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| 1 | Physiopathology of ischemic stroke and its modulation using memantine:evidence from preclinical stroke显示文摘Ischemic stroke is the most common type of cerebrovascular disease and is caused by an interruption of blood flow in the brain.In this disease,two different damage areas are identifying:the lesion core,in which cells quickly die;and the penumbra(surrounding the lesion core),in which cells are functionally weakened but may recover and restore their functions.The currently approved treatments for ischemic stroke are the recombinant tissue plasminogen activator and endovascular thrombectomy,but they have a short therapeutic window(4.5 and 6 hours after stroke onset,respectively)and a low percentage of stroke patients actually receive these treatments.Memantine is an approved drug for the treatment of Alzheimer's disease.Memantine is a noncompetitive,low affinity and use-dependent antagonist of N-methyl-D-aspartate glutamate receptor.Memantine has several advantages over developing a new drug to treat focal ischemic stroke,but the most important is that it has sufficient safe probes in preclinical models and humans,and if the preclinical studies provide more evidence about pharmacological actions in tissue protection and repair,this could help to increase the number of clinical trials.The present review summarizes the physiopathology of isquemic stroke and the pharmacological actions in neuroprotection and neuroplasticity of memantine in the post stroke stage of preclinical stroke models,to illustrate their potential to improve functional recovery in human patients. | Hilda Martínez-Coria Isabel Arrieta-Cruz María-Esther Cruz Héctor E.López-Valdés | 2021 | Neural Regeneration Research2021，16，3： | 8 |
| 2 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 3 | Molecular evlution of influenza A/ H3N2 viruses in the provinces of Quebec(Canada) during the 1997- 2000 period显示文摘 | Isabelle H Yan L Michael B | 2001 | Virus Rese2001，77，： | 1 |
| 4 | A spectral projection method for the simulation of complex three-dimensional rotating flows显示文摘 | Isabelle R Sandrine H Eric H | | 0，，： | 1 |
| 5 | Molecular evlution of influenza AP H3N2 viruses in the provinces of Quebec(Canada)during the 1997-2000 period显示文摘 | ISABELLE H YAN L MICHAEL B | 2001 | Virus Research2001，77，： | 1 |
| 6 | Do all people with schizophrenia receive the 8,-tittle benefit from diferent family intervention programs?显示文摘 | Isabel M Udefonso H Ana A | 2005 | Psychiatry Res2005，33，8： | 1 |
| 7 | Problem size effect in additions and subtraction an event-related potential study显示文摘 | Isabel N M Luisa H M | 2005 | Neuroscience2005，373，： | 1 |
| 8 | Problem size effect in additions nd subtrac- tion an event - related potential study显示文摘 | Isabel N Luisa H | 2005 | Neuroscienee2005，373，： | 1 |
| 9 | Specificity and nucleotyping studies of a gpSO - based polymerase chain reaction assay for detection of Pseudorabies virus 显示文摘 | HARDING M J ISABELLE P H JERZY R | 1997 | Can J Vet Res1997，61，： | 1 |
| 10 | Breast cancer,lactation history, and serum organochlorines显示文摘 | Isabelle R Mauricio H A Eduardo L P | 2000 | American Journal of Epidemiology2000，152，4： | 1 |
| 11 | The Relative Effect of Milk Base, Starter, and Precess on Yogurt Texture显示文摘 | ISABELLE S FLORENT R SAMIA H | 2004 | Critical Reviews in Food Science and Nutrition2004，44，： | 1 |
| 12 | The Arabidopsis BODENLOS gene encodes an auxin response protein inhibi-ting MONOPTEROS-mediated embryo patterning显示文摘 | THORSTEN H EVA B ISABEL B | 2002 | Genes & Development2002，14，13： | 1 |
| 13 | Molecular evolution of influenza A/H3N2 viruses in the provinces of Quebec(Canada)during the 1997-2000 period显示文摘 | Yan L Michael B | 2001 | Virus Res2001，77，1： | 1 |
| 14 | Symple- kin, a constitutive protein of karyo- and cytoplasmic particles involved in mRNA biogenesis in Xenopus laevis oocytes 显示文摘 | ILSE H MARTINA S ISABELLE K | 2000 | Mol Biol Cell2000，13，： | 1 |
| 15 | Molecular evolution of influenza AH3N2 viruses in the provinces of Quebec (Canada) during the 1997 - 2000 period显示文摘 | Isabelle H Yan L Michael B | 2001 | Virus Res2001，77，： | 1 |
| 16 | New insights into the fatty acid-binding protein (FABP) family in the small intestine显示文摘 | Philippe Besnard Isabelle Niot Hélène Poirier Lionel Clément André Bernard | 2002 | Molecular and Cellular Biochemistry2002，，1： | 1 |
| 17 | Distribution and speciation of ambient selenium in contrasted soils, from mineral to organic rich显示文摘 | Julie Tolu Yves Thiry Ma?té Bueno Claudy Jolivet Martine Potin-Gautier Isabelle Le Hécho | 2014 | Science of the Total Environment2014，，： | 1 |
| 18 | Use of HepG2 cell line for direct or indirect mutagens screening:comparative investigation between comet and micronucleus assays显示文摘 | ISABELLE V S LUDOVIC L H JEAN-CLAUDE L | 2003 | Mut Res2003，536，： | 1 |
| 19 | Statistical analysis and spectral estimation techniques for one-dimensional chaotic signals显示文摘 | ISABELLE S H WORNELL G W | 1997 | IEEE Transactions on Signal Process1997，45，6： | 1 |
| 20 | Integrin-linked kinase regulates the nuclear entry of the c-jun coactivatorα-NAC and its coactivation potency显示文摘 | Isabelle Q Claude G Gregory E H | 2004 | J Biol Chem2004，279，43： | 1 |
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