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| 1 | Hyperspectral vegetation indices and novel algorithms for predicting green LAI of crop canopies: Modeling and validation in the context of precision agriculture显示文摘 | Driss Haboudane John R Miller Elizabeth Pattey Pablo J Zarco-Tejada Ian B Strachan | 2004 | Remote Sensing of Environment2004，，3： | 3 |
| 2 | Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice显示文摘BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated morbidity.The protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic retinopathy.AIM To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse model.METHODS The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. Enzyme-linked immunosorbent assay(ELISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using ELISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield microscopy.RESULTS Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba mice.Furthermore, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced in Akimba mice when compared to DMSO treated mice. In addition, empagliflozin resulted in suppression of succinate levels in Akimba mice. The beneficial SCFA known as butyric acid was significantly increased in Akita mice after treatment with dapagliflozin when compared to vehicle treated mice. The norepinephrine content in the kidney was significantly reduced with both dapagliflozin and empagliflozin therapy in Akita mice and was significantly reduced in Akimba mice treated with empagliflozin.In non-diabetic C57 BL/6 J and Kimba mice, serum leptin levels were significantly reduced after dapagliflozin therapy.CONCLUSION The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1 D. Collectively, these improvements may represent an important mechanism underlying the potential benefits of SGLT2 inhibition in T1 D and its complications. | Lakshini Y Herat Natalie C Ward Aaron L Magno Elizabeth P Rakoczy Marcio G Kiuchi Markus P Schlaich Vance B Matthews | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 3 | Leader behaviors and the work environment for creativity: Perceived leader support显示文摘 | Teresa M Amabile Elizabeth A Schatzel Giovanni B Moneta Steven J Kramer | 2004 | The Leadership Quarterly2004，，1： | 2 |
| 4 | Lead and mercury exposures:interpretation and action显示文摘 | Elizabeth B Ray C Andre M | 2007 | CMAJ2007，176，1： | 1 |
| 5 | Effect of nonylphenol on serum testosterone levels and testicular steroidogenie enzyme activity in neonatal,pubertal, and adult rats显示文摘 | ELIZABETH M L GANESH B CONSTANCE W | 2002 | Chemico-Biological Interactions2002，139，1： | 1 |
| 6 | Erythropoietin (EPO) in acute kidney injury 显示文摘 | Elizabeth Moore R B | 2011 | Annals of Intensive Care2011，1，3： | 1 |
| 7 | The impact of eliminating socioeconomic and racial disparities on premature cancer deaths 显示文摘 | Rebecca S Elizabeth W Otis B | 2011 | CA Cancer J Clin2011，61，： | 1 |
| 8 | Biocontrol of plant disease:a (Gram-) positive perspective显示文摘 | Elizabeth A B E Handelsman J O | 1999 | FEMS Microbiology Letters1999，171，： | 1 |
| 9 | Use of denaturing high-performance liquid chromatography to identify Bacillus anthracis by analysis of the 16S-23S rRNA Interspacer Region and gyrA Gene显示文摘 | William H Elizabeth B Rebecca S K | 2003 | Journal of Clinical Microbiology2003，41，10： | 1 |
| 10 | Viability and stability of biological control agents on cotton and snap bean seeds显示文摘 | Monica L E Elizabeth A D J William E B J | 2001 | Pest Manag sc2001，57，8： | 1 |
| 11 | The prognostic value of histology in the assessment of patients with Budd–Chiari syndrome显示文摘 | Thjon J Tang Kenneth P Batts Piet C de Groen Bart van Hoek Elizabeth B Haagsma Wim C.J Hop Harry L.A Janssen | 2001 | Journal of Hepatology2001，，3： | 1 |
| 12 | Self-assembling chi- tosarffpoly-γ/- glutamic acid nanoparticles for targeted drug delivery显示文摘 | ZSOLT K MAGDOLNA B ELIZABETH B | 2009 | Colloid & Polym Sei2009，287，7： | 1 |
| 13 | Effect of food availability and predation on prairie vole demography: a Field experiment 显示文摘 | Elizabeth A D Ggorge O B | 1989 | Ecology1989，70，2： | 1 |
| 14 | Impact of nitrogen and environment conditions on corn as detected by hyperspectral reflectance显示文摘 | Ian B Strachan Elizabeth Pattey Boisvert B Johnne | 2002 | Remote Sensing of Environment2002，80，2： | 1 |
| 15 | Enhanced NR2A subunit expression and decreased NMDA receptor decay time at the onset of ocular dominance plasticity in the ferret显示文摘 | Elizabeth B | 1999 | J Neurophysiol1999，81，： | 1 |
| 16 | Influence of curingtemperature on the volatile components of peanuts显示文摘 | J A Singleon Harold E Pattee Elizabeth B Johns | 1971 | Agric Food hem1971，19，1： | 1 |
| 17 | Strategic transformation process: Toward purpose, people, process and power 显示文摘 | Davis Elizabeth B Kee James Newcomer Kathryn | 2010 | Organization Management Journal2010，，1： | 1 |
| 18 | Inverted repeat PCR for the rapid assembly of constructs to induce RNA interference显示文摘 | Lucia C P Roger B D Elizabeth C | 2005 | Plant and Cell Physiology2005，46，11： | 1 |
| 19 | Tree and shrub invasion in northern mixed-grass prairie显示文摘 | Todd A Grant Elizabeth Madden Gordon B | 2004 | Wildlife Society Bulletin2004，32，3： | 1 |
| 20 | Reference librarians at the reference desk in a learning commons : a mixed methods evaluation 显示文摘 | Elizabeth B Fitzpatrick Anne C Moore Beth W Lang | | The0，200，3： | 1 |
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