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| 1 | Tumor Antigen Specific Activation of Primary Human T-Cells Expressing a Virally Encoded Chimeric T-Cell Receptor Specific for p185HER2显示文摘We have developed and tested chimeric T-cell receptors (TCR) specific for p185HER2. In these experiments, retroviral vectors expressing the N29γ or N29ζ receptors were constructed in pRET6. Amphotropic viral producer cells were established in the GALV-based PG13 packaging cell line. Ficoll purified human peripheral blood lymphocytes (PBL) were virally transduced using an optimized protocol incorporating activation with immobilized anti-CD3/anti-CD28 monoclonal anti- bodies, followed by viral infection in the presence of fibronectin fragment CH296. Transduced cells were co-cultured with human tumor cell lines that overexpress (SK-OV-3) or underexpress (MCF7) p185HER2 to assay for antigen specific im- mune responses. Both CM+ and CD8+ T-cells transduced with the N29γ or N29ζ chTCR demonstrated HER2-specific anti- gen responses, as determined by release of Th1 like cytokines, and cellular cytotoxicity assays. Our results support the fea- sibility of adoptive immunotherapy with genetically modified T-cells expressing a chTCR specific for p185HER2. | 杨建民 Michael S FRIEDMAN Christopher M REYNOLDS Marianne T HUBEN Lee WILKE Jennifer FULLER 李桥 Zelig ESHHAR James J MULE Kevin T MCDONAGH | 2004 | Journal of Microbiology and Immunology2004，2，4： | 5 |
| 2 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 3 | Economic Assessment and Review of Waterless Fracturing Technologies in Shale Resource Development: A Case Study显示文摘Our database tracking of USA water usage per well indicates that traditionally shale operators have been using, on average 3 to 6 million gallons of water; even up to 8 million for the entire life cycle of the well based on its suitability for re-fracturing to stimulate their long and lateral horizontal wells. According to our data, sourcing, storage, transportation, treatment, and disposal of this large volume of water could account for up to 10% of overall drilling and completion costs. With increasingly stringent regulations governing the use of fresh water and growing challenges associated with storage and use of produced and flowback water in hydraulic fracturing, finding alternative sources of fracturing fluid is already a hot debate among both the scientific community and industry experts. On the other hand, waterless fracturing technology providers claim their technology can solve the concerns of water availability for shale development. This study reviews high-level technical issues and opportunities in this challenging and growing market and evaluates key economic drivers behind water management practices such as waterless fracturing technologies, based on a given shale gas play in the United States and experience gained in Canada. Water costs are analyzed under a variety of scenarios with and without the use of(fresh) water. The results are complemented by surveys from several oil and gas operators. Our economic analysis shows that fresh water usage offers the greatest economic return. In regions where water sourcing is a challenge, however, the short-term economic advantage of using non-fresh water-based fracturing outweighs the capital costs required by waterless fracturing methods. Until waterless methods are cost competitive, recycled water usage with low treatment offers a similar net present value(NPV) to that of sourcing freshwater via truck, for instance. | Iman Oraki Kohshou Reza Barati Meaghan Cassey Yorro Tim Leshchyshyn Adebola T. Adejumo Usman Ahmed Imre Kugler Murray Reynolds James McAndrew | 2017 | Journal of Earth Science2017，28，5： | 2 |
| 4 | Suspension microarray with deudrimer signal amplification allows direct and high-throuhput subtyping of Listeria monocytogenes from genomic DNA显示文摘 | MONICA K BORUCKI JAMES REYNOLDS DOUGLAS R Call | 2005 | J Clin Microbiol2005，43，7： | 1 |
| 5 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 6 | Association between medical injections and HIV infection in a community-based study in India显示文摘 | Marissa L Becker Sushena Reza-Paul BM Ramesh Reynold Washington Stephen Moses James F Blanchard | 2005 | AIDS2005，，12： | 1 |
| 7 | Cultured endometrial cancer cells exhibit autocrine growth factor stimulation that is not observed in cultured normal endometrial cells显示文摘 | Catherine A Owens James A | 1996 | Gynecol1996，60，： | 1 |
| 8 | Modifying the ‘pulse–reserve’ paradigm for deserts of North America: precipitation pulses, soil water, and plant responses显示文摘 | James F. Reynolds Paul R. Kemp Kiona Ogle Roberto J. Fernández | 2004 | Oecologia2004，，2： | 1 |
| 9 | Influence of the duration of a treadmill walking bout on heart rate variabili- ty at rest in physically active women 显示文摘 | James D V Reynolds L J Maldonado - Martin S | 2010 | J Phys Act Health2010，7，1： | 1 |
| 10 | Sequential Exposure to Carbon Nanotubes and Bacteria Enhances Pulmonary Inflammation and Infectivity显示文摘 | Shvedova Anna A Fabisiak James P Kisin Elena R Murray Ashley R Roberts Jenny R Tyurina Yulia Y Antonini James M Feng Wei Hong Kommineni Choudari Reynolds Jeffrey Barchowsky Aaron Castranova Vince Kagan Valerian E | 2008 | American Journal of Respiratory Cell and Molecular Biology2008，，5： | 1 |
| 11 | IL-12 enhances vaccine-induced immunity to Schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite显示文摘 | Reynolds A James S | 1996 | J Immunol1996，157，40： | 1 |
| 12 | A new contagion index to quantify spatial patterns of landscapes显示文摘 | Habin Li James F. Reynolds | 1993 | Landscape Ecology1993，，3： | 1 |
| 13 | Magnetic resonance imaging-guided biopsy of mammographically and clinically occult breast lesions显示文摘 | Isabelle Bedrosian MD James Schlencker MD Francis R. Spitz MD Susan G. Orel MD Douglas L. Fraker MD Linda S. Callans MD Mitchell Schnall MD PhD Carol Reynolds MD Brian J. Czerniecki MD PhD | 2002 | Annals of Surgical Oncology2002，，5： | 1 |
| 14 | Membrane-Based Wet Electrostatic Precipitation显示文摘 | DavidJ. Bayless Liming Shi Gregory Kremer BenJ. Stuart James Reynolds John Caine | 2005 | Journal of the Air & Waste Management Association2005，，6： | 1 |
| 15 | Earthworms modify plant biomass and nitrogen capture under conditions of soil nutrient heterogeneity and elevated atmospheric CO 2 concentrations显示文摘 | Pablo García-Palacios Fernando T. Maestre Mark A. Bradford James F. Reynolds | 2014 | Soil Biology and Biochemistry2014，，： | 1 |
| 16 | Effects of endothelin-1 on K+ current from rat ventricular myocytes显示文摘 | James AF Ramesey JE Reynolds AM | 2001 | Biochem Biophys Res Commun2001，284，： | 1 |
| 17 | Mercury removal via wet ESP 显示文摘 | James Reynolds | | Power0，148，8： | 1 |
| 18 | Mechanisms of Myocardial Infarction in Women Without Angiographically Obstructive Coronary Artery Disease显示文摘 | Harmony R. Reynolds Monvadi B. Srichai Sohah N. Iqbal James N. Slater G.B. John Mancini Frederick Feit Ivan Pena-Sing Leon Axel Michael J. Attubato Leonid Yatskar Rebecca T. Kalhorn David A. Wood Iryna V. Lobach Judith S. Hochman | 2011 | Circulation2011，，13： | 1 |
| 19 | Titanium Elastic Nails for Pediatric Femur Fractures: A Multicenter Study of Early Results with Analysis of Complications显示文摘 | John M. Flynn Timothy Hresko Richard A. K. Reynolds R. Dale Blasier Richard Davidson James Kasser | 2001 | Journal of Pediatric Orthopaedics2001，，1： | 1 |
| 20 | pathophysiology of heart failure显示文摘 | Reynolds M Delgado Ⅲ James T | 1999 | Texas heart institute Journal1999，26，1： | 1 |
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