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| 1 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 2 | Prevention ofepidural scarring after microdiscectomy : a randomizedclinical trial comparing gel and expanded polytetrafluoroethylenemembrane 显示文摘 | Ivanic GM Pink PT Schneider F | 2006 | Eur Spine J2006，15，9： | 1 |
| 3 | Intratumoral administration of endostatin plasmid inhibits vascular growth and perfusion in Mca-4 murine mammary carcinomas 显示文摘 | Jian-Zhong S Bruce F | 2001 | Cancer Res2001，61，： | 1 |
| 4 | A new approach for outcrop characterization andgeostatistical analysis of a low-sinuosity fluvial-dominated succession using digital outcrop models:Upper Triassic Oukaimeden sandstone formation,central High Atlas,Morocco显示文摘 | Ivan F David H Jonathan R | 2009 | AAPG Bulletin2009，93，6： | 1 |
| 5 | Role of endothelin-1 in lung disease显示文摘 | Karen A Ivan F McMurtry | 2001 | Respir Res2001，2，2： | 1 |
| 6 | Photol- ysis of sulfosalicylic acid in aqueous solutions over a wide pH range显示文摘 | Pozdnyakov Ivan P Plyusnin Victor F Grivin Vjacheslav P | 2006 | Journal of Applied Spectroscopy2006，181，： | 1 |
| 7 | Comparative analysis of two rates显示文摘 | Chan Ivan S F Zhang Z X | 1985 | Statistics in Medicine1985，4，： | 1 |
| 8 | Trust Factors Influencingthe Adoption of Internet-based InterorganizationalSystems 显示文摘 | Lai Ivan K W Tong VinyW L Lai Donny C F | 2011 | ElectronicCommerce Researchand Applications2011，10，1： | 1 |
| 9 | Intrinsic time-scale decomposition:timefreqeucny-energy analysis and real-time filtering of non-station-ary signals显示文摘 | MARK G F IVAN O | 2007 | Proceedings of the Royal Society A2007，463，： | 1 |
| 10 | Predictive factors of contrast-induced nephropathy in patients undergoing primary coronary angioplasty显示文摘 | Ivanes F Isorni MA Halimi JM | 2014 | Arch Cardiovasc Dis2014，107，89： | 1 |
| 11 | Brush-evoked allodynia predicts outcome of spinal cord stimulation in complex regional pain syndrome type 显示文摘 | Ivan Eijs F Smits H Geurts JW | 2010 | EurJ Pain2010，14，2： | 1 |
| 12 | Laser doppler velocimeter for laboratory training 显示文摘 | IVAN V F BORIS L D ALEXEY S K | 2002 | Seventh international conference on education and training in optics and photonics New York Proceedings of SPIE2002，4588，： | 1 |
| 13 | Absence of the interstial cells of cajal in patients with gastroparesis and correlation with clinical findings显示文摘 | Jamesom F Ivan D Zhiyue L | 2005 | J Gastrointestinal Surg2005，9，1： | 1 |
| 14 | Absence of the interstitial ceils of Cajal in patients with clinical findings显示文摘 | Jameson F Ivan D Zhiyue L | 2005 | J Gastroen- terol Surg2005，9，3： | 1 |
| 15 | Absence of the interstitial of Cajal in patients with gastroparesis and correlation with clinical findings 显示文摘 | Jameson F Ivan D Zhiyue L | 2005 | J Gastroenterol Surg2005，9，1： | 1 |
| 16 | Chemical conversion synthesis and optical properties of metal sulfide hollow microspheres显示文摘 | Zhu Y F IVan H D Shen W Z | 2008 | Langmuir2008，24，11： | 1 |
| 17 | Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle–mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response显示文摘 | Ivan Grskovic Anna Kutsch Christian Frie Gergely Groma Jacek Stermann Ursula Schl?tzer‐Schrehardt Anja Niehoff Stephen E Moss Sabrina Rosenbaum Ernst P?schl Markus Chmielewski Gunter Rappl Hinrich Abken John F Bateman Kathryn SE Cheah Mats Paulsson Bent B | 2012 | J Bone Miner Res2012，，11： | 1 |
| 18 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 19 | Structure of an HIF-lalpha-pVHL complex: hydroxyproline recognition in signaling 显示文摘 | Min JH Yang H Ivan M Gertler F Kaelin Jr WG Pavletich NP | 2002 | Science2002，296，5574： | 1 |
| 20 | Mesenehymal stem cell adllesion to cardiac microvascular endothelittm: activators and mechanisms 显示文摘 | J Vincent F M S Ivan V R Luc J A | 2006 | Am J Physiol Heart Circ Physiol2006，290，4： | 1 |
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