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| 1 | Magnetic Helical Micro-and Nanorobots:Toward Their Biomedical Applications显示文摘Magnetic helical micro- and nanorobots can perfo rm 3D navigation in various liquids with a sub-micrometer precision under low-strength rotating magnetic fields(< 10 m T). Since magnetic fields with low strengths are harmless to cells and tissues, magnetic helical micro/nanorobots are promising tools for biomedical applications, such as minimally invasive surgery, cell manipulation and analysis, and targeted therapy. This review provides general information on magnetic helical micro/nanorobots, including their fabrication, motion control, and further functionalization for biomedical applications. | Famin Qiu Bradley J.Nelson | 2015 | Engineering2015，1，1： | 9 |
| 2 | 致病疫霉线粒体DNA单倍型的分子鉴别显示文摘 | 赵志坚 李先平 李成云 隋启君 Rebecca J.Nelson J.Soledad Gamboa | 2002 | 云南农业大学学报2002，17，4： | 6 |
| 3 | Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer显示文摘Enolase 2(ENO2)is a key glycolytic enzyme in the metabolic process of glycolysis,but its potential function in pancreatic ductal adenocarcinoma(PDAC)is unclear.In this study,we observed a significant overexpression of ENO2 in PDAC tissues,and its expression was correlated with metastasis and poor prognosis in PDAC patients.K394 was identified as a major acetylation site in ENO2 that regulates its enzymatic activity,cell metabolism and PDAC progression.Knockdown of ENO2 suppressed tumor growth and liver metastasis in PDAC.Re-expression of wild-type(WT)ENO2,but not the K394 acetylation mimetic mutant,could reverse the decreased tumor malignancy.We further characterized histone deacetylase 3(HDAC3)and P300/CBP-associated factor(PCAF)as the potential deacetylase and acetyltransferase for ENO2,respectively.HDAC3-mediated deacetylation was shown to lead to ENO2 activation and enhancement of glycolysis.Importantly,insulin-like growth factor-1(IGF-1)was found to decrease K394 acetylation and stimulate ENO2 activity in a dose-and time-dependent manner.The PI3K/AKT/mTOR pathway facilitated the phosphorylation of HDAC3 on S424,which promoted K394 deacetylation and activation of ENO2.Linsitinib,an oral small-molecule inhibitor of IGF-1R,could inhibit IGF-1-induced ENO2 deacetylation by HDAC3 and the PI3K/AKT/mTOR pathway.Furthermore,linsitinib showed a different effect on the growth and metastasis of PDAC depending on the overexpression of WT versus K394-mutant ENO2.Our results reveal a novel mechanism by which acetylation negatively regulates ENO2 activity in the metastasis of PDAC by modulating glycolysis.Blockade of IGF-1-induced ENO2 deacetylation represents a promising strategy to prevent the development of PDAC. | Yan Zheng Chao Wu Jimeng Yang Yue Zhao Huliang Jia Min Xue Da Xu Feng Yang Deliang Fu Chaoqun Wang Beiyuan Hu Ze Zhang Tianen Li Shican Yan Xuan Wang Peter J.Nelson Christiane Bruns Lunxiu Qin Qiongzhu Dong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 4 | Catholic Bioethics and the Case of Terri Schiavo显示文摘 | Leonard J.Nelson Ⅲ | | 0，，35： | 1 |
| 5 | Combined magnetic resonance imaging and spectroscopic imaging approach to molecular imaging of prostate cancer显示文摘 | JohnKurhanewicz Mark G.Swanson Sarah J.Nelson Daniel B.Vigneron | 2002 | J Magn Reson Imaging2002，，4： | 1 |
| 6 | Functional connectivity from area 5 to primary motor cortex via paired-pulse transcranial magnetic stimulation显示文摘 | Angela Ziluk Azra Premji Aimee J.Nelson | | 0，，： | 1 |
| 7 | Investigation of Tumor Hyperpolarized [1-13C]-Pyruvate Dynamics U- sing Time-Resolved Multiband RF Excitation Echo-Planar MRSI显示文摘 | Peder E.Z.Larson Robert Bok Adam B.Kerr Michael Lustig Simon Hu Albert P.Chen Sarah J.Nelson John M.Pauly John Kurhanewicz Daniel B.Vigneron | | 0，，06： | 1 |
| 8 | 微创技术国外新进展显示文摘微型机器人在微创医学中的应用【据Annual Review of Biomedical Engineering 2010年4月报道】题:Microrobots for minimally invasive medicine(作者:Bradley J.Nelson等)微型机器人的广泛应用将改变医学领域的方方面面。在过去的十年里,微型机器人实现了两个特别重要的进步:达芬奇机器人微创手术的施行和胶囊内镜机器人的广泛应用(图1)。 | Bradley J.Nelson 张晓辉(译) 王锦波(校) | 2015 | 中华灾害救援医学2015，3，8： | 1 |
| 9 | The Beloved Beverly Cleary The revered author who gave children a reason to read显示文摘With witty yet economic prose and a gift for recalling the inner emotions of childhood,Beverly Cleary wove timeless tales that took young readers back to the Portland,Oregon,of her youth.Her stories served as a collective touchstone for the childhoods of many baby boomers,and succeeding generations,who saw themselves in the pages of her work.Cleary died[earlier this year]in Carmel,California,where she had lived since the 1960s.She was 104. | Valerie J.Nelson | 2021 | 空中英语教室(高级版.彭蒙惠英语)2021，，9： | 0 |
| 10 | 向非营利组织学到什么?显示文摘哪项工作更具挑战:管理非营利组织还是管理企业?在回答之前,先回想一下过去十年来管理文献的某些重要议题。比如:满足多个利益相关群体需要;制定监测企业健康度的非财务指标;理解愿景的重要性;组建热忱投入的员工队伍;普及专业技能;在不确定条件下实施管理。非营利组织的管理者可能不习惯使用上述语言, | Stephen J.Nelson 连青松 | 2006 | 经理人2006，，3： | 0 |
| 11 | Crystalline compounds for remediation of rare-earth fission products:A review显示文摘Rare earth(RE)-containing crystals have been investigated as media for the immobilization of RE fission products from nuclear waste streams.During reprocessing of spent nuclear fuel,fission products including REs,alkalis,and alkaline earths released from the fuel.One viable option to immobilize the RE fission products is to incorporate them into chemically durable crystalline phases in specific waste forms.This study summarizes the crystal structures and synthesis methods of six RE-containing compounds that have applications in remediation of RE fission products.These compounds include oxyapatite(AE_(2)RE_(8)(SiO_(4))_(6)O_(2)),oxychloride(REOCl),borosilicate(RE_(3)BSi_(2)O_(10)),pyrochlore(RE_(2)M_(2)O_(7)),monazite(REPO_(4)),and perovskite(REMO_(3))where AE denotes alkaline earth metals and M denotes transition metals.This review provides an overview of literature on the usage of these six compounds for immobilizing RE fission products and summarizes different synthesis methods for producing these compounds.Comparisons of structural parameters with different REs in each compound are also discussed. | Saehwa Chong Brian J.Riley Zayne J.Nelson | 2022 | Journal of Rare Earths2022，40，3： | 0 |
| 12 | Recent Developments in Metallic Degradable Micromotors for Biomedical and Environmental Remediation Applications显示文摘Synthetic micromotor has gained substantial attention in biomedicine and environmental remediation.Metal-based degradable micromotor composed of magnesium(Mg),zinc(Zn),and iron(Fe)have promise due to their nontoxic fuel-free propulsion,favorable biocompatibility,and safe excretion of degradation products Recent advances in degradable metallic micromotor have shown their fast movement in complex biological media,efficient cargo delivery and favorable biocompatibility.A noteworthy number of degradable metal-based micromotors employ bubble propulsion,utilizing water as fuel to generate hydrogen bubbles.This novel feature has projected degradable metallic micromotors for active in vivo drug delivery applications.In addition,understanding the degradation mechanism of these micromotors is also a key parameter for their design and performance.Its propulsion efficiency and life span govern the overall performance of a degradable metallic micromotor.Here we review the design and recent advancements of metallic degradable micromotors.Furthermore,we describe the controlled degradation,efficient in vivo drug delivery,and built-in acid neutralization capabilities of degradable micromotors with versatile biomedical applications.Moreover,we discuss micromotors’efficacy in detecting and destroying environmental pollutants.Finally,we address the limitations and future research directions of degradable metallic micromotors. | Sourav Dutta Seungmin Noh Roger Sanchis Gual Xiangzhong Chen Salvador Pané Bradley J.Nelson Hongsoo Choi | 2024 | Nano-Micro Letters2024，16，3： | 0 |
| 13 | Force microscopy of the Caenorhabditis elegans embryonic eggshell显示文摘Assays focusing on emerging biological phenomena in an animal’s life can be performed during embryogenesis.While the embryo of Caenorhabditis elegans has been extensively studied,its biomechanical properties are largely unknown.Here,we demonstrate that cellular force microscopy(CFM),a recently developed technique that combines micro-indentation with high resolution force sensing approaching that of atomic force microscopy,can be successfully applied to C.elegans embryos.We performed,for the first time,a quantitative study of the mechanical properties of the eggshell of living C.elegans embryos and demonstrate the capability of the system to detect alterations of its mechanical parameters and shell defects upon chemical treatments.In addition to investigating natural eggshells,we applied different eggshell treatments,i.e.,exposure to sodium hypochlorite and chitinase solutions,respectively,that selectively modified the multilayer eggshell structure,in order to evaluate the impact of the different layers on the mechanical integrity of the embryo.Finite element method simulations based on a simple embryo model were used to extract characteristic eggshell parameters from the experimental micro-indentation force-displacement curves.We found a strong correlation between the severity of the chemical treatment and the rigidity of the shell.Furthermore,our results showed,in contrast to previous assumptions,that short bleach treatments not only selectively remove the outermost vitelline layer of the eggshell,but also significantly degenerate the underlying chitin layer,which is primarily responsible for the mechanical stability of the egg. | Roger Krenger Jan T.Burri Thomas Lehnert Bradley J.Nelson Martin A.M.Gijs | 2020 | Microsystems & Nanoengineering2020，6，1： | 0 |
| 14 | Distance assessment of detours by jum ping spiders显示文摘To take an indirect route(detour)in order to reach a specific target requires complex cognitive processes.Yet more demanding,from the cognitive point of view,is when the goal is only visible at the beginning of the detour.In spiders from the family Sa lticidae,vision is a key sensory modal-ity mediating navigation and prey search.Their acute vision allows them to perform complicated detours,possibly as a consequence of the multitude of potential routes in their typically complex 3-dimensional habitats.We used a 4-route choice test,in which routes differed in being either short or long and in the presence or absence of a lure of a prey item,to investigate route assessment in 2 salticid species,Trite planiceps and Marpissa marina.Although both species showed evidence of motivation to follow lured-routes,judging by the number of times they re-oriented toward them while detouring,we found that Trite chose short routes in preference to long routes,but did not prefer the lured-routes.In contrast,Marpissa exhibited random route choice,although it ori-ented toward lured-routes more often than control routes(lure absent).Our results suggest that decision-making processes about which route to take occurs before embarking on a route,but this is cognitively challenging.Spiders exhibited cognitive limitations in which the lack of visibility of the goal affected success.However,the severity of cognitive limitations depended on species.We suggest that variability in spatial ability across the Salticidae may be related to the habitat complexity inhabited by each species. | Samuel AGUILAR-ARGUELLO Daniel GERHARD Ximena J.NELSON | 2020 | Current Zoology2020，66，3： | 0 |
| 15 | 布鲁斯·威利斯对抗失语症显示文摘罹患失语症被描述为就像住在一个讲陌生语言的国度里。“你了解眼前的情况。你也是原来的你——但别人不知道,”加拿大麦克马斯特大学语言病理学与神经科学教授琳恩·特克斯特拉说,“突然间,你没办法像过去那样表达自己的想法与感受,如果这种情况是渐进式的,那么你就会感觉到自己的表达能力在慢慢消失。” | Laura J.Nelson Thomas Curwen Emily Baumgaertner 陈信宏(译) | 2022 | 空中英语教室(高级版.彭蒙惠英语)2022，，10： | 0 |
| 16 | 旗舰之王——试驾铃木Boulevard M109R显示文摘它是铃木“林荫大道”(Boulevard)车系的旗舰产品.作为最新款的V形双缸巡航车,M109R的出现给市场带来了足够的震憾,有必要再次强调,对于制造商来说排量不是问题,火力越大当然是越显威猛。但是,铃木并没有陷入简单追求更大排量的思路中去,除了采用全新的命名方式外(用立方英寸来表示发动机排量),铃木更是将重点转向了工艺和效率。 | Art Friedman Tom Riles(摄影) Brian J.Nelson(摄影) 别嘉(编译) | 2006 | 摩托车趋势2006，，11： | 0 |
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