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| 1 | Oxidative Stress, Biochemical and Histopathological Alterations in the Liver and Kidney of Female Rats Exposed to Low Doses of Deltamethrin (DM):A Molecular Assessment显示文摘Objective To evaluate histopathological alterations of the liver and kidney of female rats exposed to low doses of DM and its potential genotoxic activity. Methods Female Wistar rats were randomly assigned to control (3 groups, 6 rats in each) and treatment groups (3 groups, 6 rats in each). They were subjected to subcutaneous injections of DM (at doses of 0.003, 0.03, and 0.3 mg/kg bw/d) after 30, 45, and 60 d, respectively. Results Significant alterations were recorded in liver parenchyma induced by hepatic vacuolization, fragmented chromatin in nuclei, dilatation of sinusoids and congestions. Lesions within proximal and distal tubules were observed in the kidneys. Tissue congestions and severe alterations within glomeruli were visible. DM as a pyrethroid insecticide induced significant increase (P≤0.05) of plasma MDA concentrations after 45 d. A significant increase (P≤0.05) in plasma ALT (after 45 and 60 d) and AST (after 60 d) concentrations was recorded as compared to controls. During the whole experimental period the toxic agent provoked significant DNA damages (P≤0.05), especially in the dominance of classes 3 and 4 of obtained comet. Conclusion DM even at a very low dose displays harmful effects by disrupting hepatic and renal function and causing DNA damages in puberscent female rats. Low doses of DM are hepatotoxic and nephrotoxic. | CHARGUI Issam GRISSA Intissar BENSASSI Fatma HRIRA Mohamed Yahia HAOUEM Samir HAOUAS Zohra BENCHEIKH Hassen | 2012 | Biomedical and Environmental Sciences2012，25，6： | 2 |
| 2 | Relationship between VEGFA polymorphisms and serum VEGF protein levels and recurrent spontaneous miscarriage显示文摘 | Wassim Y. Almawi Fabiola Lisa Saldanha Naeema A. Mahmood Intissar Al-Zaman Mai S. Sater Fekria E. Mustafa | 2013 | Human Reproduction2013，，： | 2 |
| 3 | 非自伴Jacobi-Gribov算子的谱分析及其广义特征向量的渐近分析(英文)显示文摘考虑对角元为q_n=μn,次对角元为α_n=iλn n+1^(1/2)而的非自伴无界Jacobi-Gribov矩阵,其中μ和λ为实数(μ为坡密子截距,λ为三坡密耦合量),i^2=-1.本文主要目的是研究Jacobi-Gribov矩阵广义特征向量的渐近性,并对[Comm.Math.Phys.,1987,113(2):263-297]中的一些结果给出了新的证明.同时详细分析了这一算子的谱. | Abdelkader Intissar | 2015 | 数学进展2015，0，3： | 1 |
| 4 | Association of endothelial nitric oxide synthase Glu298Asp,4b/a,and-786T>C gene variants with diabetic nephropathy显示文摘 | Intissar Ezzidi Nabil Mtiraoui Manel Ben Hadj Mohamed | 2008 | Journal of Diabetes and its Complications2008，5，910： | 1 |
| 5 | Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study显示文摘 | Intissar E Nabil M Ste phane C | 2009 | BMC Medical Genetics2009，10，： | 1 |
| 6 | Association of endothelial nitric oxide synthase Glu298Asp, 4b/a, and ?786T>C gene variants with diabetic nephropathy显示文摘 | Intissar Ezzidi Nabil Mtiraoui Manel Ben Hadj Mohamed Touhami Mahjoub Maha Kacem Wassim Y. Almawi | 2008 | Journal of Diabetes and Its Complications2008，，5： | 1 |
| 7 | Delamina- tion and restacking of layered double hydroxides显示文摘 | Leroux F Adachi-Pagano M Intissar M | 2001 | Jour- nal of Materials Chemistry2001，11，： | 1 |
| 8 | 新的DDR1受体信号通路促进乳腺癌多器官转移显示文摘恶性肿瘤具有无限增殖和转移生物学特征。转移导致绝大部分癌症病人死亡,具有重要的临床意义,但是相关生物学基础和分子机制仍然知之甚少。 | 高华 Goutam Chakraborty Zhanguo Zhang Intissar Akalay Mayur Gadiya Yaquan Gao Surajit Sinha Jian Hu Cizhong Jiang Muzaffar Akram Edi Brogi Birgit Leitinger Filippo G.Giancotti | 2017 | 科学新闻2017，19，4： | 0 |
| 9 | Hydrometallurgy two stage process for preparation of (Nd,La,Ce)_(2)O_(3) from end-of-life NiMH batteries显示文摘The present work aims to investigate the recovery of light rare earth elements(LREEs) oxides from end-oflife NiMH batteries using a hydro metallurgical process followed by effective precipitation.The operational leaching parameters such as phosphoric acid concentration,temperature,and the solid-liquid ratio were first optimized by Box-Behnken design.The results reveal that under optimum conditions([H_(3)PO_(4)]=2 mol/L,T=80℃,and S/L=1:10 g/mL) the leaching efficiencies of Ni,Co reach 98.1% and99.3%.While La,Ce,and Nd elements remain in the leaching residue as(La,Ce,Nd)PO_(4) with yields of 98.2%,98.6%,and 99.6% for La,Ce,and Nd,respectively.Afterward,the(La,Ce,Nd)PO_(4) is leached with HCl acid,then the rare earth oxalate was precipitated using oxalic acid at a pH of 1.8 and then the product was calcined at 800℃ for 2 h in order to synthesize the(Nd,La,Ce)_(2)O_(3).The analysis using scanning electron microscopy(SEM) coupled with energy dispersive X-ray spectroscopy(EDX) confirms the homogeneity of(Nd,La,Ce)_(2)O_(3) particles that have two morphologies,i.e.,flower and sticks with a particle size between 3and 6 μm.The unit cell parameters of(Nd,La,Ce)_(2)O_(3) were calculated after Rietveld refinement of the XRD patterns,in the space group of Fm-3m are a=b=c=0.57921 nm and the volume equal to 0.194322 nm^(3). | Karim Tanji Khalid Ouzaouit Mohamed Belghiti Isam Lamsayety Hakim Faqir Intissar Benzakour | 2024 | Journal of Rare Earths2024，42，2： | 0 |
| 10 | Novel StAR Gene Mutation Identified in a Moroccan Patient with Lipoid Congenital Adrenal Hyperplasia显示文摘Congenital Adrenal Hyperplasia(CAH)is an autosomal recessive condition that results from the deficiency of one of the steroidogenesis enzymes responsible for cortisol biosynthesis.In the majority of cases,CAH is caused by 21-hydroxylase deficiency.More rarely,the deficiency concerns 11b-hydroxylase,3b-hydroxysteroid dehydrogenase,17hydroxylase,or exceptionally StAR and P450 oxydoreductase.Here,we report the case of a 3 year and 4 months old male child,born from a consanguineous marriage who presented at 15 months old with the salt-loss syndrome.Physical examination found generalized melanoderma,micropenis and bilateral cryptorchidism.Biological assessment at the time of diagnosis revealed hyponatremia,hyperkalemia,functional renal failure,hypoglycemia,low blood cortisol level,and high blood level of ACTH,suggesting primary adrenal insufficiency.The patient presented also with the abnormality of sexual differentiation with a 46 XY karyotype,testosteronemia level was low at the baseline and after HCG stimulation,pelvic ultrasound and Magnetic Raisonance Imaging(MRI)showed bilateral testicular atrophy in the inguinal position.The genetic study revealed a likely pathogenic homozygous variant in the StAR(steroidogenic acute regulatory)gene.Therapeutically,our patient was hydrated by saline solution and treated with hydrocortisone and fludrocortisone,then benefited from a surgical testicular correction marked by a favorable evolution.Although mutations in StAR gene are rare,they can be responsible for the defect in the early stage of steroidogenesis and therefore cause a deficiency in adrenal and sexual hormones biosynthesis. | Hanane Zaddouq Althel Pharel Opoko Khadija Belhassan Intissar Haddiya Ahmed Gaouzi | 2019 | Journal of Endocrinology Research2019，1，2： | 0 |
| 11 | Bargmann空间中无界Gribov-Intissar算子的谱逼近(英文)显示文摘在[Adv.Math.(China),2015,44(3):335-353]中,我们研究了经典Bargmann空间Bo中的非自伴算子H_μ:H_μ=S_μ+H_λ,其中S_μ=μz d/(dz),H_λ=iλ(z(d^2)/(dz^2)+z^2 d/(dz)),i^2=-1,参数μ,λ都是实数.我们给出了H_μ的谱分析和H_μ的广义特征向量的渐近分析.设ek(z)=(z^k)/((k!)^(1/2)),k=1,2,…是B0的正交基.算子H_μ可以被一列三对角矩阵逼近,此三对角矩阵的主对角线元素为β_k=μk,次对角线元素α_k=iλk(k+1)^(1/2),1≤k≤n,n∈N.对于μ∈C和λ∈C,本文主要研究上述矩阵的特征值z_(k,n)(μ,λ)的局部化,它是多项式P_(n+1)^(μ,λ)(z)的零点,P_(n+1)^(μ,λ)(z)满足三项递推关系:若'∈R和λ∈R,则上述矩阵是复对称的.在这种情况下,我们证明了R上有界变分复值函数∈(z)的存在性,它使得权重为∈(z)的多项式P_n^(μ,λ)(z)是正交的.我们也考虑了H_μ的扰动H_λ'=S_λ'+H_λ,其中S_λ'=λ'z^2(d^2)/(dz^2)+S_μ,λ'∈R,H_λ可以被矩阵(h_(jk)~λ)_(j,k=1)~∞表示.证明了可以通过S_λ'的特征值和有限矩阵(h_(jk)~λ)_(j,k=1)~n的特征值的组合来逼近H_λ'的特征值. | Abdelkader Intissar | 2017 | 数学进展2017，46，1： | 0 |
| 12 | Diabetes onset before or after the age of 65 does it affect the progression of renal and cardiovascular diseases in the elderly patient?显示文摘 | Yassamine Bentata Haddiya Intissar Karimi Ilham Benabdellah Nawal Chemlal Abdeljalil Redouane Abouqal | 2016 | Journal of Geriatric Cardiology2016，13，3： | 0 |
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