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| 1 | Quality of life following laparoscopic Nissen fundoplication: Assessing short-term and long-term outcomes显示文摘AIM: To investigate the quality of life following lapa-roscopic Nissen fundoplication by assessing short-term and long-term outcomes. METHODS: From 1992 to 2005, 249 patients under-went laparoscopic Nissen fundoplication. Short-term outcome data including symptom response, side effects of surgery, endoscopy, and patient's perception of over-all success were collected prospectively. Long-term out-comes were investigated retrospectively in patients witha median follow-up of 10 years by assessment of reflux symptoms, side effects of surgery, durability of antire-flux surgery, need for additional treatment, patient's perception of success, and quality of life. Antireflux sur-gery was considered a failure based on the following criteria: moderate to severe heartburn or regurgitation; moderate to severe dysphagia reported in combination with heartburn or regurgitation; regular proton pump inhibitor medication use; endoscopic evidence of erosive esophagitis Savary-Miller grade 1-4; pathological 24-h pH monitoring; or necessity to undergo an additional surgery. The main outcome measures were short-and long-term cure rates and quality of life, with patient sat-isfaction as a secondary outcome measure. RESULTS: Conversion from laparoscopy to open sur-gery was necessary in 2.4% of patients. Mortality was zero and the 30-d morbidity was 7.6% (95%CI: 4.7%-11.7%). The median postoperative hospital stay was 2 d [interquartile range (IQR) 2-3 d]. Two hundred and forty-seven patients were interviewed for short-term analysis following endoscopy. Gastro-esophageal reflux disease was cured in 98.4% (95%CI: 95.9%-99.6%) of patients three months after surgery. New-onset dysphagia was encountered postoperatively in 13 patients (6.7%); 95% reported that the outcome was better after antireflux surgery than with preopera-tive medical treatment. One hundred and thirty-nine patients with a median follow-up of 10.2 years (IQR 7.2-11.6 years) were available for a long-term evalu-ation. Cumulative long-term cure rates were 87.7% (81.0%-92.2%) at 5 years and 72.9% (64.0%-79.9%) at 10 years. Gastrointestinal symptom rating scores and RAND-36 quality of life scores of patients with treatment success were similar to those of the general population but significantly lower in those with failed antireflux surgery. Of the patients available for long-term follow-up, 83% rated their operation a success. CONCLUSION: For the long-term, our results indicate decreasing effectiveness of laparoscopic antirefluxsurgery, although most of the patients seem to have an overall quality of life similar to that of the general population. | Ilmo Kellokumpu Markku Voutilainen Caj Haglund Martti Frkkil Peter J Roberts Hannu Kautiainen | 2013 | World Journal of Gastroenterology2013，19，24： | 7 |
| 2 | How did Finland's Economic Recession in the early 1990s Affect Socio-economic Equity in the Use of Hospital care显示文摘 | Ilmo Keskimaki | 2003 | Social Science and Medicine2003，，56： | 1 |
| 3 | Basement membrane proteins in salivary gland tumours显示文摘 | Alena Skalova Ilmo Leivo | 1992 | Virchows Archiv A Pathological Anatomy and Histopathology1992，，5： | 1 |
| 4 | Ecological modernization-origins,dilemmas and future directions显示文摘 | Mikael Skou Andersen Ilmo Massa | | Journal of Environmental Policy and Planning0，2，4： | 1 |
| 5 | Surgical care quality and oncologic outcome after D2 gastrectomy for gastric cancer显示文摘AIM: To examine the quality of surgical care and longterm oncologic outcome after D2 gastrectomy for gastric cancer.METHODS: From 1999 to 2008, a total of 109 consecutive patients underwent D2 gastrectomy without routine pancreaticosplenectomy in a multimodal setting at our institution. Oncologic outcomes together with clinical and histopathologic data were analyzed in relation to the type of surgery performed. Staging was carried out according to the Union for International Cancer Control criteria of 2002. Patients were followedup for five years at the outpatient clinic. The primary measure of outcome was long-term survival with the quality of surgery as a secondary outcome measure. Clinical data were retrospectively collected from the patient records, and causes of death were obtained from national registries.RESULTS: A total of 109 patients(58 men) with a mean age of 67.4 ± 11.2 years underwent total gastrectomy or gastric resection with D2 lymph node dissection. The tumor stage distribution was as follows: stageⅠ,(27/109) 24.8%; stage Ⅱ,(31/109) 28.4%; stage Ⅲ,(41/109) 37.6%; and stage Ⅳ,(10/109) 9.2%. Forty patients(36.7%) received chemotherapy or chemoradiotherapy. The five-year overall survival rate for all 109 patients was 45.0%, and was 47.1% for the 104 patients treated with curative R0 resection. The five-year disease-specific survival rates were 53.0% and 55.8%, respectively. In a multivariate analysis, body mass index and tumor stage were independent prognostic factors for overall survival(both P < 0.01), whereas body mass index, tumor stage, tumor site, Lauren classification, and lymph node invasion were prognostic factors for cancer-specific survival(all P < 0.05). Postoperative 30-d mortality was 1.8% and 30-d, surgical(including three anastomotic leaks, two of which were treated conservatively), and general morbidities were 26.6%, 12.8%, and 14.7%, respectively.CONCLUSION: D2 dissection is a safe surgical option for gastric cancer, providing quality surgical care and long-term oncologic outcomes that are in line with current Western standards. | Johanna Mrena Anne Mattila Jan B?hm Ismo Jantunen Ilmo Kellokumpu | 2015 | World Journal of Gastroenterology2015，21，47： | 1 |
| 6 | How can the eco-efficiency of a region be measured and monitored? 显示文摘 | Jyri Seppala Matti Melanen Ilmo Maenpaa | 2005 | Journal of Industrial Ecology2005，9，4： | 1 |
| 7 | Impact of Functional Results on Quality of Life After Rectal Cancer Surgery显示文摘 | Jaana H. Vironen M.D. Matti Kairaluoma M.D. Ph.D. Anna-Mari Aalto Ph.D. Ilmo H. Kellokumpu M.D. Ph.D | 2006 | Diseases of the Colon & Rectum2006，，5： | 1 |
| 8 | Ecological Modernization-origins,Dilemmas and Future Directions显示文摘 | Mikael Skou Andersen Ilmo Massa | 2002 | Journal of Environmental Policy and Planning2002，2，4： | 1 |
| 9 | Greenhouse gases embodied in the international trade and final consumption of Finland:an input-output analysis显示文摘 | Ilmo M(a)enp(a)(a) Hanne Siikavirta | 2007 | Energy Policy2007，35，1： | 1 |
| 10 | Depth of invasion, tumor budding, and worst pattern of invasion: Prognostic indicators in early‐stage oral tongue cancer显示文摘 | Alhadi Almangush Ibrahim O. Bello Harri Keski–S?ntti Laura K. M?kinen Joonas H. Kauppila Matti Pukkila Jaana Hagstr?m Jussi Laranne Satu Tommola Outi Nieminen Ylermi Soini Veli‐Matti Kosma Petri Koivunen Reidar Grénman Ilmo Leivo Tuula Salo | 2014 | Head Neck2014，，6： | 1 |
| 11 | Restriction fragment analysis as a source of error in detection of heteroplasmic mtDNA mutations显示文摘 | Finnila S Ilmo E Hassinen KM | 1999 | Mutation Research Genomics1999，406，24： | 1 |
| 12 | Ecological modernization -origins,dilemmas and future directions 显示文摘 | Mikael Skou Andersen Ilmo Massa | | Journal of Environmental Policy and Planning0，2，4： | 1 |
| 13 | Ecological modernization origins,dilemmas and future directions显示文摘 | MIKAEL SKOU ANDERSEN IlMO MASSA | 2002 | Journal of Environmental Policy and Planning2002，2，4： | 1 |
| 14 | Developing benchmarks for consumer-oriented life cycle assessment-based environmental information on products, services and consumption patterns显示文摘 | Ari Nissinen Juha Gr?nroos Eva Heiskanen Asmo Honkanen Juha-Matti Katajajuuri Sirpa Kurppa Timo M?kinen Ilmo M?enp?? Jyri Sepp?l? P?ivi Timonen Kirsi Usva Yrj? Virtanen Pasi Voutilainen | 2006 | Journal of Cleaner Production2006，，6： | 1 |
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