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| 1 | Colorectal cancer screening: An updated review of the available options显示文摘Colorectal cancer(CRC) is a significant cause of morbidity and mortality worldwide. However,colon cancer incidence and mortality is declining over the past decade owing to adoption of effective screening programs. Nevertheless,in some parts of the world,CRC incidence and mortality remain on the rise,likely due to factors including 'westernized' diet,lifestyle,and lack of health-care infrastructure and resources. Participation and adherence to different national screening programs remain obstacles limiting the achievement of screening goals. Different modalities are available ranging from stool based tests to radiology and endoscopy with varying sensitivity and specificity. However,the availability of these tests is limited to areas with high economic resources. Recently,FDA approved a blood-based test(Epi procolon?) for CRC screening. This blood based test may serve to increase the participation and adherence rates. Hence,leading to increase in colon cancer detection and prevention. This article will discuss various CRC screening tests with a particular focus on the data regarding the new approved blood test. Finally,we will propose an algorithm for a simple cost-effective CRC screening program. | Iyad A Issa Malak Noureddine | 2017 | World Journal of Gastroenterology2017，23，28： | 49 |
| 2 | Probiotics for antibiotic-associated diarrhea:Do we have a verdict?显示文摘Probiotics use has increased tremendously over the past ten years.This was coupled with a surge of data relating their importance in clinical practice.Antibioticassociated diarrhea,whose frequency has risen recently,was one of the earliest targets with data published more than ten years ago.Unfortunately,available trials suffer from severe discrepancies associated with variability and heterogeneity of several factors.Most published randomized controlled trials and subsequent meta-analyses suggest benefit for probiotics in the prevention of antibiotic-associated diarrhea.The same seems to also apply when the data is examined for Clostridium difficile-associated colitis.However,the largest randomized double-blind placebo-controlled trial to date examining the use of a certain preparation of probiotics in antibiotic-associated diarrhea showed disappointing results,but it was flawed with several drawbacks.The commonest species of probiotics studied across most trials is Lactobacillus;however,other types have also shown similar benefit.Probiotics have enjoyed an impeccable safety reputation.Despite a few reports of severe infections sometimes leading to septicemia,most of the available trials confirm their harmless behavior and show similaradverse events compared to placebo.Since a consensus dictating its use is still lacking,it would be advisable at this point to suggest prophylactic use of probiotics to certain patients at risk for antibiotic-associated diarrhea or to those who suffered previous episodes. | Iyad Issa Rami Moucari | 2014 | World Journal of Gastroenterology2014，20，47： | 17 |
| 3 | Mesenteric panniculitis: Various presentations and treatment regimens显示文摘Mesenteric panniculitis is a rare, benign and chronic f ibrosing inflammatory disease that affects the adipose tissue of the mesentery of the small intestine and colon. The specific etiology of the disease is unknown. The diagnosis is suggested by computed tomography and is usually confirmed by surgical biopsies. Treatment is empirical and based on a few selected drugs. Surgical resection is sometimes attempted for def initive therapy, although the surgical approach is often limited. We report two cases of mesenteric panniculitis with two different presentations and subsequently varying treatment regimens. Adequate response was obtained in both patients. We present details of these cases as well as a literature review to compare various presentations, etiologies and potential treatment modalities. | Iyad Issa Hassan Baydoun | 2009 | World Journal of Gastroenterology2009，15，30： | 12 |
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