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| 1 | Plasma betatrophin levels in patients with liver cirrhosis显示文摘AIM: To investigate the plasma levels of betatrophin in patients with cirrhosis.METHODS: Forty patients diagnosed at the clinic with liver cirrhosis according to biological, ultrasonographic,or histological criteria were included.The severity of cirrhosis was classified according to Pugh's modification of Child's classification and MELD score. Insulin resistance(IR) was assessed by the Homeostasis Model Assessment. A total of 20 patients showed a MELD score higher than 14. The control group consisted in 15 sex-and aged-matched subjects.Fasting blood samples were obtained for subsequent analysis. Serum insulin was determined by Liaison automated immune chemiluminiscence assay(DiaSorin S.p.A.) using a sandwich assay. The sensitivity of the assay was 0.2 μU/mL. The intra and interassay variation coefficients were < 4% and < 10%,respectively. The normal values were between 2 and17 μU/mL. Human active betatrophin was analyzed by specific quantitative sandwich ELISA(Aviscera Bioscience). The sensitivity of the assay was 0.4 ng/mL, and the intra and interassay reproducibility were< 6% and < 10%, respectively.RESULTS: Plasma betatrophin levels were significantly increased in patients with cirrhosis compared with those in healthy subjects(P = 0.0001). Betatrophin levels were also associated with disease severity, being higher in Child-Pugh C patients compared to Child-Pugh B(P< 0.0005) and in patients who displayed a MELD score higher than 14 points compared to patients with lower punctuation(P = 0.01). In addition, we found a positive correlation between plasma betatrophin levels and the severity of cirrhosis according to Child-Pugh classification(r = 0.53; P < 0.01) or MELD score(r = 0.45; P <0.01). In the overall cohort, a moderate correlation between serum betatrophin and plasmatic bilirrubin(r= 0.39; P < 0.01) has been observed, as well as an inverse correlation between betatrophin and albumin(r =-0.41; P < 0.01) or prothrombin time(r =-0.44;P <0.01). Moreover, insulin resistance was observed in82.5% of the cirrhotic patients. In this group of patients,betatrophin levels were significantly higher than those in the group of patients without IR(P < 0.05).CONCLUSION: Plasma betatrophin is increased in patients with cirrhosis. This increase is related to the severity of cirrhosis, as well as with the emergence of insulin resistance. | Maria Teresa Arias-Loste Maria Teresa García-Unzueta Susana Llerena Paula Iruzubieta Angela Puente Joaquín Cabezas Carmen Alonso Antonio Cuadrado José Antonio Amado Javier Crespo Emilio Fábrega | 2015 | World Journal of Gastroenterology2015，21，37： | 9 |
| 2 | 冻融法纯化水稻胚乳RNA及稻米品质重要相关基因表达谱研究显示文摘提出了一种从水稻胚乳组织中快速分离总RNA的方法,可以简便地去除RNA中存在的淀粉等多糖类杂质,所获的胚乳总RNA其质量可满足Northern印迹、微阵列制备等分子生物学实验要求。将从966个水稻品种的胚乳中分离所得的RNA制备RNA阵列,用于稻米品质重要基因Wx基因的表达谱分析,结果证实:水稻Wx基因表达丰度总体上与水稻胚乳的直链淀粉含量呈正相关;应用于Northern印迹实验,表明在水稻胚乳组织中,淀粉分支酶Rbe1具有两个长度不同的同源基因,其中一个分子量大的为胚乳特异表达,分子量小的则在水稻各组织中共表达。 | 张海燕 董海涛 *姚海根 向跃武 谭学林 方永启 邓晔 金庆超 Cabezas DANIEL 姜玉新 戴承恩 阎文昭 四川成都610066 李德葆 | 2005 | 中国水稻科学2005，19，2： | 7 |
| 3 | Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding显示文摘AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(NSBBs) and acute nonresponders received carvedilol.METHODS Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional NSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic response.RESULTS Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(NSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). No clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional NSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with carvedilol.CONCLUSION Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects for reducing portal pressure. | José Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra Javier Vaquero Antonio Cuadrado María Teresa Arias-Loste Joaquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega Javier Crespo | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 4 | Carbonaceous residues from biomass gasification as catalysts for biodiesel production显示文摘Tars and alkali ashes from biomass gasification processes currently constitute one of the major problems in biomass valorisation,generating clogging of filters and issues related with the purity of syngas production.To date,these waste residues find no useful applications and they are generally disposed upon generation in the gasification process.A detailed analysis of these residues pointed out the presence of high quantities of Ca(>30 wt%).TG experiments indicated that a treatment under air at moderate temperatures(400-800 C) decomposed the majority of carbon species,while XRD indicated the presence of a crystalline CaO phase.CaO enriched valorized materials turned out to be good heterogeneous catalysts for biodiesel production from vegetable oils,providing moderate to good activities(50%-70% after 12 h) to fatty acid methyl esters in the transesterification of sunflower oil with methanol. | Rafael Luque Antonio Pineda Juan C. Colmenares Juan M. Campelo Antonio A. Romero Juan Carlos Serrano-Ruiz Luisa F. Cabeza Jaime Cot-Gores | 2012 | Journal of Natural Gas Chemistry2012，21，3： | 4 |
| 5 | Nonlinear criterion for strength mobilization in brittle failure of rock and its extension to the tunnel scale显示文摘As underground excavations are getting deeper and field stresses increase, the behavior of intact rock blocks plays an increasingly important role in understanding and estimating the overall rock mass strength. To model the brittle behavior of intact rock blocks, the stress–strain curve is usually idealized considering a linear strength mobilization approach(cohesion-weakening-friction-strengthening, CWFS),however, it is well recognized that rock presents a nonlinear behavior in terms of the confining stress.This study extends the strength mobilization in brittle failure of rock using nonlinear criteria. To determine the model parameters, a standard statistical method that uses the complete laboratory stress–strain curves of the intact rock is employed. Several hypotheses of linear and nonlinear models are statistically compared for different types of rock and confining stress levels. Results demonstrate that the best approach to model the brittle failure of rock is to consider a nonlinear strength envelope, such as the Hoek-Brown criterion assuming a residual uniaxial compressive strength different from zero and a mi parameter that increases, both with simultaneous mobilization. This model helps to recreate highconfining conditions and a more realistic transition between peak and post-peak strength. The obtained parameters are discussed and compared with literature values to verify the validity and to develop guidelines for the estimation of parameters, providing an objective mobilization criterion. Finally, the nonlinear model was applied to a finite element code and extended to a tunnel scale in the brittle rock under high-stress conditions. A reasonable fit between the simulations and the in-situ overbreak measurements was found. | Rodolfo Cabezas Javier Vallejos | 2022 | International Journal of Mining Science and Technology2022，32，4： | 3 |
| 6 | Review on thermal energy storage with phase change: materials, heat transfer analysis and applications显示文摘 | Belén Zalba José M a Mar??n Luisa F. Cabeza Harald Mehling | 2002 | Applied Thermal Engineering2002，，3： | 3 |
| 7 | State of the art on high temperature thermal energy storage for power generation. Part 1—Concepts, materials and modellization显示文摘 | Antoni Gil Marc Medrano Ingrid Martorell Ana Lázaro Pablo Dolado Belén Zalba Luisa F. Cabeza | 2009 | Renewable and Sustainable Energy Reviews2009，，1： | 2 |
| 8 | Molecular genetics of berry colour variation in table grape显示文摘 | Diego Lijavetzky Leonor Ruiz-García José A. Cabezas María T. Andrés Gemma Bravo Ana Ibá?ez Juan Carre?o Félix Cabello Javier Ibá?ez José M. Martínez-Zapater | 2006 | Molecular Genetics and Genomics2006，，5： | 2 |
| 9 | Mass culture and biochemical variability of the marine microalga Tetraselmis suecica Kylin (Butch) with high nutrient concentrations显示文摘 | Fabregas J Herrero C Cabezas B | 1985 | Aquaculture1985，49，： | 2 |
| 10 | Outcomes of kidney transplantation in patients with hepatitis B virus infection:A systematic review and meta-analysis显示文摘AIM To assess outcomes of kidney transplantation including patient and allograft outcomes in recipients with hepatitis B virus(HBV) infection, and the trends of patient's outcomes overtime.METHODS A literature search was conducted using MEDLINE, EMBASE and Cochrane Database from inception through October 2017. Studies that reported odds ratios(OR) of mortality or renal allograft failure after kidney transplantation in patients with HBV [defined as hepatitis B surface antigen(HBs Ag) positive] were included. The comparison group consisted of HBs Agnegative kidney transplant recipients. Effect estimates from the individual study were extracted and combined using random-effect, generic inverse variance method of Der Simonian and Laird. The protocol for this metaanalysis is registered with PROSPERO(International Prospective Register of Systematic Reviews; no. CRD42017080657).RESULTS Ten observational studies with a total of 87623 kidney transplant patients were enrolled. Compared to HBs Ag-negative recipients, HBs Ag-positive status was significantly associated with increased risk of mortality after kidney transplantation(pooled OR = 2.48; 95%CI: 1.61-3.83). Meta-regression showed significant negative correlations between mortality risk after kidney transplantation in HBs Ag-positive recipients and year of study(slopes =-0.062, P = 0.001). HBs Agpositive status was also associated with increased risk of renal allograft failure with pooled OR of 1.46(95%CI: 1.08-1.96). There was also a significant negative correlation between year of study and risk of allograft failure(slopes =-0.018, P = 0.002). These associations existed in overall analysis as well as in limited cohort of hepatitis C virus-negative patients. We found no publication bias as assessed by the funnel plots and Egger's regression asymmetry test with P = 0.18 and 0.13 for the risks of mortality and allograft failure after kidney transplantation in HBs Ag-positive recipients, respectively.CONCLUSION Among kidney transplant patients, there are significant associations between HBs Ag-positive status and poor outcomes including mortality and allograft failure. However, there are potential improvements in patient and graft survivals in HBs Ag-positive recipients overtime. | Charat Thongprayoon Wisit Kaewput Konika Sharma Karn Wijarnpreecha Napat Leeaphorn Patompong Ungprasert Ankit Sakhuja Franco H Cabeza Rivera Wisit Cheungpasitporn | 2018 | World Journal of Hepatology2018，10，2： | 2 |
| 11 | Computerized physician order entry‐based system to prevent HBV reactivation in patients treated with biologic agents: The PRESCRIB project显示文摘 | Blanca Sampedro Cándido Hernández‐López José Ramón Ferrandiz Aitziber Illaro Emilio Fábrega Antonio Cuadrado Paula Iruzubieta Susana Menéndez Joaquín Cabezas Javier Crespo | 2014 | Hepatology2014，，1： | 2 |
| 12 | State of the art on high temperature thermal energy storage for power generation. Part 1—Concepts, materials and modellization显示文摘 | Antoni Gil Marc Medrano Ingrid Martorell Ana Lázaro Pablo Dolado Belén Zalba Luisa F. Cabeza | 2009 | Renewable and Sustainable Energy Reviews2009，，1： | 2 |
| 13 | Mechanisms involved in gastric Protection of melatonin against oxidants stress by isehemia-reperthsion in rats显示文摘 | Cabeza J Mofida V Martin M J | 2001 | Life Science2001，68，12： | 1 |
| 14 | Isolation of protein products from chromium containing leather waste using two consecutive enzymes and purification of final chromium product: pilot plant studies 显示文摘 | Brown E M Cabeza L F Taylor M M | 1999 | JSL TC1999，，83： | 1 |
| 15 | Nontyau corehral hematoma in young daults : a study of 42 cases显示文摘 | Martinez MB Perez SA Cabeza AC | 1991 | Med clin(bare)1991，97，19： | 1 |
| 16 | Heat transfer enhance- merit of fatty acids when used as PCMs in thermal energy storage 显示文摘 | Mazman M Cabeza L F Mehling H | 2008 | Int J Energy Res2008，32，2： | 1 |
| 17 | Materials used as PCM in thermal energy storage in buildings: a review 显示文摘 | Cabeza E Castell A Barreneche C Graeia A Fernandez A | 2011 | Renewable and Sustainable Energy Reviews2011，15，3： | 1 |
| 18 | Imaging cognitionⅡ:an empirical review of 275PET and f MRI studies显示文摘 | Cabeza R Nyberg L | 2000 | J Cogn Neurosci2000，12，： | 1 |
| 19 | A fully on-line adaptive BCI显示文摘 | Vidaurre C Schlogl A Cabeza A | 2006 | IEEE Trans Biomed Eng2006，53，6： | 1 |
| 20 | Prevalence of aspirin resistance in patients with type 2 diabetes显示文摘 | Fateh-Moghadarn S Plockinger U Cabeza N | 2005 | Acta Diabetol2005，42，2： | 1 |
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