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| 1 | Role of melatonin on diabetes-related metabolic disorders显示文摘Melatonin is a circulating hormone that is mainly re- leased from the pineal gland. It is best known as a regulator of seasonal and circadian rhythms, its levels being high during the night and low during the day. Interestingly, insulin levels are also adapted to day/night changes through melatonin-dependent synchronization. This regulation may be explained by the inhibiting action of melatonin on insulin release, which is transmitted through both the pertussis-toxin-sensitive membrane receptors MT1 and MT2 and the second messengers 3',5' -cyclic adenosine monophosphate, 3',5'-cyclic guanosine monophosphate and inositol 1,4,5-trisphosphate. Melatonin may influence diabetes and associated metabolic disturbances not only by regulating insulin secretion, but also by providing protection against reactive oxygen species, since pancreatic β-cells are very susceptible to oxidative stress because they possess only low-antioxidative capacity. On the other hand, in several genetic association studies, single nucleotide polymorphysms of the human MT2 receptor have been described as being causally linked to an elevated risk of developing type 2 diabetes. This suggests that these individuals maybe more sensitive to the actions of melatonin, thereby leading to impaired insulin secretion. Therefore, block- ing the melatonin-induced inhibition of insulin secretion may be a novel therapeutic avenue for type 2 diabetes. | Javier Espino José A Pariente Ana B Rodríguez | 2011 | World Journal of Diabetes2011，2，6： | 11 |
| 2 | Age at Onset Should Be a Major Criterion for Subclassification of Colorectal Cancer显示文摘 | José Perea Daniel Rueda Alicia Canal Yolanda Rodríguez Edurne álvaro Irene Osorio Cristina Alegre Bárbara Rivera Joaquín Martínez Javier Benítez Miguel Urioste | 2014 | The Journal of Molecular Diagnostics2014，，1： | 2 |
| 3 | Induction of monocyte chemoattractant protein-1 and interleukin-10 by TGFbl in melanoma enhances tumor infiltration and immunosuppression显示文摘 | Nacy DV Maria B Javier D etal | 2011 | CanerRes2011，71，3： | 1 |
| 4 | Human neural stem cell in vitro, A focus on their isolation and perpetuation 显示文摘 | Villa F Javier Rubio B Navarro C | 2001 | Bio Med Pharmacother2001，55，： | 1 |
| 5 | Management and outcomes of hetero- taxy syndrome associated with pulmonary atresia or pulmonary stenosis 显示文摘 | Vinod AS Javier B Raghav M | 2014 | AnnThnracSurg2014，98，6： | 1 |
| 6 | Tourist image, eval- uation variables and after purchase behavior: Inter-relationship显示文摘 | J Enrique B M Isabel Sanchez Javier Sanchez | 2001 | Tourism Management2001，22，3： | 1 |
| 7 | The molecular pathology of hereditary breast cancer:generic testing and therapeutic implications显示文摘 | Javier B Jos P | 2005 | Modern Pathology2005，18，： | 1 |
| 8 | Non-linear deeay of building stones during freeze-thaw weathering processes 显示文摘 | Javier M M David B Miguel G H | 2013 | Con- struction and Building Materials2013，38，： | 1 |
| 9 | Cloning, expression, and characterization ofavian reovirus guanylytransferase显示文摘 | Joseph H Jose M C Javier B | 2002 | Virology2002，296，2： | 1 |
| 10 | Applications of flow cytometry to clinical microbiology 显示文摘 | Alberto A B Javier A Rafael C | 2000 | Clin Microbiol Rev2000，13，2： | 1 |
| 11 | Decompressive craniectomy after middle cerebral artery infarction显示文摘 | Javier F Emanuela K Alain B | 2004 | Swiss Med Wkly2004，134，： | 1 |
| 12 | Some characteristic and non - characteristic properties of inner product spaces 显示文摘 | JAVIER A CARLOS B | 1988 | Journal of Approximation Theory1988，55，3： | 1 |
| 13 | Sorption of As, Cd and Tl as influenced by industrial by-products applied to an acidic soil : equilibrium and kinetic experiments 显示文摘 | JAVIER A C FERMANDO G LAURA B | 2006 | Chemosphere2006，65，11： | 1 |
| 14 | An economic assessment of proteins recovery from fish meal effluents by uhrafiltration显示文摘 | Marai D A Javier F Rodrigo B | 2004 | Trends in Food Science & Technology2004，15，10： | 1 |
| 15 | Wastewater recycling: Application of ozone based treatment to secondary effluents显示文摘 | Javier R Olga G Femando B | 2009 | Chemosphere2009，74，： | 1 |
| 16 | Fecal calprotectin and lactoferrin for the prediction of inflammatory bowel disease relapse显示文摘 | Javier PG Fernando B Adirian GM | | 0，，08： | 1 |
| 17 | Materials, operational energy inputs, and net energy ratio for photobiological hydrogen production 显示文摘 | GREG B JAVIER G F | 2007 | International Journal of Hydrogen Energy2007，32，9： | 1 |
| 18 | Thermal analysis and measurement of a solar pond prototype to study the non- convective zone salt gradient stability 显示文摘 | Enrique B Vinod K Javier M | 2012 | Solar Energy2012，86，5： | 1 |
| 19 | Role of different routes of tracheal colonization in the development of pneumonia in patients receiving mechanical ventilation显示文摘 | Border B Javier NC | 1999 | Chest1999，116，： | 1 |
| 20 | Common radio resource management algorithms for multimedia heterogeneous wireless networks显示文摘 | Miguel L B and Javier G | 2011 | IEEE Transactions on Mobile Computing2011，10，9： | 1 |
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