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| 1 | B cell regulation in cancer and anti-tumor immunity显示文摘The balance between immune effector cells and immunosuppressive cells and how this regulates the tumor microenvironment has been well described.A significant contribution of immune regulatory cells,including regulatory T cells,to tumor progression has been widely reported.An emerging body of evidence has recently recognized a role for B cells in modulating the immune response to tumors and lymphoid malignancies.Regulatory B cells(Bregs)are a newly designated subset of B cells that have been shown to play a pivotal role in regulating immune responses involved in inflammation,autoimmunity and,more recently,cancer.Bregs can suppress diverse cell subtypes,including T cells,through the secretion of anti-inflammatory mediators,such as IL-10,and can facilitate the conversion of T cells to regulatory T cells,thus attenuating anti-tumor immune responses.Similar B-cell subpopulations have been reported to be recruited to the tumor but to acquire their immunosuppressive properties within the tumor bed and thereby attenuate anti-tumor immune responses.However,despite a pivotal role for Bregs in promoting inflammation and carcinogenesis,the phenotypic diversity of the cell surface markers that are unique to Bregs remains unclear in mice and humans.In this review,we summarize the characteristics of Bregs and review our current knowledge of Bregs and their inhibition of anti-tumor immune responses in murine tumor models and cancer patients. | Anushruti Sarvaria J Alejandro Madrigal Aurore Saudemont | 2017 | Cellular & Molecular Immunology2017，14，8： | 40 |
| 2 | Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study显示文摘 | Hedy L Kindler Tatsuya Ioka Dirk J Richel Jaafar Bennouna Richard Létourneau Takuji Okusaka Akihiro Funakoshi Junji Furuse Young Suk Park Shinichi Ohkawa Gregory M Springett Harpreet S Wasan Peter C Trask Paul Bycott Alejandro D Ricart Sinil Kim Eric Van | 2011 | Lancet Oncology2011，，3： | 4 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | Mapping aboveground biomass by integrating geospatial and forest inventory data through a k-nearest neighbor strategy in North Central Mexico显示文摘As climate change negotiations progress,monitoring biomass and carbon stocks is becoming an important part of the current forest research.Therefore,national governments are interested in developing forest-monitoring strategies using geospatial technology.Among statistical methods for mapping biomass,there is a nonparametric approach called k-nearest neighbor(kNN).We compared four variations of distance metrics of the kNN for the spatially-explicit estimation of aboveground biomass in a portion of the Mexican north border of the intertropical zone.Satellite derived,climatic,and topographic predictor variables were combined with the Mexican National Forest Inventory(NFI)data to accomplish the purpose.Performance of distance metrics applied into the kNN algorithm was evaluated using a cross validation leave-one-out technique.The results indicate that the Most Similar Neighbor(MSN)approach maximizes the correlation between predictor and response variables(r=0.9).Our results are in agreement with those reported in the literature.These findings confirm the predictive potential of the MSN approach for mapping forest variables at pixel level under the policy of Reducing Emission from Deforestation and Forest Degradation(REDD+). | Carlos A AGUIRRE-SALADO Eduardo J TREVIO-GARZA Oscar A AGUIRRE-CALDERóN Javier JIMNEZ-PREZ Marco A GONZLEZ-TAGLE José R VALDZ-LAZALDE Guillermo SNCHEZ-DíAZ Reija HAAPANEN Alejandro I AGUIRRE-SALADO Liliana MIRANDA-ARAGóN | 2014 | Journal of Arid Land2014，6，1： | 3 |
| 5 | Evaluation of the safety and effectiveness of direct oral anticoagulants and low molecular weight heparin in gastrointestinal cancer-associated venous thromboembolism显示文摘BACKGROUND Gastrointestinal cancer(GICA)is associated with a higher incidence of venous thromboembolism(VTE)compared to other solid tumors,moreover,recurrent VTE and major bleeding(MB)complications during anticoagulation treatment have an associated increase rate.GICA-VTE remains a challenging clinical scenario with MB concerns for utilization of direct oral anticoagulants(DOAC),especially with active cancer therapies.AIM To evaluate patient risk factors,effectiveness(VTE)and safety(MB)of DOACs and low molecular weight heparin(LMWH)in patients with active GICA-VTE.METHODS A retrospective chart review of patients receiving DOACs and LMWH with GICA and symptomatic or incidental VTE treated at comprehensive cancer center from November 2013 to February 2017 was performed.Inclusion criteria included active GI cancer diagnosed at any stage or treatment+/-6 mo of VTE diagnosis,whom were prescribed 6 mo or more of DOACs or LMWH.The Chi-squared test was used for overall and the Fisher exact test for pairwise comparisons of the proportions of patients experiencing recurrent VTE and MB events.Odds ratios were used to compare the relative odds of the occurrence of the outcome given exposure to the risk factor.RESULTS A total of 144 patients were prescribed anticoagulation,in which 106 fulfilled inclusion criteria apixaban(27.3%),rivaroxaban(34.9%)and enoxaparin(37.7%),and 38 were excluded.Patients median age was 66.5 years at GICA diagnosis and 67 years at CAVTE event,with 62%males,80%Caucasian,70%stage IV,pancreatic cancer(40.5%),30%Khorana Score(≥3 points),and 43.5%on active chemotherapy.Sixty-four percent of patients completed anticoagulation therapy(range 1 to 43 mo).Recurrent VTE at 6 mo was noted in 7.5%(n=3),6.8%(n=2)and 2.7%(n=1)of patients on enoxaparin,apixaban and rivaroxaban,respectively(all P=NS).MB at 6 mo were 5%(n=2)for enoxaparin,6.8%(n=2)for apixaban and 21.6%(n=8)for rivaroxaban(overall P=0.048;vs LMWH P=0.0423;all other P=NS).Significant predictors of a primary or secondary outcome for all anticoagulation therapies included:Active systemic treatment(OR=5.1,95%CI:1.3-19.3),high Khorana Score[≥3 points](OR=5.5,95%CI:1.7-17.1),active smoker(OR=6.7,95%CI:2.1-21.0),pancreatic cancer(OR=6.8,95%CI:1.9-23.2),and stage IV disease(OR=9.9,95%CI:1.2-79.1).CONCLUSION Rivaroxaban compared to apixaban and enoxaparin had a significantly higher risk of MB on GICA-VTE patients with equivocal efficacy. | Alejandro Recio-Boiles Sumana Veeravelli Jessica Vondrak Hani M Babiker Aaron J Scott Rachna T Shroff Hitendra Patel Emad Elquza Ali McBride | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 3 |
| 6 | Gastric cancer in young people under 30 years of age: worse prognosis, or delay in diagnosis?显示文摘 | Horacio N López-Basave Diaz Romero C Alejandro Padilla Rosciano Melchor Ruan J Silvio A. ?amendys-Silva Vela Sarmiento I Ruiz Molina JM Calderillo Ruiz G Flavia Morales-Vásquez Abelardo Meneses Garcia Angel Herrera-Gomez | 2013 | Cancer Management and Research (default)2013，，： | 2 |
| 7 | The occurrence of a Maillard-type protein-polysaccharide reaction between β-lactoglobulin and chitosan显示文摘 | Beatriz Miralles Adolfo Martínez-Rodríguez Alejandro Santiago Jürgen van de Lagemaat Angeles Heras | 2005 | Food Chemistry2005，，3： | 2 |
| 8 | Carboxylate-based molybdenum alkylidene catalysts:Synthesis,characterization,and use as initiators for 1,6-heptadiyne cyclopolymerizations显示文摘 | Richard R Schrock Zachary J Tonzetich Alejandro G Lichtscheidl | 2008 | Organometallics2008，，： | 1 |
| 9 | Preparation ofporous polymer monoliths featuring enhanced surface cov-erage with gold nanoparticles显示文摘 | Lv Y Alejandro F M Fr^chet J M | 2012 | J Chromatogr A2012，1261，： | 1 |
| 10 | Escherichia coli AspP activity is enhanced by macromolecular crowding and by both glucose-1, 6-bisphosphate and nucleotide-sugars 显示文摘 | Maria T M Z Alejandro M V Francisco J M | 2007 | FEBS Lett2007，581，5： | 1 |
| 11 | Time effects on the rheological behavior of hydrophobically modified polyacryl- amide aqueous solutions mixed with sodium dodecyl sulfate (SDS)显示文摘 | Laura M G Alejandro J M Philippe M | 2008 | Colloid Surf A2008，330，23： | 1 |
| 12 | Oral treatment of chickens with Lactobacillus reuteri LM1 reduces Brachyspira pilosicoli-induced pathology显示文摘 | Luke J M Monika A T Alejandro N | 2013 | Journal of Medical Microbiolo- gy2013，62，2： | 1 |
| 13 | Histopathological and ultrastructural changes associated with herpesvirus infection in waterfowl显示文摘 | Francisco J S Pedro J S Alejandro N | 2002 | Avain Pathol2002，31，： | 1 |
| 14 | Assessing Corrosion Risk in ReinIbrced Concrete Using Wavelets 显示文摘 | P Montes-Garcia F Castellanos J Alejandro | 2010 | Corrosion Science2010，52，2： | 1 |
| 15 | Systematic reviews and meta-analyses on treatment of asthma:critical evaluation 显示文摘 | Alejandro R J Michael Mr George P B | 2000 | BMJ2000，320，7234： | 1 |
| 16 | Inhibition of endothelial cell activation by the homeobox gene Gax显示文摘 | Gorski DH Alejandro J Leal BS | 2003 | J Surg Res2003，111，1： | 1 |
| 17 | Essence of kernel Fisher discriminant: KPCA plus LDA 显示文摘 | Yang J Jin Z Yang J Y Zhang D Alejandro F F | 2004 | Pattern Recognition2004，37，： | 1 |
| 18 | A simple method of staining fresh and cultured islets显示文摘 | Latif ZA Noel J Alejandro R | 1988 | Transplantation1988，45，4： | 1 |
| 19 | Liver fibrosis assessment with semiquantitative indexes and image analysis quantification in sustained-responder and non-responder interferon-treated patients with chronic hepatitis C显示文摘 | Trinidad Caballero Alejandro Pérez-Milena Marco Masseroli Francisco O’Valle Francisco J Salmerón Raimundo M.G Del Moral Guillermo Sánchez-Salgado | 2001 | Journal of Hepatology2001，，5： | 1 |
| 20 | The nature of superacid electrophilic species in HF/ SbF5: a density functional theory study显示文摘 | Pierre M Esteves Alejandro Ramirz-Solis Claudio J A Mota | 2002 | J Am Chem Soc2002，124，11： | 1 |
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