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| 1 | A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling显示文摘The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells,which are profoundly moulded by cancer cells.An outstanding question is to what extent this heterogeneity is similar between cancers affecting different organs.Here,we profile 233,591 single cells from patients with lung,colorectal,ovary and breast cancer(n=36)and construct a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies.We identify 68 stromal cell populations,of which 46 are shared between cancer types and 22 are unique.We also characterise each population phenotypically by highlighting its marker genes,transcription factors,metabolic activities and tissue-specific expression differences.Resident cell types are characterised by substantial tissue specificity,while tumor-infiltrating cell types are largely shared across cancer types.Finally,by applying the blueprint to melanoma tumors treated with checkpoint immunotherapy and identifying a naive CD4+T-cell phenotype predictive of response to checkpoint immunotherapy,we illustrate how it can serve as a guide to interpret scRNA-seq data.In conclusion,by providing a comprehensive blueprint through an interactive web server,we generate the first panoramic view on the shared complexity of stromal cells in different cancers. | Junbin Qian Siel Olbrecht Bram Boeckx Hanne Vos Damya Laoui Emre Etlioglu Els Wauters Valentina Pomella Sara Verbandt Pieter Busschaert Ayse Bassez Amelie Franken Marlies Vanden Bempt Jieyi Xiong Birgit Weynand Yannick van Herck Asier Antoranz Francesca Maria Bosisio Bernard Thienpont Giuseppe Floris Ignace Vergote Ann Smeets Sabine Tejpar Diether Lambrechts | 2020 | Cell Research2020，30，9： | 11 |
| 2 | Peritoneal carcinomatosis of colorectal origin:Incidence,prognosis and treatment options显示文摘Peritoneal carcinomatosis (PC) is one manifestation of metastatic colorectal cancer (CRC). Tumor growth on intestinal surfaces and associated fluid accumulation eventually result in bowel obstruction and incapacitating levels of ascites, which profoundly affect the quality of life for affected patients. PC appears resistant to traditional 5-fluorouracil-based chemotherapy, and surgery was formerly reserved for palliative purposes only. In the absence of effective treatment, the histori-cal prognosis for these patients was extremely poor, with an invariably fatal outcome. These poor outcomes likely explain why PC secondary to CRC has received little attention from oncologic researchers. Thus, data are lacking regarding incidence, clinical disease course, and accurate treatment evaluation for patients with PC. Recently, population-based studies have revealed that PC occurs relatively frequently among patients withCRC. Risk factors for developing PC have been identi-fied:right-sided tumor, advanced T-stage, advanced N-stage, poor differentiation grade, and younger age at diagnosis. During the past decade, both chemother-apeutical and surgical treatments have achieved prom-ising results in these patients. A chance for long-term survival or even cure may now be offered to selected patients by combining radical surgical resection with intraperitoneal instillation of heated chemotherapy. This combined procedure has become known as hy-perthermic intraperitoneal chemotherapy. This edito-rial outlines recent advancements in the medical and surgical treatment of PC and reviews the most recent information on incidence and prognosis of this disease. Given recent progress, treatment should now be considered in every patient presenting with PC. | Yvonne LB Klaver Valery EPP Lemmens Simon W Nienhuijs Misha DP Luyer Ignace HJT de Hingh | 2012 | World Journal of Gastroenterology2012，18，39： | 9 |
| 3 | The clinical association of programmed cell death protein 4(PDCD4) with solid tumors and its prognostic significance:a meta-analysis显示文摘Background: Programmed cell death protein 4(PDCD4) is a novel tumor suppressor protein involved in pro?grammed cell death. Its association with cancer progression has been observed in multiple tumor models, but evidence supporting its association with solid tumors in humans remains controversial. This study aimed to determine the clinical signiicance and prognostic value of PDCD4 in solid tumors.Methods: A systematic literature review was performed to retrieve publications with available clinical informa?tion and survival data. The eligibility of the selected articles was based on the criteria of the Dutch Cochrane Centre proposed by the Meta?analysis Of Observational Studies in Epidemiology group. Pooled odds ratios(ORs), hazard ratios(HRs), and 95% conidence intervals(CIs) for survival analysis were calculated. Publication bias was examined by Begg's and Egger's tests.Results: Clinical data of 2227 cancer patients with solid tumors from 23 studies were evaluated. PDCD4 expression was signiicantly associated with the diferentiation status of head and neck cancer(OR 4.25, 95% CI 1.87–9.66) and digestive system cancer(OR 2.87, 95% CI 1.84–4.48). Down?regulation of PDCD4 was signiicantly associated with short overall survival of patients with head and neck(HR: 3.44, 95% CI 2.38–4.98), breast(HR: 1.86, 95% CI 1.36–2.54), digestive system(HR: 2.12, 95% CI 1.75–2.56), and urinary system cancers(HR: 3.16, 95% CI 1.06–9.41).Conclusions: The current evidence suggests that PDCD4 down?regulation is involved in the progression of several types of solid tumor and is a potential marker for solid tumor prognoses. Its clinical usefulness should be conirmed by large?scale prospective studies. | John Zeng Hong Li Wei Gao Wai-Kuen Ho Wen Bin Lei William Ignace Wei Jimmy Yu-Wai Chan Thian-Sze Wong | 2016 | Chinese Journal of Cancer2016，35，12： | 7 |
| 4 | Challenges in diagnosing adhesive small bowel obstruction显示文摘Adhesive small bowel obstruction(ASBO)is the most frequently encountered surgical disorder of the small intestine.Up to 80%of ASBO cases resolve spontaneously and do not require invasive treatment.It is important to identify such patients that will benefit from conservative treatment in order to prevent unnecessarily exposing them to the risks associated with surgical intervention,such as morbidity and further adhesion formation.For the remaining ASBO patients,timely surgical intervention is necessary to prevent small bowel strangulation,which may cause intestinal ischemia and bowel necrosis.While early identification of these patients is key to decreasing ASBO-related morbidity and mortality,the non-specific signs and laboratory findings upon clinic presentation limit timely diagnosis and implementation of appropriate clinical management.Combining the clinical presentation findings with those from other diagnostic imaging modalities,such as abdominal X-ray,computed tomography-scan and water-soluble contrast studies,will improve diagnosis of ASBO and help clinicians to better evaluate the potential of conservative management as a safe strategy for a particular patient.Nonetheless,patients who present with moderate findings by all these approaches continue to represent a challenge.A new diagnostic strategy is urgently needed to further improve our ability to identify early signs of strangulated bowel,and this diagnostic modality should be able to indicate when surgical management is required.A number of potential serum markers have been proposed for this purpose,including intestinal fatty acid binding protein andα-glutathione S transferase.On-going research is attempting to clearly define their diagnostic utility and to optimize their potential role in determining which patients should be managed surgically. | Thijs R van Oudheusden Bart AC Aerts Ignace HJT de Hingh Misha DP Luyer | 2013 | World Journal of Gastroenterology2013，19，43： | 7 |
| 5 | Effect of high-frequency loading and parathyroid hormone administration on peri-implant bone healing and osseointegration显示文摘The objective of this study is to examine the effect of low-magnitude, high-frequency(LMHF) loading, and anti-osteoporosis medications such as parathyroid hormone(PTH) and bisphosphonates on peri-implant bone healing in an osteoporosis model, and to assess their combined effects on these processes. Thirteen-week-old ovariectomized rats(n = 44) were divided into three groups:PTH, alendronate, and saline. After 3 weeks of drug administration, titanium implants were inserted into the tibiae. Each group was subdivided into two groups: with or without LMHF loading via whole-body vibration(50 Hz at 0.5 g, 15 min per day, 5 days per week). Rats were killed 4 weeks following implantation. Removal torque test, micro-CT analyses(relative gray(RG) value, water = 0,and implant = 100), and histomorphometric analyses(bone-to-implant contact(BIC) and peri-implant bone formation(bone volume/tissue volume(BV/TV))) were performed. Removal torque values and BIC were significantly differed by loading and drug administration(ANOVA). Post hoc analysis showed that PTH-treated groups were significantly higher than the other drug-treated groups. BV/TV was significantly enhanced by PTH administration. In cortical bone, RG values were significantly increased by loading.In trabecular bone, however, RG values were significantly increased by PTH administration. These findings suggest that LMHF loading and PTH can act locally and additively on the bone healing process, improving the condition of implant osseointegration. | Aya Shibamoto Toru Ogawa Joke Duyck Katleen Vandamme Ignace Naert Keiichi Sasaki | 2018 | International Journal of Oral Science2018，10，1： | 7 |
| 6 | 欧洲大豆原料及大豆食品市场显示文摘全球很多地方都在发展大豆产业,这里主要介绍欧洲的大豆食品、大豆产业的一些情况。我在欧洲做了十五年的生意,多年的工作经历给我的感觉是欧盟情况和中国相比略有不同。我先简单介绍一些欧洲大豆产业联盟、大豆蛋白产品和大豆产品、市场机遇(创新及消费者趋向、源头和可追溯性、健康交流)等情况。 | Ignace Debruyne | 2011 | 大豆科技2011，，2： | 3 |
| 7 | Giant cystic lymphangioma originating from the lesser curvature of the stomach显示文摘Cystic lymphangiomas are rare benign tumors.Most frequently occurring in children and involving the neck or axilla,these tumors are much less common in adults and very rarely involve the abdomen.The known congenital and acquired(traumatic)etiologies result in failure of the lymphatic channels and consequent proliferation of lymphatic spaces.This case report describes a very rare case of a giant mesenteric cystic lymphangioma in an adult male with no clear etiology and successful resolution by standard radical resection.A previously healthy 44-year-old male presented with a 6-wk history of progressive upper abdominal pain,vomiting,anorexia and unintentional weight loss accompanied by rapid abdominal distension.A palpable mass was detected upon physical examination of the distended abdomen and abdominal computed tomography scan showed a giant multilobulated cystic process,measuring 40 cm in diameter.Exploratory laparotomy revealed an enormous cystic mass containing 6 L of serous fluid.The process appeared to originate from the lesser omentum and the lesser curvature of the stomach.Radical resection of the tumor was performed along with a partial gastrectomy to address potential invasion into the adjacent tissues.Histological analysis confirmed the diagnosis of a multicystic lymphangioma.The postoperative recovery was uneventful and the patient was discharged after 6 d.At 3-mo follow-up,the patient was in good health with no signs of recurrence. | Thijs Ralf van Oudheusden Simon Willem Nienhuijs Thomas Bernard Joseph Demeyere Michael Derek Philip Luyer Ignace Hubertus Johannes Theodorus de Hingh | 2013 | World Journal of Gastrointestinal Surgery2013，5，10： | 3 |
| 8 | Cytoreduction and HIPEC in The Netherlands: Nationwide Long-term Outcome Following the Dutch Protocol显示文摘 | Anke M. J. Kuijpers Boj Mirck Arend G. J. Aalbers Simon W. Nienhuijs Ignace H. J. T. Hingh Martinus J. Wiezer Bert Ramshorst Robert J. Ginkel Klaas Havenga Andreas J. Bremers Johannes H. W. Wilt Elisabeth A. Velde Vic J. Verwaal | 2013 | Annals of Surgical Oncology2013，，13： | 2 |
| 9 | Reduction of Postoperative Ileus by Early Enteral Nutrition in Patients Undergoing Major Rectal Surgery: Prospective, Randomized, Controlled Trial显示文摘 | Petra G. Boelens Fanny F. B. M. Heesakkers Misha D. P. Luyer Kevin W. Y. van Barneveld Ignace H. J. T. de Hingh Grard A. P. Nieuwenhuijzen Arnout N. Roos Harm J. T. Rutten | 2014 | Annals of Surgery2014，，4： | 2 |
| 10 | Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure显示文摘 | Chi-Leung Liu Sheung-Tat Fan Chung-Mau Lo William Ignace Wei Boon-Hun Yong Ching-Lung Lai John Wong | 2003 | Transplantation2003，，8： | 2 |
| 11 | System characteristics of SPECT with a slat collimated strip detector显示文摘 | Stefaan Vandenberghe Roel Van Holen Steven Staelens Ignace Lemahieu | 2006 | Phys Med Biol2006，51，： | 1 |
| 12 | Respiratory distress due to malignant ascites palliated by hyperthermic intraperitoneal chemotherapy显示文摘Malignant ascites is a common symptom in patients with peritoneal cancer. Current assumption is that anincreased vascular permeability and obstruction of lymphatic channels lead to the accumulation of fluid in the abdominal cavity. This case report describes a severely symptomatic patient with malignant ascites. The previously healthy 73-year-old male was presented with abdominal distention causing respiratory distress. Computed tomography revealed large amounts of ascites, a recto-sigmoidal mass with locoregional lymphadenopathy and an omental cake. Biopsy taken during colonoscopy revealed an adenocarcinoma of the colon with signet cell differentiation. A widespread peritoneal carcinomatosis was found during a diagnostic laparoscopy. The extent of peritoneal disease rendered the patient not suitable for cytoreductive surgery with curative intent. The ascites proved to be refractory to ultrasound-guided paracentesis; thus, a decision was made to perform palliative hyperthermic intraperitoneal chemotherapy without cytoreductive surgery. Consequently, ascites production stopped, and the respiratory distress was relieved thereafter. The postoperative recovery was uneventful. Ascites recurred eight months later, and a second hyperthermic intraperitoneal chemotherapy procedure was performed. The patient was still alive at the time of writing, 16 mo after the initial diagnosis. | Marijn Marinus Leonardus van den Houten Thijs Ralf van Oudheusden Michael Derek Philip Luyer Simon Willem Nienhuijs Ignace Hubertus Johannes Theodorus de Hingh | 2015 | World Journal of Gastrointestinal Surgery2015，7，3： | 1 |
| 13 | The ancient mesopotamian ration system显示文摘 | Ignace Gelb | 1965 | Journal of Near Eastern Studies1965，24，3： | 1 |
| 14 | Therapeutic Decision-Making in Endoscopically Unmanageable Nonvariceal Upper Gastrointestinal Hemorrhage显示文摘 | Luc Defreyne Ignace Schrijver Johan Decruyenaere Georges Maele Wim Ceelen Danny Looze Peter Vanlangenhove | 2008 | CardioVascular and Interventional Radiology2008，，5： | 1 |
| 15 | Chinese Tonal Language Rehabilitation Following Cochlear Implantation in Children显示文摘 | William Ignace Wei Ripley Wong Yau Hui Dennis K. K. Au Buddy Y. K. Wong W. K. Ho Amy Tsang Pance Kung E. Chung | 2000 | Acta Oto-Laryngologica2000，，2： | 1 |
| 16 | Adv in Colloid Interf Sci显示文摘 | Ignac Capek | 2004 | 107 (3) : 125-1552004，107，3： | 1 |
| 17 | Freestanding and tooth-implant connected prostheses in the treatment of partially edentulous patients Ⅰ: an up to 15-years clinical evaluation 显示文摘 | Ignace EN | 2001 | Clin Oral Impl Res2001，12，2： | 1 |
| 18 | An Imaging System with Calibrated Color Image Acquisi- tion for Use in Dermatology 显示文摘 | Yves Vander Haeghen Jean Marie Andre Daniel Naeyaert Ignace Lemahieu | 2000 | Transactions on Medical Imaging2000，19，07： | 1 |
| 19 | Altretamine (hexamethylmelamine) in the treatment of platinum resistant ovarian cancer:a phase Ⅱ study显示文摘 | Nina Keldsen Hanne Havsteen Ignace Vergote | 2003 | Gynecol Oncol2003，88，： | 1 |
| 20 | Dynamics oftranspiration and evaporation following a moisture pulse in semiaridgrassland: A chamber-based isotope method for partitioning fluxcomponents显示文摘 | YEPEZ E A HUXMAN T E IGNACE D D | 2005 | Agricultural and forest meteorology2005，132，3： | 1 |
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