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| 1 | Review:DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis显示文摘Tissue homeostasis requires a carefully-orchestrated balance between cell proliferation, cellular senescence and cell death. Cells proliferate through a cell cycle that is tightly regulated by cyclin-dependent kinase activities. Cellular senescence is a safeguard program limiting the proliferative competence of cells in living organisms. Apoptosis eliminates unwanted cells by the coordinated activity of gene products that regulate and effect cell death. The intimate link between the cell cycle, cellular senes- cence, apoptosis regulation, cancer development and tumor responses to cancer treatment has become eminently apparent. Extensive research on tumor suppressor genes, oncogenes, the cell cycle and apoptosis regulatory genes has revealed how the DNA damage-sensing and -signaling pathways, referred to as the DNA-damage response network, are tied to cell proliferation, cell-cycle arrest, cellular senescence and apoptosis. DNA-damage responses are complex, involving “sensor” proteins that sense the damage, and transmit signals to “transducer” proteins, which, in turn, convey the signals to numerous “effector” proteins implicated in specific cellular pathways, including DNA repair mechanisms, cell-cycle checkpoints, cellular senescence and apoptosis. The Bcl-2 family of proteins stands among the most crucial regulators of apoptosis and performs vital functions in deciding whether a cell will live or die after cancer chemotherapy and irradiation. In addition, several studies have now revealed that members of the Bcl-2 family also interface with the cell cycle, DNA repair/recombination and cellular senescence, effects that are generally distinct from their function in apoptosis. In this review, we report progress in understanding the molecular networks that regulate cell-cycle checkpoints, cellular senescence and apoptosis after DNA damage, and discuss the influence of some Bcl-2 family members on cell-cycle checkpoint regulation. | SCHMITT Estelle PAQUET Claudie BEAUCHEMIN Myriam BERTRAND Richard | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，6： | 17 |
| 2 | ABA-Mediated Inhibition of Germination Is Related to the Inhibition of Genes Encoding Cell-Wall Biosynthetic and Architecture: Modifying Enzymes and Structural Proteins in Medicago truncatula Embryo Axis显示文摘胚根出现和储备动员是被认为控制萌芽的二个不同计划。两个节目被 abscissic 酸(骆驼毛的织物) 影响,但是这荷尔蒙怎么控制种子萌芽,仍然糟糕被知道。Phenotypic 和 Medicago truncatula 的胚胎轴的显微镜的观察在 10 在处于有丝分裂的抑制状况的萌芽期间被触发 ? M oryzalin 证明房间分割没被要求允许胚根出现。镇压减少性的杂交证明在胚胎轴的超过 10% 起来调整的基因编码了与房间墙生合成有关的蛋白质。-expansins, pectin-esterase, xylogucan-endotransglycosidase,纤维素 synthase,和 extensins 的表示在种子的胚胎轴被监视在水上发芽了,经常、临时的骆驼毛的织物。在在控制并且强烈的萌芽的结束由骆驼毛的织物禁止了以前,这些基因是 overexpressed。在种子回来在水上被转移并且继续了到萌芽以后,表示在临时处理的 ABA 被重建。这作为贡献者证明这些基因到萌芽的结束并且加强在胚胎轴在与房间扩大的关系松开并且改变的房间墙是在萌芽的一个决定因素特征的想法。我们的结果也证明那件骆驼毛的织物通过胚根出现的控制控制萌芽,也就是由禁止房间墙松开和扩大。 | Christine Gimeno-Gilles Eric Lelievre Laure Viau Mustafa Malik-Ghulam Claudie Ricoult Andreas Niebel Nathalie Leduc Anis M. Limami | 2009 | Molecular Plant2009，2，1： | 8 |
| 3 | Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): A literature review显示文摘 | Kiran Gupta Jeffrey D. Miller Jim Z. Li Mason W. Russell Claudie Charbonneau | 2007 | Cancer Treatment Reviews2007，，3： | 3 |
| 4 | Fulminant sepsis after liver biopsy:A long forgotten complication?显示文摘We report on a 74-year-old patient with recurrent cholangitis and a large juxtapapillary duodenal diverticulum. Despite drainage of the common bile duct by an endoscopically placed stent, the elevated liver enzymes normalized only partially. To rule out other possible causes of liver injury, a percutaneous liver biopsy was done. After the liver biopsy the patient developed fulminant septic shock and died within 24 h. We discuss the possible causes of the septic shock following percutaneous liver biopsy in our patient and give a concise overview of the literature. | Corinna Claudi Martin Henschel Jürgen Vogel Michael Schepke Erwin Biecker | 2013 | World Journal of Clinical Cases2013，1，1： | 2 |
| 5 | Particular aspects of platinum compounds used at present in cancer treatment显示文摘 | Bernard Desoize Claudie Madoulet | 2002 | Critical Reviews in Oncology and Hematology2002，，3： | 2 |
| 6 | Particular aspects of platinum compounds used at present in cancer treatment显示文摘 | Bernard Desoize Claudie Madoulet | 2002 | Critical Reviews in Oncology and Hematology2002，，3： | 1 |
| 7 | High vacuum DTA-TGA instrumentation for air-sensitive compounds显示文摘 | ASHBY E C CLAUDY P BOUQUET J | 1975 | Journal of Chemical Education1975，52，9： | 1 |
| 8 | Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): A literature review显示文摘 | Kiran Gupta Jeffrey D. Miller Jim Z. Li Mason W. Russell Claudie Charbonneau | 2007 | Cancer Treatment Reviews2007，，3： | 1 |
| 9 | Physicochemical characterization of cholesterolbeta-cyclodexterin inclusion complexes显示文摘 | Claudy P Letoffe JM Germa INP | 1991 | Joumal of Thermal Analysis1991，37，11： | 1 |
| 10 | Crude oils:characterization of waxes precipitated on cooling by dsc and thermomicroscopy显示文摘 | Létoffé J M Claudy P Kok M V | 1995 | Fuel1995，74，6： | 1 |
| 11 | Detection of undegraded fibrin and tumor necrosis factor-alpha in venous leg ulcers显示文摘 | Claudy AL Mirshahim M Soria C | 1991 | J Am Acad Dermatol1991，25，4： | 1 |
| 12 | Comparative study of calcipotriol (MC 903) ointment and betamethasone 17-valerate ointment in patients with psoriasis vulgaris显示文摘 | Cunliffe WJ Berth-Jones J Claudy A | 1992 | J Am Acad Dermatol1992，26，51： | 1 |
| 13 | Splenic Cysts显示文摘 | Mark Berner Hansen Anne Claudi Moller | 2004 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2004，，6： | 1 |
| 14 | Physlopathology of contact dermatitis显示文摘 | Krasteva M Chabeau G Claudy A Nicolas JF | 1995 | J Eur Acad Dermatol Venereol1995，5，2： | 1 |
| 15 | Human macrophages constitut targets for immunotoxic inorganic arsenic 显示文摘 | Anthony Lemariw Claudie Morzadec Emilie Bourdonnay | 2006 | Immunology2006，，177： | 1 |
| 16 | Crude oils: characterization of waxes precipitated on cooling by DSC and tbermomicroscopy显示文摘 | LETOFFE J M CLAUDY P KOK M V | 1995 | Fuel1995，74，6： | 1 |
| 17 | An attempt to clarify the mechanism of the penetration enhancing effects of lipophilic vehicles with diffefential scanning calorimetry 显示文摘 | Bernhard CL | 1995 | J Pharrn Pharrnacol1995，47，： | 1 |
| 18 | Skin cancers in organ transplant recipients显示文摘 | KanitakisJ Euvrard S Claudy A | 2006 | J Am Acad Dermatol2006，54，6： | 1 |
| 19 | Distribution and speciation of ambient selenium in contrasted soils, from mineral to organic rich显示文摘 | Julie Tolu Yves Thiry Ma?té Bueno Claudy Jolivet Martine Potin-Gautier Isabelle Le Hécho | 2014 | Science of the Total Environment2014，，： | 1 |
| 20 | Physicochemical characterization of cholesterol-beta-cyclodexterin inclusion complexes显示文摘 | Claudy P Letoffe J M Germain P | 1991 | Journal of Thermal Analysis1991，37，11： | 1 |
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