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| 1 | Non-invasive diagnosis of gastric mucosal atrophy in an asymptomatic population with high prevalence of gastric cancer显示文摘AIM: To validate a non-invasive method to detect gastric mucosal atrophy in a Chilean population with high prevalence of gastric cancer and a poor survival rate. METHODS: We first determined the optimal cut-off level of serum pepsinogen (PG)-1, PG-1/PG-2 ratio and 17-gastrin in 31 voluntary symptomatic patients (mean age: 66.1 years), of them 61% had histologically confirmed gastric atrophy. Then, in a population-based sample of 536 healthy individuals (209 residents in counties with higher relative risk and 327 residents in counties with lower relative risk for gastric cancer), we measured serum anti-H pylori antibodies, PG and 17-gastrin and estimated their risk of gastric cancer. RESULTS: We found that serum PG-1 < 61.5 μg/L, PG-1/PG-2 ratio < 2.2 and 17-gastrin > 13.3 pmol/L had a high specificity (91%-100%) and a fair sensitivity (56%-78%) to detect corpus-predominant atrophy. Based on low serum PG-1 and PG-1/PG-2 ratio together as diagnostic criteria, 12.5% of the asymptomatic subjects had corpus-predominant atrophy (0% of those under 25 years and 20.2% over 65 years old). The frequency of gastric atrophy was similar (12% vs 13%) but H pylori infection rate was slightly higher (77% vs 71%) in the high-risk compared to the low-risk counties. Based on their estimated gastric cancer risk, individuals were classified as: low-risk group (no H pylori infection and no atrophy; n = 115; 21.4%); moderate-risk group(H pylori infection but no atrophy; n = 354, 66.0%); and high-risk group (gastric atrophy, with or without H pylori infection; n = 67, 12.5%). The high-risk group was significantly older (mean age: 61.9 ± 13.3 years), more frequently men and less educated as compared with the low-risk group. CONCLUSION: We propose to concentrate on an upper gastrointestinal endoscopy for detection of early gastric cancer in the high-risk group. This intervention model could improve the poor prognosis of gastric cancer in Chile. | Antonio Rollan Catterina Ferreccio Alessandra Gederlini Carolina Serrano Javiera Torres Paul Harris | 2006 | World Journal of Gastroenterology2006，12，44： | 14 |
| 2 | Neuroprotective effects of erythropoietin on neurodegenerative and ischemic brain diseases: the role of erythropoietin receptor显示文摘Erythropoietin(Epo) is a fundamental hormone in the regulation of hematopoiesis, and other secondary roles mediated by the binding of the hormone to its specific receptor(Epo R), which leads to an activation of key signaling pathways that induce an increase in cell differentiation, apoptosis control and neuroprotection. It has been suggested that their function depends on final conformation of glycosylations, related with affinity to the receptor and its half-life. The presence of Epo R has been reported in different tissues including central nervous system, where it has been demonstrated to exert a neuroprotective function against oxidative stress conditions, such as ischemic injury and neurodegenerative diseases. There is also evidence of an increase in Epo R expression in brain cell lysates of Alzheimer's patients with respect to healthy patients. These results are related with extensive in vitro experimental data of neuroprotection obtained from cell lines, primary cell cultures and hippocampal slices. Additionally, this data is correlated with in vivo experiments(water maze test) in mouse models of Alzheimer's disease where Epo treatment improved cognitive function. These studies support the idea that receptor activation induces a neuroprotective effect in neurodegenerative disorders including dementias, and especially Alzheimer's disease. Taken together, available evidence suggests that Epo appears to be a central element for Epo R activation and neuroprotective properties in the central nervous system. In this review, we will describe the mechanisms associated with neuroprotection and its relation with the activation of Epo R in order with identify new targets to develop pharmacological strategies. | Carolina Castillo Hernández Carlos Felipe Burgos Angela Hidalgo Gajardo Tiare Silva-Grecchi Javiera Gavilan Jorge Roberto Toledo Jorge Fuentealba | 2017 | Neural Regeneration Research2017，12，9： | 5 |
| 3 | Postoperative adjunctive bevacizumab versus placebo in primary trabeculectomy surgery for glaucoma显示文摘AIM: To compare the effectiveness of postoperative adjunctive use of subconjunctival bevacizumab in altering the outcome of primary trabeculectomy in terms of sustained lowering of intraocular pressure(IOP) and reduction of postoperative bleb vascularization and fibrosis.METHODS: A prospective, one center, randomized, placebo-control study. Fifty-nine patients(59 eyes) with uncontrolled IOP under maximal tolerated medical treatment(MTMT) were recruited. A primary trabeculectomy with mitomycin C(MMC) was done and the patients were randomized to either postoperative subconjunctival injection of bevacizumab(1.25 mg/0.05 mL) or balanced salt solution(BSS). Forty-seven patients(47 eyes) completed at least one year of follow up and were included in the study. The main outcome measure was the IOP, and secondary outcome measures include bleb morphology, vascularization, and fibrosis, as well as the need for glaucoma medications and 5-fluorouracil(5-FU) needling.RESULTS: At 1-year follow up, there was no significant difference between groups for IOP(P=0.65), bleb morphology(P=0.65), and the need for glaucoma medications(P=0.65) or 5-FU needling requirements(P=0.11). However, the bevacizumab group had a higher rate of success results, lower use of glaucoma medications after surgery, and optimal bleb aspect in more patients, but more 5-FU needling procedures required. CONCLUSION: A bigger sample size is needed in order to determine whether the differences found in the bevacizumab group are statistically significant. | Sana’Muhsen Javiera Compan Tze Lai Christoph Kranemann Catherine Birt | 2019 | International Journal of Ophthalmology(English edition)2019，12，10： | 4 |
| 4 | The antimicrobial activity of microencapsulated thymol and carvacrol显示文摘 | Abel Guarda Javiera F. Rubilar Joseph Miltz Maria Jose Galotto | 2011 | International Journal of Food Microbiology2011，，2： | 2 |
| 5 | The antimicrobial activity of microencapsulated thymol and carvacrol显示文摘 | Abel Guarda Javiera F Rubilar Joseph Miltz | 2011 | International Journal of Food Microbiology2011，146，： | 1 |
| 6 | 1 Central Bank Intervention and Ex- change Rates:the Case of Sweden显示文摘 | Javiera Aguilar Stefan Nydah | | 0，，10： | 1 |
| 7 | Simulated digestion of proanthocyanidins in grape skin and seed extracts and the effects of digestion on the angiotensin I-converting enzyme (ACE) inhibitory activity显示文摘 | Katherina Fernández Javiera Labra | 2013 | 2013 (1-4)2013，，1： | 1 |
| 8 | The National Citizens’Technology Forum:lessons for the future显示文摘 | Mark Philbrick Javiera Barandiaran | 2009 | Science and Public Policy2009，，5： | 1 |
| 9 | The antimicrobial activity of microencapsulated thymol and carvacrol 显示文摘 | Abel Guarda Javiera F Rubilar Joseph Miltz | 2011 | International Journal of Food Microbiology2011，146，： | 1 |
| 10 | Central bank intervention and exchange rates:the case of Sweden显示文摘 | Javiera A Stefan N | 2000 | J Intern Financi MarketsInstit Money2000，，10： | 1 |
| 11 | Atenolol versus propranolol for the treatment of infantile hemangiomas: a randomized controlled study显示文摘 | álvaro Abarzúa-Araya Cristián P. Navarrete-Dechent Felipe Heusser Javiera Retamal María Soledad Zegpi-Trueba | 2014 | Journal of the American Academy of Dermatology2014，，： | 1 |
| 12 | Diversity of cultivable fungi associated with Antarctic marine sponges and screening for their antimicrobial, antitumoral and antioxidant potential显示文摘 | Marlene Henríquez Karen Vergara Javiera Norambuena Andrea Beiza Felipe Maza Pamela Ubilla Ivanna Araya Renato Chávez Aurelio San-Martín José Darias María J. Darias Inmaculada Vaca | 2014 | World Journal of Microbiology and Biotechnology2014，，1： | 1 |
| 13 | Subjective valuation of the transit transfer experience:the case of Santiago de Chile显示文摘 | Francisca Javiera Navarrete Juan de Dios Ort6zar | 2013 | Transport Policy2013，25，： | 1 |
| 14 | Physico -mechanical properties of chitosan films with carvacroland grape seed extract 显示文摘 | Rubilar Javiera F Cruz Rui MS Silva Helder D | 2012 | Journal of Food Engineering2012，115，4： | 1 |
| 15 | The antimicrobial activity of microencapsulated thymol and carvacrol显示文摘 | ABEL G JAVIERA F R JOSEPH M | 2011 | International Journal of Food Microbiology2011，146，： | 1 |
| 16 | Simulated digestion of proanthocyanidins in grape skin and seed extracts and the effects of digestion on the angiotensin I-converting enzyme (ACE) inhibitory activity 显示文摘 | Katherina Ferndndez Javiera Labra | 2013 | Food Chemistry2013，139，： | 1 |
| 17 | Desulfurization of model diesel fuel on activated carbon modified with iron oxyhydroxic e nanoparticles: Effect oftert butylbenzene and naphthalene concentrations 显示文摘 | JAVIERA ARCIBAR O RENE R M | 2013 | Energy 8< Fuels2013，27，9： | 1 |
| 18 | Sleeve Gastrectomy as Treatment for Severe Obesity after Orthotopic Liver Transplantation显示文摘 | Jean M. Butte Nicolás Devaud Nicolás P. Jarufe Camilo Boza Gustavo Pérez Javiera Torres Rosa M. Pérez-Ayuso Marco Arrese Jorge Martínez | 2007 | Obesity Surgery2007，，11： | 1 |
| 19 | Diversity of cultivable fungi associated with Antarctic marine sponges and screening for their antimicrobial,antitumoral and antioxidant Potential显示文摘 | Marlene H Karen V Javiera N | 2014 | World Journal Microbiol Biotechnol2014，30，： | 1 |
| 20 | Helicobacter pylori Gastritis in Children Is Associated With a Regulatory T-Cell Response显示文摘 | Paul R. Harris Shelton W. Wright Carolina Serrano Francisca Riera Ignacio Duarte Javiera Torres Alfredo Pe?a Antonio Rollán Paola Viviani Ernesto Guiraldes Julia M. Schmitz Robin G. Lorenz Lea Novak Lesley E. Smythies Phillip D. Smith | 2008 | Gastroenterology2008，，2： | 1 |
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