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| 1 | Video capsule endoscopy:Perspectives of a revolutionary technique显示文摘Video capsule endoscopy(VCE)was launched in 2000and has revolutionized direct endoscopic imaging of the gut.VCE is now a first-line procedure for exploring the small bowel in cases of obscure digestive bleeding and is also indicated in some patients with Crohn’s disease,celiac disease,and polyposis syndrome.A video capsule has also been designed for visualizing the esophagus in order to detect Barrett’s esophagus or esophageal varices.Different capsules are now available and differ with regard to dimensions,image acquisition rate,battery life,field of view,and possible optical enhancements.More recently,the use of VCE has been extended to exploring the colon.Within the last 5 years,tremendous developments have been made toward increasing the capabilities of the colon capsule.Although colon capsule cannot be proposed as a first-line colorectal cancer screening procedure,colon capsule may be used in patients with incomplete colonoscopy or in patients who are unwilling to undergo colonoscopy.In the near future,new technological developments will improve the diagnostic yield of VCE and broaden its therapeutic capabilities. | Simon Bouchard Mostafa Ibrahim Andre Van Gossum | 2014 | World Journal of Gastroenterology2014，20，46： | 12 |
| 2 | Evaluation of Fujinon intelligent chromo endoscopy-assisted capsule endoscopy in patients with obscure gastroenterology bleeding显示文摘AIM:To investigate the potential benef it of Fujinon in-telligent chromo endoscopy(FICE)-assisted small bowel capsule endoscopy(SBCE)for detection and character-ization of small bowel lesions in patients with obscure gastroenterology bleeding(OGIB).METHODS:The SBCE examinations(Pillcam SB2,Giv-en Imaging Ltd)were retrospectively analyzed by two GI fellows(observers)with and without FICE enhance-ment.Randomization was such that a fellow did not assess the same examination with and without FICE enhancement.The senior consultant described f indings as P0,P1 and P2 lesions(non-pathological,intermedi-ate bleed potential,high bleed potential),which were considered as reference f indings.Main outcome mea-surements:Inter-observer correlation was calculated using kappa statistics.Sensitivity and specif icity for P2 lesions was calculated for FICE and white light SBCE.RESULTS:In 60 patients,the intra-class kappa cor-relations between the observers and reference f indings were 0.88 and 0.92(P2),0.61 and 0.79(P1),for SBCE using FICE and white light,respectively.Overall 157 le-sions were diagnosed using FICE as compared to 114 with white light SBCE(P = 0.15).For P2 lesions,the sensitivity was 94% vs 97% and specif icity was 95% vs 96% for FICE and white light,respectively.Five(P2 le-sions)out of 55 arterio-venous malformations could be better characterized by FICE as compared to white light SBCE.Significantly more P0 lesions were diagnosed when FICE was used as compared to white light(39 vs 8,P < 0.001).CONCLUSION:FICE was not better than white light for diagnosing and characterizing signif icant lesions on SBCE for OGIB.FICE detected signif icantly more non-pathological lesions.Nevertheless,some vascular le-sions could be more accurately characterized with FICE as compared to white light SBCE. | Tarun Gupta Mostafa Ibrahim Jacques Deviere André Van Gossum | 2011 | World Journal of Gastroenterology2011，17，41： | 8 |
| 3 | Ejaculatory dysfunction in men with diabetes mellitus显示文摘Diabetes mellitus(DM)is a metabolic disorder that is characterized by elevated blood glucose levels due to absolute or relative insulin deficiency,in the background ofβ-cell dysfunction,insulin resistance,or both.Such chronic hyperglycemia is linked to long-term damage to blood vessels,nerves,and various organs.Currently,the worldwide burden of DM and its complications is in increase.Male sexual dysfunction is one of the famous complications of DM,including abnormal orgasmic/ejaculatory functions,desire/libido,and erection.Ejaculatory dysfunction encompasses several disorders related to DM and its complications,such as premature ejaculation,anejaculation(AE),delayed ejaculation,retrograde ejaculation(RE),ejaculatory pain,anesthetic ejaculation,decreased ejaculate volume,and decreased force of ejaculation.The problems linked to ejaculatory dysfunction may extend beyond the poor quality of life in diabetics as both AE and RE are alleged to alter the fertility potential of these patients.However,although both diabetes patients and their physicians are increasingly aware of diabetic ejaculatory dysfunction,this awareness still lags behind that of other diabetes complications.Therefore,all these disorders should be looked for thoroughly during the clinical evaluation of diabetic men.Besides,introducing the suitable option and/or maneuvers to treat these disorders should be tailored according to each case.This review aimed to explore the most important findings regarding ejaculatory dysfunction in diabetes from pre-clinical and clinical perspectives. | Taymour Mostafa Ibrahim A Abdel-Hamid | 2021 | World Journal of Diabetes2021，12，7： | 6 |
| 4 | Molecular study on Y chromosome microdeletions in Egyptian males with idiopathic infertility显示文摘Aim:To determine the frequency of genetic deletions within the azoospermia factors in Egyptian infertile males.Methods:The Yq microdeletions in 33 infertile males with undetectable chromosomal anomalies were examined by mutiplex polymerase chain reaction (PCR).Deletions were confirmed using single PCR amplifications.Results:Four out of the total 33 (12%) men had Yqll microdeletions,thus supporting the average reported figures in other populations.Three of those 4 cases had single short tandem sequence deletions with discrete histological findings of their testes.Single sY272 deletion within AZFc was associated with Sertoli cell only syndrome,whereas a patient with isolated sY84 deletion within AZFa had immature testicular structure.The remaining case had a large deletion in AZFa-c and short stature.Conclusion:The present study supports the hypothesis that the Yq11 encompasses genetic determinants of stature besides genes controlling spermatogenesis.(Asian J Androl 2004 Mar;6:53-57) | Mostafa K. El Awady Sohair F. El Shater Ehab Ragaa Khaled Atef Ibrahim M. Shaheen Nagwa A. Megiud | 2004 | Asian Journal of Andrology2004，6，1： | 6 |
| 5 | Association between low molecular polypeptide 7 single nucleotide polymorphism and response to therapy in hepatitis C virus infection显示文摘AIM: To investigate the relationship between low molecular polypeptide-7 (LMP-7) gene polymorphism and response to interferon (IFN) therapy in chronic hepatitis C virus (HCV) patients. METHODS: LMP-7 polymorphism at codon 49 with nucleotide substitution from A to C was amplified in 104 chronic HCV patients of genotype 4. The amplicons were digested with restriction endonuclease Bsm I and the produced restriction fragment length polymorphism was analyzed. Patients received IFN + regional blood volume therapy for 48 wk and the frequency of thissingle nucleotide polymorphism (SNP) was statistically correlated with treatment response. The exclusion criteria for these patients were stated by the national health program for treating viral hepatitis. Main exclusion criteria included co-infection with hepatitis B virus or schistosomiasis, thyroid dysfunction, uncontrolled diabetes mellitus, history of long term drug or alcohol intake and autoimmune hepatitis. Multivariate analyses were done to correlate LMP-7 SNP plus several factors such as age, gender, weight, serum alpha-fetoprotein (AFP) and alanine aminotransferase levels, liver activity, fibrosis score and viral load with response to therapy. RESULTS: The data presented in this study clearly demonstrated statistically significant differences between sustained virological response (SVR) (defined as the absence of HCV RNA levels in the patient's sera at least 6 mo after discontinuation of treatment) and non-response (NR) (where HCV RNA levels in the patient's sera never become undetectable for 6 mo during or after treatment). Variables were described as odds ratio with 95%CI. The data were considered significant if P values were ≤ 0.05; highly significant if P < 0.01 and very highly significant if P < 0.001. Current data showed that 91.7% of patients carrying LMP-7 C/C allele were associated with SVR, while the other two genotypes C/A and A/A were associated with NR patients, 83.3% and 64.3% respectively, showing that genotype CC was strongly associated with response to interferon (95%CI: 12.0719-134.6572, P = 0.0001). The majority of parameters recorded in SVR and NR patients included higher values of mean age (P = 0.004), alanine aminotransferase (P = 0.001), AFP (P = 0.001), body weight (P = 0.025), viral load (P = 0.025), higher fibrosis and histological activity index indices among NR vs SVR patients. Also, the multivariate statistical analysis of the different factors of fibro-sis score, liver activity grade, genotypes and alleles of LMP-7 gene polymorphism in responders and NRs of HCV patients in this study showed that HCV patients with A allele had a very highly significant association with the NRs, high fibrosis and higher liver activity, while the C allele had a very highly significant association with the responders, low fibrosis and lower liver activity (95%CI: 3.5800-13.2519, P = 0.0001).CONCLUSION: LMP-7 SNP is a candidate gene that should be considered when designing a mathematical model for predicting response to therapy and disease progression in HCV patients. | Moataza H Omran Basma E Fotouh Samar S Youssef Noha E Ibrahim Wael Nabil EL-Sayed M Mahdy Wafaa G Shosha Mostafa K El-Awady | 2013 | World Journal of Hepatology2013，5，3： | 4 |
| 6 | Tumor necrosis factor-α-G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients显示文摘AIM To investigate the association of tumor necrosis factor alpha(TNFα)-G308 A polymorphism with different liver pathological changes in treatment-na?ve Egyptian patients infected with hepatitis C virus(HCV) genotype 4.METHODS This study included 180 subjects,composed of 120 treatment-na?ve chronic HCV patients with different fibrosis grades(F0-F4) and 60 healthy controls. The TNFα-G308 A region was amplified by PCR and the different genotypes were detected by restriction fragment length polymorphism analysis. The TNFα protein was detected by enzyme-linked immunosorbent assay. The influence of different TNFα-G308 A genotypes on TNFα expression and liver disease progression were statistically analyzed. The OR and 95%CI were calculated to assess the relative risk confidence.RESULTS Current data showed that the TNFα-G308 A SNP frequency was significantly different between controls and HCV infected patients(P = 0.001). Both the AA genotype and A allele were significantly higher in late fibrosis patients(F2-F4,n = 60) than in early fibrosis patients(F0-F1,n = 60)(P = 0.05,0.04 respectively). Moreover,the GA or AA genotypes increased the TNFα serum level greater than the GG genotype(P = 0.002). The results showed a clear association between severe liver pathological conditions(inflammation,steatosis and fibrosis) and(GA + AA) genotypes(P = 0.035,0.03,0.04 respectively). The stepwise logistic regression analysis showed that the TNFα genotypes(GA + AA) were significantly associated with liver inflammation(OR = 3.776,95%CI: 1.399-10.194,P = 0.009),severe steatosis(OR = 4.49,95%CI: 1.441-14.0,P = 0.010) and fibrosis progression(OR = 2.84,95%CI: 1.080-7.472,P = 0.034). Also,the A allele was an independent risk factor for liver inflammation(P = 0.003),steatosis(P = 0.003) and fibrosis(P = 0.014). CONCLUSION TNFα SNP at nucleotide-308 represents an important genetic marker that can be used for the prognosis of different liver pathological changes in HCV infected | Noha G Bader El Din Sally Farouk Reem El-Shenawy Marwa K Ibrahim Reham M Dawood Mostafa M Elhady Ahmed M Salem Naglaa Zayed Ahmed Khairy Mostafa K El Awady | 2016 | World Journal of Gastroenterology2016，22，34： | 3 |
| 7 | Determination of Polarity Terms of Some Nitrogen-Containing Surfactants and Simulated Hydrophobic Tail Models by Gas Chromatography显示文摘Some polarity terms of two groups of nitrogen-containing surfactants (six alkanolamides and nine polyoxyethylenated long chain amines) are measured through gas chromatography. The apparent methanol carbon number (CMeOH) and polarity index (IP) values are determined on the investigated surfactants as stationary phases in packed columns. Similarly, CMeOH and IP values are determined on simulated hydrophobic tail (SHT) models. The obtained results reveal that the introduction of SHT approach permits the distinction between the polarities of different surfactants and their head groups. The measured polarity terms are discussed as related to hydrophile-lipophile balance (HLB) number and the hydrophobic group carbon number (RCN). Some equations relating the measured polarity values and these variable have been developed. | BARAKAT Y IBRAHIM V MOSTAFA N E SHAKER N O | 2005 | 色谱2005，23，4： | 3 |
| 8 | Survival and outcomes for co-infection of chronic hepatitis C with and without cirrhosis and COVID-19: A multicenter retrospective study显示文摘BACKGROUND Chronic liver disease,particularly cirrhosis,is associated with worse outcomes in patients infected with coronavirus disease 2019(COVID-19).AIM To assess outcomes of COVID-19 infection among patients with pre-existing hepatitis C with or without liver cirrhosis.METHODS This multicenter,retrospective cohort study included all cases of confirmed coinfection of severe acute respiratory syndrome coronavirus 2 and chronic hepatitis C with or without liver cirrhosis who were admitted to six hospitals(Al-Sahel Hospital,Al-Matareya Hospital,Al-Ahrar Hospital,Ahmed Maher Teaching Hospital,Al-Gomhoreya Hospital,and the National Hepatology and Tropical Medicine Research Institute)affiliated with the General Organization for Teaching Hospitals and Institutes in Egypt.Patients were recruited from May 1,2020,to July 31,2020.Demographic,laboratory,imaging features,and outcomes were collected.Multivariate regression analysis was performed to detect factors affecting mortality.RESULTS This retrospective cohort study included 125 patients with chronic hepatitis C and COVID-19 co-infection,of which 64(51.20%)had liver cirrhosis and 40(32.00%)died.Fever,cough,dyspnea,and fatigue were the most frequent symptoms in patients with liver cirrhosis.Cough,sore throat,fatigue,myalgia,and diarrhea were significantly more common in patients with liver cirrhosis than in noncirrhotic patients.There was no difference between patients with and without cirrhosis regarding comorbidities.Fifteen patients(23.40%)with liver cirrhosis presented with hepatic encephalopathy.Patients with liver cirrhosis were more likely than non-cirrhotic patients to have combined ground-glass opacities and consolidations in CT chest scans:28(43.75%)vs 4(6.55%),respectively(P value<0.001).These patients also were more likely to have severe COVID-19 infection,compared to patients without liver cirrhosis:29(45.31%)vs 11(18.04%),respectively(P value<0.003).Mortality was higher in patients with liver cirrhosis,compared to those with no cirrhosis:33(51.56%)vs 9(14.75%),respectively(P value<0.001).All patients in Child-Pugh class A recovered and were discharged.Cirrhotic mortality occurred among decompensated patients only.A multivariate regression analysis revealed the following independent factors affecting mortality:Male gender(OR 7.17,95%CI:2.19–23.51;P value=0.001),diabetes mellitus(OR 4.03,95%CI:1.49–10.91;P value=0.006),and liver cirrhosis(OR 1.103,95%CI:1.037–1.282;P value<0.0001).We found no differences in liver function,COVID-19 disease severity,or outcomes between patients who previously received direct-acting antiviral therapy(and achieved sustained virological response)and patients who did not receive this therapy.CONCLUSION Patients with liver cirrhosis are susceptible to higher severity and mortality if infected with COVID-19.Male gender,diabetes mellitus,and liver cirrhosis are independent factors associated with increased mortality risk. | Shimaa Afify Basem Eysa Fatma Abdel Hamid Omnia M Abo-Elazm Mohamed A Edris Rabab Maher Ahmed Abdelhalim Muhammad Mostafa Abdel Ghaffar Dalia A Omran Hend Ibrahim Shousha | 2021 | World Journal of Gastroenterology2021，27，42： | 2 |
| 9 | Densification of alumina produced by urea formaldehyde sol-gel polymeric route显示文摘 | Ibrahim D M Khalil T Mostafa A A | 1999 | Ceramics International1999，25，3： | 1 |
| 10 | The role of surgery in management of necrotizing enterocolitis显示文摘 | Ehayeb AA Mostafa MM Ibrahim NH | 2010 | Int J Surg2010，8，6： | 1 |
| 11 | The role of surgery in mana-gement of necrotizing enterocolitis显示文摘 | Eltayeb AA Mostafa MM Ibrahim NH | 2010 | Int J Surg2010，8，6： | 1 |
| 12 | The effect of combined spinal-epidural anesthesia versus general anesthesia on the recovery time of intestinal function in young infants undergoing intestinal surgery: a randomized, prospective, controlled trial显示文摘 | Mostafa Somri Ibrahim Matter Constantinos A. Parisinos Ron Shaoul Jorge G. Mogilner David Bader Eldar Asphandiarov Luis A. Gaitini | 2012 | Journal of Clinical Anesthesia2012，，6： | 1 |
| 13 | The role of surgery in management of necrotizing enterocolitis 显示文摘 | Eltayeb AA Mostafa MM Ibrahim NH Eltayeb AA | 2010 | Int J Surg2010，8，6： | 1 |
| 14 | MgO stabilized tialite prepared by urea formaldehyde polymeric route显示文摘 | Ibrahim D M Mostafa A A | 1999 | Br Ceram Trails1999，98，4： | 1 |
| 15 | The role of measuremen! of serum autoantibodies in predietion of pediatric neuropsychiatric systemic lupus erythematosus显示文摘 | Mostafa G A Ibrahim D H Shehab A A | 2010 | J Neuroimmunol2010，227，12： | 1 |
| 16 | Effect of air injection under subsurface drip irrigation on yield and water use efficiency ofcorn in a sandy clay loam soil 显示文摘 | Abuarab M Mostafa E Ibrahim M | 2013 | Journal of Advanced Re- search2013，4，6： | 1 |
| 17 | Analysis of Twitter Data Using Evolutionary Clustering during the COVID-19 Pandemic显示文摘People started posting textual tweets on Twitter as soon as the novel coronavirus(COVID-19)emerged.Analyzing these tweets can assist institutions in better decision-making and prioritizing their tasks.Therefore,this study aimed to analyze 43 million tweets collected between March 22 and March 30,2020 and describe the trend of public attention given to the topics related to the COVID-19 epidemic using evolutionary clustering analysis.The results indicated that unigram terms were trended more frequently than bigram and trigram terms.A large number of tweets about the COVID-19 were disseminated and received widespread public attention during the epidemic.The high-frequency words such as“death”,“test”,“spread”,and“lockdown”suggest that people fear of being infected,and those who got infection are afraid of death.The results also showed that people agreed to stay at home due to the fear of the spread,and they were calling for social distancing since they become aware of the COVID-19.It can be suggested that social media posts may affect human psychology and behavior.These results may help governments and health organizations to better understand the psychology of the public,and thereby,better communicate with them to prevent and manage the panic. | Ibrahim Arpaci Shadi Alshehabi Mostafa Al-Emran Mahmoud Khasawneh Ibrahim Mahariq Thabet Abdeljawad Aboul Ella Hassanien | 2020 | Computers, Materials & Continua2020，，10： | 1 |
| 18 | Biomarkers of Barrett's esophagus显示文摘Barrett's esophagus is the strongest risk for esophageal adenocarcinoma(EAC). Metaplasia in patients with BE may progress to dysplasia and then invasive carcinoma. Well-defined diagnostic, progressive, predictive, and prognostic biomarkers are needed to identify the presence of the disease, estimate the risk of malignant transformation, and predict the therapeutic outcome and survival of EAC patients. There are many predictive and prognostic markers that lack substantial validation, and do not allow stratification of patients with gastroesophageal reflux disease in clinical practice for outcome and effectiveness of therapy. In this short review we summarize the current knowledge regarding possible biomarkers, focusing on the pathophysiologic mechanisms to improve prognostic and therapeutic approaches. | Yasser Mahrous Fouad Ibrahim Mostafa Reem Yehia Hisham El-Khayat | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 1 |
| 19 | An experiment investigatlon on the W-Cu composites显示文摘 | Ibrahim A Abdallah M Mostafa S F | 2009 | Material and Design2009，30，4： | 1 |
| 20 | Densification of alumina produced by urea formaldehyde sol-gel polymeric route显示文摘 | Ibrahim D M Khalil T Mostafa A A | 1999 | Ceramics International1999，25，3： | 1 |
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