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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Role of staging laparoscopy in peri-pancreatic and hepatobiliary malignancy显示文摘Even after extensive preoperative assessment,staging laparoscopy may allow avoidance of non-therapeutic laparotomy in patients with radiographically occult metastatic or locally unresectable disease.Staging laparoscopy is associated with decreased postoperative pain,a shorter hospital stay and a higher likelihood of receiving systemic therapy compared to laparotomy but its yield has decreased with improvements in imaging techniques.Current uses of staging laparoscopy include the following:(1) In the staging of pancreatic adenocarcinoma,laparoscopic staging allows for the identif ication of sub-radiographic metastatic disease in locally advanced cancer in approximately 30% of patients and,in radiographically resectable cancer,may identify metastatic disease in 10%-15% of cases;(2) In colorectal liver metastases,selective use of laparoscopic staging in patients with a clinical risk score of over 2 identifies unresectable disease in approximately 20% of patients;(3) In hepatocellular carcinoma,laparoscopic staging could be selectively used in high-risk patients such as those with clinically apparent liver cirrhosis and in patients with major vascular invasion or bilobar tumors;and(4) In biliary tract malignancy,staging laparoscopy may be used in all patients with potentially resectable primary gallbladder cancer and in selected patients with T2/T3 hilar cholangiocarcinoma.Because of the decreasing yield of SL secondary to improvements in imaging techniques,staging laparoscopy should be used selectively for patients with pancreatic and hepatobiliary malignancy to avoid unnecessary non-therapeutic laparotomy and to improve resource utilization.Each individual surgeon should apply his or her threshold as to whether staging laparoscopy is indicated according to the quality of preoperative imaging studies and the availability of resources at their own institution. | Sebastien Gaujoux Peter J Allen | 2010 | World Journal of Gastrointestinal Surgery2010，2，9： | 12 |
| 3 | On environmental threats to male infertility显示文摘 | Allen J Wilcox Jens Peter E Bonde | 2013 | Asian Journal of Andrology2013，15，2： | 7 |
| 4 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 5 | Maintaining knowledge about temporal intervals 显示文摘 | Allen J | 1983 | Communications of the ACM1983，26，： | 2 |
| 6 | A comparison of liquid hot water and steam pretreatments of sugar cane bagasse for bioconversion to ethanol显示文摘 | Mark Laser Deborah Schulman Stephen G Allen Joseph Lichwa Michael J Antal Lee R Lynd | 2001 | Bioresource Technology2001，，1： | 2 |
| 7 | Prognosis of invasive intraductal papillary mucinous neoplasms of the pancreas显示文摘Intraductal papillary mucinous neoplasms(IPMN) are mucin producing cystic neoplasms of the pancreas histologically classified as having non-invasive and invasive components.The five-year survival rates for non-invasive and associated invasive carcinoma are 90% and 40%,respectively in resected IPMN lesions.Invasive carcinoma within IPMN lesions can be further classified by histological subtype into colloid carcinoma and tubular carcinoma.Estimated five-year survival rates following resection of colloid carcinoma range from 57%-83% and estimated five-year survival following resection of tubular carcinoma range from 24%-55%.The difference in survival outcome between invasive colloid and tubular IPMN appears to be a function of disease biology,as patients with the tubular subtype tend to have larger tumors with a propensity for metastasis to regional lymph nodes.When matched to resected conventional pancreatic adenocarcinoma lesions by the Memorial Sloan Kettering Cancer Center pancreatic adenocarcinoma nomogram,the colloid carcinoma histological subtype has an improved estimated five-year survival outcome compared to conventional pancreatic adenocarcinoma,87% and 23%(P = 0.0001),respectively.Resected lesions with the tubular carcinoma subtype overall have a similar five-year survival outcome compared to conventional pancreatic adenocarcinoma.However,when these groups were stratified by regional lymph node status patients with negative regional lymph nodes and the tubular subtype experienced significantly better survival than patients with a similar nodal status and ductal adenocarcinoma with estimated five-year survival rates of 73% and 27%(P = 0.01),respectively. | Adam C Yopp Peter J Allen | 2010 | World Journal of Gastrointestinal Surgery2010，2，10： | 2 |
| 8 | Emulation of neutron irradiation effects with protons: validation of principle显示文摘 | G.S Was J.T Busby T Allen E.A Kenik A Jensson S.M Bruemmer J Gan A.D Edwards P.M Scott P.L Andreson | 2002 | Journal of Nuclear Materials2002，，2： | 2 |
| 9 | Measurements of transpiration from savannah shrubs using sap flow gauges显示文摘 | ALLEN S J GRIME V L | 1995 | Agri and For Meter1995，75，： | 2 |
| 10 | The application of the inert-marker technique to solid/solid and solid/liquid iron/zinc couples显示文摘 | Allen C Mackowiak J | 1962 | J Inst Met1962，91，： | 2 |
| 11 | Fusion neutron and ion emission from deuterium and deuterated methane cluster plasmas显示文摘 | K W Madison P K Patel D Price A Edens, M Allen, T E Cowan, J Zweiback, T Ditmire | | 0，，： | 2 |
| 12 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 13 | Water source partitioning among trees growing on shallow karst soils in a seasonally dry tropical climate显示文摘 | Querejeta J I Estrada-Medina H Allen M F | 2007 | Oecologia2007，152，： | 1 |
| 14 | The coexistence of multiple distribution systems for financial services: The case of property-liability insurance显示文摘 | Berger Allen N Cummins J David Weiss Mary A | 1997 | Journal of Business1997，10，： | 1 |
| 15 | Image method for efficiently simulating small room acoustics显示文摘 | ALLEN J BERKLEY D | 1979 | Journal of the Acoustic Society of America1979，，： | 1 |
| 16 | Measurement and estimation of evaporation from soil under sparse barley crops in northem Syria显示文摘 | Allen S J | 1990 | Agric Forest Meteorol1990，49，4： | 1 |
| 17 | Asymptotic profile of thesteady states for an SIS epidemic patch model显示文摘 | Allen L J S Bolker B M Lou Y Nevai A L | 2007 | SIAM J Appl Math2007，，67： | 1 |
| 18 | The localization of target antigens and autoantibodies in linear IgA disease is variable; correlation of immunogold electron microscopy and immunoblotting显示文摘 | Zhou S Ferguson DJ Allen J | 1998 | Br J Dermatol1998，139，： | 1 |
| 19 | In vivoFate ofUnimers and Micelles ofa Poly(ethylene glycol)-block-poly(caprolactone)Copolymer inMice Following IntravenousAdministration显示文摘 | Liu J Zeng F Allen C | 2007 | Eur J Pharm2007，65，3： | 1 |
| 20 | Overexpression of an Arabidopsis peroxisomal ascorbate peroxidase gene in tobacco increases protection against oxidative stress显示文摘 | WANG J ZHANG H ALLEN R D | 1999 | Plant Cell Physiology1999，40，7： | 1 |
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