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| 1 | High Expression of NKG2A/CD94 and Low Expression of Granzyme B Are Associated with Reduced Cord Blood NK Cell Activity显示文摘Human umbilical cord blood (CB) has recently been used as a source of stem cells in transplantation. NK cells derived from CB are the key effector cells involved in graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL). It was reported that the activity of CB NK cells was lower than that of adult peripheral blood (PB) NK cells. In this study,we analyzed the expression of some NK cell receptors and cytotoxicity-related molecules in CB and PB NK cells. The expressions of activating NK receptors,CD16,NKG2D and NKp46,did not show significant difference between CB and PB NK cells. But the expression of inhibitory receptor NKG2A/CD94 was significantly higher on CB NK cells. As to the effector function molecules,granzyme B was expressed significantly lower in CB NK cells,but the expressions of intracellular perforin,IFN-γ,TNF-α and cell surface FasL and TRAIL did not show difference between CB and PB NK cells. The results indicated that the high expression of NKG2A/CD94 and low expression of granzyme B may be related with the reduced activity of CB NK cells. | Yanyan Wang1,2,Han Xu1,2,Xiaodong Zheng1,Haiming Wei1,Rui Sun1 and Zhigang Tian1,31Institute of Immunology,Hefei National Laboratory for Physical Materials at Microscale and School of Life Sciences,University of Science and Technology of China,Hefei 230027,China 2Yanyan Wang and Han Xu equally contributed to the present study | 2007 | Cellular & Molecular Immunology2007，4，5： | 5 |
| 2 | 肝癌复发转移微环境研究进展显示文摘 | 邱斌玉 温浩 张金辉 | 2010 | 肝胆外科杂志2010，18，1： | 4 |
| 3 | 乏氧对人外周血NK细胞NKG2A、NKG2D及CD44表达的影响显示文摘目的:观察乏氧微环境对人外周血自然杀伤细胞(NK)表面自然杀伤细胞2族成员A(NKG2A)、自然杀伤细胞2族成员D(NKG2D)及CD44分子表达的影响,探讨乏氧抑制NK细胞杀伤活性的分子机制。方法:采用密度梯度离心法分离健康人外周血单个核细胞(PBMC),贴壁去除单核细胞获得外周血淋巴细胞(PBL),分别置常氧(21%O2)、乏氧(1%O2)以及有或无人重组白细胞介素2(rhIL-2)(1×106U/L)刺激条件下培养16h,流式细胞术(FCM)检测不同NK细胞亚群NKG2A、NKG2D以及CD44分子的表达。结果:常氧条件,人外周血CD3-CD56+NK细胞NKG2A、NKG2D表达的阳性率分别为16.16%和78.45%,乏氧条件下二者表达的阳性率分别为15.16%和71.08%;rhIL-2上调NKG2A和NKG2D的表达,乏氧不影响rhIL-2对NKG2D、NKG2A的上调作用;rhIL-2显著上调NK细胞CD44的表达,乏氧抑制CD44的表达(P<0.05)。结论:乏氧下调外周血NK细胞表面受体NKG2D及CD44的表达,但对NKG2A的表达无显著影响。由此提示,NKG2D及CD44分子可能在乏氧引起的NK细胞杀伤活性抑制中具有重要作用。 | 孙锦堂 张岩 解奇 李泽武 董兆刚 邵倩倩 杨美香 曲迅 | 2009 | 中国病理生理杂志2009，25，2： | 2 |
| 4 | 自然杀伤细胞抗肝癌的研究新进展显示文摘肝癌是最常见的恶性肿瘤之一,预后差,复发率高。免疫治疗已成为继手术、放疗、化疗后的第四种治疗模式,其中自然杀伤细胞可以在细胞、分子及基因水平抑制肿瘤转移及复发,在肝癌的免疫治疗中起关键性作用,在开展新的治疗模式以及提高肝癌患者生活质量方面具有很广阔的应用前景。 | 康璇 王琦 | 2008 | 国际消化病杂志2008，28，1： | 0 |
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