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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions显示文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico. | Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 3 | Preparation ofporous polymer monoliths featuring enhanced surface cov-erage with gold nanoparticles显示文摘 | Lv Y Alejandro F M Fr^chet J M | 2012 | J Chromatogr A2012，1261，： | 1 |
| 4 | Application ofdensity functional theory to the study of the reaction of NOwith char-bound nitrogen during combustion显示文摘 | Alejandro M Truong T N Sarofim A F | 2000 | Journal of Physical Chemistry2000，104，： | 1 |
| 5 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs显示文摘 | Altschul S F Thomas L M Alejandro A S | 1997 | Nucleic Acids Res1997，25，17： | 1 |
| 6 | Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin epithelin precursor (GEP), a prosurvival factor for ovarian cancer 显示文摘 | KAMRAVA M SIMPKINS F ALEJANDRO E | 2005 | Oncogene2005，24，47： | 1 |
| 7 | Polyacetylenes, terpenoids and flavonoids from Bupleurum spinosum 显示文摘 | Alejandro F B Ali H Munozedorado M | 1998 | Phytochem1998，48，7： | 1 |
| 8 | Purification of apolyphenol oxidase isoform from potato (Solanum tuberosum )tubers 显示文摘 | Costanza M Alessandra F Alejandro H | 2003 | Phytochemistry2003，63，7： | 1 |
| 9 | Gapped BLAST and PSI-BLAST:a new generation of protein database search programs 显示文摘 | Stephen F Thomas L M Alejandro A S Jinghui Zhang Zheng Zhang Webb M David J L | 1997 | Nucleic Acids Res1997，25，17： | 1 |
| 10 | Selenium environmental cycling and bioavailability: A structural chemist point of view显示文摘 | Alejandro F M Charlet Laurent | 2009 | Reviews Environmental Science and Bio/ Technology2009，81，： | 1 |
| 11 | Mechanisms involved in the formation of phosphosilicate glass from a phosphoric acid dopant ource 显示文摘 | Vais V Mrcariea M Alejandro F B | 2011 | Progress in Potovolatics2011，19，3： | 1 |
| 12 | Visual and optical perfor- mance with hybrid multifocal intraocular lenses 显示文摘 | David M Alejandro C Teresa F | 2010 | Clinical and experimental Optometry2010，93，6： | 1 |
| 13 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs 显示文摘 | Stephen F A Thomas L M Alejandro A S | 1997 | Nucleic Acids Res1997，25，： | 1 |
| 14 | Large-scale investigation of weed seed identification by machine vision显示文摘 | Pablo M Granitto Pablo F Verdes Alejandro Ceccatto H | | 0，，01： | 1 |
| 15 | Assessing implications of land - use and land - cover change dynamics for conservation of a highly diverse tropical rain forest 显示文摘 | Alejandro F S Miguel M R Omar R M | 2007 | Biological Conservation2007，138，12： | 1 |
| 16 | Assessing implications of land-use and land-cover change dynamics for conservation of a highly diverse tropical rain forest 显示文摘 | ALEJANDRO F S MIGUEL M R OMAR R M | 2007 | Biological Conservation2007，138，12： | 1 |
| 17 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs 显示文摘 | Altschul S F Thomas L M Alejandro A | 1997 | Nucl Acids Res1997，25，： | 1 |
| 18 | Gapped BLAST and PSI-BLAST:a new generation of protein database search programs显示文摘 | Stephen F A Thomas L M Alejandro A S | | 0，，17： | 1 |
| 19 | Assessing implications of land-use and land-cover change dynamics for conservation of a highly diverse tropical rain forest 显示文摘 | Alejandro F S Miguel M R Omar R M | 2007 | Biological Conserva-tion2007，138，12： | 1 |
| 20 | Gapped BLAST and PSI-LAST: a new generation of protein database search program 显示文摘 | Altschul S F Thomas L M Alejandro A | 1997 | Nucl Acids Res1997，25，： | 1 |
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