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| 1 | 卒中存活者体力活动和锻炼建议:美国心脏协会/美国卒中协会针对医疗专业人员的声明显示文摘目的这份科学声明为卒中存活者的体力活动和锻炼建议提供了一份证据纵览。证据提示,卒中存活者会经历体力下降(physical deconditioning)并导致久坐的生活方式。因此,本更新版科学声明旨在为医务人员提供全面的指导,使其更好地理解体力活动的益处,并为卒中存活者各个恢复阶段的锻炼方案提供推荐意见。方法写作组成员由美国心脏协会(American Heart Association,AHA)卒中委员会的科学声明监督委员会和AHA手稿监督委员会任命。作者利用系统文献综述,参考公开发表的临床和流行病学研究、发病率和死亡率报告、临床与公共卫生指南、权威声明、个人文件以及专家意见,对现有的证据进行总结并指出目前的知识空白。结果卒中后体力活动不足非常普遍。大量证据明确支持对卒中存活者进行运动训练,包括有氧运动和力量训练。运动训练能改善功能能力、日常生活活动的执行能力以及生活质量,同时降低随后的心血管事件风险。卒中存活者的体力活动目标和锻炼方案需个体化制定以最大限度地增高长期依从性。结论写作组给出的推荐是,体力活动和锻炼方案应融入卒中存活者的治疗。卒中存活者体力活动的推动应强调低到中等强度的有氧活动、增强肌肉力量、减少久坐的生活方式以及对卒中二级预防的危险因素管理。 | Sandra A. Billinger Ross Arena Julie Bemhardt Janice J. Eng Barry A. Franklin Cheryl Mortag Johnson Marilyn MacKay-Lyons Richard F. Macko Gillian E. Mead Elliot J. Roth Marianne Shaughnessy Ada Tang 孙新亭 张通 | 2014 | 国际脑血管病杂志2014，22，10： | 80 |
| 2 | EGF promoter SNPs, plasma EGF levels and risk of breast cancer in Chinese women显示文摘 | Wang, Y. | 2008 | 南京医科大学学报(自然科学版)2008，28，12： | 32 |
| 3 | DYNAMIC RECOVERY AND DYNAMIC RECRYSTALLIZATION OF 7005 ALUMINIUM ALLOY DURING HOT COMPRESSION显示文摘Dynamic recovery and dynamic recrystallizatin behaviors of AA7005 aluminium alloy (Al - Zn - Mg) during hot compression are investigated by isothermal compression testing.The interdependence of flow stress,stress, strain rate,true strain and deformation temperature for the alloy is analyzed by introduc- ing Zener-Hollomon parameter. A steady - state flow of the 7005 alloy is confirmed to be a thermal- ly activated process.which is governed by rate-controlling mechanisms of dislocations.A hyperbolic sine relationship can satisfactorily correlate temperature, strain rate with flow stress through an Arrhe- nius term that involves thermal activation parameters. The dynamic recovery mechanisms of the alloy are discussed.Cross- slip of jogged screw dislocations is the main dynamic recovery mechanism over the deformation temperatures and strain rates.Subgrains are highly developed in the originally elongat- ed grains.The size of the subgrain increases with decrease of the natural logarithm of Zener- Hol - lomon parameter.Local dynamic recrystallization is operative when the alloy is deformed at temperature of 500℃ and strain rate of 0. 001s - 1. | J. Shen S. S. Xie and J. H. tang (General Research Institute for Non - ferrous Metals,Beijing 100088, China) | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，1： | 33 |
| 4 | Input-occupancy-output models of the non-competitive type and their application - an examination of the China-US trade surplus显示文摘本文构建了一种能够反映中国加工贸易特点的非竞争(进口)型投入占用产出模型,提出了一个国家全部出口与分部门、分大类商品的单位出口对国内增加值和就业的拉动效应的计算方法,从数学上证明了出口总值等于出口商品所包含的完全国内增加值与完全进口额之和,并据此编制了2002年中美两国的非竞争(进口)型投入占用产出表,测算和分析了中美两国出口对各自国内增加值和就业的影响。 | Lawrence J. Lau Xikang Chen Cuihong Yang Leonard K. Cheng K. C. Fung Yun-Wing Sung Kunfu Zhu Jiansuo Pei Zhipeng Tang | 2010 | Social Sciences in China2010，31，1： | 24 |
| 5 | Nitric Oxide Mediates Gravitropic Bending in Soybean Roots显示文摘 | Xiangyang Hu Steven J. Neill Zhangcheng Tang Weiming Cai | 2005 | 中国生物学文摘2005，19，7： | 23 |
| 6 | A Review of the Functional and Anatomical Default Mode Network in Schizophrenia显示文摘Schizophrenia is a severe mental disorder characterized by impaired perception,delusions,thought disorder,abnormal emotion regulation,altered motor function,and impaired drive. The default mode network(DMN),since it was first proposed in 2001,has become a central research theme in neuropsychiatric disorders,including schizophrenia. In this review,first we define the DMN and describe its functional activity,functional and anatomical connectivity,heritability,and inverse correlation with the task positive network. Second,we review empirical studies of the anatomical and functional DMN,and anti-correlation between DMN and the task positive network in schizophrenia. Finally,we review preliminary evidence about the relationship between antipsychotic medications and regulation of the DMN,review the role of DMN as a treatment biomarker for this disease,and consider the DMN effects of individualized therapies for schizophrenia. | Mao-Lin Hu Xiao-Fen Zong J. John Mann Jun-Jie Zheng Yan-Hui Liao Zong-Chang Li Ying He Xiao-Gang Chen Jin-Song Tang | 2017 | Neuroscience Bulletin2017，33，1： | 19 |
| 7 | 罗东(台湾)土—结构相互作用大比例模型试验的启示(Ⅰ)显示文摘地震反应预测结果评估——逐个方法评估评估地震反应结果的基本方法,是将结构预先选定点上的阻尼比为5%的加速度反应谱与其记录反应谱进行对比。虽然报告提到了好几个点的反应。 | A. H. Hadjian W. S. Tseng C. Y. Chang D. Anderson N. C. Tsai Y. K. Tang H. T. Tang J. C. Stepp 谢君斐 | 1993 | 世界地震工程1993，9，3： | 9 |
| 8 | Gibberellin-regulated XET is differentially induced by auxin in rice leaf sheath bases during gravitropic bending显示文摘 | Dayong Cui Steven J. Neill Zhangcheng Tang Weiming Cai | 2005 | 中国生物学文摘2005，19，7： | 9 |
| 9 | A novel mesh-free poly-cell Galerkin method显示文摘A novel numerical method is explored and namedas mesh-free poly-cell Galerkin method.An improved mov-ing least-square(MLS)scheme is presented,which can avoidthe matrix inversion in standard MLS and can be used toconstruct shape functions possessing delta Kronecher prop-erty.A new type of local support is introduced to ensure thealignment of integral domains with the cells of the back-ground mesh,which will reduce the difficult in integration.An intensive numerical study is conducted to test the accu-racy of the present method.It is observed that solutions withgood accuracy can be obtained with the present method. | C. Zheng X. H. Tang J. H. Zhang S. C. Wu | 2009 | Acta Mechanica Sinica2009，25，4： | 8 |
| 10 | Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy显示文摘It remains unclear why the clinically used anti-CTLA-4 antibodies, popularly called checkpoint inhibitors, have severe immunotherapy-related adverse effects (irAEs) and yet suboptimal cancer immunotherapeutic effects (CITE). Here we report that while irAE-prone Ipilimumab and TremeIgG1 rapidly direct cell surface CTLA-4 for lysosomal degradation, the non-irAE-prone antibodies we generated, HL12 or HL32, dissociate from CTLA-4 after endocytosis and allow CTLA-4 recycling to cell surface by the LRBA-dependent mechanism. Disrupting CTLA-4 recycling results in robust CTLA-4 downregulation by all anti-CTLA-4 antibodies and confers toxicity to a non-irAE-prone anti-CTLA-4 mAb. Conversely, increasing the pH sensitivity of TremeIgG1 by introducing designed tyrosine-to-histidine mutations prevents antibody-triggered lysosomal CTLA-4 downregulation and dramatically attenuates irAE. Surprisingly, by avoiding CTLA-4 downregulation and due to their increased bioavailability, pH-sensitive anti-CTLA-4 antibodies are more effective in intratumor regulatory T-cell depletion and rejection of large established tumors. Our data establish a new paradigm for cancer research that allows for abrogating irAE while increasing CITE of anti-CTLA-4 antibodies. | Yan Zhang Xuexiang Du Mingyue Liu Fei Tang Peng Zhang Chunxia Ai James K. Fields Eric J. Sundberg Olga S. Latinovic Martin Devenport Pan Zheng Yang Liu | 2019 | Cell Research2019，29，8： | 6 |
| 11 | Air quality during the 2008 Beijing Olympic Games显示文摘 | David G. Streets Joshua S. Fu Carey J. Jang Jiming Hao Kebin He Xiaoyan Tang Yuanhang Zhang Zifa Wang Zuopan Li Qiang Zhang Litao Wang Binyu Wang Carolyne Yu | 2006 | Atmospheric Environment2006，，3： | 6 |
| 12 | Sodium Citrate: A Universal Reducing Agent for Reduction/ Decoration of Graphene Oxide with Au Nanoparticles显示文摘一个灵巧的方法为减少的 graphene 氧化物 nanosheets (RGONS ) 的合成被建议,使用 graphene 氧化物并且 Au 减少 nanoparticle 的 graphene 氧化物 nanosheet (Au-RGONS ) 混血儿材料(去) 作为先锋和钠柠檬酸盐作为 reductant 和 stabilizer。产生 RGONS 和 Au-RGONS 混血儿材料被紫外力的光谱学描绘, X 光检查光电子光谱学, Fourier 变换红外线的光谱学,拉曼光谱学,原子力量显微镜学,传播电子显微镜学,和 X 光检查衍射。RGONS 和 Au-RGONS 混血儿材料通过在剩余之间的氢契约形成了稳定的胶体的分散,这被发现 RGONS 的表面和钠柠檬酸盐的 hydroxyl/carboxyl 组上的包含氧的功能。到三种 biomolecules 的 RGONS 和 Au-RGONS 混合的修改材料的玻璃质的碳电极(GCE ) 的电气化学的回答被调查,并且所有相对赤裸的 GCE 在电气化学的性能他们显示出显著增加。 | Zhe Zhang Huihui Chen Chunyan Xing Mingyi Guo Fugang Xu Xiaodan Wang Hermann J. Gruber Bailin Zhang Jilin Tang | 2011 | Nano Research2011，4，6： | 5 |
| 13 | Genesis of the Bianjiadayuan Pb-Zn polymetallic deposit, Inner Mongolia, China:Constraints from in-situ sulfur isotope and trace element geochemistry of pyrite显示文摘The Southern Great Xing’an Range (SGXR) which forms part of the eastern segment of the Central Asian Orogenic Belt (CAOB) is known as one of the most important Cu-Mo-Pb-Zn-Ag-Au metallogenic belts in China,hosting a number of porphyry Mo (Cu),skarn Fe (Sn),epithermal Au-Ag,and hydrothermal veintype Ag-Pb-Zn ore deposits.Here we investigate the Bianjiadayuan hydrothermal vein-type Ag-Pb-Zn ore deposit in the southern part of the SGXR.Porphyry Sn ±Cu ± Mo mineralization is also developed to the west of the Ag-Pb-Zn veins in the ore field.We identify a five-stage mineralization process based on field and petrologic studies including (i) the early porphyry mineralization stage,(ii) main porphyry mineralization stage,(iii) transition mineralization stage,(iv) vein-type mineralization stage and (v) late mineralization stage.Pyrite is the predominant sulfide mineral in all stages except in the late mineralization stage,and we identify corresponding four types of pyrites: Py1 is medium-grained subhedral to euhedral occurring in the early barren quartz vein;Py2 is medium- to fine-grained euhedral pyrite mainly coexisting with molybdenite,chalcopyrite,minor sphalerite and galena;Py3 is fine-grained,subhedral to irregular pyrite and displays cataclastic textures with micro-fractures;Py4 occurs as euhedral microcrystals and forms irregularly shaped aggregate with sphalerite and galena.LA-ICP-MS trace element analyses of pyrite show that Cu,Pb,Zn,Ag,Sn,Cd and Sb are partitioned into pyrite as structurally bound metals or mineral micro/nano-inclusions,whereas Co,Ni,As and Se enter the lattice via isomorphism in all types of pyrite.The Cu,Zn,Ag,Cd concentrations gradually increase from Py1 to Py4,which we correlate with cooling and mixing of ore-forming fluid with meteoric water.Py2 contains the highest contents of Co,Ni,Se,Te and Bi,suggesting high temperature conditions for the porphyry mineralization stage.Ratios of Co/Ni (0.03-10.79,average 2.13) and sulphur isotope composition of sulfide indicate typical hydrothermal origin for pyrites.The δ^34SCDT values of Py1 (0.42‰-1.61‰,average 1.16‰),Py2 (-1.23‰ to 0.82‰,average 0.35‰),Py3 (-0.36‰ to 2.47‰,average 0.97‰),Py4 (2.51‰-3.72‰,average 3.06‰),and other sulfides are consistent with those of typical porphyry deposit (-5‰ to 5‰),indicating that the Pb-Zn polymetallic mineralization in the Bianjiadayuan deposit is genetically linked to the Yanshanian (JurassiceCretaceous) magmatic-hydrothermal events.Variations of d34S values are ascribed to the changes in physical and chemical conditions during the evolution and migration of the ore-forming fluid.We propose that the high Sn content of pyrite in the Bianjiadayuan hydrothermal vein-type PbeZn polymetallic deposit can be used as a possible pathfinder to prospect for Sn mineralization in the surrounding area or deeper level of the ore field in this region. | Kai-Rui Song Li Tang Shou-Ting Zhang M. Santosh Christopher J. Spencer Yu Zhao Hao-Xing Li Liang Wang An-Li Zhang Yin-Qiang Sun | 2019 | Geoscience Frontiers2019，10，5： | 4 |
| 14 | Overview of surface ozone variability in East Asia-North Pacific region during IGAC/APARE(1994—1996)显示文摘Surface ozone(O\-3) was measured at Oki Island(Japan), Cheju Island(South Korea), Lanyu Island(Taiwan Province, China), Cape D’Aguilar(Hong Kong SAR) and Lin’an, Longfenshan, Waliguan(China mainland) during January 1994—December 1996 as a component of IGAC/APARE(International Global Atmospheric Chemistry/East Asia-North Pacific Regional Experiment). This paper gave a joint discussion on the observational results at these stations over the study region. Investigations showed that the average of surface O 3 mixing ratios at the seven sites are 47.9±15.8, 48.1±17.9, 30.2±16.4, 31.6±17.5, 36.3±17.5, 34.8±11.5 and 48.2±9.5 ppbv, respectively. Significant diurnal variations of surface O 3 have been observed at Oki, Cheju, D’Aguilar, Lin’an and Longfenshan. Their annual averaged diurnal differences range from 8 to 23 ppbv and differ in each season. Surface O 3 at Lanyu and Waliguan do not show strong diurnal variability. Seasonal cycles of surface O 3 showed difference at the temperate and the subtropical remote sites. Oki has a summer minimum-spring maximum, while Lanyu has a summer minimum-autumn maximum. The suburban sites at D’Aguilar and Lin’an report high-level O 3 in autumn and low level O 3 in summer. Surface O 3 remains high in autumn and low in winter at the rural site Longfenshan. For the global background station Waliguan, surface O 3 exhibits a broad spring-summer maximum and autumn-winter minimum. The backward air trajectories to these sites have shown different pathways of long-range transport of air pollution from East Asia Continent to North Pacific Ocean. Surface O 3 was found to be strongly and positively correlated with CO at Oki and Lanyu, especially in spring and autumn, reflecting the substantial photochemical buildup of O\-3 on a regional scale. It is believed that the regional sources of pollution in East Asia have enhanced the average surface O 3 concentrations in the background atmosphere of North Pacific. | K.S. Lam T.J.Wang T. Wang J. Tang . Y.Kajii C.M. Liu S.G. Shim | 2004 | Journal of Environmental Sciences2004，16，4： | 4 |
| 15 | Epidemiological characteristics of diabetes mellitus and impaired glucose regulation in a Chinese adult population: the Shanghai Diabetes Studies, a cross-sectional 3-year follow-up study in Shanghai urban communities显示文摘 | W. P. Jia C. Pang L. Chen Y. Q. Bao J. X. Lu H. J. Lu J. L. Tang Y. M. Wu Y. H. Zuo S. Y. Jiang K. S. Xiang | 2007 | Diabetologia2007，，2： | 4 |
| 16 | Functionalization of high-moment magnetic nanodisks for cell manipulation and separation显示文摘合成 antiferromagnetic (SAF ) nanoparticles 是有高单个粒子的磁性的时刻的组织层的粒子。以便 covalently 把这些 nanoparticles 绑在房间,他们是涂的,硅石壳与 streptavidin 由变化形式列在后面。硅石涂层产生两 SAF@SiO2 核心壳 nanoparticles 和硅石没有核心的 nanoparticles。用简单磁性的分离,硅石 nanoparticles 被移开, SAF@SiO2 nanoparticles 被净化。在 streptavidin 变化形式以后,这些粒子被用来染色肺癌症房间,高度做他们有磁力地应答。染色的房间能响应一个外部磁场旋转并且当包含这些房间的一件血样品通过 sifter 流动时,能被捕获。 | Mingliang Zhang Christopher M. Earhart Chinchun Ooi Robert J. Wilson Mary Tang Shan X. Wang | 2013 | Nano Research2013，6，10： | 4 |
| 17 | Hyperbranched Organometallic Polyynes:Optical and Thermal Properties and Their Transformation into Soft Ferromagnetic Ceramics显示文摘 | M. Hauβlert H. Dong J. W. Y. Lam A. Qin H. Tong B. Z. Tang | 2005 | 复旦学报(自然科学版)2005，44，5： | 3 |
| 18 | Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody显示文摘肝炎 E 病毒(HEV ) ,一个非包的、积极感觉的、搁浅单人赛的 RNA 病毒,是伤寒肝炎的一个主要原因。分类进家庭 Hepeviridae, HEV 包括四遗传型(遗传型 1-4 ) ,它属于单个 serotype。我们描述 monoclonal 抗体(mAb ) ,有 ~ 2.53-3.45 nM 的 8G12,同等地认出 HEV 的所有四遗传型,有约束力的亲密关系。mAb 8G12 有一保护,抵销能力,它能显著地在主人房间堵住病毒感染。动物与 1, 3 和 4 证实了跨遗传型的抵销的遗传型学习 8G12 和它肝炎 E 疾病的有效预防的能力。有丰富的遗传型的 HEV E2s 领域(病毒衣壳的最耸出的区域) 的 8G12 的复杂水晶结构 1 和 4 在 4.0 和 2.3 Å 被决定;分辨率分别地。这些结构表明 8G12 在 E2s dimerization 区域通过 epitopes 认出两遗传型。有像病毒的粒子的基于结构的 mutagenesis 和房间模型试金识别了为 8G12 中立化是必要的几保存残余(Glu549, Lys554 和 Gly591 ) 。而且, 8G12 的 epitope 作为涉及病毒主人相互作用的关键 epitope 被识别。这些调查结果将帮助为 HEV 感染的最丰富的形式的预防开发普通策略。 | Ying Gu Xuhua Tang Xiao Zhang Cuiling Song Minghua Zheng Kaihang Wang Jun Zhang Mun-Hon Ng Choy-Leong Hew Shaowei Li Ningshao Xia J. Sivaraman | 2015 | Cell Research2015，25，5： | 3 |
| 19 | A novel twice-interpolation finite element method for solid mechanics problems显示文摘明确的表达和新奇两次插值的数字评估有限元素方法(TFEM ) 为稳固的力学问题被介绍。在这个方法,为 Galerkin 弱形式的试用功能通过连续插值的二个阶段被构造。主要插值跟随女性的标准的一模一样的过程并且是进一步的根据两节的价值复制了并且平均从主要插值获得的节的坡度。因此构造的试用功能有连续节的坡度并且没有增加全部的自由,包含更高的顺序多项式。几个基准例子和一个真实水坝问题被用来以精确性和集中检验 TFEM。与标准相比女性, TFEM 能完成显著地更好的精确性,没有任何变光滑的操作,更高的集中率,和连续节的压力能被获得。TFEM 对元素的网孔的质量感觉迟钝,这也被发现。另外,没有任何修正,现在的 TFEM 能对待不可压缩的材料。关键词两次插值有限元素方法 - 应力变光滑 - 容量的锁住 - 工程由中国(50474053, 50475134 和 50675081 ) 和 863 工程(2007AA042142 ) 的国家自然科学基础支持了的网孔失真。 | C. Zheng S. C. Wu X. H. Tang J. H. Zhang | 2010 | Acta Mechanica Sinica2010，26，2： | 3 |
| 20 | Thermostable and alkalophilic maltogenic amylase of Bacillus thermoalkalophilus ET2 in monomer-dimer equilibrium显示文摘 | Cheong, K. A. Tang, S. Y. Cheong, T. K. Cha, H Kim, J. W. Park, K. H. | 2007 | 中国生物学文摘2007，21，1： | 3 |
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