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| 1 | Ulcerative colitis显示文摘 | Ingrid Ordás Lars Eckmann Mark Talamini Daniel C Baumgart William J Sandborn | 2012 | The Lancet2012，，9853： | 5 |
| 2 | Ulcerative colitis显示文摘 | Ingrid Ordás Lars Eckmann Mark Talamini Daniel C Baumgart William J Sandborn | 2012 | 2012 (9853)2012，，9853： | 3 |
| 3 | Ulcerative colitis显示文摘 | Ingrid Ordás Lars Eckmann Mark Talamini Daniel C Baumgart William J Sandborn | 2012 | The Lancet . 2012 (9853)2012，，： | 2 |
| 4 | Ulcerative colitis显示文摘 | Ingrid Ordás Lars Eckmann Mark Talamini Daniel C Baumgart William J Sandborn | 2012 | The Lancet2012，，9853： | 2 |
| 5 | Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses显示文摘His-tRNA synthetase (HARS) is targeted by autoantibodies in chronic and acute inflammatory anti-Jo-1-positive antisynthetase syndrome. The extensive activation and migration of immune cells into lung and muscle are associated with interstitial lung disease, myositis, and morbidity. It is unknown whether the sequestration of HARS is an epiphenomenon or plays a causal role in the disease. Here, we show that HARS circulates in healthy individuals, but it is largely undetectable in the serum of anti-Jo-1-positive antisynthetase syndrome patients. In cultured primary human skeletal muscle myoblasts (HSkMC), HARS is released in increasing amounts during their differentiation into myotubes. We further show that HARS regulates immune cell engagement and inhibits CD4+ and CD8+ T-cell activation. In mouse and rodent models of acute inflammatory diseases, HARS administration downregulates immune activation. In contrast, neutralization of extracellular HARS by high-titer antibody responses during tissue injury increases susceptibility to immune attack, similar to what is seen in humans with anti-Jo-1-positive disease. Collectively, these data suggest that extracellular HARS is homeostatic in normal subjects, and its sequestration contributes to the morbidity of the anti-Jo-1-positive antisynthetase syndrome. | Ryan AAdams Cátia Fernandes-Cerqueira Antonella Notarnicola Elisabeth Mertsching Zhiwen Xu Wing-Sze Lo Kathleen Ogilvie Kyle PChiang Jeanette Ampudia Sanna Rosengren Andrea Cubitt David JKing John DMendlein Xiang-Lei Yang Leslie ANangle Ingrid ELundberg Per-Johan Jakobsson Paul Schimmel | 2021 | Cellular & Molecular Immunology2021，18，6： | 2 |
| 6 | Roles of ATP binding cassette transporters A1 and G1, scavenger receptor BI and membrane lipid domains in cholesterol export from macrophages 显示文摘 | Jessup W Ingrid C Gelissen | 2006 | Curr Opin Lipidol2006，17，3： | 1 |
| 7 | Panniculitis in childhood显示文摘 | Ingrid C Polcari Sarah L Stein | 2010 | Dermatologic Therapy2010，23，： | 1 |
| 8 | Ulcerative colitis显示文摘 | Ingrid Ordás Lars Eckmann Mark Talamini Daniel C Baumgart William J Sandborn | 2012 | The Lancet2012，，9853： | 1 |
| 9 | The Lowering of Plasma Lipids following a Weight Reduction Program Is Related to Increased Expression of the LDL Receptor and Lipoprotein Lipase 显示文摘 | Madhu Patalay Ingrid E Lofgren Hedley C | 2005 | J Nutr Apr2005，135，： | 1 |
| 10 | Chemical characterization and functional properties of a potato protein concentrate prepared by large-scale expanded bed adsorption chromatography显示文摘 | Sissel Lkra Merete H Helland Ingrid C Claussen | 2008 | LWT-Food Science and Technology2008，41，6： | 1 |
| 11 | RTX toxin genotypes and phenotypes in Actinobacillus pleuropueumoniae field strains显示文摘 | Marianne B Johannes F D B Ingrid M C A J | 1994 | Journal of Clinical Microbiology1994，32，11： | 1 |
| 12 | Species substitution for carbon storage: Sessile oak versus Corsican pine in France as a case study显示文摘 | Patrick V Céline M Ingrid S | 2009 | Forest Ecology and Management2009，257，4： | 1 |
| 13 | Antioxidant assessment of an an-thocyanin-enriched blackberry extract 显示文摘 | INGRID E HU C DAVID G P | 2007 | Food Chem2007，101，3： | 1 |
| 14 | The role of climate change in the occurrence of algal blooms : Lake Burragorang, Aus- tralia 显示文摘 | LETICIA C VILHENA INGRID H | 2010 | Limnology and Oceanography2010，55，： | 1 |
| 15 | The relevant internal rate of return 显示文摘 | Hartman Joseph C Schafrick Ingrid C | 2004 | The Engineering Economist2004，49，2： | 1 |
| 16 | The lowering of plasma lipids following a weight reduction program is related to increased expression of the LDL receptor and lipoprotein lipase显示文摘 | Madhu Patalay Ingrid E Lofgren Hedley C | 2005 | J Nutr Apr2005，135，： | 1 |
| 17 | Metal accumulation by aquacuhured seedings of Indian mustard 显示文摘 | DAVID E S INGRID J P ROGER C P | 1997 | Environmental Science and Technology1997，31，： | 1 |
| 18 | Antioxidant assessment of an anthocyanin-enriched blackberry extract 显示文摘 | INGRID E HU C DAVID G P | 2007 | Food Chemistry2007，，101： | 1 |
| 19 | Plant effects on spatial and temporal patterns of nitrogen cycling in shortgrass steppe 显示文摘 | Howard E E Ingrid C B and Arvin R M | 1998 | Ecosystems1998，1，： | 1 |
| 20 | Chemical speciation of accumulated metals in plants:evidence from X-ray absorption spectroscopy显示文摘 | David E S Roger C P Ingrid J P | 2002 | Microchemical Journal2002，71，： | 1 |
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