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| 1 | Total glucosides of paeony attenuates animal psoriasis induced inflammatory response through inhibiting STAT1 and STAT3 phosphorylation显示文摘OBJECTIVE Psoriasis is an immune system meditated disease,especially T cells.It disturbed many people around the world and hard to therapy.Paeonia lactiflora Pall has been used as a medicine in china for thousands of years.Recent studies has found that the main component of Paeonia lactiflora Pall can alleviates the immune response in many diseases.In this study,we researched the effects and possible mechanisms of total glucosides of paeony(TGP)on animal psoriasis in order to study the therapeutic effects and mechanisms of TGP in 5%propranolol creaminduced psoriasis in guinea pigs and Imiquimod(IMQ)cream-induced psoriasis in mice.METHODS The effect of TGP was evaluated using a psoriasis-like model of guinea pigs and mice.Ear thickness was accessed,and pathology injury was observed by HE staining.The levels of serum IL-1β,IL-6,IL-12,IL-17,IL-23,TNF-α,and IFN-γ,skin IL-17A,IL-22 and orphan nuclear receptor(RORγt)mRNA expression,proliferating cell nuclear antigen(PCNA),total or phosphorylated signal transducers and activators of transcription(STAT1 and STAT3)were determined by ELISA,real time PCR,immu⁃nohistochemical staining,and Western blotting,respectively.RESULTS Compared with model group,TGP treatment decreased the ear thickness,improved pathology of psoriasis,alleviated IMQ-induced keratinocyte proliferation,reduced the inflammatory cytokine,and downregulated IL-17A,IL-22,and RORγt mRNA in mice.Further study indicated that TGP inhibited STAT1 and STAT3 phosphorylation in lesion skins of psoriasis-like mice.CONCLUSION TGP alleviates the symptoms of psoriasis-like guinea pigs and mice,and the possible mechanism may relate to inhibit T helper 17(TH17)cell differentiation and keratinocytes proliferation by inhibiting STAT1 and STAT3 phosphorylation. | LI Bin-bin HE Shu-cheng LIU Rui HUANG Liang-liang LIU Ge WANG Rui-xuan YANG Zhuo-yue LIU Xin-yi LENG Ye LIU Dan YE Cheng-yu LI Yun-man CHEN Yong-jian IN Hong FANG Wei-rong | 2019 | 中国药理学与毒理学杂志2019，33，9： | 21 |
| 2 | Transretinoic acid inhibits rats gastric epithelial dysplasia induced by N-methyi-N-nitro-N-nitrosoguanidine:influences on cell apoptosis and expression of its regulatory genes显示文摘INTRODUCTIONGastric epithelial dysplasia (GED) hypothetically is a straight-forward concept: dysplastic epithelium replacing the normal gastric epithelium of the stomach [1].In the stomach ,like any other segment of the gut ,it is defined as an unequivocal non-invasive epithelial change[2,3].The observation of gastric dysplasia as a cancerous lesion was recognized over a century ago ,but it is only after the advent of gastroscopy that its clinical significance has been stressed[4-7]. | Ru Tao Cui~1 Gan Cai~2 Zhao Bao Yin~(2*) Yong Cheng~2 Qiu Hong Yang~1 Tao Tian~(3#) ~1Liver Center,Beijing Friendship Hospital Affiliated to CapitalUniversity of Medical Sciences~2Department of Gastroenterology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai China and Department of Pathophysiology.Shanghai Medical University.Shanghai,China ~3Pathological Department,Shanghai Medical University (?)Now working at UCLA,USA ~#Now working at University of Michigan,USADr.Ru Tao Cui graduated and got the bachelor degree from Shandong University of Traditional Chinese Medicine in 1994,got doctor degree from Shanghai University of Traditional Chinese Medicine in 2000,now studying as a postdoc,majoring gastroenterology,having 29 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 8 |
| 3 | Gradient analysis of landscape spatial and temporal pattern changes in Beijing metropolitan area显示文摘The gradient based landscape metrics analysis is now widely used to study the landscape pattern changes in respond to the urbanization.In order to discover the trend of spatio-temporal changes in Beijing metropolitan area during the past 15 years,several landscape metrics are computed using a moving window along a 96 km long transect across Beijing metropolitan area from west to east.Specially,the spatial extent of sub-landscape,which is determined by the moving window’s size,is profoundly examined.The results show that the metrics varies smoothly and regularly along the selected transect when the window size is greater than 6 km×6 km,and irregularly fluctuated for the smaller window size,that the spatial and temporal landscape characteristics of Beijing city match the hypothetical framework of spatio-temporal urban sprawl in the form of alternating processes of diffusion and coalescence well,and that some new trends of the urban sprawl style in Beijing metropolitan area,such as leap-frog manner,are also detected by the gradient landscape analysis. | YANG YeTao1,ZHOU QiMing2,GONG JianYa3 & WANG YingYing4 1 Institute of Geophysics and Geomatics,China University of Geosciences,Wuhan 430074,China 2 Department of Geography,Hong Kong Baptist University,Hong Kong 3 State Key Laboratory of Information Engineering in Surveying,Mapping and Remote Sensing,Wuhan University,Wuhan 430074,China 4 Hubei Provincial Bureau of Meteorology,Wuhan 430074,China | 2010 | Science China(Technological Sciences)2010，53，S1： | 5 |
| 4 | Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues显示文摘 | Keon Hee Yoo In Keun Jang Myoung Woo Lee Hyo Eun Kim Mal Sook Yang Youngwoo Eom Jong Eun Lee Young Jin Kim Seong Kyu Yang Hye Lim Jung Ki Woong Sung Cheol Woo Kim Hong Hoe Koo | 2009 | Cellular Immunology2009，，2： | 2 |
| 5 | Usefulness of continuous renal replacement therapy for correcting hypernatremia in a patient with severe congestive heart failure显示文摘 | Hoon Suk Park Yu Ah Hong Hyun Gyung Kim Sun Ryoung Choi In O. Sun Byung Ha Chung Cheol Whee Park Chul Woo Yang Yong Soo Kim Bum Soon Choi | 2012 | Hemodial Int2012，，4： | 1 |
| 6 | Benefit of Early Statin Therapy in Patients With Acute Myocardial Infarction Who Have Extremely Low Low-Density Lipoprotein Cholesterol显示文摘 | Ki Hong Lee Myung Ho Jeong Ha Mi Kim Youngkeun Ahn Jong Hyun Kim Shung Chull Chae Young Jo Kim Seung Ho Hur In Whan Seong Taek Jong Hong Dong Hoon Choi Myeong Chan Cho Chong Jin Kim Ki Bae Seung Wook Sung Chung Yang Soo Jang Seung Woon Rha Jang Ho Bae Jeo | 2011 | Journal of the American College of Cardiology2011，，16： | 1 |
| 7 | Neuroprotective effects of ischemic preconditioning on hippocampal CA1 pyramidal neurons through maintaining calbindin D28k immunoreactivity following subsequent transient cerebral ischemia显示文摘Ischemic preconditioning elicited by a non-fatal brief occlusion of blood flow has been applied for an experimental therapeutic strategy against a subsequent fatal ischemic insult. In this study, we investigated the neuroprotective effects of ischemic preconditioning(2-minute transient cerebral ischemia) on calbindin D28k immunoreactivity in the gerbil hippocampal CA1 area following a subsequent fatal transient ischemic insult(5-minute transient cerebral ischemia). A large number of pyramidal neurons in the hippocampal CA1 area died 4 days after 5-minute transient cerebral ischemia. Ischemic preconditioning reduced the death of pyramidal neurons in the hippocampal CA1 area. Calbindin D28k immunoreactivity was greatly attenuated at 2 days after 5-minute transient cerebral ischemia and it was hardly detected at 5 days post-ischemia. Ischemic preconditioning maintained calbindin D28 k immunoreactivity after transient cerebral ischemia. These findings suggest that ischemic preconditioning can attenuate transient cerebral ischemia-caused damage to the pyramidal neurons in the hippocampal CA1 area through maintaining calbindin D28k immunoreactivity. | In Hye Kim Yong Hwan Jeon Tae-Kyeong Lee Jeong Hwi Cho Jae-Chul Lee Joon Ha Park Ji Hyeon Ahn Bich-Na Shin Yang Hee Kim Seongkweon Hong Bing Chun Yan Moo-Ho Won Yun Lyul Lee | 2017 | Neural Regeneration Research2017，12，6： | 1 |
| 8 | Synthesis of silicone - acrylic resins and their applications to superweatherable coatings显示文摘 | PARK HONG SOO YANG IN MO WU JONG PYO | 2001 | J Appl Poly Sci2001，81，7： | 1 |
| 9 | Comparison of clinical outcomes between octogenarians and non-octogenarians with acute myocardial infarction in the drug-eluting stent era: Analysis of the Korean Acute Myocardial Infarction Registry显示文摘 | Futoshi Yamanaka Myung Ho Jeong Shigeru Saito Youngkeun Ahn Shung Chull Chae Seung Ho Hur Taek Jong Hong Young Jo Kim In Whan Seong Jei Keon Chae Jay Young Rhew In Ho Chae Myeong Chan Cho Jang Ho Bae Seung Woon Rha Chong Jin Kim Donghoon Choi Yang Soo Jan | 2013 | Journal of Cardiology2013，，： | 1 |
| 10 | Therapeutic potential of neuromodulation for demyelinating diseases显示文摘Neuromodulation represents a cutting edge class of both invasive and non-invasive therapeutic methods which alter the activity of neurons.Currently,several different techniques have been developed-or are currently being investigated–to treat a wide variety of neurological and neuropsychiatric disorders.Recently,in vivo and in vitro studies have revealed that neuromodulation can also induce myelination,meaning that it could hold potential as a therapy for various demyelinating diseases including multiple sclerosis and progressive multifocal leukencepalopathy.These findings come on the heels of a paradigm shift in the view of myelin's role within the nervous system from a static structure to an active co-regulator of central nervous system plasticity and participant in neuron-mediated modulation.In the present review,we highlight several of the recent findings regarding the role of neural activity in altering myelination including several soluble and contact-dependent factors that seem to mediate neural activitydependent myelination.We also highlight several considerations for neuromodulatory techniques,including the need for further research into spatiotemporal precision,dosage,and the safety and efficacy of transcranial focused ultrasound stimulation,an emerging neuromodulation technology.As the field of neuromodulation continues to evolve,it could potentially bring forth methods for the treatment of demyelinating diseases,and as such,further investigation into the mechanisms of neuron-dependent myelination as well as neuro-imaging modalities that can monitor myelination activity is warranted. | Elliot H.Choi Chioma Nwakalor Nolan J.Brown Joonho Lee Michael Y.Oh In Hong Yang | 2021 | Neural Regeneration Research2021，16，2： | 1 |
| 11 | Quantum secure direct communication network with hyperentanglement显示文摘We propose a quantum secure direct communication protocol with entanglement swapping and hyperentanglement.Any two users, Alice and Bob, can communicate with each other in a quantum network, even though there is no direct quantum channel between them. The trust center, Trent, who provides a quantum channel to link them by performing entanglement swapping, cannot eavesdrop on their communication. This protocol provides a high channel capacity because it uses hyperentanglement, which can be generated using a beta barium borate crystal. | Chang Ho Hong Jino Heo Jong In Lim Hyung Jin Yang | 2014 | Chinese Physics B2014，23，9： | 1 |
| 12 | Synthesis of ultrafine LiCoO2 powders by the sol- gel method显示文摘 | Yang Kook Sun In Hwan On Seong Ahn Hong | 1996 | J Mat Sci1996，31，： | 1 |
| 13 | Musculoskeletal Applications of PET/MR显示文摘 | In Lee Yoo Jin Sung Hong Seoung-Oh Yang | 2014 | Semin Musculoskelet Radiol2014，，： | 1 |
| 14 | Obesity paradox in Korean patients undergoing primary percutaneous coronary intervention in ST-segment elevation myocardial infarction显示文摘 | Won Yu Kang Myung Ho Jeong Young Keun Ahn Jong Hyun Kim Shung Chull Chae Young Jo Kim Seung Ho Hur In Whan Seong Taek Jong Hong Dong Hoon Choi Myeong Chan Cho Chong Jin Kim Ki Bae Seung Wook Sung Chung Yang Soo Jang Seung Woon Rha Jang Ho Bae Jeong Gwan C | 2009 | Journal of Cardiology2009，，1： | 1 |
| 15 | A Quantum Communication Protocol Transferring Unknown Photons Using Path-Polarization Hybrid Entanglement显示文摘We propose a protocol for transferring photons of unknown states to a distant location using path-polarization hybrid entanglement.Our protocol uses a polarizing beam splitter(PBS),a beam splitter(BS),a CNOT-operation,four unitary operations and polarizing detectors.In our protocol,the hybrid entangled states are generated by the PBS,and it is transmitted through the quantum channel containing the BS and CNOT-gate.The measurement results of the polarizing detectors and classical communications determine which unitary operation will be used in the last step for recovering initial states.The security of the channel in transmitting unknown photons between two parties is confirmed by the results of the measurement of each target photon in the control mode. | Jino Heo Chang Ho Hong Jong In Lim Hyung Jin Yang | 2013 | Chinese Physics Letters2013，30，4： | 0 |
| 16 | A Quantum Network System of QSS-QDC Using χ-Type Entangled States显示文摘A multiuser quantum direct communication network system for N users utilizing χ-type entangled states is prupused. The network system is composed of a communication center,N users,and N quantum lines linking the center and the N users.There is no quantum line among users,and therefore only N quantum lines are necessary for communication between users.Using one χ-type entangled state, in this protocol we are able to send two bits of information through direct communication and,at the same time,share two bits of quantum keys. The security of the protocol is then analyzed. | Chang Ho Hong Jin O Heo Jong in Lim Hyung jin Yang | 2012 | Chinese Physics Letters2012，29，5： | 0 |
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