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| 1 | Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey显示文摘AIM: To investigate prevalence of Clonorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea.METHODS: Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire.RESULTS: Of 3080 patients with gastrointestinal diseases, 396 (12.9%) had clonorchiasis and 1140 patients (37.2%) had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 (20.9%) patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than non-infected patients [34/396 (8.6%) vs 145/2684 (5.4%), P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation (P = 0.008). Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis.CONCLUSION: Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite. | Ho Gak Kim Jimin Han Myung-Hwan Kim Kyu Hyun Cho Im Hee Shin Gwang Ha Kim Jae Seon Kim Jin Bong Kim Tae Nyeun Kim Tae Hyeon Kim Tae Hyo Kim Jae Woo Kim Ji Kon Ryu Young-Soo Moon Jong Ho Moon Sung Jae Park Chan Guk Park Sung-Jo Bang Chang Heon Yang Kyo-Sang Yoo Byung Moo Yoo Kyu Taek Lee Dong Ki Lee Byung Seok Lee Sang Soo Lee Seung Ok Lee Woo Jin Lee Chang Min Cho Young-Eun Joo Gab Jin Cheon Young Woo Choi Jae Bok Chung Yong Bum Yoon | 2009 | World Journal of Gastroenterology2009，15，1： | 15 |
| 2 | Efficacy of Saam acupuncture treatment on improvement of immune cell numbers in cancer patients:a pilot study显示文摘OBJECTIVE: To collect preliminary data on the effects of Saam acupuncture with regard to the immunity in cancer patients.METHODS: Ten cancer patients were analyzed for improvements in immunity. Acupuncture was applied at the 5 acupuncture points, Jingqu(LU 8), Zutonggu(BL 66), Yanggu(SI 5), Yangchi(TE 4), and Zhongwan(CV 12) for 2 weeks with 4 sessions. We assessed the effect of Korean Saam acupuncture on the immune system in cancer patients by measuring particular blood cell subsets, including CD3 +,CD4+, CD8+, CD19+, and CD56+ cells, as well as total white blood cell count, absolute neutrophil count, and fatigue score. The measurement was performed before and after acupuncture and at a 2-week follow-up.RESULTS: There was a statistically significant increase in the number of CD3+(P=0.023) and CD8+ cells(P<0.001) and T-cell subsets, as well as a decrease in the fatigue severity scale(FSS) score(P=0.001) after Saam acupuncture using the 5 acupoints.CONCLUSION: Acupuncture may improve the immune system by increasing the counts of a few immune cells and relieve fatigue in cancer patients by decreasing FSS scores. Although this was a non-controlled study, it constitutes preliminary research investigating the potential effects of Saam acupuncture in increasing the counts of several immune cells in cancer patients. | Dae-Joon Kim Seong-Hoon Park Jung-Chul Seo Kyung Soon Kim Ki Cheul Sohn Im Hee Shin Hun Mo Ryoo | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 11 |
| 3 | Clinicopathologic factors influencing the accuracy of EUS for superficial esophageal carcinoma显示文摘AIM:To identify clinicopathologic factors influencing the accuracy of a high-frequency catheter probe endoscopic ultrasonography(EUS)for superficial esophageal carcinomas(SECs).METHODS:A total of 126 patients with endoscopically suspected SEC,who underwent EUS and curative treatment at Pusan National University Hospital during2005-2013,were enrolled.We reviewed the medical records of the 126 patients and compared EUS findings with histopathologic results according to clinicopathologic factors.RESULTS:A total of 114 lesions in 113 patients were included in the final analysis.The EUS assessment of tumor invasion depth was accurate in 78.9%(90/114)patients.Accuracy did not differ according to histologic type,tumor differentiation,tumor location,or macroscopic shape.However,accuracy significantly decreased for tumors≥3 cm in size(P=0.002).Overestimation and underestimation of the invasion depth occurred for 11(9.6%)and 13 lesions(11.4%),respectively.In multivariate analyses,tumor size≥3 cm was the only factor significantly associated with EUS accuracy(P=0.031),and was specifically associated with the underestimation of invasion depth.CONCLUSION:EUS using a high-frequency catheter probe generally provides highly accurate assessments of SEC invasion depth,but its accuracy decreases for tumors≥3 cm. | Jung Im Jung Gwang Ha Kim Hoseok I Do Youn Park Tae Kyun Kim Young Hwa Cho Yong Wan Sung Mun Ki Choi Bong Eun Lee Geun Am Song | 2014 | World Journal of Gastroenterology2014，20，20： | 9 |
| 4 | Removal of primary iron rich phase from aluminum-silicon melt by centrifugal separation显示文摘Recycling is a major consideration in continued aluminum use due to the enormous demand for high quality products. Some impurity elements gradually accumulate through the repetitive reuse of aluminum alloy scrap. Of them, the iron content should be suppressed under the allowed limit. In the present research, a novel separation method was introduced to remove primary iron-rich intermetallic compounds by centrifugation during solidification of Al-Si-Fe alloys. This method does not use the density difference between two phases as in other centrifugal methods, but uses the order of solidification in Al-Si-Fe alloys, because iron promotes the formation of intermetallic compounds with other alloying elements as a primary phase. Two Al-Si-Fe alloys which have different iron contents were chosen as the starting materials. The iron-rich phase could be efficiently removed by centrifuging under a centrifugal force of 40 g. Coarse intermetallic compounds were found in the sample inside the crucible, while rather fine intermetallic compounds were found in the sample outside the crucible. Primary intermetallic compounds were linked to each other via aluminum-rich matrix, and formed like a network. The highest iron removal fraction is 67% and the lowest one is 7% for Al-12Si-1.7Fe alloy. And they are 82% and 18% for Al-12Si-3.4Fe alloy, respectively. | Seong Woo Kim Un Ho Im Hyeong Cheol Cha Se Hyeong Kim Ji Eun Jang Ki Young Kim | 2013 | China Foundry2013，10，2： | 8 |
| 5 | A highly sensitive chemical gas detecting transistor based on highly crystalline CVD-grown MoSe2 films显示文摘有原子厚度的分层的半导体由于他们的高级搬运人活动性,大 surface-to-volume 比率,和对他们的包围环境的快速的电的回答在高效的电子设备作为活跃元素正在变得日益重要。这里,我们报导高度敏感的 chemical-vapor-deposition-grown 的第一实现多层的 MoSe 2 地效果晶体管(联邦货物税) 在一没有 2 气体传感器。这个传感器展出了超离频敏感(S = ca。1,907 为在 300 ppm 的没有 2) ,即时反应,并且快速的开关切换。我们的 MoSe 2 气体传感器的高敏感在 2 气体专心于在离开状态政体在洞电流导致重要增加的 MoSe 2, 的 NO 劝诱的原子价乐队附近处于差距状态被归因于变化。设备建模和量运输模拟表明没有 2 集中的差距状态的变化是在 MoSe 2 的关键机制基于联邦货物税没有 2 气体传感器。这全面研究,它探讨材料生长,设备制造,描述,和设备模拟,不是仅仅为高效的化学传感器显示 MoSe 2 联邦货物税的用途,而且建立怎么出现理解化学的一个基础在分层的半导体设备影响搬运人运输。 | Jongyeol Baek Demin Yin Na Liu Inturu Omkaram Chulseung Jung Healin Im Seongin Hong Seung Min Kim Young Ki Hong Jaehyun Hur Youngki Yoon Sunkook Kim | 2017 | Nano Research2017，10，6： | 4 |
| 6 | Efficacy of a Metallic Stent Covered with a Paclitaxel-Incorporated Membrane Versus a Covered Metal Stent for Malignant Biliary Obstruction: A Prospective Comparative Study显示文摘 | Sung Ill Jang Jie-Hyun Kim Jung Whan You Kwangwon Rhee Se Joon Lee Ho Gak Kim Jimin Han Im Hee Shin Sang-Heum Park Dong Ki Lee | 2013 | Digestive Diseases and Sciences2013，，3： | 2 |
| 7 | 来自一项艾日布林联合吉西他滨对比紫杉醇联合吉西他滨作为HER2阴性转移性乳腺癌的一线化疗的Ⅱ期、多中心、随机试验的包含神经病变相关量表的生活质量结果:韩国癌症研究组试验(KCSG BR13-11)显示文摘背景与目的一项比较艾日布林联合吉西他滨(eribulin plus gemcitabine,EG)或紫杉醇联合吉西他滨(paclitaxel plus gemcitabine,PG)作为转移性乳腺癌(metastatic breast cancer,MBC)患者一线化疗方案的II期临床试验发现,EG方案的神经毒性较低,但疗效与PG方案相似。在本研究中,我们分析了该临床实验中的癌症患者生命质量测评量表–紫杉烷(functional assessment of cancer therapy-taxane,FACT-Taxane)问卷评分以确定他们的生活质量(quality of life,QoL)。方法使用韩国版的FACT-Taxane问卷评估QoL。在评估基线之后,前12个疗程中每2个疗程评估1次QoL,之后每3个疗程评估1次QoL。使用线性混合模型评估EG组和PG组QoL的差异。结果在118例入组患者中,117例在基线时回复了FACT-Taxane问卷,PG组中有1例患者没有回复。EG组和PG组之间的基线QoL评分没有差异。在治疗期间,除了第11个疗程外,在第2–13个化疗疗程后,PG组紫杉烷亚量表评分显著高于EG组(均P<0.05)。神经病变特异性分析显示PG组患者的神经病症状比EG组患者更早出现且更严重(P<0.001)。结论在我们的QoL分析中,与PG方案相比,EG方案延迟并减少神经病变的发生。因此,艾日布林是MBC一线化疗药物紫杉醇的合理替代品。 | Ji‑Yeon Kim Seri Park Seock‑Ah Im Sung‑Bae Kim Joohyuk Sohn Keun Seok Lee Yee Soo Chae Ki Hyeong Lee Jee Hyun Kim Young‑Hyuck Im Tae‑Yong Kim Kyung‑Hun Lee Jin‑Hee Ahn Gun Min Kim In Hae Park Soo Jung Lee Hye Sook Han Se Hyun Kim Kyung Hae Jung Yeon Hee Park Korean Cancer Study Group | 2019 | 癌症2019，38，8： | 2 |
| 8 | Foldable and washable textile-based OLEDs with a multi-functional near-room-temperature encapsulation layer for smart e-textiles显示文摘Wearable electronic devices are being developed because of their wide potential applications and user convenience.Among them,wearable organic light emitting diodes(OLEDs)play an important role in visualizing the data signal processed in wearable electronics to humans.In this study,textile-based OLEDs were fabricated and their practical utility was demonstrated.The textilebased OLEDs exhibited a stable operating lifetime under ambient conditions,enough mechanical durability to endure the deformation by the movement of humans,and washability for maintaining its optoelectronic properties even in water condition such as rain,sweat,or washing.In this study,the main technology used to realize this textile-based OLED was multi-functional nearroom-temperature encapsulation.The outstanding impermeability of TiO_(2)film deposited at near-room-temperature was demonstrated.The internal residual stress in the encapsulation layer was controlled,and the device was capped by highly crosslinked hydrophobic polymer film,providing a highly impermeable,mechanically flexible,and waterproof encapsulation. | So Yeong Jeong Hye Rin Shim Yunha Na Ki Suk Kang Yongmin Jeon Seungyeop Choi Eun Gyo Jeong Yong Cheon Park Ha-Eun Cho Junwoo Lee Jeong Hyun Kwon Sung Gap Im Kyung Cheol Choi | 2021 | npj Flexible Electronics2021，5，1： | 2 |
| 9 | Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1(G93A)mice and SOD1(G17S and G86S)ALS patients显示文摘Background:MicroRNAs(miRNAs)are endogenous non-coding RNAS that regulate gene expression at the post-transcriptional level and are key modulators in neurodegenerative diseases.Overexpressed miRNAs play an important role in amyotrophic lateral sclerosis(ALS);however,the pathogenic mechanisms of deregulated miRNAS are still unclear.Methods:We aimed to assess the dysfunction of RNAS or miRNAs in fALS(SOD1 mutations).We compared the RNA-seq of subcellular fractions in NSC-34 WT(hSOD1)and MT(hSOD1(G93A))cells to find altered RNAs or miRNAs.We identified that Hif1a and Mef2c were upregulated,and Mctp1 and Rarb were downregulated in the cytoplasm of NSC-34 MT cells.Results:SOD1 mutations decreased the level of miR-18b-5p.Induced Hif1a which is the target for miR-18b increased Mef2c expression as a transcription factor.Mef2c upregulated miR-206 as a transcription factor.Inhibition of Mctp1 and Rarb,which are targets of miR-206,induced intracellular Ca^2+ levels and reduced cell differentiation,respectively.The miR-18b-5p pathway was also observed in G93A Tg mice,fALS(G86S)patient,and iPSC-derived motor neurons from fALS(G17S)patient.Conclusions:Our data indicate that SOD1 mutation decreases miR-18b-5p,which sequentially regulates Hif1a,Mef2c,miR-206,Mctp1 and Rarb in fALS-linked SOD1 mutation.These results provide new insights into the downregulation of miR-18b-5p-dependent pathogenic mechanisms of ALS. | Ki Yoon Kim Yu Ri Kim Kyung Won Choi Mijung Lee Somyung Lee Wooseok Im Je-Young Shin Jin Young Kim Yoon Ho Hong Manho Kim Jong-ll Kim Jung-Joon Sung | 2020 | Translational Neurodegeneration2020，9，3： | 2 |
| 10 | Adoptive transfer of treg cells combined with mesenchymal stem cells facilitates repopulation of endogenous treg cells in a murine acute GVHD model 显示文摘 | Lee ES LIm JY Im KI | 2015 | PLoS One2015，10，01： | 1 |
| 11 | Use of 3′-deoxy-3′-[18F]fluorothymidine PET to monitor early responses to radiation therapy in murine SCCVII tumors显示文摘 | You-Jung Yang Jin-Sook Ryu Seog-Young Kim Seung Jun Oh Ki Chun Im Heuiran Lee Sang-wook Lee Kyung Ja Cho Gi-Jeong Cheon Dae Hyuk Moon | 2006 | European Journal of Nuclear Medicine and Molecular Imaging2006，，4： | 1 |
| 12 | Receptor activator of nuclear factor kappa B ligand-mediated osteoclastogenesis is elevated in ankylosing spondylitis显示文摘 | Im CH Kang EH Ki JY | 2009 | Clin Exp Rheumatol2009，27，4： | 1 |
| 13 | An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach显示文摘 | Sung Kim Do Hoon Lim Jeeyun Lee Won Ki Kang John S. MacDonald Chan Hyung Park Se Hoon Park Se-Hoon Lee Kihyun Kim Joon Oh Park Won Seog Kim Chul Won Jung Young Suk Park Young-Hyuck Im Tae Sung Sohn Jae Hyung Noh Jin Seok Heo Yong Il Kim Chul Keun Park Keu | 2005 | International Journal of Radiation Oncology Biology Physics2005，，5： | 1 |
| 14 | Chromatin movement visualized with photoactivable GFP-labeled his- tone H4显示文摘 | Wiesmeijer KI Krouwels IM Tanke HJ | 2008 | Differentiation2008，76，1： | 1 |
| 15 | A phase II study of capecitabine and cisplatin (XP) as first-line chemotherapy in patients with advanced esophageal squamous cell carcinoma显示文摘 | Jeeyun Lee Young-Hyuck Im Eun Yoon Cho Yong Sang Hong Hyo Rak Lee Hyo Song Kim Mi-Jin Kim Kwhanmien Kim Won Ki Kang Keunchil Park Young Mog Shim | 2008 | Cancer Chemotherapy and Pharmacology2008，，1： | 1 |
| 16 | Osteogenic differentiation and angiogenesis with cocuhured adipose-derived stromal cells and bone marrow stromal ceils 显示文摘 | Kim KI Park S Im GI | 2014 | Biomaterials2014，35，17： | 1 |
| 17 | Extranodal nasal type NK/T-cell Lymphoma: Elucidating clinical prognostic factors for risk-based stratification of therapy显示文摘 | Jeeyun Lee Yeon Hee Park Won Seog Kim Seung-Sook Lee Baek-Yeol Ryoo Sung Hyun Yang Keon Woo Park Jung Hoon Kang Joon Oh Park Se Hoon Lee Kihyun Kim Chul Won Jung Young Suk Park Young-Hyuck Im Won Ki Kang Mark H. Lee Young H. Ko Yong Chan Ahn Keunchil Park | 2005 | European Journal of Cancer2005，，10： | 1 |
| 18 | Osteogenic differentiation and angiogenesis with cocultured adipose-derived stromal cells and bone marrow stromal cells显示文摘 | Kim KI Park S Im GI | 2014 | Biomaterials2014，35，17： | 1 |
| 19 | Functional evaluation of parathyroid adenoma using 99mTc-MIBI parathyroid SPECT/CT: correlation with functional markers and disease severity显示文摘 | Hyung-Jun Im In Ki Lee Jin Chul Paeng Kyu Eun Lee Gi Jeong Cheon Keon Wook Kang June-Key Chung Dong Soo Lee | 2014 | Nuclear Medicine Communications2014，，： | 1 |
| 20 | Phylogenetic relationship of ribosomal ITS2 and mitochondrial CO I among diploid and triploid Paragonimus westermani isolates显示文摘 | Park GM Yong TS Im KI | | 0，，： | 1 |
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