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| 1 | Genomic and genetic alterations influence the progression of gastric cancer显示文摘Gastric cancer is one of the leading causes of cancerrelated deaths worldwide, although the incidence has gradually decreased in many Western countries. Two main gastric cancer histotypes, intestinal and diffuse, are recognised. Although most of the described genetic alterations have been observed in both types, different genetic pathways have been hypothesized. Genetic and epigenetic events, including 1q loss of heterozygosity (LOH), microsatellite instability and hypermethylation, have mostly been reported in intestinal-type gastric carcinoma and its precursor lesions, whereas 17p LOH, mutation or loss of E-cadherin are more often implicated in the development of diffuse-type gastric cancer.In this review, we summarize the sometimes contradictory findings regarding those markers which influence the progression of gastric adenocarcinoma. | Stefania Nobili Lorenzo Bruno Ida Landini Cristina Napoli Paolo Bechi Francesco Tonelli Carlos A Rubio Enrico Mini Gabriella Nesi | 2011 | World Journal of Gastroenterology2011，17，3： | 17 |
| 2 | Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice显示文摘AIM: To study isolation and chemical characterization of pectin derived from the common cranberry Vaccinium oxycoccos L. (oxycoccusan OP) and the testing of its preventive effect on experimental colitis.METHODS: Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS: In the mice treated with OP, colonic macroscopic scores (1.1 ± 0.4 vs 2.7, P < 0.01) and the total square area of damage (10 ± 2 vs 21 ± 7, P < 0.01) were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons (42 ± 11 vs 112 ± 40, P < 0.01) and enhance the amount of mucus of colitis mice (0.9 ± 0.1 vs 0.4 ± 0.1, P < 0.01). The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice (3.6 ± 0.7 vs 5.1 ± 0.8, P < 0.01). OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability (161 ± 34 vs 241 ± 21, P < 0.01). Adhesionof peritoneal neutrophils and macrophages was also shown to decrease after administration of OP (141 ± 50 vs 235 ± 37, P < 0.05).CONCLUSION: Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan. | Sergey V Popov Pavel A Markov Ida R Nikitina Sergey Petrishev Vasily Smirnov Yury S Ovodov | 2006 | World Journal of Gastroenterology2006，12，41： | 9 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Curing Kinetics of Tannin and Lignin Biobased Adhesives Determined by DSC and ABES显示文摘The curing process of two biobased adhesives:pine tanninhexamine(TH)and organosolv lignin non-isocyanate polyurethane(NIPU),suitable for interior nonstructural use,were compared with commercial urea-formaldehyde(UF)adhesive.Changes in chemical structure before and after the curing process were observed with Fouriertransform infrared spectroscopy(FTIR).The process of adhesive curing was monitored with differential scanning calorimetry(DSC)and the automated bonding evaluation system(ABES).Both DSC and ABES measurements confirmed UF as the fastest and NIPU as the slowest curing adhesive observed.Taking into account the ABES results,the optimal pressing parameters for the TH adhesive would be 4 min at 175℃,for the NIPU adhesive 7 min at 200℃and for the UF 1.5 min at 100℃.Strong linear correlation was observed between mechanical and chemical curing for the UF and NIPU adhesives,whereas lower correlation was observed for the TH adhesive.At all observed adhesives,the DSC measurements were underestimating the curing process determined by ABES in the first part and overestimating it at the end.The underestimation was the most evident with the TH adhesive and the less with the UF adhesive.When comparing the uncured and cured FTIR spectra of all three types of adhesives,a drastic decrease in the characteristic band of-OH groups at 3330–3400 cm^(−1)and an increase in the signal intensity at 2920 cm^(−1)of aliphatic-CH2-groups were observed.For the UF adhesive,the C=O stretching frequency has shifted from 1632 cm^(−1)for uncured to three different bands at 1766,1701,and 1655 cm^(−1)for cured UF.The sharp band for phenolic alcohols at 1236 cm^(−1)of C–O stretch and hydroxyl O–H functional group at 1009 cm^(−1)and at 684 cm^(−1)of uncured TH adhesive diminished during curing,which indicates that a crosslinking reaction occurs via-OH groups.The peak of the C=O group of urethane bridges at 1697 cm^(−1)for uncured NIPU shifted to lower wavenumber at 1633 cm^(−1)for cured NIPU. | Jaša Saražin Ida Poljanšek Antonio Pizzi MilanŠernek | 2022 | Journal of Renewable Materials2022，10，8： | 2 |
| 5 | Relationship between water mobility and distribution and sensory attributes in pork slaughtered at an age between 90 and 180 days 显示文摘 | Hanne Christine Bertram Ida K Straadt Jens A Jensen Margit Dall Aaslyng | 2007 | Meat Science2007，77，： | 1 |
| 6 | Differential control of CD22 ligand expression on B and T lymphocytes,and enhanced expression in murine systemic lupus显示文摘 | Lajaunias F Ida A Kikuchi S | 2003 | Arthritis Rheum2003，48，6： | 1 |
| 7 | Incremental value ofT2-we i gh t ed and d i f f us i on-weighted MRI for predictionof biochemical recurrenceafter radical prostatectomy inclinically localized prostatecancer 显示文摘 | N i sh ida K Yuen S Kamo i K et a 1 | 2011 | Acta Radiol2011，52，2： | 1 |
| 8 | Clinical outcome of surgical per-iodontal therapy:a short-term retrospective study显示文摘 | Hayakawa H Fujinami K Ida A | | 0，，04： | 1 |
| 9 | Improving detection of dairy cow estrus using fuzzy logic显示文摘 | BRUNASSI L D A MOURA D J D NAAS IDA | 2010 | ScientiaAgricola2010，67，5： | 1 |
| 10 | IL-18 in pregnancy: me elevauon of IL-18 in maternal peripheral blood during labour and complicated pregnancies显示文摘 | Ida A Tsuji Y Muranaka J et at | 2000 | J Reprod Immunol2000，47，1： | 1 |
| 11 | Electrostatic generation of algi- hate microbeads loaded with brewing yeast 显示文摘 | Viktor A Nedonic Bojana Obradovic Ida Leskose Cukalovic | 2011 | Process Biochemistry2011，，37： | 1 |
| 12 | IL-18 in pregnancy; the elevation of IL-18 in maternal peripheral blood during labour and complicated pregnancies 显示文摘 | IDA A TSUJI Y MURANAKA J | 2000 | J Reprod Immunol2000，47，1： | 1 |
| 13 | Real-time PGR for quantification of Streptococcus mutans显示文摘 | Yano A Kaneko N Ida H Yamaguchi T | 2002 | FEMS Microbiol Lett2002，217，1： | 1 |
| 14 | Reduction of epithelial den- dritic cells in keratotic lesion of oral lichen planus 显示文摘 | Mravak-Stipetic M Pirkic A idas I | 1998 | Coil Antropol1998，22，： | 1 |
| 15 | Activating transcription factor 4 mediates up-regulation of alanine aminotransferase 2 gene expression under metabolic stress显示文摘 | María C. Salgado Isidoro Metón Ida G. Anemaet Isabel V. Baanante | 2014 | BBA - Gene Regulatory Mechanisms2014，，4： | 1 |
| 16 | Nitric Oxide Limits Pressor Responses to Sympathetic Activa tion in Rat Spinal Cord 显示文摘 | Leonard F A Douglas J M Ida J L-S | 2000 | Hypertension2000，36，： | 1 |
| 17 | IL-18 in pregnancy;the elevation of IL-18 in maternal peripheral blood during labour and complicated pregnancies 显示文摘 | Ida A Tsuji Y Muranaka J | 2000 | J Reprod Immunol2000，47，： | 1 |
| 18 | Real-time PCR for quantification of Streptococcusmutans mutans 显示文摘 | Yano A Kaneko N Ida H | 2002 | FEMS Microbiology Letters2002，217，1： | 1 |
| 19 | 1 The proportion of consolidation to ground-grass opacity on high resolution CT is a good predictor for distinguishing the population of non-invasive peripheral adenocarc-inoma显示文摘 | Ohde Y N aga iK Yosh ida J et a | 2003 | Lung Cancer2003，42，： | 1 |
| 20 | Electrostatic Generation of Alginate Microbeads Loaded with Brewing Yeast 显示文摘 | Viktor A N Bojana O Ida L | 2001 | Process Biochem2001，37，1： | 1 |
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