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| 1 | NK细胞用于肿瘤免疫治疗的研究进展显示文摘 | 田志刚 孙汭 William J.Murphy | 2001 | 中华微生物学和免疫学杂志2001，21，2： | 9 |
| 2 | Natural Killer Cells:Biology and Clinical Use in Cancer Therapy显示文摘Natural killer (NK) cells have the ability to mediate both bone marrow rejection and promote engraftment, as well as the ability to elicit potent anti-tumor effects. However the clinical results for these processes are still elusive. Greater understanding of NK cell biology, from activating and inhibitory receptor functions to the role of NK cells in allogeneic transplantation, needs to be appreciated in order to draw out the clinical potential of NK cells. Mechanisms of bone marrow cell (BMC) rejection are known to be dependant on inhibitory receptors specific for major histocompatibility complex (MHC) molecules and on activating receptors that have many potential ligands. The modulation of activating and inhibitory receptors may hold the key to clinical success involving NK cells. Pre-clinical studies in mice have shown that different combinations of activating and inhibitory receptors on NK cells can reduce graft-versus-host disease (GVHD), promote engraftment, and provide superior graft-versus-tumor (GVT) responses. Recent clinical data have shown that the use of KIR-ligand incompatibility produces tremendous graft-versus-leukemia effect in patients with acute myeloid leukemia at high risk of relapse. This review will attempt to be a synthesis of current knowledge concerning NK cells, their involvement in BMT, and their use as an immunotherapy for cancer and other hematologic malignancies. Cellular & Molecular Immunology. 2004;1(1):12-21. | William H.D.Hallett William J.Murphy | 2004 | Cellular & Molecular Immunology2004，1，1： | 4 |
| 3 | 在小鼠骨髓移植中CCR5与急性移植物抗宿主病的相关性研究(英文)显示文摘本研究评价供者CCR5在经过强化预处理的骨髓移植动物模型受者体内的作用,为今后的异基因造血干细胞移植的临床应用提供科学依据。经过致死剂量照射的BALB/c小鼠接受异基因C57BL/6小鼠的骨髓移植。根据回输的细胞不同实验分为4组:B6CCR5KO组,受者接受C57BL/6CCR5-/-小鼠骨髓和脾脏细胞;B6WT组,受者接受野生型C57BL/6小鼠骨髓和脾脏细胞;B6CCR5KOBMC组,受者只接受C57BL/6CCR5-/-小鼠骨髓细胞;B6WTBMC组,受者只接受野生型C57BL/6小鼠骨髓细胞。结果表明:较之B6WT组,B6CCR5KO组小鼠以更快的速度死于急性GVHD;其受者体内的CD8+T细胞更大量的增殖;其T细胞恢复后产生更多的INF-γ和TNF-α并且由于其T细胞有丝分裂原刀豆素水平处于较高水平,从而进一步促进T细胞的增殖,提示CCR5的作用之一是下调参与排异反应的供者CD8+T细胞的增殖。组织学评价提示,移植剔除CCR5基因受者细胞的小鼠肾脏出现了病理损伤并且肝脏存在有更为严重的病理变化。结论:剔除CCR5基因的异基因骨髓移植使GVHD发病率的增加,供者CD8+T细胞在受者体内增殖增加以及肝肾损害加重,这提示CCR5在异基因骨髓移植中起着重要作用。 | 王昭 William J.Murphy | 2006 | 中国实验血液学杂志2006，14，5： | 2 |
| 4 | The Prince and the Pauper? CEO Pay in the United States and United Kingdom显示文摘 | Martin J.Conyon Kevin J.Murphy | | 0，，467： | 1 |
| 5 | Generation of Transgene‐Free Lung Disease‐Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette显示文摘 | AbaSomers Jyh‐ChangJean Cesar A.Sommer AmelOmari Christopher C.Ford Jason A.Mills LeiYing Andreia GianottiSommer Jenny M.Jean Brenden W.Smith RobertLafyatis Marie‐FranceDemierre Daniel J.Weiss Deborah L.French PaulGadue George J.Murphy GustavoMostoslavsky | 2010 | STEM CELLS2010，，10： | 1 |
| 6 | Performance Pay and Top-managernent Incentives显示文摘 | Jensen Michael Kevin J.Murphy | | 0，，： | 1 |
| 7 | Excision of Reprogramming Transgenes Improves the Differentiation Potential of iPS Cells Generated with a Single Excisable Vector显示文摘 | Cesar A.Sommer Andreia GianottiSommer Tyler A.Longmire ConstantinaChristodoulou Dolly D.Thomas MonicaGostissa Fred W.Alt George J.Murphy Darrell N.Kotton GustavoMostoslavsky | 2010 | STEM CELLS2010，，1： | 1 |
| 8 | Top Executives Are Worth Every Nickel They Get显示文摘 | Kevin J.Murphy | | 0，，3： | 1 |
| 9 | Canagliflozin improves glycaemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin显示文摘 | D.Devineni L.Morrow M.Hompesch D.Skee A.Vandebosch J.Murphy K.Ways S.Schwartz | 2012 | Diabetes Obesity and Metabolism2012，，6： | 1 |
| 10 | Performance Pay and Top-Management Incentives显示文摘 | Michael C.Jensen Kevin J.Murphy | | 0，，02： | 1 |
| 11 | A near infrared spectroscopy calibration for the prediction of fresh grass quality on Irish pastures显示文摘The aim of this study was to develop near infrared spectroscopy(NIRS)calibrations to predict quality parameters,dry matter(DM,g kg1)and crude protein(CP,g kg1 DM),in fresh un-dried grass.Knowledge of these parameters would enable more precise allocation of quality herbage to grazing livestock.Perennial ryegrass samples(n=1615)were collected over the 2017 and 2018 grazing seasons at Teagasc Moorepark to develop a NIRS calibration dataset.Additional samples were collected for an independent validation dataset(n=197)during the 2019 grazing season.Samples were scanned using a FOSS 6500 spectrometer at 2 nm intervals in the range of 1100~2500 nm and absorption was recorded as log 1/Reflectance.Reference wet chemistry analysis was carried out for both parameters and the resultant data were calibrated against spectral data by means of modified partial least squares regression.A range of mathematical spectral treatments were examined for each calibration,which were ranked in order of standard error of prediction(SEP)and ratio of percent deviation(RPD).Best performing calibrations achieved high predictive precision for DM(R2=0.86 SEP=9.46 g kg1,RPD=2.60)and moderate precision for CP(R2=0.84 SEP=20.38 g kg1 DM,RPD=2.37).These calibrations will aid the optimisation of grassland management and the development of precision agricultural technologies. | Darren J.Murphy Bernadette O’Brien Michael O’Donovan Tomas Condon Michael D.Murphy | 2022 | Information Processing in Agriculture2022，9，2： | 1 |
| 12 | Corporate Performance an Managerial Remuneration:An Empirical Analvsis显示文摘 | Kevln J.Murphy | | 0，，： | 1 |
| 13 | Double balloon enteroscopy in Crohn’s disease: Where are we now and where should we go?显示文摘 | Seamus J.Murphy AsherKornbluth | 2010 | Inflamm Bowel Dis2010，，1： | 1 |
| 14 | 创业洞察力、技术创新与新产品开发显示文摘洞察力是机会识别的关键前提,但由于理论模糊不清,定义差别较大,使得洞察力模型不够成熟。本文从积累、转化与选择商机信息的视角来重新定义洞察力概念,假设洞察力产生于创新之前,而创新是引起企业内新产品和服务开发的中介变量。经验研究中,我们在两个具有不同文化背景的国家收集数据,分层回归分析结果支持了我们的假设。本文的主要贡献在于界定和测量了创业理论中的洞察力概念,并讨论了技术创新在创业洞察力和新产品与服务中的中介作用。 | 朱仁宏 唐津彤 Patrick J.Murphy | 2009 | 当代财经2009，，3： | 0 |
| 15 | Unsupervised ore/waste classification on open-cut mine faces using close-range hyperspectral data显示文摘The remote mapping of minerals and discrimination of ore and waste on surfaces are important tasks for geological applications such as those in mining.Such tasks have become possible using ground-based,close-range hyperspectral sensors which can remotely measure the reflectance properties of the environ-ment with high spatial and spectral resolution.However,autonomous mapping of mineral spectra mea-sured on an open-cut mine face remains a challenging problem due to the subtleness of differences in spectral absorption features between mineral and rock classes as well as variability in the illumination of the scene.An additional layer of difficulty arises when there is no annotated data available to train a supervised learning algorithm.A pipeline for unsupervised mapping of spectra on a mine face is pro-posed which draws from several recent advances in the hyperspectral machine learning literature.The proposed pipeline brings together unsupervised and self-supervised algorithms in a unified system to map minerals on a mine face without the need for human-annotated training data.The pipeline is eval-uated with a hyperspectral image dataset of an open-cut mine face comprising mineral ore martite and non-mineralised shale.The combined system is shown to produce a superior map to its constituent algo-rithms,and the consistency of its mapping capability is demonstrated using data acquired at two differ-ent times of day. | Lloyd Windrim Arman Melkumyan Richard J.Murphy Anna Chlingaryan Raymond Leung | 2023 | Geoscience Frontiers2023，14，4： | 0 |
| 16 | Whole-genome sequences shed light on the demographic history and contemporary genetic erosion of free-ranging jaguar(Panthera onca) populations显示文摘Whole-genome sequences provide massive amounts of data that can illuminate many aspects of a species’biology and evolutionary history,as well as valuable information for conservation planning.This is particularly important for large carnivores,whose large area requirements and typical low densities make them prone to undergo rapid genetic erosion(e.g.accumulation of runs of homozygosity,Diez del Molino et al.,2018;Leroy et al.,2018)in the face of habitat loss and human persecution.One such species is the jaguar(Pan-thera onca),the largest extant felid in the Americas,whose range has already declined by>50%and some of whose remaining popu-lations have been severely impacted by human-induced habitat frag-mentation(De La Torre et al.,2018). | Gustavo P.Lorenzana Henrique V.Figueirò Jeremy Johnson Elinor Karlsson Ronaldo G.Morato Dênis A.Sana Laury Cullen Joares A.May Jr. Edsel A.Moraes Jr. Daniel L.Z.Kantek Leandro Silveira William J.Murphy Oliver A.Ryder Eduardo Eizirik | 2022 | Journal of Genetics and Genomics2022，49，1： | 0 |
| 17 | 3种僵硬度评估方法的效度与信度(英文)显示文摘背景:通常根据运动损伤和运动表现来评估僵硬度。本研究旨在通过分析1组受试者的数据,比较3种僵硬度评估方法的效度和信度。方法:为确定日间信度,15名女子篮网球运动员在1周内完成2次僵硬度评估。内容包括单侧跳跃(垂直僵硬度测试)、腓肠自由振荡以及组成腓肠三头肌几块肌肉的压力测定。为建立聚合建构效度将僵硬度与静态及动态力量测试相比较。结果:僵硬度重复测试结果表明,垂直僵硬度可达到中到高度信度,肌压力测定的信度可达到中到很高程度。与此相反,自由振荡技术的信度为低到中度。蹲跳期间垂直僵硬度与发力速度显著相关,同时下肢三处的肌力测定的僵硬度与等距力量速率也显著相关。此外,偏心利用率与肌力计测量的各种僵硬度结果间呈显著负相关。自由振荡技术与各种性能测量结果之间无相关关系。结论:垂直僵硬度和肌力计测量是有效、可信的刚度评估方法。 | Elizabeth C.Pruyn Mark L.Watsford Aron J.Murphy | 2016 | Journal of Sport and Health Science2016，5，4： | 0 |
| 18 | Retinoic acid signaling acts as a rheostat to balance Treg function显示文摘Regulatory T cells(Tregs)promote immune homeostasis by maintaining self-tolerance and regulating inflammatory responses.Under certain inflammatory conditions,Tregs can lose their lineage stability and function.Previous studies have reported that ex vivo exposure to retinoic acid(RA)enhances Treg function and stability.However,it is unknown how RA receptor signaling in Tregs influences these processes in vivo.Herein,we employed mouse models in which RA signaling is silenced by the expression of the dominant negative receptor(DN)RARαin all T cells.Despite the fact that DNRARαconventional T cells are hypofunctional,Tregs had increased CD25 expression,STAT5 pathway activation,mTORC1 signaling and supersuppressor function.Furthermore,DNRARαTregs had increased inhibitory molecule expression,amino acid transporter expression,and metabolic fitness and decreased antiapoptotic proteins.Supersuppressor function was observed when wild-type mice were treated with a pharmacologic pan-RAR antagonist.Unexpectedly,Treg-specific expression of DNRARαresulted in distinct phenotypes,such that a single allele of DNRARαin Tregs heightened their suppressive function,and biallelic expression led to loss of suppression and autoimmunity.The loss of Treg function was not cell intrinsic,as Tregs that developed in a noninflammatory milieu in chimeric mice reconstituted with DNRARαand wild-type bone marrow maintained the enhanced suppressive capacity.Fate mapping suggested that maintaining Treg stability in an inflammatory milieu requires RA signaling.Our findings indicate that RA signaling acts as a rheostat to balance Treg function in inflammatory and noninflammatory conditions in a dose-dependent manner. | Govindarajan Thangavelu Gabriela Andrejeva Sara Bolivar-Wagers Sujeong Jin Michael C.Zaiken Michael Loschi Ethan G.Aguilar Scott N.Furlan Chrysothemis C.Brown Yu-Chi Lee Cameron McDonald Hyman Colby J.Feser Angela Panoskaltsis-Mortari Keli L.Hippen Kelli P.MacDonald William J.Murphy Ivan Maillard Geoffrey R.Hill David H.Munn Robert Zeiser Leslie S.Kean Jeffrey C.Rathmell Hongbo Chi Randolph J.Noelle Bruce R.Blazar | 2022 | Cellular & Molecular Immunology2022，19，7： | 0 |
| 19 | Moving Resources to the People or Moving the People to the Resources? A Hypothetical Consideration for Addressing Sustainability显示文摘Water and energy are rarely linked politically or technologically,yet both resources are intimately dependant upon each other.Energy is consumed by the extraction,distribution,and treatment of water.Water is consumed in the production and use of energy.Our study looks at this nexus,specifically,for resource islands—communities located considerable distances from their water and energy resources.Resource | J.Murphy D.Perrone G.Hornberger | 2009 | 地学前缘2009，16，S1： | 0 |
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