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| 1 | Adoptive immunotherapy for acute leukemia:New insights in chimeric antigen receptors显示文摘Relapses remain a major concern in acute leukemia. It is well known that leukemia stem cells(LSCs) hide in hematopoietic niches and escape to the immune system surveillance through the outgrowth of poorly immunogenic tumor-cell variants and the suppression of the active immune response. Despitethe introduction of new reagents and new therapeutic approaches, no treatment strategies have been able to definitively eradicate LSCs. However, recent adoptive immunotherapy in cancer is expected to revolutionize our way to fight against this disease, by redirecting the immune system in order to eliminate relapse issues. Initially described at the onset of the 90's, chimeric antigen receptors(CARs) are recombinant receptors transferred in various T cell subsets, providing specific antigens binding in a non-major histocompatibility complex restricted manner, and effective on a large variety of human leukocyte antigen-divers cell populations. Once transferred, engineered T cells act like an expanding 'living drug' specifically targeting the tumor-associated antigen, and ensure long-term antitumor memory. Over the last decades, substantial improvements have been made in CARs design. CAR T cells have finally reached the clinical practice and first clinical trials have shown promising results. In acute lymphoblastic leukemia, high rate of complete and prolonged clinical responses have been observed after anti-CD19 CAR T cell therapy, with specific but manageable adverse events. In this review, our goal was to describe CAR structures and functions, and to summarize recent data regarding pre-clinical studies and clinical trials in acute leukemia. | Mael Heiblig Mohamed Elhamri Mauricette Michallet Xavier Thomas | 2015 | World Journal of Stem Cells2015，7，7： | 9 |
| 2 | An experimental and theoretical investigation of a small,high aspect-ratio,free-piston,two-stroke engine显示文摘This paper presents a design for a novel,palm sized,high-aspect-ratio engine.To simplify fabrication and keep the device unobtrusive,a design incorporating a two-cycle engine having a flat,rectangular piston with spring return was selected.An experimental engine based on this concept producing a significant amount of useful work was developed.Although results were encouraging,this geometry raised many issues to be investigated and resolved,including the effects of piston sealing,scavenging,heat losses,and combustion efficiency.Due to the complex interplay between these effects,experimental investigation was time consuming and simple models were found to be inadequate.Therefore,a more complex theoretical model accounting for these effects was developed and used to evaluate the sensitivity of engine performance to each of these parameters.The predictions of this model were used to develop recommendations for improving the experimentally developed engine. | Chiluwata E.Lungu Mael Disseau Daniel C.Stubbs Jechiel Jagoda David E.Scarborough | 2020 | Propulsion and Power Research2020，9，4： | 2 |
| 3 | Identifying Organizational Identi-fication显示文摘 | MAEL F A ASHFORTH B E | 1992 | Educational and Psychological Measurement1992，52，4： | 1 |
| 4 | TLR5 signaling stimulates the innate production of IL-17 and IL-22 byCD3(neg)CD127+ immune cells in spleenand mucosa显示文摘 | Van Maele L Carnoy C Cayet D | 2010 | J Immunol2010，185，2： | 1 |
| 5 | Identifying Organizational Identification显示文摘 | Mael F.A Ashforth B.E | | 0，，04： | 1 |
| 6 | Loyal from day one:Biodata,organizational identification,and turnover among new-comers显示文摘 | Mael F Ashforth B E | | 0，，02： | 1 |
| 7 | Characteristics and outcomes of patients with seizures according to the time of onset in relation to stroke显示文摘 | de Reuck J Sieben A van Maele G | 2008 | Eur Neurol2008，59，5： | 1 |
| 8 | Alumni and Their Alma Mater: A Partial Test of the Reformulated Model of Organizational Identification 显示文摘 | Mael F Ashforth B E | 1992 | Journal of Organizational Behavior1992，13，： | 1 |
| 9 | Stroke in patients with migraine显示文摘 | De Reuck J Paemeleire K Van Maele G | 2010 | Neurol Neurochir Pol2010，44，2： | 1 |
| 10 | Social Identity Theory and the Organization显示文摘 | Ashforth B E Mael F | 1989 | Academy of Management Review1989，14，1： | 1 |
| 11 | Social identity theory and the organization 显示文摘 | ASHFORTH B E MAEL F | 1989 | Academy of Management Review1989，14，1： | 1 |
| 12 | Seizures and epilepsy in patients with a spontaneous intracerebral haematoma显示文摘 | de Reuck J Hemelsoet D van Maele G | 2007 | Clin Neurol Neurosurg2007，109，6： | 1 |
| 13 | Social Identity Theory and the Organization 显示文摘 | Ashforth B E Mael F | 1989 | Academy of Management Review1989，14，1： | 1 |
| 14 | Alumni and their alma mater:A partial test of the reformulated model of organizational identification 显示文摘 | MAEL F ASHFORTH B E | 1992 | Journal of organizational Behavior1992，13，2： | 1 |
| 15 | Alumni and their alma mater:A par-tial test of the reformulated model of organizational identifi- cation 显示文摘 | Mael F Ashforth B E | 1992 | Journal of Organizational Behavior1992，13，2： | 1 |
| 16 | Cryopreservation of human germinal vesicle stage and in vitro matured M II oocytes: influence of cryopreservation media on the survival, fertilization, and early cleavage divisions显示文摘 | Anuradha Goud Pravin Goud Chen Qian Josiane Van der Elst Georges Van Maele Marc Dhont | 2000 | Fertility and Sterility2000，，3： | 1 |
| 17 | The cortical involvement of territorial infarcts as a risk factor for strokerelated seizures显示文摘 | de Reuck J de Groote L van Maele G | 2008 | Cerebrovasc Dis2008，25，12： | 1 |
| 18 | A biomechanieal comparison of plate configuration in distal humerus frat'tures显示文摘 | Arnander M W Reeves A Mael eod I A | 2008 | J Orthop Trauma2008，22，3： | 1 |
| 19 | Alumni and Their Alma Mater : A Partial Test of the Reformulated Model of Organizational Identification 显示文摘 | Mael F Ashforth B E | 1992 | Journal of Organ- izational Behavior1992，13，2： | 1 |
| 20 | Alumni and Their Alma Mater: A Partial Test of the Reformulated Model of Organizational Identification 显示文摘 | MAEL F ASHFORTH B E | 1992 | Journal of Organizational Behavior1992，13，2： | 1 |
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