with flattening to be avoided.According to the micro-mechanical results obtained by AFM,compared with unflatten bamboo,the Young’s modulus of the cell membrane in transverse direction(YT)decreases to 1.00 GPa while the corresponding Young’s modulus in radial direction(YR)increases to 7.29 GPa. | Zhichao Lou Tiancheng Yuan Qiuyi Wang Xinwu Wu Shouheng Hu Xiaomeng Hao Xianmiao Liu Yanjun Li | 2021 | Journal of Renewable Materials2021，9，5： | 4 |
| 9 | A comparison study of the simulation accuracy between WRF and MM5 in simulating local atmospheric circulations over Greater Beijing显示文摘Several multi-scale numerical simulation experiments were carried out using the mesoscale modeling systems MM5V3.7 and WRFV2.2 for Greater Beijing to estimate the accuracy of WRF and MM5 in simulating the characteristics and variations of mesoscale local circulation in the atmospheric boundary layer of this area. We simulated the horizontal distribution and diurnal variations of temperature and wind fields near the ground and compared them with Automatic Weather System (AWS) data collected from 19 AWS stations in Beijing. Correlation and error analyses were also made. The modeling and statistical results showed that both WRF and MM5 model the temperature field near the ground significantly better than they model the wind field. The temperature field simulated by MM5 is more coincident than that of WRF with the AWS observation records, while WRF does better than MM5 in simulating the wind field, especially under the condition of gusty wind. Neither WRF nor MM5 can capture the fine structure of urban architectural complexity, which is the main error in the wind field simulation. Both models underestimate the land surface temperature at night and overestimate the temperature during the day. All the above results are supported by statistical analysis. | LIU ZhenXin LIU ShuHua HU Fei LI Ju MA YanJun LIU HePing | 2012 | Science China Earth Sciences2012，55，3： | 4 |
| 10 | Numerical simulation of seepage flow field in groundwater source heat pump system and its influence on temperature field显示文摘Energy utilization in the aquifers is a new technology closely related to development of heat pump technique. It is significant for the flow distribution to be predicted in the aquifer surrounding the Groundwater Source Heat Pump System (GSHPS). The authors presented a new concept of 'flow transfixion' by analyzing general features of aquifers, and then discussed interaction of the flow transfixion with the heat transfixion, which has practical significance to projects. A numerical model of groundwater flow was established based on the basic tenets of water-heat transferring in the aquifer. On this basis the flow field and the temperature field of GSHPS for a site in Shenyang City were numerically simulated. The basis of the flow transfixion was obtained; it was discussed for the influence of the flow transfixion on the heat transfixion. To a certain extent, the study offers some reference for the projects' design of GSHP in the studied area. | Jihua HU Yanjun ZHANG Danyan DU Gang WU Ziwang YU Chen WANG Fuquan NI | 2008 | Global Geology2008，11，3： | 4 |
| 11 | Study on the Coincident-Loop Transient Electromagnetic Method in Seafloor Exploration——Taking Jiaodong Polymetallic Mine as a Model显示文摘The transient electromagnetic(TEM)method becomes more urgent than ever for marine ex-ploration due to abundant resource reserves and the increasing undersea engineering construction activities,especially in the offshore exploration of mineral deposits such as Sanshandao gold mine.However,the re-search and application of TEM method in marine environment are still challenged by many problems.Such contradiction motivates our study on the coincident-loop TEM in seafloor exploration.The TEM response of coincident loops is firstly derived in the integral form,based on the potential functions in Helmholtz equ-ations for a magnetic source locating in the whole-space layered model.The frequency-domain vertical magnetic field is described as the Hankel integral with double first-order Bessel functions of first kind.Se-condly,the time-domain induced voltage is obtained by transforming the frequency-domain response through the cosine transform and then taking the derivative of time.To simultaneously solve the Hankel transform and the cosine transform,a novel algorithm is introduced by adapting the fixed-point quadra-ture and extrapolation via the Shanks transformation.Finally,a typical conductivity model for marine po-lymetallic deposit is designed to investigate the characteristic of TEM response under various conditions.Numerical results demonstrate that existence of conductive seawater causes the TEM response to increase significantly and decay slower.The air-sea reflected electromagnetic waves lead to a significantly large fake negative response(NR)in shallower seawater with depth less than 300 m.Increase in the height of loops will weaken and delay the anomaly response and shorten the observation time-window.The height of configu-ration should be no more than 100 m for shallower targets and 50 m for deeper targets,respectively.The observation time-window should cover 10-1000 ms.Increase in the radius of loops only enhances the TEM response proportionally but hardly improves the relative anomaly.The vertical resolution on the low-resistivity target approximates 20 m for the configuration considered in the study.Decreases in D.C.resistivity and chargeability cause the positive response(PR)to increase significantly and decay more ra-pidly.Meanwhile,the NR is advanced and enlarged significantly and decays slower compared with the PR.The influence of time constant is not monotony and there exists an optimal value for producing the maxi-mum NR.As the frequency parameter increases,the PR is caused to decay more rapidly without magni-tude change and the NR is advanced and decays more rapidly with significant increase in magnitude.The influence of frequency parameter is more pronounced than that of time constant. | Yixing Ma Junhua Hu Yanjun Chang Zujian Liu | 2021 | Journal of Earth Science2021，32，1： | 3 |
| 12 | Interaction of Caffeine with Bovine Serum Albumin: Determination of Binding Constants and the Binding Site by Spectroscopic Methods显示文摘 | Wu, Qiong Jiang, Fenglei Li, Chaohong Hu, Yanjun Liu, Yi | 2011 | Chinese Journal of Chemistry2011，29，3： | 3 |
| 13 | Orthogonal resource sharing scheme for device-to-device communication overlaying cellular networks: a cooperative relay based approach显示文摘In this paper, we propose a device-to-device(D2D) communication scheme to improve local services in cellular networks. By employing cooperative relay(CR) technology, D2 D and cellular communications can operate in orthogonal resource sharing(ORS) mode with the aim of optimizing the data rates for local D2 D users while fulfilling the minimum rate requirements for prioritized cellular users. In the proposed CR-based ORS scheme, we consider a cellular communication that is willing to share part of the occupied bandwidth resource with some D2 D communications. Hence, the newly-obtained resource can be used by a D2 D communication for the following two purposes, i.e., to compensate the rate loss of the cellular communication through cooperative relaying and to communicate its own information so as to increase its own rate. We formulated this CR-based ORS problem as a non-convex optimization problem. Hence, a global maximizer may not exist for the problem.To find the optimal solution for the problem, an effective heuristic algorithm is developed. Simulation results show that the proposed D2 D communication scheme can significantly increase the rates of local D2 D users and also fulfill the minimum rate requirements of cellular users. | ZHANG GuoPeng LIU Peng YANG Kun DU Yao HU YanJun | 2015 | Science China(Information Sciences)2015，58，10： | 3 |
| 14 | A Micro Structure POF Relative Humidity Sensor Modified With Agarose Based on Surface Plasmon Resonance and Evanescent Wave Loss显示文摘A novel high sensitivity relative humidity(RH)sensor was proposed by using micro structure plastic optical fiber(POF)based on the surface plasmon resonance(SPR)effect and the evanescent wave(EW)loss.The micro structure was fabricated on the POF and coated with a gold layer and agarose,adopting the sputtering and dip-coating technique.These construction effects on the attenuation of power caused by the SPR effect and the EW loss were used to perform RH detections.The agarose9s different refractive indexes(RIs)caused fluctuations in the transmission power when the humidity increased.The demonstrated experimental results showed that the proposed sensor achieved a linear response from 20%RH to 80%RH with a high sensitivity of 0.595μW/%.The proposed sensor had the advantages of fast response and recovery.Furthermore,the temperature dependence and the repeatability test of the sensor were also performed. | Yanjun HU Abdul GHAFFAR Yulong HOU Wenyi LIU Fei LI Jun WANG | 2021 | Photonic Sensors2021，11，4： | 3 |
| 15 | Study of caffeine binding to human serum albumin using optical spectroscopic methods显示文摘The binding of caffeine to human serum albumin (HSA) under physiological conditions has been stud-ied by the methods of fluorescence,UV-vis absorbance and circular dichroism (CD) spectroscopy. The mechanism of quenching of HSA fluorescence by caffeine was shown to involve a dynamic quenching procedure. The number of binding sites n and apparent binding constant Kb were measured by the fluorescence quenching method and the thermodynamic parameters △H,△G,△S were calculated. The results indicate that the binding is mainly enthalpy-driven,with van der Waals interactions and hydrogen bonding playing major roles in the reaction. The distance r between donor (HSA) and acceptor (caffeine) was obtained according to the Frster theory of non-radiative energy transfer. Synchronous fluorescence,CD and three-dimensional fluorescence spectroscopy showed that the microenvironment and conformation of HSA were altered during the reaction. | WU Qiong LI ChaoHong HU YanJun LIU Yi | 2009 | Science China Chemistry2009，52，12： | 2 |
| 16 | Two Ultraviolet Radiation Datasets that Cover China显示文摘Ultraviolet(UV) radiation has significant effects on ecosystems, environments, and human health, as well as atmospheric processes and climate change. Two ultraviolet radiation datasets are described in this paper. One contains hourly observations of UV radiation measured at 40 Chinese Ecosystem Research Network stations from 2005 to 2015. CUV3 broadband radiometers were used to observe the UV radiation, with an accuracy of 5%, which meets the World Meteorology Organization's measurement standards. The extremum method was used to control the quality of the measured datasets. The other dataset contains daily cumulative UV radiation estimates that were calculated using an all-sky estimation model combined with a hybrid model. The reconstructed daily UV radiation data span from 1961 to 2014. The mean absolute bias error and root-mean-square error are smaller than 30% at most stations, and most of the mean bias error values are negative, which indicates underestimation of the UV radiation intensity. These datasets can improve our basic knowledge of the spatial and temporal variations in UV radiation. Additionally, these datasets can be used in studies of potential ozone formation and atmospheric oxidation, as well as simulations of ecological processes. | Hui LIU Bo HU Yuesi WANG Guangren LIU Liqin TANG Dongsheng JI Yongfei BAI Weikai BAO Xin CHEN Yunming CHEN Weixin DING Xiaozeng HAN Fei HE Hui HUANG Zhenying HUANG Xinrong LI Yan LI Wenzhao LIU Luxiang LIN Zhu OUYANG Boqiang QIN Weijun SHEN Yanjun SHEN Hongxin SU Changchun SONG Bo SUN Song SUN Anzhi WANG Genxu WANG Huimin WANG Silong WANG Youshao WANG Wenxue WEI Ping XIE Zongqiang XIE Xiaoyuan YAN Fanjiang ZENG Fawei ZHANG Yangjian ZHANG Yiping ZHANG Chengyi ZHAO Wenzhi ZHAO Xueyong ZHAO Guoyi ZHOU Bo ZHU | 2017 | Advances in Atmospheric Sciences2017，34，7： | 2 |
| 17 | Binding of anti-inflammatory drug cromolyn sodium to bovine serum albu-min显示文摘 | Hu Yanjun Liu Yi Sun Bingquan | 2006 | International Journal of Biological Macromolecules2006，39，45： | 1 |
| 18 | Endogenous auxin and its manipulation influence in vitro shoot organogenesis of citrus epicotyl explants显示文摘Endogenous auxin is an important regulator of in vivo organ development,but its role in in vitro organogenesis is unclear.It has been observed that the basal end of epicotyl cuttings of juvenile citrus seedlings produces fewer shoots than the apical end.Here,we report that elevated endogenous auxin levels in the basal end of citrus epicotyl cuttings are inhibitory for in vitro shoot organogenesis.Using transgenic citrus plants expressing an auxin-inducible GUS reporter gene,we have observed elevated levels of auxin at the basal end of stem cuttings that are mediated by polar auxin transport.Depleting endogenous auxin or blocking polar auxin transport enhances shoot organogenesis.An auxin transport inhibitor,N-1-naphthylphthalamic acid(NPA),can also enhance shoot organogenesis independent of its action on polar auxin transport.Finally,we demonstrate that the promotional effects of depleting endogenous auxin or blocking polar auxin transport on shoot organogenesis are cytokinin-dependent.Our study thus provides meaningful insights into possible roles of endogenous auxin and polar auxin transport,as well as auxin–cytokinin interactions,in in vitro shoot organogenesis.Meanwhile,our results may also provide practical strategies for improving in vitro shoot organogenesis for citrus and many other plant species. | Wei Hu Sabrina Fagundez Lorenzo Katin-Grazzini Yanjun Li Wei Li Yingnan Chen Xiaomin Wang Ziniu Deng Shenxi Xie Richard J McAvoy Yi Li | 2017 | Horticulture Research2017，4，1： | 1 |
| 19 | Lipid distribution in a subtropical southern China stalagmite as a record of soil ecosystem response to palaeoclimate change 显示文摘 | Xie Shucheng Yi Yi Huang Junhua Hu Chaoyong Cai Yanjun Matthew Collins Andy Baker | 2003 | Quaternary Research2003，，60： | 1 |
| 20 | Studies of interaction between colchicine and bovine serum albumin by fluorescence quenching method显示文摘 | HU Yanjun LIU Yi ZHANG Lixia | 2005 | Journal of Molecular Structure2005，750，： | 1 |
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