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| 1 | 赣南大吉山五里亭岩体的锆石ELA-ICP-MS定年及其与钨成矿关系的新认识显示文摘大吉山是南岭地区一个著名的大型钨多金属矿床,五里亭岩体是矿区出露规模最大的火成岩体,岩性为中粗粒似斑状黑云母二长花岗岩。锆石 ELA-ICP-MS 定年结果表明其形成年龄为 237.5±4.8 Ma,属印支期岩浆活动的产物。与南岭地区典型钨多金属矿床成矿岩体相比,五里亭岩体贫硅,富钙、镁、铁,Rb/Sr、Rb/Ba 和 U/Th 比值低,K/Rb 比值高,铕负异常不显著,分异指数低,尚未达到矿化岩体的分异演化程度,不具备矿化岩体的地球化学特征。元素—同位素综合示踪显示区内白云母碱长花岗岩为五里亭岩体经高度分异演化的产物,它与钨多金属矿成矿直接有关。矿区范围内出露的闪长岩起源于地幔,这一岩浆侵位所引起的高热场环境有利于花岗质岩石的形成与演化,对成矿具有重要的意义。 | 邱检生 McInnes BIA 徐夕生 Allen C M | 2004 | 地质论评2004，50，2： | 78 |
| 2 | 广东龙窝花岗闪长质岩体的年代学、地球化学及岩石成因显示文摘龙窝岩体是南岭地区燕山早期具幔源组分贡献的花岗岩的典型代表,其主体岩性为花岗闪长岩,岩体中含有深色闪长质包体,锆石ELA-ICP-MS定年结果表明花岗闪长岩的形成年龄为169.1±2.5Ma,属中侏罗世岩浆活动的产物。地球化学特征上,该岩体铝弱过饱和(A/NKC=1.0~1.1),相对贫碱,富钾(K_2O/Na_2O=1.15~1.45),富轻稀土和大离子亲石元素(如Rb、Cs、Th、U),贫高场强元素(如Nb、Ti)。闪长质包体具有与寄主岩相似的矿物组合,但铁镁矿物含量及过渡族元素(V、CR、Co、Ni)丰度相对偏高,二者的主量和微量元素表现出混合成因的演化趋势。寄主岩与包体具有相近的Sr、Nd同位素组成,I_(Sr)和ε_(Nd)(t)值分别为0.70843~0.70995、-6.53~-8.89和0.70797~0.70882、-4.71~-9.24,均表现出壳幔混源花岗岩类岩石的特点。二元混合模拟计算显示寄主岩与包体成岩过程中地幔物质的混入比例分别为32.9%~40.4%和 31.8%~46.4%。通过对岩石产出构造背景及地质地球化学特征的综合分析,表明龙窝花岗闪长岩及其中的闪长质包体是在伸展-引张环境下,由幔源基性岩浆及其诱发的壳源长英质岩浆混合作用的产物。 | 邱检生 胡建 McInnes B I A 蒋少涌 徐夕生 Allen C M | 2004 | 岩石学报2004，20，6： | 19 |
| 3 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 4 | CRPC的治疗靶点及新型药物研究进展显示文摘前列腺癌是男性泌尿生殖系统常见的恶性肿瘤之一。目前去势抵抗性前列腺癌(CRPC)患者中位生存期仅12个月,预后极差。尽管去势治疗(ADT)去除了循环中绝大多数雄激素,但其仍然受残留雄激素的影响。本文综述了CYP17A1抑制剂(阿比特龙等)、5α-还原酶抑制剂(非那雄胺、度他雄胺)、醛-酮还原酶抑制剂、类固醇硫酸酯酶抑制剂、雄激素受体抑制剂(比卡鲁胺、恩扎鲁胺、阿帕鲁胺等)、镭-223、免疫治疗、派姆单抗等治疗CRPC的新型药物研究进展。 | 陈波 曹德宏 陈泽昱 郭建兵 彭珠峰 杨璐 林天海 刘振华 刘承飞 GAO ALLEN C 董强 柳良仁 魏强 | 2019 | 现代泌尿外科杂志2019，24，7： | 4 |
| 5 | Identification and characterization of mutations in hepatitis B virus resistant to Lamivudine显示文摘 | AllEN M I DESLAURIERS M ANDREWS C W | 1998 | Hepatology1998，27，6： | 2 |
| 6 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 7 | Effect of semisolid microstructure on solidified phase content in 1xxx Al alloys 显示文摘 | Allen C M O'reilly K A Q and Cantor B | 2001 | Acta Materialia2001，49，： | 2 |
| 8 | Prognosis of invasive intraductal papillary mucinous neoplasms of the pancreas显示文摘Intraductal papillary mucinous neoplasms(IPMN) are mucin producing cystic neoplasms of the pancreas histologically classified as having non-invasive and invasive components.The five-year survival rates for non-invasive and associated invasive carcinoma are 90% and 40%,respectively in resected IPMN lesions.Invasive carcinoma within IPMN lesions can be further classified by histological subtype into colloid carcinoma and tubular carcinoma.Estimated five-year survival rates following resection of colloid carcinoma range from 57%-83% and estimated five-year survival following resection of tubular carcinoma range from 24%-55%.The difference in survival outcome between invasive colloid and tubular IPMN appears to be a function of disease biology,as patients with the tubular subtype tend to have larger tumors with a propensity for metastasis to regional lymph nodes.When matched to resected conventional pancreatic adenocarcinoma lesions by the Memorial Sloan Kettering Cancer Center pancreatic adenocarcinoma nomogram,the colloid carcinoma histological subtype has an improved estimated five-year survival outcome compared to conventional pancreatic adenocarcinoma,87% and 23%(P = 0.0001),respectively.Resected lesions with the tubular carcinoma subtype overall have a similar five-year survival outcome compared to conventional pancreatic adenocarcinoma.However,when these groups were stratified by regional lymph node status patients with negative regional lymph nodes and the tubular subtype experienced significantly better survival than patients with a similar nodal status and ductal adenocarcinoma with estimated five-year survival rates of 73% and 27%(P = 0.01),respectively. | Adam C Yopp Peter J Allen | 2010 | World Journal of Gastrointestinal Surgery2010，2，10： | 2 |
| 9 | Nano-engineering block copolymer aggregates for drug delivery 显示文摘 | Allen C Eisenberg A Maysinger D | 1999 | Colloids Surf B Biointerfaces1999，16，1： | 2 |
| 10 | The application of the inert-marker technique to solid/solid and solid/liquid iron/zinc couples显示文摘 | Allen C Mackowiak J | 1962 | J Inst Met1962，91，： | 2 |
| 11 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 12 | Spatial and temporal variation of nitrous oxide and methane flux between subtropical mangrove sediments and the atmosphere显示文摘 | ALLEN D E DALAL R C RENNENBERG H | 2007 | Soil Biology and Biochemistry2007，39，2： | 1 |
| 13 | In vivoFate ofUnimers and Micelles ofa Poly(ethylene glycol)-block-poly(caprolactone)Copolymer inMice Following IntravenousAdministration显示文摘 | Liu J Zeng F Allen C | 2007 | Eur J Pharm2007，65，3： | 1 |
| 14 | Commitment to Organizations and Occupations:Extension and Test of a Three-Component Conceptualization显示文摘 | Meyer J P Allen N J Smith C A | 1993 | Journal of Applied Psychology1993，78，： | 1 |
| 15 | Neutron Diffraction Methods for the Study of Residual Stress Fields显示文摘 | ALLEN A J HUTCHINGS M T WINDSOR C G | 1985 | Adv Phys1985，34，4： | 1 |
| 16 | Wide band imped- ance matching: H∞ performance bounds显示文摘 | SCHWARTZ D F ALLEN J C | 2004 | IEEE Transactions on Circuit and Systems--II: Express Briefs2004，51，7： | 1 |
| 17 | Red imported fire ant impacts on northern bobwhite populations显示文摘 | Allen C R Lutz R S Demarais S | 1995 | Ecol Appl1995，，3： | 1 |
| 18 | The impact of FLT3 intenaal tandem duplication mutant level, number, size,and interaction with NPM1 mutations in a large co- hort of young adult patients with acute myeloid leukemia 显示文摘 | GALE R E GREEN C ALLEN C | 2008 | Blood2008，111，： | 1 |
| 19 | Leptin is a four - helix bundle:secondary structure by NMR显示文摘 | Allen D K Gerald W B Lisa M C | 1997 | FEBS Letters1997，407，2： | 1 |
| 20 | Strategies for the development of nanocrystalline materials through devitrification显示文摘 | FOLEY J C ALLEN D R PEREPEZKO J H | 1997 | Mater Sci Eng1997，，： | 1 |
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