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| 1 | Impact and clinical usefulness of genetic data in the surgical management of colorectal cancer liver metastasis: a narrative review显示文摘Importance:In patients who undergo surgery for colorectal cancer liver metastases(CRLM),a number of somatic mutations have been associated with worse overall(OS)and recurrence-free survival(RFS).Although useful,an association with prognosis does not necessarily equate to an impact on surgical management.Objective:The aim of this review was to investigate whether the best-studied somatic mutations impact surgical management of CRLM by informing:(I)post-hepatectomy surveillance;(II)selection of surgical technique;(III)selection of optimal margin width;and(IV)selection of patients for surgery.Lastly,we discuss the refinement of genetic data from overall mutation status to specific variants,as well as lesser studied somatic mutations.Evidence Review:We conducted a computerized search using PubMed and Google Scholar for reports published so far,using mesh headings and keywords related to genetic data and CRLM.Findings:Genetic data may impact surgical management of CRLM in three ways.Firstly,KRAS mutations can predict lung recurrences.Secondly,KRAS mutations may help tailor margin width.Thirdly,KRAS mutations may help tailor surgical technique.Conclusions:Although genetic data may impact post-hepatectomy surveillance,selection of surgical technique and optimal margin width,their use to guide surgical selection remains elusive,as the data cannot support denying surgery to patients according to their somatic mutation profile. | Georgios Antonios Margonis Martin E.Kreis Jaeyun Jane Wang Carsten Kamphues Christopher L.Wolfgang Matthew J.Weiss | 2020 | Hepatobiliary Surgery and Nutrition2020，9，6： | 3 |
| 2 | 积极坐姿对躯体运动的影响(英文)显示文摘背景:久坐极易导致腰痛。本研究旨在确定积极坐姿是否会增加躯体运动。方法:15名健康女性志愿者分别在气垫、稳定球和硬面这三种不同材质的坐具上坐30分钟。用Vicon运动捕捉系统检测躯干运动,用两块AMTI力板收集两脚的压力中心。结果:躯干中心质量的平均速度随坐具表面柔软度增加而明显增加。受试者坐于稳定球上时两脚前后方向上的压力中心明显不同于坐在气垫和硬面椅上。结论:积极坐姿能促进躯体运动并有益于腰部健康。 | Henry Wang Kaitlyn J.Weiss Mason C.Haggerty Jacqueline E.Heath | 2014 | Journal of Sport and Health Science2014，3，4： | 3 |
| 3 | Surgery for oligometastasis of pancreatic cancer显示文摘The incidence of pancreatic adenocarcinoma(PDAC) has steadily increased over the past several decades. The majority of PDAC patients will present with distant metastases, limiting surgical management in this population. Hepatectomy and pulmonary metastasectomy(PM) has been well established for colorectal cancer patients with isolated, resectable hepatic or pulmonary metastatic disease. Recent advancements in effective systemic therapy for PDAC have led to the selection of certain patients where metastectomy may be potentially indicated. However, the indication for resection of oligometastases in PDAC is not well defined. This review will discuss the current literature on the surgical management of metastatic disease for PDAC with a specific focus on surgical resection for isolated hepatic and pulmonary metastases. | Fengchun Lu Katherine E.Poruk Matthew J.Weiss | 2015 | Chinese Journal of Cancer Research2015，27，4： | 3 |
| 4 | 丹麦钢铁公司板坯连铸机自动化改造显示文摘1999年9月。奥钢联工程技术公司(VAI)自动化部成功完成丹麦钢铁公司板坯连铸机自动化系统改造工程,目标是以更先进的喷淋冷却模型取代老式的喷水控制系统,同时提高板坯质量和铸机产量以及实行更为合理的生产和质量管理。整个改造工程历时仅6个月,其中包括制定技术规范、项目实施、系统调试和试运行。改造后,板坯质量、特别是内部裂纹和宏观偏析方面有极大改善。 | B.Lodin T.K.Laustsen A.Kjaer J.Weiss H.Preissl P.Juza | 2000 | 中国冶金2000，10，3： | 2 |
| 5 | 肝切除术治疗结直肠癌肝转移的患者选择显示文摘1简介
结直肠癌最常见的血行转移器官为肝脏。大约有一半的患者在结直肠癌病程中发展为肝转移癌[1]。针对肝转移病灶,肝切除术仍是唯一可能的根治性治疗,其5年生存率约50%[2],10年治愈率接近20%[3]。此外,有效的系统和局部化疗结合手术切除可以达到在未治愈的情况下使患者长期存活[4]。因此, | Matthew J.Weiss Michael I.D'Angelica 夏发达 姜晖 | 2013 | 中国普通外科杂志2013，22，7： | 2 |
| 6 | Immune Properties of Human Umbilical Cord Wharton’s Jelly‐Derived Cells显示文摘 | Mark L.Weiss CameronAnderson SatishMedicetty Kiran B.Seshareddy Rita J.Weiss IreneVanderWerff DerylTroyer Kevin R.McIntosh | 2009 | STEM CELLS2009，，11： | 2 |
| 7 | Neurobiological Alterations Associated With Traumatic Stress显示文摘 | Sandra J.Weiss | 2007 | Perspectives in Psychiatric Care2007，，3： | 1 |
| 8 | The temperament of pre‐term, low birth weight infants and its potential biological substrates显示文摘 | Sandra J.Weiss Mary St.Jonn‐Seed PeggyWilson | 2004 | Health2004，，6： | 1 |
| 9 | Direction finding in the presence of mutual coupling显示文摘 | B.Friedlander J.Weiss | | 0，，： | 1 |
| 10 | Generation of Transgene‐Free Lung Disease‐Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette显示文摘 | AbaSomers Jyh‐ChangJean Cesar A.Sommer AmelOmari Christopher C.Ford Jason A.Mills LeiYing Andreia GianottiSommer Jenny M.Jean Brenden W.Smith RobertLafyatis Marie‐FranceDemierre Daniel J.Weiss Deborah L.French PaulGadue George J.Murphy GustavoMostoslavsky | 2010 | STEM CELLS2010，，10： | 1 |
| 11 | Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy显示文摘Background:Tauopathies comprise a family of neurodegenerative disorders including Alzheimer’s disease for which there is an urgent and unmet need for disease-modifying treatments.Tauopathies are characterized by pathological tau hyperphosphorylation,which has been shown to correlate tightly with disease progression and memory loss in patients suffering from Alzheimer’s disease.We recently demonstrated an essential requirement for 3-O-sulfated heparan sulfate in pathological tau hyperphosphorylation in zebrafish,a prominent model organism for human drug discovery.Here,we investigated whether in vivo treatment with surfen or its derivatives oxalyl surfen and hemisurfen,small molecules with heparan sulfate antagonist properties,could mitigate tau hyperphosphorylation and neuronal deficits in a zebrafish model of tauopathies.Results:In vivo treatment of Tg[HuC::hTau^(P301L);DsRed]embryos for 2 days with surfen or oxalyl surfen significantly reduced the accumulation of the pThr181 tau phospho-epitope measured by ELISA by 30%and 51%,respectively.Western blot analysis also showed a significant decrease of pThr181 and pSer396/pSer404 in embryos treated with surfen or oxalyl surfen.Immunohistochemical analysis further confirmed that treatment with surfen or oxalyl surfen significantly decreased the AT8 tau epitope in spinal motoneurons.In addition,in vivo treatment of Tg[HuC::hTau^(P301L);DsRed]embryos with surfen or oxalyl surfen significantly rescued spinal motoneuron axon-branching defects and,as a likely consequence,the impaired stereotypical touch-evoked escape response.Importantly,treatment with hemisurfen,a surfen derivative devoid of heparan sulfate antagonist activity,does not affect tau hyperphosphorylation,nor neuronal or behavioural deficits in Tg[HuC::hTau^(P301L);DsRed]embryos.Conclusion:Our findings demonstrate for the first time that surfen,a well-tolerated molecule in clinical settings,and its derivative,oxalyl surfen,could mitigate or delay neuronal defects in tauopathies,including Alzheimer’s disease. | Seyedeh Maryam Alavi Naini Constantin Yanicostas Rahma Hassan-Abdi Sébastien Blondeel Mohamed Bennis Ryan J.Weiss Yitzhak Tor Jeffrey D.Esko Nadia Soussi-Yanicostas | 2018 | Translational Neurodegeneration2018，7，1： | 1 |
| 12 | Direct posi-tion determination of cyclostationary singnals显示文摘 | Alit Mendelson Reuven Anthony J.Weiss | | 0，，： | 1 |
| 13 | The temperament of pre‐term, low birth weight infants and its potential biological substrates显示文摘 | Sandra J.Weiss Mary St.Jonn‐Seed PeggyWilson | 2004 | Res Nurs Health2004，，6： | 1 |
| 14 | Immune Properties of Human Umbilical Cord Wharton’s Jelly‐Derived Cells显示文摘 | Mark L.Weiss CameronAnderson SatishMedicetty Kiran B.Seshareddy Rita J.Weiss IreneVanderWerff DerylTroyer Kevin R.McIntosh | 2009 | STEM CELLS2009，，： | 1 |
| 15 | Lessons learned from hepatocellular carcinoma may cause a paradigm shift in intraductal papillary mucinous neoplasms:a narrative review and discussion of conceptual similarities in tumor progression and recurrence显示文摘Although the natural history of recurrence/progression in patients with intraductal papillary mucinous neoplasms (IPMN) of the pancreas has not been studied thoroughly, the three principal mechanisms have been identified: (a) presence of residual disease at the transection margin, (b) presence of intraductal/intraparenchymal metastases and (c) development of new primary lesions. Mechanisms (a) and (b) result in metastatic lesions that are genetically related to the primary, while new primary lesions (mechanism c) are genetically distinct. Interestingly, recurrence/progression in IPMN displays conceptual parallels with the well-established paradigm of disease recurrence in patients with hepatocellular carcinoma (HCC). Specifically, patients with HCC may also develop recurrent tumors due to microscopic residual disease/intrahepatic metastasis which are genetically similar to the primary while the development of genetically unrelated, de novo HCC after curative-intent resection is also common. The latter has been attributed to the presence of a widespread genetic abnormality ( 'field defect' ) in the liver (ie, cirrhosis). Given the conceptual similarities between IPMN and HCC, a pancreatic 'field defect' may also be hypothesized to exist. This review does not suggest that HCC and IPMN have identical pathogeneses, but rather that they have conceptual similarities in tumor recurrence/progression;thus, lessons learned from HCC could be applied to IPMN research and subsequent management. Conceptual similarities in tumor progression and recurrence may also be observed between IPMN and other malignancies. However, HCC was selected because it is well studied and can serve as a paradigm. | Georgios Antonios Margonis Nikolaos Andreatos Jane Wang Matthew J.Weiss Christopher L.Wolfgang | 2022 | Journal of Pancreatology2022，5，1： | 0 |
| 16 | 锌指蛋白snail1通过抑制脂肪酶ATGL的表达调控脂肪分解显示文摘脂肪分解为新陈代谢提供能量。然而,脂肪分解功能异常会导致脂质异常积累和脂毒性。甘油三酯脂肪酶(ATGL)是体内脂肪催化分解的第一步限速酶,但其调控机制尚不明确。 | Chengxin Sun Lin Jiang Yan Liu Hong Shen Stephen J.Weiss 周义发 Liangyou Rui | 2017 | 科学新闻2017，0，4： | 0 |
| 17 | 春天计划——美国预报员和科研人员之间合作互动的范例显示文摘 | John S.Kain Paul R.Janish Steven J.Weiss Michael E.Baldwin Russell S.Schneider Harold E.Brooks 李霞 任宜勇 | 2005 | 干旱气象2005，23，3： | 0 |
| 18 | 动物界的爱因斯坦们显示文摘新的研究表明:猴子可以进行艺术创作,海豚可以互相聊天,动物智力王国有更多“佼佼者”。提到智力,人类是动物王国中的佼佼者。或者我们是这样告诉自己的。 | Michael J.Weiss 咏希 | 2007 | 新东方英语(中学版)2007，0，4： | 0 |
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